Description:FIELD OF THE INVENTION
The present invention relates to a polyherbal spray for wound healing. The present invention in particular relates to a polyherbal spray comprising, extracts of different parts of couorupita guianensis, extracts of different parts of Citrus sinensis, and other suitable ingredients.
BACKGROUND OF INENTION
One of the greatest barriers to the establishment of infection by pathogenic bacteria in internal tissues is a wound caused by the disruption of skin and it is also called injury and trauma. Example includes burn, skin puncture and boil, accidental or surgical wound.
Infection can occur if bacteria breach this barrier. Infectious diseases kill people all around the world. Antibiotic resistance has become an international issue. So, it is necessary to treat a wound because it will be the reason for death.
Wounds come in a wide variety of types and causes, and health care providers define them in a variety of ways. They might be chronic, like diabetic skin ulcers, or acute, like a gunshot wound or an animal bite. Wounds can be open or closed, depending on whether the skin has been weakened and the underlying tissues have been exposed (e.g. a bruised rib or cerebral contusion).
Acute wounds are classified into eight categories by emergency professionals and first-aid personnel:
Abrasions: Scrapes are caused by friction against another rough surface rubbing the skin away (e.g. rope burns and skinned knees)
Avulsions: When a complete structure or a portion of it is violently ripped out, such as a permanent tooth or an ear lobe, this occurs. Avulsions can be caused by explosions, bullets, or animal bites.
Contusions: These injuries, often known as bruises, occur when a violent trauma injures an internal structure without breaking the skin. Contusions can be caused by blunt instrument blows to the chest, abdomen, or head (e.g., a football or a fist).
Crush injuries: When a heavy object falls on a person, the skin splits and the underlying structures break or rip.
Cuts: Cutting wounds with a sharp knife to leave even edges They could be as minor as a paper cut or as major as a surgical incision.
Lacerations: These dividing wounds, often known as rips, produce ragged edges. They are caused by a massive force acting on the body, either from within the body, as in childbirth, or from outside the body, as in a punch.
Missile injuries: They're also known as velocity wounds, and they're caused by a fast-moving projectile, usually a bullet, penetrating the body.
Punctures: Sharp things like nails, knives, and broken glass cause deep, narrow wounds.
Acute wounds are the most common type of wound. An disruption of the wound healing process is the most common way for a wound to become chronic. Acute wounds proceed without incident through hemostasis, inflammation, proliferation, and remodelling. During the inflammatory stage, when body is fighting to defend the damage site and jumpstart the healing process, wounds become chronic.
Chronic wounds are more likely to occur in people who have one or more of the following conditions:
• Diabetes, High cholesterol levels,
• Serious burns,
• Cancer,
• HIV/AIDS,
• Chronic medical problems,
• Vascular problems,
• Heart problems,
• Hypertension,
• Atherosclerosis,
• Anemia
• Veins varicose,
• Thrombosis of the deep veins,
• Elderly,
• Immobility,
• Obesity,
• Smoking and a poor diet are examples of unhealthy lives,
• Sedentary behavior,
• Ulcerative colitis in the past,
• Several operations,
• Bed rest,
• Immune system dysfunction,
• Occupational hazards such as radiation exposure or lengthy durations of sitting.
When bacteria, for example, thrive within the damaged skin of a wound, it causes an infection. Increased discomfort, swelling, and redness are all possible symptoms. Nausea, chills, and fever are common symptoms of more serious diseases.
A tiny cut or infection may usually be treated at home by a person. Small wounds, such as minor cuts and scratches, can typically be treated safely at home. Most tiny wounds will progressively improve with adequate treatment until they totally heal. However, if a wound becomes infected, it may worsen rather than improve. The intensity of any pain, redness, or swelling will usually rise.
Other symptoms associated with wound infections include:
Warm skin surrounding the area,
yellow or green discharge,
an unpleasant odour from the lesion,
red streaks on the skin around the wound,
fever and chills,
pains and aches,
nausea,
vomiting
When bacteria enter the wound and multiply, cuts, grazes, and other breaks in the skin can become infected. Bacteria could have come from the injured person's skin, the surroundings, or the instrument that caused the injury.
Infection of the wound is more likely if:
The wound is huge, deep, or jagged in appearance,
dirt or other objects got into the wound,
The wound was caused by a bite from an animal or another person,
by an injury caused by a dirty, rusted, or contaminated instrument.
Infection can also be exacerbated by certain medical disorders and environmental factors. Among them are:
Diabetes,
poor blood circulation,
a weakened immune system, such as in people living with HIV or those taking immunosuppressive medications,
a lack of mobility, such as in people who spend most of their time in bed,
advancing age - older adults are more susceptible to wound infection,
nutrient and vitamin deficiencies
If a wound infection is not treated, it can spread to other parts of the body, causing major problems such as:
Cellulitis: it is an infection that affects the skin's deeper layers and tissues, causing swelling, redness, and pain in the affected area. Fever, disorientation, nausea, and vomiting are some of the other symptoms.
Osteomyelitis: Pain, redness, and swelling around the affected area are indications of osteomyelitis, a bacterial infection of the bone. Other symptoms associated with osteomyelitis include fatigue and fever.
Sepsis: When an infection enters the bloodstream, sepsis is a severe immunological reaction that can ensue. Sepsis is a life-threatening condition that can cause multiple organ failure. According to the CDC Trusted Source, sepsis kills over 270,000 people in the United States each year.
Necrotizing fasciitis: It is an uncommon disorder that arises when a bacterial infection spreads deep beneath the skin to a tissue called the facial lining. Necrotizing fasciitis is a medical emergency that causes significant skin damage and discomfort, as well as the potential for the infection to spread throughout the body.
Treatment which is used art this time foe wound healing purpose is either ointment or cream or anti-biotics which has so many disadvantages and also there is no patient compliance.
There is a need of designed dosage form in an appropriate dosing and to overcome these problems of patient compliance.

To overcome the above stated problems the inventors of the present invention surprisingly found that a poly herbal spray with appropriate range of the natural drugs extracts can be used in wound healing treatment. The objective of the present inventions is discussed below.

OBJECTIVE OF THE INVENTION
The main objective of the invention is to provide a poly herbal spray for wound healing.
The other objective of the invention is to provide a poly herbal spray which is a herbal remedy for wound infection.
The objective of the invention is to provide a poly herbal spray which is safe and effective in the treatment of wound infections.
Yet another objective of the invention is to provide a poly herbal spray which is free from chemicals and synthetic compounds.
Another object of the present invention is that it does not have undesirable side effects.
Yet another object of the present invention is to provide effective and low cost method for treatment of wounds.
SUMMARY OF THE INVENTION
This summary is provided to introduce a selection of concepts in a simplified format that are further described in the detailed description of the invention.
This summary is not intended to identify key or essential inventive concepts of the invention, nor is it intended for determining the scope of the invention
The main aspect of the invention is to provide a poly herbal spray for wound healing.
Another aspect of the invention is to provide a poly herbal spray comprising extracts of different parts of Couroupita Guianensis, extracts of different parts of Citrus Sinensis and other suitable ingredients.
The poly herbal spray formulation of the present invention contains the presence of alkaloids, terpenoids, flavanoids, tannins, saponins, reducing sugar, amino acids in juice and extract.
The main embodiment of the invention is to provide a poly herbal spray of 100ml of total weight, comprising 1% to 95% of Fruit pulp extract of Couroupita Guinensis, 1% to 25% range of Fruit Peel extract of Couroupita Guinensis, 1% to 45% range of extract of Reproductive part of Couroupita Guinensis , range of 1% to 55% extract of flower of Couropita Guinensis. range of 1% to 55% extract of peel of Citrus sinensis and range of 1% to 55% extract of fruit juice of Citrus sinensis and other supportive ingredients.
According to an embodiment of the present invention, the formulation is effective for wound healing caused by bacterial strain including Staphylococcus aureus, Pseudomonas aeruginosa, Escheresia coli and Kelbsiella pneumonia
To the accomplishment of the foregoing and related ends, certain illustrative aspects of the disclosure are described herein in connection with the following description. These aspects are indicative, however, of but a few of the various ways in which the principles of the disclosure can be employed and the subject disclosure is intended to include all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description of the disclosure.
To further clarify advantages and features of the present invention, a more particular description of the invention will be rendered by reference to specific embodiments thereof. It is appreciated that this drawing depicts only typical embodiments of the invention and are therefore not to be considered limiting its scope. The invention will be described and explained with additional specificity and detail
DESCRIPTION OF THE INVENTION
For the purpose of promoting an understanding of the principles of the invention, reference will be described in specific language. It will be understood by those skilled in the art that the foregoing general description and the following detailed description are explanatory of the invention and are not intended to be restrictive thereof.
Reference throughout this specification to “an aspect”, “another aspect” or similar language means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one 10 embodiment of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described.
As used herein, whether in a transitional phrase or in the body of a claim, the terms “comprise(s)” and “comprising” are to be interpreted as having an open-ended meaning. That is, the terms are to be interpreted synonymously with the phrases “having at least” or “including at least”. When used in the context of a process, the term “comprising” means that the process includes at least the recited steps, but may include additional steps. When used in the context of a composition, the term “comprising” means that the composition includes at least the recited features or components, but may also include additional features or components.
As used herein, the singular forms “a,” “an” and “the” specifically also encompass the plural forms of the terms to which they refer, unless the content clearly dictates otherwise.
The term “about” is used herein to means approximately, in the region of, roughly, or around. When the term “about” is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the numerical values set forth. In general, the term “about” or “approximately” is used herein to modify a numerical value above and below the stated value by a variance of 20%.
The main embodiment of the invention is to provide a poly herbal spray comprising extracts of different parts of Couroupita Guianensis, extracts of different parts of Citrus Sinensis and other suitable ingredients.
According to one other embodiment the weight of the poly herbal Spray is 100ml to 150ml, preferably the weight of the poly herbal spray is 100ml to 130ml, more preferably the weight of the poly herbal spray is 100ml to 120, most preferably the weight is 100ml.
Couroupita guianensis (Cannon ball) is a huge deciduous tropical tree native to the Amazon rainforest that grows to be 90 feet tall. The leaves are simple with a serrate edge and grow up to 6" long; it blooms in racemes with yellow, crimson, and pink flowers that are aromatic. Flowers are enormous, waxy aromatic smelling flowers that grow directly on the trunk's bark, measuring 3" to 5" in diameter (cauliflory).
Fruits are enormous globose woody balls that dangle in clusters like balls on a thread and resemble big rusty cannonballs. Small seeds are contained in a white, foul-smelling edible goo. Containers and utensils are made from the hard shells. In Sri Lankan Buddhist culture, cannon ball flowers have a special significance. It's known as Nagalingam flower in Tamil Nadu.
The sivalingam shape is visible in the flower's centre, and snake-shaped pollen is the flower's specialty. It also has a pleasant fragrance. Shiva Pooja can be performed using this unique flower. The plant is native to the rainforests of Northeastern South America's Guianas; it's a favourite ornamental in Caribbean and Southeast Asian botanic gardens, and it's classified as a rare tree and flower in India.
It can give us various activities like Antimicrobial or antibacterial activity, antioxidant activity, antiulcer activity, anticancer activity, antidepressant activity, analgesic & anti-inflammatory activity, antifertility activity, antimycobacterial activity, antibiolim activity, antifungal activity, antipyretic activity, anxiolytic activity, immunomodulatory activity, neuropharmacological activity, wound healing activity, antiarthritic activity, antistress activity, antidiarrheal activity, ovicidal, antinociceptive activity, antifeedent & larvacidal activity etc.
According to the preferred embodiment the Couroupita Guianensis fruit pulp extract is in range from 1% to 95%, preferably the range is 20% to 90%, more preferably the range is 30% to 85%, more preferably the range is 40% to 80%, most preferably the range is 50% to 78%.
According to the preferred embodiment the Couroupita Guianensis fruit peel extract is in range from 1% to 25%, preferably the range is 1% to 20%, more preferably the range is 1% to 15%, more preferably the range is 1% to 10%, most preferably the range is 1% to 8%.

According to one preferred embodiment the Couroupita Guianensis flower reproductive part extract is in range from 1% to 25%, preferably the range is 1% to 20%, more preferably the range is 1% to 15%, more preferably the range is 1% to 10%, most preferably the range is 1% to 8%.
According to one preferred embodiment the Couroupita Guianensis flower petal is in range from 1% to 55%, preferably the range is 1% to 40%, more preferably the range is 1% to 30%, more preferably the range is 1% to 20%, most preferably the range is 1% to 10%.
Citrus sinensis belongs to family Rutaceae. It is a tiny evergreen tree that can grow to be up to 7.5 metres tall, and in extreme cases up to 15 metres tall. It originated in Southern China, where it has been cultivated for many years, but it is now grown commercially in tropical and semi-tropical countries, as well as certain warm temperate zones, making it the world's most frequently planted fruit tree.
Orange tree leaves are leathery and Evergreen, ranging in form from elliptical to rectangular to oval, 6.5-15 cm long and 25-9.5 cm broad, with narrow wings on the petioles. It has fragrant white flowers with 5 petals and 20-25 yellow stamens that bloom alone or in whorls of 6, about 5 cm wide.
The little white or purple flowers Nectar is produced by scented hermaphroditic flowers for insect pollination. The fruit is globose to oval in shape, measuring 6.5 to 9.5 cm in diameter and turning orange or yellow as it ripens.
The pericarp, also known as the peel, skin, or rind, and the endorcarp, or pilp and juice sacs, are two different parts of the fruit. The epidermis of epicuticular wax with numerous tiny aromatic oil glands gives the skin its distinctive odour and having different activities like Antibacterial or antimicrobial activity, antifungal activity, antiparasitic activity, antiprofilerative activity, antioxidant activity, hypocholesterolemic activity, anti-obesity activity, activity in cardiovascular system , anti-osteoporotic activity, protective of UV activity, relaxant ,sedative and anxiolytic activities, insecticidal activity, etc.
According to one preferred embodiment the Citrus Sinensis peel extract is in range from 1% to 55%, preferably the range is 1% to 40%, more preferably the range is 1% to 30%, more preferably the range is 1% to 20%, most preferably the range is 1% to 10%.
According to one preferred embodiment the Citrus Sinensis juice extract is in range from 1% to 55%, preferably the range is 1% to 40%, more preferably the range is 1% to 30%, more preferably the range is 1% to 20%, most preferably the range is 1% to 10%.
Other supportive agents are used in the formulation to make good and effective formulation and for supporting active ingredients or natural drugs in the formulation.
The main embodiment of the invention is to provide a poly herbal spray of 100ml of total weight, comprising 1% to 95% of Fruit pulp extract of Couroupita Guinensis, 1% to 25% range of Fruit Peel extract of Couroupita Guinensis, 1% to 45% range of extract of Reproductive part of Couroupita Guinensis , range of 1% to 55% extract of flower of Couropita Guinensis. range of 1% to 55% extract of peel of Citrus sinensis and range of 1% to 55% extract of fruit juice of Citrus sinensis and other supportive ingredients.
, Claims:CLAIMS
We claim
1. A polyherbal spray for wound healing comprising the extracts of different parts of couroupita guianensis, Citrus sinensis and suitable ingredients, wherein all the extracts contains alkaloids, terpenoids, flavanoids, tannins, saponins, reducing sugar Ami no acids in juice and extract.
2. The polyherbal spray for wound healing as claimed in claim 1, wherein the fruit pulp extract of Couropita guianensis is in range from 1% to 95%.
3. The polyherbal spray for wound healing as claimed in claim 1, wherein the fruit peel extract of Couropita guianensis is in range from 1% to 25%.
4. The polyherbal spray for wound healing as claimed in claim 1, wherein the reproductive part extract of Couropita guianensis is in range from 1% to 45%.
5. The polyherbal spray for wound healing as claimed in claim 1, wherein the flower petal extract of Couropita guianensis is in range from 1% to 55%.
6. The polyherbal spray for wound healing as claimed in claim 1, wherein the peel extract of the Citrus sinensis is in range from 1% to 55%.
7. The polyherbal spray for wound healing as claimed in claim 1, wherein the juice extract of Citrus sinensis is in range from 1% to 55%.
8. The polyherbal spray for wound healing as claimed in claim 1, wherein the suitable ingredients like water, permission enhancer, and other is used.
9. The polyherbal spray for wound healing as claimed in claim 1, wherein the pulp, petal and reproductive part extract of Couropita guianensis and peel and juice extracts of Citrus sinensis have wound healing, anti bacterial amd antifungal activity which inhibits the growth of bacteria and prevent the formation of microbial colonies.
10. The polyherbal spray for wound healing as claimed in claim 1, wherein the formulation is effective on bacterial strain including staphylococcus aureus, pseudomonas aeruginosa, Escheresia coli and kelbsiella pneumoniae.