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A Novel Process For Purification Of Tacrolimus Using A New Polymer Resin And Copper Salts
Abstract: The invention is a novel process for purification of Tacrolimus using a new polymer resin and copper salts containing cupric ions. The novel polymer resin contains polyviny1 pyrrolidone, metha acrylate diviny1 benzene based compounds. In the said process manufacturing of a new polymer resin and use of cupric salt is very much cost effective. The same metal salts can also be used along with other neutral non-ionic adsorption resins of polyethylene i.e. HP20, HP20SS, Sepabeads SP207 and the like. The concentration of copper ions may be generally 0.20 to 1.5 mo1/L, preferably 0.30 to 0.40 mol/L. As an aqueous medium for the copper ion containing aqueous solvent, an aqueous acetone, an aqueous alcohol, an aqueous acetonitrile or the like.
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