FORM 2

COMPLETE AFTER PROVISIONAL
30 JUL 2002

THE PATENTS ACT, 1970
(39 of 1970)
COMPLETE SPECIFICATION
[See section 10]
A PROCESS FOR PREPARING A POLYMER COMPOSITION WITH IMPROVED GEL STRENGTH FOR MOLDING SOLUBLE CONTAINERS;
SCITECH CENTRE, A COMPANY INCORPORATED UNDER SECTION 25, OF THE COMPANIES ACT, 1956, WHOSE ADDRESS IS 7, PRABHAT NAGAR, JOGESHWARI (WEST), MUMBAI - 400 102, MAHARASHTRA, INDIA;

GRANTED

THE FOLLOWING SPECIFICATION
PARTICULARLY DESCRIBES AND
ASCERTAINS THE NATURE OF THE INVENTION AND THE MAIMER IN WHICH IT IS TO BE PERF(


TITLE
A PROCESS FOR PREPARING A POLYMER COMPOSITION WITH IMPROVED GEL STRENGTH FOR MOLDING SOLUBLE CONTAINERS
FIELD OF THE INVENTION
This invention relates to an improved process for preparation of polymer gels with enhanced gel strengths resulting in soluble containers including capsules with improved stress resistance, flexible workability, consistent quality and low cost. This invention teaches a process for the preparation of polymer composition for molding cellulose derivative soluble container and more particularly to Hydroxy Propyl Methyl Cellulose soluble container composition for a variety of applications in several industries such as pharmaceutical, agrochemical, food, cosmoceuticals, nutraceuticals, agricultural etc.
PRIOR ART
Gelatin in combination with other additives has been one of the most widely used raw material though water soluble cellulose derivatives as substitute for gelatin are gaining prominence because of its ability to produce films with water content less than 10% without adversely affecting the quality of the capsules formed, in terms of their film uniformity and low cracking during detachment of the molded article from the pin after drying. Several approaches using these materials have been developed for the manufacture of soluble containers including capsules to house or carry products in small or large
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quantities. In general the compositions of the aqueous solution of a capsule base for the production of non-gelatin capsules comprise of. water-soluble cellulose derivative as base material, a gelatinizing agent and an auxiliary for gelation. The process of production of capsules involves the immersion of a capsule molding pin in the aqueous solution of capsule base, drawing out the molding pin from the aqueous solution of this capsule base, and allowing the adhered solution to gel on the molding pin surface to form a film followed by drying and detaching the film from the molding pin and cutting the thus formed film to the required size. The film characteristics vary with changes in composition, gelling and drying conditions.
US Patent Nos. 5,264,223 and 5,431,917 describe compositions and processes for the production of capsule using water-soluble cellulose derivatives such as hydroxypropylmethylcellulose ("HPMC"), hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, and the like. However HPMC has been indicated as the most preferred material in terms of film molding and mechanical strength at a condition of lower water content. The gelatinizing agent is carrageenan and the auxiliary for gelation is a water-soluble compound containing potassium ion, ammonium ion or calcium ion. The HPMC is about 5 to 25 parts by weight, the gelatinizing agent is from about 0.1 % to about 0.5% by weight and the auxiliary for gelation is from about 0.01% to about 0.5% by weight. In these patents though the general substitutions in the cellulose ethers are indicated, the physical characteristics that are responsible for the film characteristics during the process such as the molecular weights or the viscosities of the
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HPMC have not been specified. It must be recognized that HPMCs themselves exhibit a wide range of physical characteristics especially rheology and thermogelling properties and that these properties determine the course of the gel properties and interact differently with the gelatinizing agents and the auxiliaries.
The gelatinizing agents are selected from the group consisting of carrageenan, polysaccharide of tamarind seed, pectin, curdlan, gelatin, furcelleran and agar. These prior arts are directed to provide a hard capsule having no fragility under the condition of lower humidity due to the lower water content in equilibrium in the capsule film thereby preventing the cracking of the capsule film.
US Patent No. 5,756,123 and the European patent document EP714656 B1 [claims] disclose a capsule shell comprising of 79.6% -98.7% by weight of a hydroxypropylmethyl cellulose, 0.03% - 0.5% by weight of carrageenan, and 0.14% - 3.19% by weight of potassium ion and/or a calcium ion obtained by drying a solution comprising 18%-28% by weight of HPMC whose 2% solution has a viscosity of 2.4 -5.4 centistokes at 20 degrees centigrade as the base, 0.01%-0.09% by weight of carrageenan as a gelling agent and 0.05%-0.6% by weight of potassium ion and /or calcium ion as co-gelling agent. It further specifies the optimum viscosity range of the 2% aqueous solution of the HPMC to be 3.0 to 4.6 centistokes obtained from commercial HPMC or blends of commercially available HPMC in combination with the other components of the compositions described in this patent and in US Patents 5264223 and 5431917. The capsule shell exhibits
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disintegration ability equivalent to gelatin shells without degrading thai ability even under special conditions containing much calcium ions.
European patent document EP0946637B1 discloses polymer compositions for film forming particularly hard and soft capsules, comprising water-soluble ethers, hydrocolloids and sequestering agents. The viscosity of the cellulose ether or blend is 3 to 15 cps in 2% aqueous solution at 20 degrees centigrade preferred 5 to 10 cps, especially preferred 6 cps. The composition as disclosed is 90% to 99.98% by weight of a cellulose ether or mixture of cellulose ethers with water contents of 2% to 10%; 0.01% to 5% by weight of a hydrocolloid or mixtures of hydrocolloids and 0.01% to 8% by weight of a sequestering agent or mixtures of sequestering agents. The hydrocolloids include synthetic gums such as gellan gum which may be combined with several other naturally occurring gums such as seaweeds, gaur gum etc. The improved elasticity of such compositions is stated to make it useful for the encapsulation of caplets in a capsule, especially in a tamper proof form. Though this publication mentions problem of brittleness due to use of low molecular weight HPMC, it has not disclosed any solution to this problem. The capsules obtained show improved dissolution behaviour, an enhanced elasticity and higher transparency as compared to gelatin capsules.
US Patent No. 4,001,211 describes improved thermogelling HPMC compositions in a hot pin dipping process for use in preparing pharmaceutical capsules by the pin dip coating process by utilizing the proper blending of the properties of water soluble methyl and C2-C3
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hydroxyalkyl cellulose ethers to achieve an essentially Newtonian dip coating solution and a high thermal gel yield strength. The patent also discloses that the cellulose ether should have a relatively narrow molecular weight distribution. Blends of low viscosity methylcellulose and hydroxypropylmethyl cellulose provide particularly suitable dip solution properties, gel yield strength and capsule dissolution rates.
German Patent document DE19926714 discloses another composition for producing hard capsules with a low moisture content, which comprises water 76.15% - 81.04%, HPMC 18% - 20% (viscosity of 4-8 cps of its 2% solution at 20 degrees centigrade), gellan gum 0.8% -1.2%, tri-sodium citrate 0.05% - 0.1% , glycerol 0.01% - 0.1%, fatty acid ester 0.1% - 0.5%. The capsules produced by composition of this patent do not break even though the moisture content is less than 10%, retain higher stability as compared to gelatin capsules but their degree of dissolution is approximately 5 minutes slower than gelatin capsules.
The prior art related to film formation and capsule manufacturing using HPMC have tackled the problem of providing hard capsules for pharmaceutical drugs having no fragility under the condition of a lower humidity due to lower water content in equilibrium in the capsule film thereby preventing the cracking of the capsule.
However, the compositions involving HPMC in the inventions disclosed in prior art continue to have weakness in the production process as the window of temperature, relative humidity ("RH") and air velocity for the drying process becomes very small and is of critical significance as
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small deviations in the drying conditions lead to star ends, wrinkles, gel rupture, verruca, striations etc. The set mass on the pin does not withstand the stress of drying resulting in defects leading to production of capsules of inconsistent quality. In addition, in the production line when such capsules with defects reach the joiner block, they cause jamming and machine tripping adversely affecting the throughput of the manufacturing line. The residual stresses in the capsuies can cause the capsule to become oval, loose shape, deform and often become unfit for the end user application. The prior art (US Patent No. 5,756,123) have specifically disclosed and recommended the use of HPMC with viscosities in the range of 2.4-5.4 centistokes of their 2% aqueous solutions at 20 degrees centigrade. Similarly EP0946637B1 specifically indicates the usable viscosities of the cellulose ether or blend to be 3-15 cps in 2% aqueous solution at 20 degrees centigrade preferably 5 to 10 cps and most preferably 6cps. These disclosures have indicated that HPMC to be used must necessarily fall within the viscosity range specified and that above or below the ranges indicated cause problems in the immersion solution and produce films with undesirable characteristics. Further, large size capsules even if made using the prior art composition are not rigid for the wall thicknesses these are designed. The capsules collapse, deform and lose shape during manufacturing and subsequent storage resulting in high rejections.
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OBJECTS OF THE INVENTION
An object of the present invention is to provide an improved process for preparation of capsule composition involving alkyl and / or hydroxyalkyl substituted cellulose of specific characteristics, gelling agents selected from a group of hydrocolloids and polysaccharides either singularly or as a mixture, solubilising agents, sequestering agents and other additives to manufacture high gel strength of capsule base solution and forming films of enhanced tensile strength, higher percent elongation and allowing faster water removal rates to withstand stresses during drying and ensuring production of capsules of consistent quality with high throughput.
Another object of the invention is to provide improved process for preparation of capsule composition whereby it would be possible to widen the range of the usable and cost effective HPMCs in terms of their molecular weight distribution and viscosities in the process disclosed to achieve the production of the desired capsules.
Yet another object of the present invention is directed to provide improved process for production of capsules by the use optional use of glidants such as silicon dioxide in the composition/
Another object of the present invention is to optionally use non-ionic surfactants such as sodium lauryl sulfate, Tween 80 and the like in the composition , for better wettability and uniform pickup on the molded pin, in the process for production of capsules. It will also widen the choice of suppliers for the cellulose ether.
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Yet another object of the present invention is to enable production of small and large size capsules of consistent quality for diverse applications.
SUMMARY OF THE INVENTION
Thus according to the present invention there is provided an improved process for preparation of cellulose ether soluble container composition such composition comprising a selective blend of high molecular weight cellulose ether and low molecular weight cellulose ether with gelling agents selected from the group of hydrocolloids and polysaccharides along with sequestering agents / co-gelling agents and solubilizing agents as may be required.
DESCRIPTION OF DRAWINGS
Fig. 1 represents the graph illustrating the increase in shear stress of the HPMC blend solution as it is cooled from 65°C to 20°C according to the present invention;
Fig. 2 shows the thermal stability curves for cap of the capsule according to the present invention and the prior art; and
Fig. 3 Shows the thermal stability curves for the body of capsule according to the present invention and the prior art.
DISCLOSURE OF THE INVENTION:
According to the present invention there is provided an improved process for preparation of polymer composition for molding cellulose ether soluble container such composition comprising a blend of high
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molecular weight cellulose ether and low molecular weight cellulose ether with gelling agents selected from the group of hydrocolloids and polysaccharides along with sequestering agents and / or co-gelling agents and solubilizing agents as may be required.
Preferably, the above disclosed improved process for preparing cellulose derivative soluble container composition comprises -
- blending selectively, high molecular weight cellulose and low molecular weight cellulose ether in ratios in the range from 5:95 to 95:5.
- mixing gelling agents in amounts from 0.01% to 12% of the weight of the blend of the two or more cellulose ethers (depending on the type of gelling agent which is a hydrocolloid or a mixture of hydrocolloids);
- mixing sequestering agents and/or co-gelling agent in amounts from 25% to 85% by weight of the gelling agent;
- with or without said solubilizing agent in amounts from 2% to 30% by wt. of the blend of the ethers.
The solubilizing agent used can be any additive to cause a solubilizing effect, such as PEG(Polyethylene Glycol) of different molecular weights viz, PEG 400 to PEG 4000 or 1,2 - propane di-ol (propylene glycol).
The cellulose ethers are selected from the group consisting of Hydroxy propyl methyl cellulose, Hydroxy Propyl ethyl cellulose, Hydroxy ethyl methyl cellulose and the like.
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The above disclosed selective inventive polymer composition of the invention is directed to avoid the prior art problems and help in providing additional strength to the gelled mass on the pin which gives the benefit of reduction in rejects like - wrinkles, striations, gel rupture, verruca etc. without the need to control drying conditions critically. The solubilizing agent helps in better hydration imparting better clarity and faster dissolution of HPMC in water during soiution preparation.
In accordance with another aspect, the present invention provides a process for molding of capsules using the composition wherein such process comprising:
preparing a selective blend of high molecular weight cellulose ether and low molecular weight cellulose ether with gelling agents selected from the group of hydrocolloids and polysaccharides along with sequestering agents / co-gelling agents and solubilizing agents as may be required in dip bath and feed tanks of capsule production system ; and carrying out the capsule production using conventional capsule production system ;
In accordance with a preferred aspect such process of molding capsules comprising:
providing said improved polymer composition as a solution comprising:
- said selective blend of high molecular weight cellulose and low molecular weight cellulose ether in ratios in the range from 5:95 to 95:5.
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- said gelling agents in amounts from 0.01% to 12% of the weight of the blend of the two or more cellulose ethers(depending on the type of gelling agent which is a hydrocolloid or a mixture of hydrocolloids);
- said sequestering agents and / or co-gelling agents in amounts from 25% to 85% by weight of the gelling agent;
with or without said solubilizing agent in amounts from 2% to 30% by wt. of the blend of the ethers;
- dipping the dipping pins in said solution at a temperature from 60°C to
75°C in dip bath;
- maintaining the capsules thus obtained on the dipping pins in cool condition in the temperature range from 15°C to 28°C and air velocity range from 100 feet per minute ("FPM") to 1000 FPM for gelling;
- subjecting the capsules in the dipping pins to drying in the temperature range from 20°C to 35°C and a air velocity in the range from 500 FPM to 3000 FPM to obtain capsules of desired surface finish size and character.
Importantly in accordance with the present invention, contrary to all prior art, it is possible to use HPMC of higher viscosities in the preparation of the base capsule solution. Accordingly in the present invention it has surprisingly been found that HPMCs 2910 & 2906 as described in the USP 24/NF19 are particularly suitable to get the benefits described. For the purpose of this invention, "HPMC Blend" would mean Hydroxy Propyl Methyl Cellulose of any of the two or a
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blend of the two substitution types 2910 and 2906 of either high molecular weight or low molecular weight or both. A blend of high molecular weight HPMC and a low molecular weight HPMC, herein after called as "HPMC Blend", has any one or both substitution types. HPMC Blend would also mean, a blend of different molecular weight HPMCs, where atleast one HPMC has a higher molecular weight than the other.
Further, a high molecular weight HPMC, for the purpose of this invention would mean, a HPMC with a viscosity above about 16 cps of 2% aqueous solution at 20°C to about 4000 cps of a 2% aqueous solution at 20°C. Similarly, a low molecular weight HPMC for the purpose of this invention would mean, a HPMC with a viscosity below 15 cps of a 2% aqueous solution at 20°C to about 3 cps of a 2% aqueous solution at 20°C.
Further, the "HPMC Blend" for the purpose of this invention would also mean blend of two or more HPMCs having a film strength from 400 kg/cm2 to 600 kg/cm2 ("low film strength HPMC") and another HPMC having a film strength from 700 kg/cm2 to 1500 kg/cm2 ("high film strength HPMC"). The HPMC Blend would consist of such HPMCs with different film strengths, where atleast one HPMC would be a high film strength HPMC.
Film strength is defined here as the tensile strength of a 100 micron thickness HPMC film from 3% moisture content. The film strength is measured on a Shimadzu autograph tensile test device as per the
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prescribed standard procedures at a temperature from 20°C to about 25°C at an RH from 65%.
The amount of the mixture of the HPMC Blend is preferably about 80% to 99.98% by capsule weight. The viscosity of the high molecularf weight HPMC ranges from 16 cps to 4000 cps in 2% aqueous solution ' at 20°C and that of the low molecular weight HPMC is about 3, cps to 15 cps in 2% aqueous solution at 20°C. The preferred viscosity of the high molecular weight HPMC is about 20 cps to 1000 cps & especially preferred is about 35 cps to 200 cps. The preferred viscosity of the low molecular weight HPMC is about 3 cps to 12 cps and the most preferred is about 3 cps to 7 cps in 2% aqueous solution at 20°C. The viscosity of the blend of the two or more HPMCs, where at least one is a high molecular weight HPMC, has a blend viscosity from 6 cps to 50 cps, preferably about 15 cps to 42 cps and most preferably from 23 cps to 34 cps in 2% aqueous solution at 20°C.
One or more hydrocolloids used in the composition of the present invention include such items as synthetic gum or mixture of more than one synthetic gum, which are capable of gelling without the addition of alkaline or alkaline earth metal ions. Mixtures of gums may include natural seaweeds, natural seed gums, natural plant exudates, natural fruit extracts, bio-synthetic gums, bio-synthetic processed starch or cellulosic materials. These includes Ispaghula husk derived from the Plantago seed of Plantago ovata Forsk. Examples of which include Fibrolax, Fybrogel, Isogel, Regulan, Psyllium hydrophilic mucilloid, Psyllium hydrocolloid, Psyllium seed gum, Effer-Syllium, Fiberall,
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Metamucil, Perdiem Fiber, Serutan which are obtained from the epidermis of the Plantago ovata seeds. Such mixtures may also include alginates, agar gum, guar gum, locust bean gum (carob), carrageenan, tara gum, gum arabic, ghatti gum, Khaya grandifolia gum, tragacanth gum, karaya gum, pectin, arabian (araban), xanthan, gellan, starch, Konjac mannan, galactomannan, funoran, and other exocellular polysaccharides of which are preferred the exocellular polysaccharides, such as xanthan, acetan, gellan, welan, rhamsan, furcelleran, succinoglycan, scleroglycan, schizophyllan, tamarind gum, curdlan, pullulan, dextran. Alternatively, gums that can be used are kappa-carrageenan or gellan gum, which may be used singularly or as mixtures. Most preferred is a mixture consisting of Xanthan gum, Locust Bean gum (carob), agar & kappa-carrageenan used as a gelling agent to produce gelling properties without the need to use a co-gelling agent in the composition. Such gums are also commercially available for example, TIC PRETESTED® Agaroid RS-507 manufactured by TIC Gums, Inc., Maryland, USA. The ratios of each of the gums in the TIC PRETESTED® Agaroid RS-507 are - Xanthan gum is about 25% to 35%, Locust Bean gum (carob) is about 30% to 40%, agar is about 30% to 50% and carrageenan is from 15% to 25% standardized with dextrin about 1.5% to 3%. The amount of gum present in the composition is preferably about 0.01% to 12% by weight, more preferably from 0.1% to 8% and most preferably from 0.7% to 5%.
One or more sequestering agents may be used, the preferred ones being ethylenediaminetetraacetic acid, acetic acid, boric acid, citric
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acid, gluconic acid, lactic acid, phosphoric acid, tartaric acid, or salts thereof, metaphosphates, dihydroxyethylglycine, lecithin or beta cyclodextrin and combinations thereof. Especially preferred is ethylenediaminetetraacetic acid or salts thereof or citric acid or salts thereof. The sequestering mechanism can be adjusted by addition of either monovalent or divalent cations, such a Ca++, Mg++, K+, Na+, Li+, NH4+ or the like. Alternatively, in case of kappa-carrageenan, potassium chloride can be used as a co-gelling agent. The amount for both the sequestering agent or the co-gelling agent is preferably from 25% to 85%, by weight relative to the gelling agent, more preferably from 40% to 75%.
Additionally, silicon di-oxide may be added to improve the flow of capsules, the quantity of which is from 0.01% to 2% of the total weight of the HPMC Blend, more preferably is about 0.2% to 0.8%.
Additives ordinarily used in hard capsules, such as dyes and pigments may be added from 0% to 10% of the weight of blended HPMC.
THE PROCESS
A co-gelling agent or a sequestering agent is added to hot water at a temperature of at least 85°C followed by the addition of a gelling agent under high shear mixing. HPMC Blend (high & low viscosity) is added followed by a solubilizing agent. The temperature is maintained from 65°C to 80°C with continued stirring from 8 to 10 hours at a stirrer tip speed or from 3 to 5 metres per second. The solution is then transferred to dipbaths and feed tanks, which are attached to the
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conventional gelatin capsule production system. The solution temperature for dipping is maintained about 60°C to 75°C. After dipping, the capsules are kept under cold air at a temperature in the range of 15°C to 28°C for gelling for a period from 25 to 60 seconds under air velocity of around about 100 feet per minute ("FPM") to 1000 FPM. The dipping pins were then transferred for drying at about 20°C to 35°C and kept under air flow under a velocity from 500 FPM to 2000 FPM. Under this air velocity the capsules do not form star ends or wrinkles. After half an hour the capsules are transferred to another zone for drying at a temperature of 27°C to 35°C under air velocity from 1000 FPM to 3000 FPM to achieve a stripping moisture from 4% to 10%.
In another embodiment of the process of this invention one may also follow a process of making solution where a dry blend of all the dry ingredients such as HPMC Blend, gum, gelling aids or sequestering agents is prepared in a blender and then added to the Mixer by vacuum suction or manually for solution preparation. The temperature and other parameters described in the above examples remain the same.
The invention may be better understood by the reference to the following example which is intended for the purpose of illustration and is not to be construed as, in any way limiting the scope of the present invention, which is defined in the claims appended thereto.
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EXAMPLES
The composition and process of the present invention is described hereunder in greater detail in relation to nonlimiting examples illustrated herein under.
Table - 1 illustrates the different blending ratios used -
TABLE -1

S.No Blend Designation BLENDING RATIOS

HPMC (6 cps viscosity) HPMC (50 cps viscosity)
1. A 80 20
2. B 70 30
3. C 50 50
4. D 40 60
5. E 30 70
Concentration of the dipping solution described in each trial was kept from 13% (w/w) to 20% (w/w).
Trial-1:
For this trial blend ratio A, B, C & E were used.
Citric acid (216 gm) was dispersed in DM water (51kg) at a temperature of 85°C followed by addition of gellan gum (300gms). HPMC Blend (10 kg) was then added followed by addition of propylene glycol (300 gm). The mixture was kept under stirring at a temperature of around around 65°C for about 8 hours.
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Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing it at 23°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures ranged from 25°C to 35°C and the velocities of drying air ranged from 1000 FPM to 3000 FPM.
Trial -2:
For this trial blend ratio E was used.
Potassium Chloride (150 gm) was dispersed in about 85°C DM water (51kg), followed by addition of kappa-Carrageenan (300gms). HPMC Blend (10 kg) was then added followed by addition of propylene glycol (300 gm). The mixture was kept under stirring at about 65°C for about 8 hours.
Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing under 25°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures ranged from about 25°C to a maximum of 35°C and the velocities of air blow ranging from 1000 FPM to 3000 FPM.
Trial -3:
For this trial blend ratio D & E was used.
A mixture of Agar, Xanthan gum, Locust bean gum and Carrageenan (150 gm) available as a ready mix under the name of TIC PRETESTED® Agaroid RS-507 manufactured by TIC Gums, Inc., Maryland USA was dispersed in about 85°C DM water (25kg). HPMC
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Blend (5 kg) was then added followed by addition of propylene glycol (150 gm). The mixture was kept under stirring for 9 hours at a temperature around 75°C.
Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing under about 25°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures ranged from about 25°C to a maximum of 35°C and the velocities ranged from about 1000 FPM to about 3000 FPM.
Trial -4:
For this trial blend ratio A was used.
Citric Acid (0.72 gm) was dispersed in DM water (990gms) at a temperature around 85°C, followed by addition of gellan gum (1 gm). A 1:1 blend of Xanthan gum & LBG (carob) (1 gm) was added. HPMC Blend (200 gms) was then added. The mixture was kept under stirring for 8 hours about 65°C.
Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing under 25°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures range from 25°C to 35°C and the velocities of air flow ranging from about 1000 FPM to about 3000 FPM.
Trial -5:
For this trial blend ratio C was used.
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Potassium Chloride (1 gm) was dispersed in 85°C DM water (1001 gms), followed by addition of kappa-Carrageenan (2 gms), followed by addition of LBG (carob) (2 gms). HPMC Blend (200 gms) was then added. The mixture was kept under stirring for about 8 to 10 hours about 65°C.
Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing under 25°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures range from 25°C to 35°C and the velocities ranged from about 1000 FPM to about 3000 FPM.
Trial -6:
For this trial blend ratio A and D was used.
Citric Acid (11.25 gms) was dispersed in 85°C DM water (24.8kg), followed by gellan gum (25 gms). Potassium Chloride (11.25 gm) was then added, followed by addition of kappa-Carrageenan (25gms). HPMC Blend (5 kg) was then added. The mixture was kept under stirring for 5 hours about 62°C
Capsules were produced by inserting the dipping moulds into the solution, then drawing out, exposing under 25°C air for gelling and subsequently drying, stripping, cutting & joining. The drying temperatures ranged from 25°C to 35°C and the velocities ranged from about 1000 FPM to about 3000 FPM.
Capsules with improved film strength, were successfully made.
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Small as well as large size capsules could be produced using all of the above-illustrated examples. Table 2 shows a sample set of capsule sizes produced is given:
TABLE - 2

S.No Size Cap
diameter
(mm) Body
diameter
(mm) Closed
length
(mm)
Human Capsules (small size)
1. 000 9.91 9.55 26.4
2. 00 8.55 8.23 23.5
3. 0 7.66 7.35 21.4
Large Size capsules
1. Su07 23.4 22.7 88.5
2. 7 23.4 22.7 78
3. 10 23.4 22.6 64
4. 11 20.87 20.1 47.5
5. 12 15.29 14.5 40.5
6. 13 15.28 14.5 30
7. 12el 15.24 14.6 57
CONCLUSION:
Gel Characteristics
The gel characteristics of the films produced from the compositions and processes described in this invention are illustrated in Figure 1 of the accompanying drawings of this specification.
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The shear stress being an indicator of the gel strength has been measured using a Brookfield Rheometer Model DV III+, which was connected to a computer for on line data capturing.
HPMC Blend solutions of different compositions were prepared. A sample was taken in a Brookfield standard small sample adaptor SC4 (16ml). The spindle used was S-29. The small sample adaptor was placed in the Brookfield standard water-jacketed chamber (13R). The starting temperature of the sample was maintained at 65°C. The program for viscosity checking was started. The spindle (S-29) speed was 15 rpm, the corresponding shear rate was 3.75 sec "1 and the spindle was rotated continuously. Cooling of the solution was then started. The sample was cooled to 20°C at a constant rate. A data point was captured every five seconds. The graph clearly indicates the increase in gel strength for the HPMC Blend composition.
Fig-1: Represents the shear stress of the HPMC solution as it is cooled from 65°C to 20°C. The figure clearly indicates the rise in shear stress in Newton per square meter.
EVALUATION OF THE CAPSULES PRODUCED
Tests were conducted for evaluating the capsules produced. These are presented here.
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TEST-1- Disintegration of capsules after exposure to formaldehyde (HCHO) for one hour and storage in sealed bags for 72 hours.

Inventive product Gelatin capsules (control)
Empty capsules 8 mins 8 sees > 45 mins
Filled capsules TFR 6 mins > 45 mins

TTR 9 mins 34 sees

TFR = Time of First Release TTR= Time of Total Release
TEST 2: Dissolution (%) of capsules after exposure to formaldehyde (HCHO) for one hour & storage in sealed bags for 72 hours.
Capsules were filled with Acetaminophen.

Sample No. Inventive Product Gelatin Capsules (Control)
1. 92.5% Did not dissolve
2. 90.9% Did not dissolve
3. 95.1% Did not dissolve
Test-1 & Test-2 show that the inventive product does not exhibit any cross-linking with formaldehyde that hinders disintegration and dissolution.
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TEST-3: Brittleness test
The moisture of the capsules was progressively reduced by exposure to lithium chloride. The capsules were then tested for brittleness using the rod method. Precentage of capsules brittle was recorded for each moisture content.

Inventive Product Gelatin capsules (control)
Moisture Content Brittleness Moisture content Brittleness
6.05% 0 14.65% 0
5.37% 0 14.42% 0
5.1% 0 14.38% 0
4.89% 0 13.75% 0
4.54% 0 13.6% 4%
4.32% 2% 13.03% 10%
3.55% 2% 12.9% 14%
The test clearly shows that the inventive product does not get brittle even at low moisture contents.
TEST-4: Thermal stability test
This was done to study the effect on the inventive product, control product and the comparative products when exposed to heat. The first indication of heat damage is a reduction in diameter. The initial diameter of the samples was measured. These were then exposed to 44°C in an oven. The diameters of cap & body were then measured every 10 minutes. The readings were then tabulated and a graph
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plotted of drop in diameter (in microns) against the time of exposure. The graphical representation is shown as Figure-2 & Figure-3.
Drop in diameter in microns

Time (mins) Inventive product Comparative product 1 Comparative product 2 Gelatin Capsules

Cap Body Cap Body Cap Body Cap Body
0 0 0 0 0 0 0 0 0
10 13 14 22 10 20 14 22 11
20 18 19 34 26 23 21 30 20
30 28 26 43 31 30 31 39 28
40 31 28 50 38 34 38 44 38
50 31 30 52 43 47 44 50 49
60 32 33 52 46 54 53 56 58
70 37 34 56 48 57 52 62 64
80 44 38 58 49 61 55 67 65
Comparative product 1 is size 0 cellulose capsule as disclosed in the European patent document EP0946637B1.
Comparative product 2 is size 0 cellulose capsule as disclosed in the European patent document EP714656B1.
The data and the graphical representation as in Figure-2 & Figure-3 clearly show that the inventive product is superior when exposed to heat.
The data and the graphical representation as in Figure-2 & Figure-3 clearly show that the inventive product is superior when exposed to heat.
26

Capsules or soluble containers prepared as per this invention find applications in drugs and pharmaceuticals, agrochemical industry, packaging in food industry, cosmoceuticals, and nutraceuticals
Thus, while there have been shown and described and pointed out fundamental novel features of the present invention as applied to preferred embodiments thereof, it will be understood that various omissions and substitutions and changes in the form and details of the methods described may be made by those skilled in the art without departing from the spirit of the present invention. For example, it is expressly intended that all combinations of those elements and/or method steps which perform substantially the same function in substantially the same way to achieve the same results are within the scope of the invention. Substitutions of elements from one described embodiment to another are also fully intended and contemplated. It is the intention, therefore, to be limited only as indicated by the scope of the claims appended hereto.
27

We Claim:
1. An improved process for preparation of (polymer composition) for molding cellulose derivative soluble container such proeess-composing: blending a first cellulose ether having a viscosity range of 16cps to 4000 cps in a 2 weighf % aqueous solution at a temperature of 20 °C and a second cellulose ether having a viscosity range of 3 cps to 15 cps in a 2 weight % aqueous solution at a temperature of 20 °C; heating and mixing the prepared cellulose ether blend adding a gelling agent, sequestering agent and /or co-gelling agent.
2. The process according to claim 1 wherein the viscosity of the first cellulose ether is in the range of 20 cps to 1000 cps.
3. The process according to claim 2 wherein the viscosity is in the range from 35 cps to 200 cps.
4. The process according to claim 1 wherein the viscosity of the second cellulose ether is in the range from 3 cps to 7 cps.
5. The process according to claim 1 wherein the blending of the first cellulose ether and the second cellulose ether is carried out to a proportion within the range of 5:95 to about 95:5 which also includes any proportion inside this range.
6. The process according to claim 1 wherein the viscosity of the cellulose ether blend in the composition is in the range from 6 cps to 50 cps in a 2 weight % aqueous solution at 20 °C
7. The process according to claim 6 wherein the viscosity is in the range from 15 cps to 42 cps.
8. The process according to claim 7 wherein the viscosity is in the range from 23 cps to 34 cps.

9. The process according to claim 5 wherein the cellulose ether blend constitutes to about 80 % to 99.98 % by weight of the entire container weight.
10.The process according to claim 1 wherein the cellulose ether is water soluble and is selected from hydroxypropylmethyl cellulose (HPMC), hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylmethyl cellulose.
11. The process according to claim 1 wherein the aqueous solution is prepared by mixing co-gelling agent or sequestering agent in hot water at a temperature of at least above 85° C followed by addition of gelling agent under high shear mixing.
12. The process according to claim 11 wherein the gelling agent is selected from one or more among hydrocoiloids and polysaccharides.

13. The process according to claim 12 wherein the hydrocoiloids include one or more synthetic gums.
14. The process according to claim 12 wherein the polysaccharides are preferably exocellular polysaccharides.
15. A process according to claims 1-14 wherein the composition is further molded into a container.
16. A process according to claim 15 wherein the molded container is a hard
capsule.

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Dated this 30tn day of July, 2002

FOR SCITECH CENTRE By their Agent
\URASTRI)
(MANIS
KRISHNA & 3AURASTRI