FIELD OF THE INVENTION
The present invention relates with a novel process towards make the product through the
materials of Vitex peduncularis in addition of ammonium chloride, lime, edible sugar, black salt,
East Indian arrowroot powder, borax powder, lemon extract, acetic acid, black pepper and
menthol which have maintained the quality and efficacy of plant materials relates to formulation
of synergistic preparation and having many advantages to keep shining of plant materials and
particularly quality as such colour up to 18- 24 months and avoid to contamination. The
inventive processes of preparation of additive ingredients are novel and synergistic composition
making unexpected efficacious of the plant materials.
BACKGROUND OF THE INVENTION WITH REGARD TO PRIOR ART
There are large numbers of plant.species which have potent action in crude from. However, there
are a great problem to prepare products from the plants. It is due to technical difficulties of
efficacy during long period of storage of plant materials for manufacturing of products and
maintaining the quality. Therefore, there are great need to invent methods of process for maintain
quality of raw materials for long term use.
The plant Vitex peduncularis Wallich ex Schaeur is a medium sized tree belonging to family
Verbenaceae. There is evidence that the stem bark, root bark and leaves (The British Medical
journal February 5, 1921; 186-188) of Vitex peduncularis is useful as anti malarial and for the
treatment of black water fever and as diuretic. The most popular name of the plant in Bihar,
Jharkhand, Bengal and adjoining state is 'Charaigorwa', 'Minjurgorwa', 'Simjanga' etc. The
fresh stem bark extract 4-6 teaspoonful every four hours found about as effective as leaf
infusions.

The document related to earlier studies carried out on the plant Vitex peduncularis have also
shown their efficacy as analgesic activity (Kumar, K. 2006. Final Technical Report, Ministry of
Environment & Forests, Govt, of India, New Delhi, Project F. No. 14/48/2001- RE page no. 67).
The studies of 125 years of malaria research shows significant result from the leaves of the plant
(www.mrcindia.org/conf/abstracts/8pdf, page no. 55).
The compound vitexin (Bheemshankar Rao, Ch. and Venkiteswarlu, 1956, Current Science 25:
328) is present in the plant.
A patent no 3130/DEL/2005 published on 02/10/2009 Journal No. 40/2009 entitled, "Bioactive
water fraction from Vitex peduncularis" wherein the bioactive water fraction obtained from the
leaves useful for the malaria.
The antioxidant activities of dried stem bark {Journal of Tropical Medicinal Plants 2004, 5(2):
217-219) while leaf and stem extract on different organic solvent observed anti bacterial
{International journal of pharmacy and pharmaceutical science, 2012 4(4): 177-180), Iridioides
with anti- inflammatory activity {Planta medica, 2002; 68: 72-73), ameliorative effect {Journal
of Herbal Medicine 2014; 4(3): 115-174). has been reported.
There are many unexplored phytocomponents might be present having responsible for such kind
of activity. However, there are not any products or lesser product in the market based on the
above plant material which claims for the antimalerial, antipyretic and analgesic. It is due to
singly the plant ingredients have fewer efficacies in comparison with other products for the same
purpose. But, now till days in best of the knowledge of inventor there are lesser products in the
market which is prescribed by the physicians.

The vast problems related to the plant are to maintain the efficacy during long term storage. Like
many other plants the leaves and barks when keep in storage lost the quality. As the fresh
infusion and extract is important for the therapeutic purpose. The maximum percentage of
available market chemical preservatives sometime hazardous for health having toxicity and does
not have therapeutic properties.
Hence, there are need to invent novel process to glean the properties of plant materials and the
present invention fulfills the need. The inventive processes of preparation of additive ingredients
are novel and synergistic composition making unexpected efficacious of the plant materials.
Indeed, the fresh leaves and barks decoction and infusion used as antipyretic and other related
complications. The invention deals about the long term maintenances of quality of leaves and
bark of the plant for use after harvesting during storage from safe ingredients without any strong
chemical based pesticides or insecticides.
OBJECT OF THE INVENTION
The objective of invention is to invent not any kind of mere admixture; but an admixture
resulting into synergistic properties of a mixture they differ significantly in properties with
regard to their efficacy as the plant materials of fresh leaves and bark of Vitex peduncularis
keeping in quality and for long period use as efficacious.
Another important objective of invention is to make the composition useful for manufacturing in
decoction, syrup, tablets and prepare beverage from the coarsely powder.

Yet another objective is to invent the best proportion and ratio of ingredients in composition.
Another objective is to invent better process from the suitable ingredients in an admissible
quantity which are safe.
Still another objective is to make the composition very much effective would useful for the
product.
An object of the present invention is novel process comprises with the present invention
synergistic composition of ingredients and admixture resulted to keep the dried coarse powder of
leaves and bark of Vitex peduncularis materials effective up to 18-24 months processed towards
synergistic properties of by an inventive additives mixture 2-3 % for bark while 4-6 % for leaves
comprises in the total wt. with ammonium chloride, lime, edible sugar, black salt, East Indian
arrowroot powder, borax, lemon extract, acetic acid, black pepper and menthol in the ratio of
0.3 %: 1.2 %: 20 %: 18.5 %: 17 %: 0.5 %: 15 %: 2 %: 21 %: 4.5 % in accordance to plant
materials.
Yet in another object of the novel process of raw materials of leaves and powder as claim in 1
wherein to keep as coarse powder for preparation of decoction, tablets, syrup is of for all variety
e.g. Vitex peduncularis like var. roxburghiana and var. peduncularis.
One of the objects is novel process with synergistic formulation as claim in 1 wherein the
processes of raw materials of leaves and bark both are separately efficacious and admixture of
same quantity.

Important object of a novel process to prepare raw materials in the form of coarsely powder as
claim in 1 wherein with synergistic formulation from the process of raw materials of leaves and
bark both efficacious in good storage and packaging condition and keep away from direct
sunlight, moist palaces, loose container and related conditions.
STATEMENT OF THE INVENTION
In accordance of the present invention the of process the plant materials of Vitex peduncularis to
keep as good quality materials for long term use to avoid absorbing moisture, tolerant of variable
temperature during storage and packaging for preparation efficacious products/formulation
involving innovative steps as synergistic composition. The plant products particularly leaves and
bark of Vitex peduncularis have significance as antipyretic and analgesic. The present invention
is related to a novel composition along with several other ingredients which is found much
effective due to synergistic and having utility in syrup formulation, making tablets and powder as
products. The ratio of composition is invention which is not only as admixture; but indeed
observed suitable for preparation of products and shown highly potent therapeutic action
specially fever, cough, cold and relief from body pain etc. through inventive process.
A novel process under the present invention consists the synergistic composition of ingredients
and admixture resulted to keep the coarse powder of leaves and bark of Vitex peduncularis
materials effective up to 18-24 months processed through the synergistic properties of by the
virtue of an inventive mixture 4-7 % comprises out of total wt. with ammonium chloride, lime,
edible sugar, black salt, East Indian arrowroot powder, borax powder, lemon extract, acetic acid,
black pepper and menthol selected from safe components and have suitable for the process of
plants..

SUMMARY OF THE INVENTION
The present invention relates to process and synergistic formulation from the leaves and bark of
Vitex peduncularis have significance as antipyretic, anti-inflammatory, antimicrobial and other
related properties. However, to make product or formulation there are great difficulties to
maintain their efficacy for long term during storage. The green leaves may collect after rainy
season. During spring and summer the leaves fells down and become curled. Hence, in the
present invention the leaves and bark materials of the above plant along with suitable ingredients
have been processed with safe composition named to make efficacious and synergistic and to
keep long period up to two years.. The materials after the composition invented in the present
invention have been processed through novel method. The.aims of the invention are to avoid any
kind of insecticides and pesticides which although preserve the product but could not enhance
the activity. The novel admixture which has synergistic effective for the above purpose up to two
years by an inventive mixture 4-7 % comprises out of total wt. with ammonium chloride, lime,
edible sugar, black salt, East Indian arrowroot powder, borax powder, lemon extract, acetic acid,
black pepper and menthol.

4. DETAIL DESCRIPTION OF THE INVENTION (Description shall start from next
page)
The plant materials processed have maintaining the quality of efficacy for one and. half year to
two years and having no detonation. The raw materials of Vitex peduncularis mainly leaf and
stem bark / root barks processed with selected ingredients in the composition which has
unexpected significant results. The whole preparation as composition when powdered it has
wide utility to make decoction, syrup formulation, tablets and beverages. The leaves and barks of
Vitex peduncularis treated separately. The different composition ratios along with ingredients are
presented in various examples.
In an embodiment of the present invention total materials the leaves of shade dried coarsely
powdered leaves processed with 2-3 % ingredients of admixture while 4-6 % in bark.
In an embodiment the present invention of innovative admixture of percentage are ammonium
chloride (0.3%), lime (1.2%), edible sugar (20%), black salt (18.5%), East Indian arrowroot
powder (17%), borax (0.5%), lemon extract (15%) acetic acid (2%), black pepper (21%) and
menthol (4.5%).
In an embodiment the leaves are processed separately and methods of processing of barks are
quite different but the materials of admixture are quite same with different proportion.
In an embodiment the present invention for process of raw materials of leaves and powder to
keep as coarse powder for preparation of decoction, tablets, syrup is of for all variety e.g. Vitex
peduncularis like var. roxburghiana and van peduncularis.
Yet in another embodiment during the process of addition of mixture in different steps the
calculation of different materials is in accordance to total weight of plant materials.

Yet in an embodiment a novel process with synergistic formulation as claim in 1 wherein the
process of raw materials of leaves and bark are separately efficacious and admixture of same
quantity are of same effect.
The process of plant materials are as follows wherein:
Leaves of Vitex peduncularis
a) Freshly collected mature leaves, brushed in fresh water to remove foreign particles.
Shade dried the materials or in drier marinating room temperature only.
b) Crushed to make the dried leaves in to small pieces and weighed of known quantity for
processing.
c) The materials crushed in to coarsely powder and weighed for a known quantity.
d) The ammonium chloride and lime weighed in calculation of whole admixture added in
the materials to prepare coarse powder of leaves and heated in stainless still container for
30 minute in 25°C. The lime is used as hydrated lime.
e) In the material as in (d) the edible sugar, black salt and East Indian arrowroot powder are
mixed in coarse powder and dipped in hot water and dried.
f) The material (e) mixed with borax powder and lemon extract and left for 2-3 days in a
closed container.
g) The coarse powder as obtained is mixed with the acetic acid and left for 8 to 10 hours.
h) The fine powder of black peeper and menthol mixed with above material (g) utilize for
storage in closed container and packaging.

Barks either from stems or roots or both of Vitex peduncularis
a) Freshly collected bark without any damaging of the stem, roots or plant of tree either
from root or stem or both washed in running water to remove foreign particles.
b) Crushed the materials into small pieces and shade dried.
c) The materials crushed in to coarsely powder and weighed for a known quantity.
d) In above materials (c) the materials of ammonium chloride, lime, edible sugar and
black salt mixed separately as calculated their amount for known weight.
e) The preparation heated in a stainless steel tank in 25-30° C.
f) The East Indian arrowroot powder, borax powder, lemon extract processed and
mixed with materials on as above (e) and left for 10 hours.
g) The proportion of acetic acid and black pepper properly mixed the materials as
obtained in (f) and heated in 20- 25° C.
h) The processed materials completely left for 10-12 hours.
i) The obtained materials as on (h) mixed with menthol and ready for the storage and
standard packaging in a closed container particularly stainless steel.

In an embodiment the clinically efficacy reports after observing pharmacological action it has
been found that 90.2 % - 91% have benefited in pyrexia while 93- 94 % in headache and body
pain during fever, 80.3 % - 85% for cough and cold who have used the processed materials in
accordance to the present invention at the dosage of decoction of preparation 5-10 ml./ 2 gm
powder twice in a day up to 4 days and varies in accordance of plant materials leaves and bark .
Yet in clinical evaluation there are not any side effects and not any symptom appears while the
patients are from 16-70 age groups irrespective with sex and religions.
Yet, in one important embodiment the processed materials of the leaves and bark as invented
observed fresh without contamination up to 18- 24 months in good packaging and storage
condition.

ADVANTAGES OF THE INVENTION
1. The present invention provides A novel process for the Vitex peduncularis plant materials
and synergistic formulation thereof.
2. The material of leaves and bark of the plant stored in 18-24 months without any kind of
loss of efficacy during storage.
3. There are safe ingredients used for process of plants materials as coarse powder material
to keep effective without any side effect in inventive preparation and process as invented
through the invention.
4. There is not any synthetic colorant or hazardous chemical used.
5. The invention has great significant for formulation safe and efficacious product and wide
industrial use.
The present invention as described above, it is to be understood that this invention is not limited
to particular methodologies and materials described, as these may vary as per the person skilled
in the art. It is also to be understood that the terminology used in the description is for the
purpose of describing the particular embodiments only, and is not intended to limit the scope of
the present invention.
Therefore, the foregoing is considered as illustrative only of the principles of the invention.
Further, since numerous modifications and changes will readily occur to those skilled in the art,
it is not desired to limit the invention to the exact formulation as described, and accordingly, all
suitable modifications and equivalents may be resorted to, falling within the scope of the
invention.

I CLAIM:
1. A novel process comprises with the present invention synergistic composition of
ingredients and admixture resulted to keep the dried coarse powder of leaves and
bark of Vitex peduncularis materials effective up to 18-24 months processed
towards synergistic properties of by an inventive additives mixture 2-3 % for bark
while 4-6 % for leaves comprises in the total wt. with ammonium chloride, lime,
edible sugar, black salt, East Indian arrowroot powder, borax, lemon extract,
acetic acid, black pepper and menthol in the ratio of 0.3 %: 1.2 %: 20 %: 18.5 %:
17 %: 0.5 %: 15 %: 2 %: 21 %: 4.5 % in accordance to plant materials.
2. A novel synergistic for formulation relates to the process as claim in 1 wherein is
for relieve from, fever, body pain, cough and cold.
3. A novel process of raw materials of leaves and powder as claim in 1 wherein to
keep as coarse powder for preparation of decoction, tablets, syrup is of for all
variety e.g. Vitex peduncularis like var. roxburghiana and var. peduncularis).
4. A novel process with synergistic formulation involving the step and methodology
for the plant materials as claim in 1 wherein:
Leaves of Vitex peduncularis
a) Freshly collected mature leaves, brushed in fresh water to remove foreign
particles.
Shade dried the materials or in drier marinating room temperature only.
b) Crushed to make the dried leaves in to small pieces and weighed of known
quantity for processing.
c) The materials crushed in to coarsely powder and weighed for a known quantity..
d) The ammonium chloride and lime weighed in calculation of whole admixture
added in the materials to prepare coarse powder of leaves and heated in stainless
still container for 30 minute in 25°C. The lime is used as hydrated lime.
e) In the material as in (d) the edible sugar, black salt and East Indian arrowroot
powder are mixed in coarse powder and dipped in hot water and dried.
f) The material (e) mixed with borax powder and lemon extract and left for 2-3

days in a closed container.
g) The coarse powder as obtained is mixed with the acetic acid and left for 8 to 10
hours.
h) The fine powder of black peeper and menthol mixed with above material (g)
utilize for storage in closed container and packaging.
Barks either from stems or roots or both of Vitex peduncularis
a) Freshly collected bark without any damaging of the stem, roots or plant of tree
either from root or stem or both washed in running water to remove foreign
particles.
b) Crushed the materials into small pieces and shade dried.
c) The materials crushed in to coarsely powder and weighed for a known quantity.
d) In above materials (c) the materials of ammonium chloride, lime, edible sugar
and black salt mixed separately as calculated their amount for known weight.
e) The preparation heated in a stainless steel tank in 25-30° C.
f) The East Indian arrowroot powder, borax powder, lemon extract processed and
mixed with materials on as above (e) and left for 10 hours.
g) The proportion of acetic acid and black pepper properly mixed the materials as
obtained in (f) and heated in 20- 25° C.
h) The processed materials completely left for 10-12 hours.
i) The obtained materials as on (h) mixed with menthol and ready for the storage
and standard packaging in a closed container particularly stainless steel.
5) A novel synergistic process with formulation comprises with ammonium chloride,
lime, edible sugar, black salt, East Indian arrowroot powder, borax lemon extract,
acetic acid, black pepper and menthol in the ratio of as claim in 1.
6) A novel process with synergistic formulation as claim in 1 wherein the preparation of
decoction, tablets, syrup from coarse powder and as such processed coarse powder is
efficacious.
7) A novel process with synergistic formulation as claim in 1 wherein the preparation of
decoction, tablets, syrup from coarse powder and as such processed coarse powder is
efficacious, safe and have no side effects.

8) A novel process with synergistic formulation as claim in 1 wherein the process of raw
materials of leaves and bark both are separately efficacious and admixture of same
quantity.
9) A novel process to prepare raw materials in the form of coarsely powder as claim in
1 wherein with synergistic formulation from the process of raw materials of leaves
and bark both efficacious in good storage and packaging condition and keep away
from direct sunlight, moist palaces, loose container and related conditions.
10) A novel synergistic efficacious process for formulation is only for oral use and not
for any kind of topical application.