A Process For Preparation Of Lumefantrine

Abstract: The present invention relates to a novel process for preparing an antimalarial drug 2-(dibutylamino)-1 -[(9Z)-2,7-dichloro-9-(4- chlorobenzylidene)-9H-fluoren-4-yl]ethanolcommonly known as Lumifantrine of formula I, which comprises reacting of 2-(2,7-dichloro-9-fluoren-4-yl)oxirane with di-n-butyl amine in a solvent under pressure to give 2-dibutylamino-l-[2,7-dichloro-9H-fluorene-4-yl]ethanol, which is further condensed with p-chlorobenzaldehyde in presence of solvent to give title compound Lumifantrine of formula I.

Patent Information

Application #

Filing Date

27 June 2014

Publication Number

01/2016

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

Inventors

Specification

Documents

Application Documents

#	Name	Date
1	2089-MUM-2014-AFR-18-08-2014.pdf	2014-08-18
2	2089-MUM-2014-FORM1(21-8-2014).pdf	2018-08-11
3	2089-MUM-2014-FORM 3.pdf	2018-08-11
4	2089-MUM-2014-FORM 2.pdf	2018-08-11
5	2089-MUM-2014-FORM 2(TITLE PAGE).pdf	2018-08-11
6	2089-MUM-2014-Form 18-140518.pdf	2018-08-11
7	2089-MUM-2014-FORM 1.pdf	2018-08-11
8	2089-MUM-2014-DESCRIPTION(COMPLETE).pdf	2018-08-11
9	2089-MUM-2014-CORRESPONDENCE.pdf	2018-08-11
10	2089-MUM-2014-CORRESPONDENCE-140518.pdf	2018-08-11
11	2089-MUM-2014-CORRESPONDENCE(21-8-2014).pdf	2018-08-11
12	2089-MUM-2014-CLAIMS.pdf	2018-08-11
13	2089-MUM-2014-ABSTRACT.pdf	2018-08-11
14	2089-MUM-2014-FER.pdf	2019-07-30
15	2089-MUM-2014-AbandonedLetter.pdf	2020-02-13

Search Strategy

1	Search_Strategy_2089_MUM_2014_29-07-2019.pdf