TECHNICAL FIELD
[001] The subject matter described herein in general relates to the field of cosmetic and health care products, and in particular to the field of delivery system for increasing bio-availability.
BACKGROUND OF INVENTION
[002] Extracts of the Indian neem tree (Azadirachta indica) has been used as a insecticide for years, to which the insects have not developed a resistance. Among many available secondary metabolites of neem, azadirachtin a tetranortriterpenoid limonoid isolated from the seed kernels, is the major compound with exceptional biological activities at very low residual power. Although azadirachtin finds its application in various fields including hygiene care, personal care, home care medicine, and organic farming (EP1191851 Bl), the delivery of azadirachtin to the target area has been a challenge. This is because azadirachtin has poor solubility in aqueous solution; and undergoes rapid degradation upon exposure to sunlight and heat (J. B. Stokes etal., J. Environ. Sci. Health, A17(l), 57-65 (1982). [003] Conventional methods such as physical and chemical modifications, particle size reduction, crystal engineering, inclusion complex, pH have been adopted to enhance the stability, and aqueous solubility of azadirachtin till date (Savjani K.T etal. ISRN Pharm. 2012; 2012: 195727). For example, US 4,556,562 discloses improvement in storage properties of azadirachtin in aqueous ethanol emulsions by adjusting the concentration of azadirachtin in the range 2000 to 4000 ppm and adjusting the pH in the range 3.5 to 6.0.
[004] Certain other conventional methods include the use of organic solvents which as carriers for delivery of azadirachtin to the target area. However, the use of such carriers in large scale formulations is rather limited, since most of the solvents degrade azadirachtin. Liposomal encapsulation of azadirachtin in is yet another method that permits sustained, controlled release, and higher loading capacity for poor water-soluble actives with enhanced bioavailability and reduced degradation. (Zhao L etal, Colloids and Surfaces B: Biointerfaces, 2012, 97, 101-108) SUMMARY OF THE INVENTION

[005] In an aspect of the present invention, there is provided a polymeric micellar
composition comprising: a) azadirachtin; b) at least one first polymer; and c) at
least one second polymer, wherein azadirachtin to the at least one first polymer to
the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to
1:0.5:3.4.
[006] In another aspect of the present invention, there is provided a process for
preparing a polymeric micellar composition comprising: a) obtaining azadirachtin;
b) obtaining at least one first polymer; c) obtaining at least second polymer; and d)
contacting azadirachtin, the at least one first polymer, the at least one second
polymer, to obtain the polymeric micellar composition, wherein azadirachtin to the
at least one first polymer to the at least one second polymer weight ratio is in the
range of 1:0.3:0.25 to 1:0.5:3.4.
[007] These and other features, aspects, and advantages of the present subject
matter will be better understood with reference to the following description and
appended claims. This summary is provided to introduce a selection of concepts in
a simplified form. This summary is not intended to identify key features or
essential features of the claimed subject matter, nor is it intended to be used to limit
the scope of the claimed subject matter.
BRIEF DESCRIPTION OF THE DRAWINGS
[008] The detailed description is described with reference to the accompanying
figures. The same numbers are used throughout the drawings to reference like
features and components.
[009] Figures 1A and IB illustrate confocal microscopic images of the polymeric
micellar composition, in accordance with an implementation of the present subject
matter.
[0010] Figure 2 illustrates stability of polymeric micellar composition, in
accordance with an implementation of the present subject matter.
[0011] Figure 3 illustrates static release profile of polymeric micellar composition,
in accordance with an implementation of the present subject matter.
DETAILED DESCRIPTION OF THE INVENTION

[0012] Those skilled in the art will be aware that the present disclosure is subject to
variations and modifications other than those specifically described. It is to be
understood that the present disclosure includes all such variations and
modifications. The disclosure also includes all such steps, features, compositions,
and compounds referred to or indicated in this specification, individually or
collectively, and any and all combinations of any or more of such steps or features.
Definitions
[0013] For convenience, before further description of the present disclosure,
certain terms employed in the specification, and examples are delineated here.
These definitions should be read in the light of the remainder of the disclosure and
understood as by a person of skill in the art. The terms used herein have the
meanings recognized and known to those of skill in the art, however, for
convenience and completeness, particular terms and their meanings are set forth
below.
[0014] The articles "a", "an" and "the" are used to refer to one or to more than one
(i.e., to at least one) of the grammatical object of the article.
[0015] The terms "comprise" and "comprising" are used in the inclusive, open
sense, meaning that additional elements may be included. It is not intended to be
construed as "consists of only".
[0016] Throughout this specification, unless the context requires otherwise the
word "comprise", and variations such as "comprises" and "comprising", will be
understood to imply the inclusion of a stated element or step or group of element or
steps but not the exclusion of any other element or step or group of element or
steps.
[0017] The term "including" is used to mean "including but not limited to".
"Including" and "including but not limited to" are used interchangeably.
[0018] Ratios, concentrations, amounts, and other numerical data may be presented
herein in a range format. It is to be understood that such range format is used
merely for convenience and brevity and should be interpreted flexibly to include
not only the numerical values explicitly recited as the limits of the range, but also

to include all the individual numerical values or sub-ranges encompassed within
that range as if each numerical value and sub-range is explicitly recited.
[0019] The term "at least one" is used to mean one or more and thus includes
individual components as well as mixtures/combinations.
[0020] The term "active loading" refers to a method for loading the active or drug
into a drug delivery system, such as a polymeric micelle. In this method, the
internalization of the active, i.e., azadirachtin, into the preformed polymeric
micelles is typically driven by a transmembrane pH gradient. The pH outside the
polymeric micelle allows some of the active to exist in unionized form, because of
which the active can migrate across the lipid bilayer. Once inside the polymeric
micelle, the active becomes ionized due to the differing pH and becomes trapped
inside the polymeric micelle.
[0021] The term "encapsulation efficiency" is the measure of the amount of
drug/composition that ends up encapsulated in the polymer as opposed to lost in the
aqueous solution.
[0022] Azadirachta indica, i.e., the neem, plant which is original from Myanmar
and the arid regions of the Indian subcontinent, present from India to Indonesia, has
been introduced throughout the tropical region of the globe. It is extensively used
in several areas, such as medicine, veterinarian medicine, farming, pharmacy,
cosmetic and furniture industry, plant reforestation, and the like. It is a tree which
is tolerant to the most adverse culture conditions (high temperatures, poor and
saline soils, etc.), which is one of the factors that justifies its quick spread all over
the world.
[0023] Neem properties are due to many secondary metabolites, mainly triterpenes
and limonoids, available in many parts of the plant. Among such compounds,
emphasis is given to azadirachtin, main constituent of the plant and of commercial
formulations. Azadirachtin is a limonoid which is mostly concentrated in the fruits,
although it can be found in lesser amounts all over the plant.
[0024] Unless defined otherwise, all technical and scientific terms used herein have
the same meaning as commonly understood by one of ordinary skill in the art to
which this disclosure belongs. Although any methods and materials similar or

equivalent to those described herein can be used in the practice or testing of the disclosure, the preferred methods, and materials are now described. All publications mentioned herein are incorporated herein by reference. [0025] The present disclosure is not to be limited in scope by the specific embodiments described herein, which are intended for the purposes of exemplification only. Functionally-equivalent products, compositions, and methods are clearly within the scope of the disclosure, as described herein. [0026] As mentioned previously, azadirachtin suffer from poor aqueous solubility and stability. Conventional methods for enhancing the stability and aqueous solubility of azadirachtin was by making physical and chemical modifications, particle size reduction, crystal engineering, inclusion complex, use of organic solvents as carriers for delivery of azadirachtin to the target area. However, the use of such carriers in large scale formulations is rather limited since most of the solvents degrade azadirachtin. The present disclosure attempts to solve the said problem by using a making a polymeric micellar composition which encapsulates azadirachtin and allows effective delivery of said azadirachtin. [0027] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4. In another embodiment of the present disclosure, the at least one active to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.35:0.4 to 1:0.45:3.2.
[0028] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4. In another embodiment of the present disclosure, the at least one active to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.4 to 1:0.4:3.2.

[0029] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein the at least one first polymer is polyvinylpyrrolidone. Polyvinylpyrrolidone is the homopolymer of N-vinyl-2-pyrrolidone, with a K value of 12 to 90. The K value is an index for correlating relative viscosity with the average degree of polymerization. In an embodiment, the at least one first polymer is polyvinylpyrrolidone having K values selected from a group consisting of K12, K15, K17, K25, K30, K40, K60, K90, or a mixture thereof. In another embodiment, the at least one first polymer is polyvinylpyrrolidone having K values of 40.
[0030] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone. [0031] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone. [0032] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide. In other words, the at least one second polymer is a poloxamer. Generally, poloxamers are the hydrophilic co¬polymer of ethylene oxide is sandwiched between the hydrophobic chains of propylene oxide. The varying length of polymer blocks giving rise to different polymers identified as 124, 188, 237, 338 407 showing a slight difference in their properties. In another embodiment, the at least one second polymer is poloxamer 407.
[0033] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first

polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide.
[0034] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide.
[0035] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000. In another embodiment of the present disclosure, the at least one second polymer has an average molecular weight in range of 38,000 to 41,000.
[0036] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0037] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0038] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, wherein the at least one first polymer is polyvinylpyrrolidone, and

wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0039] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0040] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one second polymer is copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0041] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one second polymer is copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0042] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.

[0043] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
[0044] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4. In another embodiment, azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8. In yet another embodiment, the azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6. In yet another embodiment, azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.
[0045] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4. [0046] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4. [0047] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide.

[0048] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide. [0049] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8. [0050] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is copolymer of ethylene oxide and propylene oxide. [0051] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6. [0052] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide. [0053] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.

[0054] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide. [0055] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 -25 % with respect to the composition. In another embodiment of the present disclosure, there is provided a polymeric micellar composition comprising, a) azadirachtin having a weight percentage in range of 0.002 - 9 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.004 - 1 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.004 - 16 % with respect to the composition.
[0056] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4
[0057] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in

range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4.
[0058] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4.
[0059] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4.
[0060] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one

second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4. [0061] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4. [0062] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4.
[0063] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to

the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4.
[0064] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4.
[0065] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8.
[0066] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8.

[0067] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8.
[0068] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6.
[0069] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6.
[0070] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in

range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6.
[0071] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.
[0072] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.
[0073] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the
1 "7

composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.
[0074] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%. In another embodiment, the composition has an encapsulation efficiency in the range of 91.28 - 99.87% [0075] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0- 99.9%.
[0076] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0- 99.9%.
[0077] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.

[0078] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.
[0079] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.
[0080] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.
[0081] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in

range of 0.001 -25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.
[0082] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%.
[0083] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 -99.9%.
[0084] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in

range of 0.001 -25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 -99.9%.
[0085] In an embodiment of the present disclosure, there is provided a polymeric micellar composition as described herein, wherein the composition has an active loading in the range of 6.0 to 9.0%. In another embodiment, the composition has an active loading in the range of 6.15 - 8.88%.
[0086] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0087] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0088] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and

propylene oxide, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0089] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0090] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0091] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0092] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first

polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0093] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin; b at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9%, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0094] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0095] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in

range of 0.001 -25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0096] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an active loading in the range of 6.0 to 9.0%. [0097] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 to 99.9%, and wherein the composition has an active loading in the range of 6.0 to 9.0%.

[0098] In an embodiment of the present disclosure, there is provided a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 -25 % with respect to the composition, and wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein the composition has an encapsulation efficiency in the range of 91.0 to 99.9%, and wherein the composition has an active loading in the range of 6.0 to 9.0%.
[0099] In an embodiment of the present disclosure, there is provided a formulation comprising: i) the polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer; wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4. and ii) at least one excipient. In an embodiment of the present disclosure, the at least one excipient is selected from the group consisting of diluent, carrier, emulsifying agent, photo stabilizer, neutralizer, preservative, and combinations thereof.
[00100] In an embodiment of the present disclosure, there is provided a formulation comprising: i) the polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer; wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4. and ii) at least one excipient. In an embodiment of the present disclosure, the at least one excipient is selected from the group consisting of diluent, carrier, emulsifying agent, photo stabilizer, neutralizer, preservative, and combinations thereof.

[00101] In an embodiment of the present disclosure, there is provided a formulation comprising: i) the polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer; wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4. and ii) at least one excipient selected from the group consisting of diluent, carrier, emulsifying agent, photo stabilizer, neutralizer, preservative, and combinations thereof. [00102] In an embodiment of the present disclosure, there is provided a formulation comprising: i) the polymeric micellar composition comprising: a) azadirachtin; b) at least one first polymer; and c) at least one second polymer; wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4. and ii) at least one excipient selected from the group consisting of diluent, carrier, emulsifying agent, photo stabilizer, neutralizer, preservative, and combinations thereof. [00103] In an embodiment of the present disclosure, there is provided a process for preparation of a polymeric micellar composition comprising the steps of: a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00104] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin; and b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00105] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin; and b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in

the range of 1:0.4:0.25 to 1:0.4:3.4, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00106] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin; and b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone; and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00107] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin; and b) at least one first polymer; and c) at least one second polymer, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone; and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00108] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer

weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00109] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00110] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrollidone; and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.

[00111] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrollidone; and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00112] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00113] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with

respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00114] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00115] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at

least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00116] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00117] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.

[00118] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00119] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.

[00120] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00121] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin,

the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.
[00122] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, and wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00123] In an embodiment of the present disclosure, there is provided a process for preparing a polymeric micellar composition comprising: a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition; b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4, and wherein the at least one first polymer is polyvinylpyrrolidone, and wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide, and wherein the composition has an encapsulation efficiency in the range of 91.0 - 99.9 %, and wherein the composition has an active loading in the range of 6.0 to 9.0%, and

wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000, and wherein said process comprising the steps of a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition. [00124] In an embodiment of the present disclosure, there is provided a formulation as described herein, wherein the composition is dispensed in a form selected from bio-insecticidal formulations. In another embodiment of the present disclosure, the formulation is dispensed in the form of liquid formulations. EXAMPLES
[00125] The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may apply. [00126] As described earlier, azadirachtin poor solubility, making them poor candidates for medicinal applications. Conventional methods for enhancing the stability and aqueous solubility of azadirachtin was by making physical and chemical modifications, particle size reduction, crystal engineering, inclusion complex, use of organic solvents as carriers for delivery of azadirachtin to the target area. However, the use of such carriers in large scale formulations is rather limited since most of the solvents degrade azadirachtin. The present disclosure aims to solve the said problem encapsulating the azadirachtin in a polymeric micellar composition comprising copolymer of ethylene oxide and propylene oxide and polyvinylpyrrolidone at a definite weight ratio. Surprisingly, polymeric

micelles were found to increase the cellular uptake and bioavailability of azadirachtin when compared to free azadirachtin. MATERIALS AND AMETHODS
[00127] Azadirachtin 40% enriched neem seed kernel extract was used for encapsulation. Azadirachtin or aza can be sourced from well-known commercial vendors and converted to a value-added composition as described in the present disclosure. Polyvinylpyrrolidone 40 (PVP40) was purchased from Sigma, USA. Poloxamer 407 (poloxamer) was purchased from BASF India Limited, ethanol and acetonitrile (HPLC grade) were purchased from Fisher Scientific, India. Example 1: Preparation of polymeric micellar composition [00128] The ingredients, namely azadirachtin (aza), PVP40 (first polymer), and poloxamer (second polymer), were independently obtained and mixed together in identified ratios (as described herein) to obtain the micellar composition. The polymeric micelles can be prepared using known methods in the art, such as solvent casting, thin-film processing, single-step solid dispersion method and thin-film dispersion. The various concentration used for preparation were listed in Table 1. The azadirachtin loaded polymeric micelles solution were stored at room temperature for further use.
Table 1: Concentration of azadirachtin, poloxamer 407 (second polymer), and polyvinylpyrrolidone 40 (first polymer), used for the micellar preparation.

36

Example 2: Morphology analysis
[00129] Subsequent to synthesis as mentioned in Example 1, the micelles were suitably investigated for morphological analysis. A Zeiss LSM 710 confocal laser scanning microscopy (CLSM) was used to investigate the structure and morphology of the micelles. All confocal fluorescence pictures were obtained using 40x objective oil immersion, laser line 488 nm, Laser power 2%, Grain 809, image size 512x512 (8bit), Zoom 1, pinhole 32 uN. The software used for the CLSM imaging was Zeiss 2010.
[00130] The structural morphology of azadirachtin loaded polymeric micelles were examined by CLSM (Table 2 below). Visualization of azadirachtin loaded micellar preparation using confocal laser scanning microscopy 40x which are formed at critical concentration of micellization and forming a three-dimensional network as shown in Figure 1A and IB. Mixed shape (tubes and spherical, Experiment code A and B of Table 1) is shown in Figure 1A. Globular structure (experiment code C, D, E and F of Table 1) was observed in Figure IB is loaded with azadirachtin. A uniform morphology is considered beneficial for commercial applications as the structure-activity relationship can be thoroughly examined. Hence, the samples C-F were found to be satisfactory.
Table 2- Morphological analysis of azadirachtin loaded micellar preparation using confocal laser scanning microscopy.


Example 3: Stability
[00131] Appropriate amount of azadirachtin loaded micelles were dissolved in Milli Q water and stored at room temperature and monitored periodically (once a week; for 2 months) for any changes in appearance. Once the hydrophobic molecules are completely solubilized in the core of the micelle, no precipitation will be observed. Any change in the appearance of the solution indicates instability. The observations have been shown in Figure 2. Appearance of free azadirachtin (also referred to as aza) dissolved in ethanol (first from left; aza) is provided for comparison. The Aza micelles (compositions provided in Table 2) were prepared were tested. The ratios of azadirachtin to polyvinylpyrrolidone to poloxamer for 1A,2B, 3C, 4D, 5E, and 6F are 1:0.4:0.1, 1:0.4:0.2, 1:0.4:0.4, 1:0.4:0.8, 1:0.4:1.6, and 1:0.4:3.2, respectively. No change was observed in the appearance of the aqueous solution containing the micellar compositions even after 2 months, which clearly indicates that loaded-azadirachtin was retained inside the micelles without disruption at room temperature over an extended period of time. Thus, highlighting the long-term stability of the micellar composition. Example 4: Determination of drug loading entrapment efficiency [00132] Drug loading (DL %) and encapsulation efficiency % (EE) of the Aza micelles were estimated using high performance liquid chromatography (HPLC; Agilent 1200 with PDA Detector). Briefly, an appropriate amount of Aza micelles was dissolved in required volume of methanol. Then 20uL of the mixture was chromatographed in to HPLC consisting of an auto sampler using the isocratic mobile phase of water: acetonitrile in the ratio 70:30. The flow rate was set at 1 mL/rnin with Inertsil ODS 3V, 250*4.6mm, 5um column, the oven temperature was set at 45°C and a run time of 30 min. The detection wave-length for Aza was set at 215 nm, and the elution time for Aza was 28.8 min under chromatographic conditions described above.
[00133] Drug loading (DL %) and encapsulation efficiency (EE %) of the Aza micelles were calculated using the equation (a) and (b) below:

Active
Active — loading (DL%) = —— * 100 (a)
{Polymer + Active)
T-, i ,. i-r r ■ ■ ^i-.i-.n/\ Experimental active loadinq „ _._. ,, N
Encapsulation — Efficiency (EE%) = * 100 (b)
Theoritical active loading
[00134] DL% and EE % of the azadirachtin loaded polymeric micelles were summarized in Table 3 below. Aza loaded micelles prepared by thin-film hydration method, showed maximum DL% (8.88 %.) and EE % (99.87%) when compared to 5 other ratios.
Table 3- Summary of azadirachtin loading parameter into polymeric micelles.

Example 5: Static release of azadirachtin micelles
[00135] The dissolution study was carried out in 100 ml conical flasks containing 10 the dissolution media (0.1% Tween 20 solution in distilled water) with the closure caps which were incubated at 35°C. Appropriate amount of aza micelles from different formulation were taken in the dissolution media. At definite interval, the conical flasks were shaken well, and a 100 ul aliquot was taken for the analysis of analysis of aza content using UV spectrophotometer at 214 nm. Experiments were 15 performed in triplicate.
[00136] Aza release from the micelles into the medium was influenced by number of physio-chemical parameters including the nature of the medium, temperature and so on. The static release rate of aza from the micelles prepared with different

ratios of Poloxamer 407 and PV40, by hydration method, has been presented in Figure 3. Concentration of the copolymers plays a major role in releasing the actives into the environment. It was observed that greater the loading of azadirachtin into the micelles, higher is the release rate. The release rate of three representative micelles prepared at the ratio 1:0.4:0.1 (EE%-66.35), 1:0.4:0.8 (EE%-99.87%) and 1:0.4:3.2 (EE% -91.28%) were 96.97%, 81.93%, and 68% respectively after 24h hours. Example 6: Bio-availability and Bio-efficacy test.
[00137] In order to know the systemic efficacy, three groups (Control and 2 Test group; 6 each) of four to five months old Eucalyptus ramets were grown in a mesh enclosed field cage insectarium. Then test group 2 and 3 were infested with Leptocybe invasa infestation (gall formation) for 24 hrs. Approximately, 10 ppm of free and encapsulated aza were prepared and sprayed on the leaves, petiole and stem to run off. The bio-efficacy of encapsulated azadirachtin on Leptocybe invasa is presented in Table 4 below.

Test group 1 (untreated), Test group 2 (treated with free aza), Test group 3 (treated with Aza micelles)
[00138] Galls were under developed in test group 3 (treated with aza micelles), whereas fully developed healthy galls were seen in the test group 2 (treated with free aza). Moreover, when galls from test group 3 were dissected and observed

under stereo microscopy, tiny mummified Leptocybe invasa larva were seen. Thus, clearly confirming that micellar composition of the present disclosure, facilitates the diffusion of aza across the plant cellular membrane and increases the systemic bioavailability. The increased bioavailability can be appreciated when comparing the results from test group 2, which has been treated with free or un-encapsulated aza.
Advantages of the present disclosure;
[00139] The present disclosure reveals a polymeric micellar composition capable of increasing bioavailability of poorly soluble azadirachtin. The composition was i found to be stable over a period of 2 months; and was found to allow an encapsulation efficiency of up to 99.87%. Further, the micelles facilitate the diffusion of azadirachtin across the plant cellular membrane and increases the systemic bioavailability. The polymeric micellar composition is capable of being processed easily using known methods in the art and can also be further adapted to commercially useful formulations.

I/We Claim;
1. A polymeric micellar composition comprising:
a) azadirachtin; and
b) at least one first polymer; and
c) at least one second polymer,
wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.3:0.25 to 1:0.5:3.4.
2. The polymeric micellar composition as claimed in claim 1, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is in the range of 1:0.4:0.25 to 1:0.4:3.4.
3. The polymeric micellar composition as claimed in claim 1, wherein the at least one first polymer is polyvinylpyrrolidone.
4. The polymeric micellar composition as claimed in claim 1, wherein the at least one second polymer is a copolymer of ethylene oxide and propylene oxide.
5. The polymeric micellar composition as claimed in any one of the claims 1 and 4, wherein the at least one second polymer has an average molecular weight in range of 37,000 to 42,000.
6. The polymeric micellar composition as claimed in claim 1, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.4.
7. The polymeric micellar composition as claimed in claim 1, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:0.8.
8. The polymeric micellar composition as claimed in claim 1, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:1.6.
9. The polymeric micellar composition as claimed in claim 1, wherein azadirachtin to the at least one first polymer to the at least one second polymer weight ratio is 1:0.4:3.2.

10. The polymeric micellar composition as claimed in any one of the claims
1-9, the composition comprising:
a) azadirachtin having a weight percentage in range of 0.001 - 10 % with respect to the composition;
b) at least one first polymer having a weight percentage in range of 0.001 - 5 % with respect to the composition; and
c) at least one second polymer having a weight percentage in range of 0.001 - 25 % with respect to the composition.

11. The polymeric micellar composition as claimed in any one of the claims 1-10, wherein the composition has an encapsulation efficiency in the range of 91.0-99.9%.
12. The polymeric micellar composition as claimed in any one of the claims 1-10, wherein the composition has an active loading in the range of 6.0 to 9.0%.
13. A formulation comprising: (a) the polymeric micellar composition as claimed in any one of the claims 1-12; (b) at least one excipient.
14. A process for preparing the polymeric micellar composition as claimed in any one of the claims 1-13, the process comprising the steps of: a) obtaining azadirachtin; b) obtaining at least one first polymer; c) obtaining at least second polymer; and d) contacting azadirachtin, the at least one first polymer, the at least one second polymer, to obtain the polymeric micellar composition.