Abstract: A Novel Process for Preparing Phosphotidylcholine Paste from soya lecithin liquid/powder. Extracting soya lecithin liquid using ethyl alcohol/isopropyl alcohol in extractor for precipitating out phosphotidylcholine (35 to 95%) as top layer and other phospholipids at bottom and transferring the phosphotidylcholine (35 to 95 %) precipitated/miscella from top layer to a storage vessel; Then distillation of miscella /phosphotidylcholine precipitate of the top layer by passing though a heat exchanger for condensing ethyl alcohol/iso prpopyl alcohol vapors for reuse and recovering phosphotidylcholine (35 to 95%) liquid through a flasher and finally filtering the said phosphotidylcholine (35 to 95%) liquid and storing in a vessel; And extracting phosphotidylcholine (35 to 95%) liquid using acetone/ether in a extractor for settling out phosphotidylcholine (35-95%) precipitate at bottom.
CLIAMS:
1. A Novel Process for Preparing Phosphotidylcholine Paste from soya lecithin liquid/powder comprising following steps
(a) extracting soya lecithin liquid using ethyl alcohol/isopropyl alcohol in extractor for precipitating out phosphotidylcholine (35 to 95%) as top layer and other phospholipids at bottom and transferring the phosphotidylcholine (35 to 95 %) precipitated/miscella from top layer to a storage vessel;
(b) distillation of miscella /phosphotidylcholine precipitate of the top layer by passing though a heat exchanger for condensing ethyl alcohol/iso prpopyl alcohol vapors for reuse and recovering phosphotidylcholine (35 to 95%) liquid through a flasher;
(c) filtering the said phosphotidylcholine (35 to 95%) liquid and storing in a vessel;
(d) extracting phosphotidylcholine (35 to 95%) liquid using acetone/ether in a extractor for settling out phosphotidylcholine (35-95%) precipitate at bottom.
2. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein the said lecithin liquid/ powder and the lecithin liquid is added slowly in the extractor under continuous stirring for about six hours and then settled for about an hour.
3. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein the said phosphotidylcholine (35 to 95%) liquid and said acetone/ether is taken in ration of 1:10 w/w and the said phosphotidylcholine (35 to 95%) liquid is added slowly for about an hours under continues stirring for about 4 hours maintaining temperature of 25-30 C at atmospheric pressure and then settle for about half an hour.
4. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein in the acetone used is distilled acetone and recycled after extraction and distillation.
5. A Novel Process for Preparing Phosphotidylcholine Paste of preparing phosphotidylcholine (35 to 95%) paste from soya lecithin liquid/powder substantially as here in described.
,TagSPECI:
FORM 2
THE PATENT ACT 1970
(39 of 1970) &
The Patents Rules, 2003
COMPLETE SPECIFICATION
(See section 10 and rule 13)
1. TITLE OF THE INVENTION
A Novel Process for Preparing Phosphotidylcholine Paste
2. APPLICANT (S)
(a) Nabros Pharma Private Limited
(b) Nabros Tower Opposite Art Galary,
Behind British Library, Law Garden,
Ellisbridge, Ellisbridge, Ahmedabad,
Gujarat 380006
(c) Indian
The following specification particularly describes the invention and the manner in which it is to be performed.
A Novel Process for Preparing Phosphotidylcholine Paste
Field of the Invention
The present invention relates to process of preparing phosphotidylcholine paste as phosphotidylcholine (35 % to 95%) from soya lecithin, which is more effective and very much useful for food and drug preparation specially considering low cholesterol level necessary for C of liver cirhosis and related to Hepataties B, Hepatatis C and different liver treatment.
Background of the Invention
Phosphotidylcholine is a chemical contained in eggs, soybeans, mustard, sunflower, and other foods. Particular embodiments of this invention incorporate various known solvent-based separation methods using the solvent systems here disclosed to be most effective in this novel application. Specific phospholipids can be extracted in high purity from mixtures of phospholipids derived from egg yolks, soya beans or other sources because of the different degrees of solubility of the phospholipids in the solvent used. The term "phosphotidylcholine" is sometimes used interchangeably with "lecithin," although the two are different. Choline is a component of phosphotidylcholine, which is a component of lecithin. Although closely related, these terms are not the same. Because the body uses phosphotidylcholine to make a brain chemical called acetylcholine, there is some interest in using it for treating “brain-centered” conditions such as memory loss, Alzheimer’s disease, anxiety, manic-depressive disorders, and a movement disorder called tardive dyskinesia. Phosphatidylcholine is also used for treating hepatitis, eczema, gallbladder disease, circulation problems, high cholesterol, and premenstrual syndrome (PMS); for improving the effectiveness of kidney dialysis; for boosting the immune system; and for preventing aging. Healthcare providers sometimes give phosphotidylcholine intravenously (by IV) for chest pain, fat globules in the blood (fat embolism), high cholesterol, liver disease, and fatty plaque deposits in arteries. Phosphotidylcholine is injected under the skin (subcutaneously) for treating non-cancerous fatty tumors (lipomas), excess fat around the eyelids, and yellowish cholesterol deposits just under the surface of the skin (xanthelasmas). Phosphotidylcholine is the primary active ingredient contained in cosmetic injection products used to "dissolve" fat. These products include Lipodissolve, Lipolight, Lipolyse, Lipotherapy, and others. Some cosmetic centers in several countries initially imported a prescription intravenous drug product from Germany known as Lipostabil. They used it subcutaneously for cosmetic purposes; however, the manufacturer of this product does not promote it for this use due to lack of reliable evidence.
To overcome such limitation in the present invention phosphotidylcholine paste (35 % to 95%) is obtain by extraction process form soybens which is more effective and useful for drug preparation.
Object of the Invention
The main object of the present invention is advantageous in that it is both less time consuming and less costly than other known methods.
The further main objection of this inventor is provide process of in preparing phosphotidylcholine paste (35 to 95%) from soya powder/lecithin liquid which is more effective in food and drug preparation specifically considering low cholesterol level necessary for all types of liver treatment.
The invention is more effective and useful for drug preparation and food preparation from soya powder/lecithin liquid which is more effective for all types of liver treatment.
Summary of the Invention
The present invention relates to process of preparing phosphotidylcholine paste as phosphotidylcholine (35 % to 95%) from soya lecithin, which is more effective and very much useful for food and drug preparation specially considering low cholesterol level necessary for C of liver cirhosis and related to Hepatatis B, Hepatatis C and different liver treatment.
The main object of the present invention is advantageous in that it is both less time consuming and less costly than other known methods.
The further main objection of this inventor is provide process of in preparing phosphotidylcholine paste (35 to 95%) from soya powder/lecithin liquid which is more effective in food and drug preparation specifically considering low cholesterol level necessary for all types of liver treatment.
The invention is more effective and useful for drug preparation and food preparation from soya powder/lecithin liquid which is more effective for all types of liver treatment
BRIEF DESCRIPTION OF THE DRAWINGS
It will be convenient to further describe the present invention with respect to the accompanying drawings that illustrate possible arrangements of the invention. Other arrangements of the invention are possible, and consequently the particularity of the accompanying drawings is not intended to be limiting of the present invention.
Fig.1 process flow diagram of the present invention method
Detailed description of the invention
Before explaining the present invention in detail, it is to be understood that the invention is not limited in its application to the details of the construction and arrangement of parts illustrated in the accompanying drawings. The invention is capable of other embodiments, as depicted in different figures as described above and of being practiced or carried out in a variety of ways. It is to be understood that the phraseology and terminology employed herein is for the purpose of description and not of limitation.
The present invention provides process of preparing phosphotidylcholine paste (35- 95%) comprising the following steps.
- Extracting soy lecithin liquid/powder using isopropyl alcohol in extractor precipitating out using 100 kg of isopropyl alcohol and 20 Kg of soya lecithin powder/liquid in dissolve and one hour for the settlement.
- 1 hour stirring of miscella in vessel than steady keep in another vessel where there is settlement of rest of the phospholipids and etc.
- Distillation of the same miscella the paste precipitated of the top layer by passing through heat exchange for considering alcohol vapors for reuse and recovering phosphotidylcholine paste through a flasher.
- Put it in cold room for 24 hours at 50C temperature
- Mud should be taken as residue. After taking form the cold room.
- Maintain again the balance mud/residue in the liquid also should be settle for another 12 hours.
- After that again balanced alcohol should take in vaccum.
- Wash the mad for 4-5 times with alcohol and collect the residue during each washing. Everything should be in roto operator. The again distillation and get pure alcohol.
- After distillation paste should being the body of roto operator.
- Then remove the alcohol.
- Then again distill with alcohol in the roto and paste will be inside the roto operator wall.
- Then keep it for 6 hours in 45 C
- After removing alcohol keep the paste (35 to 95%) in outside bucket and then 5 to 6 times wash with acetone where remaining all oil will be removed.
- Recover acetone in the vessel after that the phosphotidylcholine paste (35 to 95%) should be put again in the vessel by putting 10 liter alcohol dissolved it, filter it and after that put in roto operator and recover the alcohol and the balanced paste in the vessel as final paste which is consider to be depended upon the mixing of lecithin liquid/power with the percentage of phosphotidyl choline and paste will be form accordingly (35 to 95%)
- Keep it and storage as final product in 2-8 C temperature in plastic bag which is away from light.
While, the invention has been described with respect to the given embodiment, it will be appreciated that many variations, modifications and other applications of the invention may be made. However, it is to be expressly understood that such modifications and adaptations are within the scope of the present invention, as set forth in the following claims.
I CLAIM:
1. A Novel Process for Preparing Phosphotidylcholine Paste from soya lecithin liquid/powder comprising following steps
(a) extracting soya lecithin liquid using ethyl alcohol/isopropyl alcohol in extractor for precipitating out phosphotidylcholine (35 to 95%) as top layer and other phospholipids at bottom and transferring the phosphotidylcholine (35 to 95 %) precipitated/miscella from top layer to a storage vessel;
(b) distillation of miscella /phosphotidylcholine precipitate of the top layer by passing though a heat exchanger for condensing ethyl alcohol/iso prpopyl alcohol vapors for reuse and recovering phosphotidylcholine (35 to 95%) liquid through a flasher;
(c) filtering the said phosphotidylcholine (35 to 95%) liquid and storing in a vessel;
(d) extracting phosphotidylcholine (35 to 95%) liquid using acetone/ether in a extractor for settling out phosphotidylcholine (35-95%) precipitate at bottom.
2. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein the said lecithin liquid/ powder and the lecithin liquid is added slowly in the extractor under continuous stirring for about six hours and then settled for about an hour.
3. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein the said phosphotidylcholine (35 to 95%) liquid and said acetone/ether is taken in ration of 1:10 w/w and the said phosphotidylcholine (35 to 95%) liquid is added slowly for about an hours under continues stirring for about 4 hours maintaining temperature of 25-30 C at atmospheric pressure and then settle for about half an hour.
4. A Novel Process for Preparing Phosphotidylcholine Paste as claimed in claim 1 wherein in the acetone used is distilled acetone and recycled after extraction and distillation.
5. A Novel Process for Preparing Phosphotidylcholine Paste of preparing phosphotidylcholine (35 to 95%) paste from soya lecithin liquid/powder substantially as here in described.
For,
Nabros Pharma Private Limited
________________________
Shah Navnit Mulchand
| # | Name | Date |
|---|---|---|
| 1 | 2826-MUM-2014-US(14)-HearingNotice-(HearingDate-01-12-2020).pdf | 2021-10-03 |
| 1 | FORM28 [10-09-2015(online)].pdf | 2015-09-10 |
| 2 | 2826-MUM-2014-NBA Approval Submission [03-03-2021(online)].pdf | 2021-03-03 |
| 2 | EVIDENCE FOR SSI [10-09-2015(online)].pdf | 2015-09-10 |
| 3 | FORM-5.pdf | 2018-08-11 |
| 3 | 2826-MUM-2014-Annexure [07-12-2020(online)].pdf | 2020-12-07 |
| 4 | FORM-3.pdf | 2018-08-11 |
| 4 | 2826-MUM-2014-Response to office action [07-12-2020(online)].pdf | 2020-12-07 |
| 5 | FORM-26.pdf | 2018-08-11 |
| 5 | 2826-MUM-2014-PETITION UNDER RULE 137 [01-12-2020(online)].pdf | 2020-12-01 |
| 6 | FORM 2final.pdf | 2018-08-11 |
| 6 | 2826-MUM-2014-RELEVANT DOCUMENTS [01-12-2020(online)].pdf | 2020-12-01 |
| 7 | fig.pdf | 2018-08-11 |
| 7 | 2826-MUM-2014-Correspondence to notify the Controller [30-11-2020(online)].pdf | 2020-11-30 |
| 8 | 2826-MUM-2014-FER.pdf | 2019-06-19 |
| 8 | 2826-MUM-2014-ABSTRACT [04-12-2019(online)].pdf | 2019-12-04 |
| 9 | 2826-MUM-2014-CLAIMS [04-12-2019(online)].pdf | 2019-12-04 |
| 9 | 2826-MUM-2014-OTHERS [04-12-2019(online)].pdf | 2019-12-04 |
| 10 | 2826-MUM-2014-DRAWING [04-12-2019(online)].pdf | 2019-12-04 |
| 10 | 2826-MUM-2014-FER_SER_REPLY [04-12-2019(online)].pdf | 2019-12-04 |
| 11 | 2826-MUM-2014-DRAWING [04-12-2019(online)].pdf | 2019-12-04 |
| 11 | 2826-MUM-2014-FER_SER_REPLY [04-12-2019(online)].pdf | 2019-12-04 |
| 12 | 2826-MUM-2014-CLAIMS [04-12-2019(online)].pdf | 2019-12-04 |
| 12 | 2826-MUM-2014-OTHERS [04-12-2019(online)].pdf | 2019-12-04 |
| 13 | 2826-MUM-2014-ABSTRACT [04-12-2019(online)].pdf | 2019-12-04 |
| 13 | 2826-MUM-2014-FER.pdf | 2019-06-19 |
| 14 | 2826-MUM-2014-Correspondence to notify the Controller [30-11-2020(online)].pdf | 2020-11-30 |
| 14 | fig.pdf | 2018-08-11 |
| 15 | 2826-MUM-2014-RELEVANT DOCUMENTS [01-12-2020(online)].pdf | 2020-12-01 |
| 15 | FORM 2final.pdf | 2018-08-11 |
| 16 | 2826-MUM-2014-PETITION UNDER RULE 137 [01-12-2020(online)].pdf | 2020-12-01 |
| 16 | FORM-26.pdf | 2018-08-11 |
| 17 | 2826-MUM-2014-Response to office action [07-12-2020(online)].pdf | 2020-12-07 |
| 17 | FORM-3.pdf | 2018-08-11 |
| 18 | FORM-5.pdf | 2018-08-11 |
| 18 | 2826-MUM-2014-Annexure [07-12-2020(online)].pdf | 2020-12-07 |
| 19 | EVIDENCE FOR SSI [10-09-2015(online)].pdf | 2015-09-10 |
| 19 | 2826-MUM-2014-NBA Approval Submission [03-03-2021(online)].pdf | 2021-03-03 |
| 20 | FORM28 [10-09-2015(online)].pdf | 2015-09-10 |
| 20 | 2826-MUM-2014-US(14)-HearingNotice-(HearingDate-01-12-2020).pdf | 2021-10-03 |
| 1 | SearchStrategy_04-06-2019.pdf |