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A Pharmaceutical Composition To Combat Artemisinin Resistance In Malaria
Abstract: The present disclosure relates to a pharmaceutical composition to combat artemisinin resistance in malaria with the identification of Plasmodium falciparum (Pf) glutamine synthetase (GS) as a drug target. Pf GS is important for maintaining asparagine levels in the parasite and promote protein synthesis. Since ART-resistant parasites undergo fitness loss in amino acid/nutrient-limiting conditions and GS levels are upregulated during ART exposure, targeting Pf GS and asparagine requirement can be harnessed to prevent ART resistance. The present disclosure also provides a method of suppressing the growth of Plasmodium falciparum and a method of treating malaria using GS inhibitors.
Notices, Deadlines & Correspondence
Patent Information
Applicants
Institute of Life Sciences
Inventors
1. VISWANATHAN ARUN NAGARAJ
2. GOVINDARAJAN PADMANABAN
3. SOURAV GHOSH
4. RAJIB KUNDU
5. MANJUNATHA CHANDANA
6. ADITYA ANAND
Specification
DESC:Please see the attachment ,CLAIMS:Please see the attachment
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202231018911-STATEMENT OF UNDERTAKING (FORM 3) [30-03-2022(online)].pdf | 2022-03-30 |
| 2 | 202231018911-PROVISIONAL SPECIFICATION [30-03-2022(online)].pdf | 2022-03-30 |
| 3 | 202231018911-POWER OF AUTHORITY [30-03-2022(online)].pdf | 2022-03-30 |
| 4 | 202231018911-FORM FOR SMALL ENTITY(FORM-28) [30-03-2022(online)].pdf | 2022-03-30 |
| 5 | 202231018911-FORM 1 [30-03-2022(online)].pdf | 2022-03-30 |
| 6 | 202231018911-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [30-03-2022(online)].pdf | 2022-03-30 |
| 7 | 202231018911-EDUCATIONAL INSTITUTION(S) [30-03-2022(online)].pdf | 2022-03-30 |
| 8 | 202231018911-DECLARATION OF INVENTORSHIP (FORM 5) [30-03-2022(online)].pdf | 2022-03-30 |
| 9 | 202231018911-Proof of Right [28-05-2022(online)].pdf | 2022-05-28 |
| 11 | 202231018911-Sequence Listing in PDF [29-03-2023(online)].pdf | 2023-03-29 |
| 12 | 202231018911-FORM 18 [29-03-2023(online)].pdf | 2023-03-29 |
| 13 | 202231018911-DRAWING [29-03-2023(online)].pdf | 2023-03-29 |
| 14 | 202231018911-CORRESPONDENCE-OTHERS [29-03-2023(online)].pdf | 2023-03-29 |
| 15 | 202231018911-COMPLETE SPECIFICATION [29-03-2023(online)].pdf | 2023-03-29 |
| 16 | 202231018911-FORM 3 [30-03-2023(online)].pdf | 2023-03-30 |
| 17 | 202231018911-Request Letter-Correspondence [20-04-2023(online)].pdf | 2023-04-20 |
| 18 | 202231018911-Covering Letter [20-04-2023(online)].pdf | 2023-04-20 |
| 19 | 202231018911-FER.pdf | 2024-12-23 |
| 20 | 202231018911-FORM 3 [25-02-2025(online)].pdf | 2025-02-25 |
| 21 | 202231018911-FER_SER_REPLY [04-06-2025(online)].pdf | 2025-06-04 |
| 22 | 202231018911-CLAIMS [04-06-2025(online)].pdf | 2025-06-04 |
Search Strategy
| 1 | 202231018911E_18-11-2024.pdf |