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A Process For The Preparation Of Isomers Of 11 [3 (Dimethylamino) Propylidene] 6,11 Dihydrodibenz[B,E] Oxepin 2 Acetic Acid Hydrochloride
Abstract: The present invention relates to an improved process for the preparation of 11-(Z)-[3-(Dimethylamino) propylidene]-6, 11-dihydrodibenz[b,e]oxepin-2-acetic acid (Olopatadine hydrochloride) by reaction of 11-oxo-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid with Grignard reagent of 1-halo-3-dimethylaminopropane and further dehydrated with or without isolation of the intermediate 11-(3-dimethylaminopropyl)-11-hydroxy-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid. The present invention relates novel polymorphs of 11-(Z)-[3-Dimethylamino) propylidene]-6, 11-dihydrodibenz[b,e]oxepin-2-acetic acid (Olopatadine hydrochloride). The present invention further relates to preparation of 11-(E)-[3-Dimethylamino) propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
14 March 2006
Publication Number
48/2008
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2013-07-31
Renewal Date
Applicants
USV LIMITED
B.S.D. MARG, STATION ROAD, GOVANDI, MUMBAI 400 088,
Inventors
1. TARUR, RADHAKRISHNAN VENKATASUBRAMANIAN
A-301 Vaishali Towers,B.R Road,
Mulund (W),
Mumbai400 080
2. BHISE, NANDU BABAN
402,Pearl Bldg.,
Nirmal Life Style,
L.B.S Marg,Mulund (W),
Mumbai 400 080
3. SATHE, DHANANJAY GOVIND
202/A-1,Golden Park,
L.B.S. Marg,
Panchpakhadi
Thane 400 602
4. NAIDU, AVINASH VENKATARAMAN
C-3, Tirupati Balaji
Apartments M G Road
Vishnu Nagar,
Dombivli 421 202
5. AHER, UMESH PARASHRAM
Flat No.3,B-Wing,
Vanashri Shrushti
Khadakpada,
Kalyan 421 304
6. PATIL, SACHIN SHIVAJI
Sankharam Niwas,
Naik wadi,
Kon Kalyan 421 304
7. VARMA, SUDHIR ANANGPAL
R-6,Bhiwa Patil Chawl,
Masoba Maidan,
Chikanghar,
Kalayan (W) 421 304
8. SAWANT, KAMLESH DIGAMBAR
NA
9. NAIK, TUSHAR ANIL
NA
10. AMRE, RAKESH RAMCHANDRA
NA
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 223-mum-2006-abstract(14-3-2006).pdf | 2018-08-09 |
| 1 | 223-mum-2006-correspondence 2(24-11-2006).pdf | 2006-11-24 |
| 2 | 223-mum-2006-abstract(15-2-2007).pdf | 2018-08-09 |
| 2 | 223-mum-2006-correspondence(ipo)-(12-12-2006).pdf | 2006-12-12 |
| 3 | 223-MUM-2006-FORM 18(10-12-2008).pdf | 2008-12-10 |
| 3 | 223-MUM-2006-ABSTRACT-(31-7-2013).pdf | 2018-08-09 |
| 4 | 223-MUM-2006-CORRESPONDENCE(10-12-2008).pdf | 2008-12-10 |
| 4 | 223-MUM-2006-CLAIM-(31-7-2013).pdf | 2018-08-09 |
| 5 | 223-MUM-2006-CORRESPONDENCE-(12-03-2015).pdf | 2015-03-12 |
| 5 | 223-mum-2006-claims(14-3-2006).pdf | 2018-08-09 |
| 6 | 223-MUM-2006-CLAIMS(AMENDED)-(21-6-2012).pdf | 2018-08-09 |
| 6 | 223-MUM-2006 -CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(14-03-2016).pdf | 2016-03-14 |
| 7 | 223-MUM-2006_EXAMREPORT.pdf | 2018-08-09 |
| 7 | 223-mum-2006-claims(complete)-(15-2-2007).pdf | 2018-08-09 |
| 8 | 223-MUM-2006-SPECIFICATION(MARKED COPY)-(21-6-2012).pdf | 2018-08-09 |
| 8 | 223-mum-2006-correspondence 1(29-5-2007).pdf | 2018-08-09 |
| 9 | 223-MUM-2006-CORRESPONDENCE(19-2-2009).pdf | 2018-08-09 |
| 9 | 223-MUM-2006-SPECIFICATION(AMENDED)-(21-6-2012).pdf | 2018-08-09 |
| 10 | 223-MUM-2006-CORRESPONDENCE(27-1-2012).pdf | 2018-08-09 |
| 10 | 223-MUM-2006-REPLY TO EXAMINATION REPORT(21-6-2012).pdf | 2018-08-09 |
| 11 | 223-MUM-2006-CORRESPONDENCE(31-7-2013).pdf | 2018-08-09 |
| 11 | 223-MUM-2006-FORM PCT-ISA-237(27-1-2012).pdf | 2018-08-09 |
| 12 | 223-mum-2006-description(complete)-(15-2-2007).pdf | 2018-08-09 |
| 12 | 223-MUM-2006-FORM PCT-IB-373(27-1-2012).pdf | 2018-08-09 |
| 13 | 223-mum-2006-description(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 13 | 223-mum-2006-form 5(15-2-2007).pdf | 2018-08-09 |
| 14 | 223-mum-2006-description(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 14 | 223-mum-2006-form 5(14-3-2006).pdf | 2018-08-09 |
| 15 | 223-MUM-2006-DESCRIPTION-(31-7-2013).pdf | 2018-08-09 |
| 16 | 223-mum-2006-drawing(15-2-2007).pdf | 2018-08-09 |
| 16 | 223-mum-2006-form 3(29-5-2007).pdf | 2018-08-09 |
| 17 | 223-MUM-2006-FORM 3(27-1-2012).pdf | 2018-08-09 |
| 17 | 223-MUM-2006-DRAWING-(31-7-2013).pdf | 2018-08-09 |
| 18 | 223-mum-2006-form 3(17-2-2006).pdf | 2018-08-09 |
| 18 | 223-mum-2006-form 1(14-3-2006).pdf | 2018-08-09 |
| 19 | 223-mum-2006-form 1(17-2-2006).pdf | 2018-08-09 |
| 19 | 223-mum-2006-form 26(16-1-2007).pdf | 2018-08-09 |
| 20 | 223-MUM-2006-FORM 1(21-6-2012).pdf | 2018-08-09 |
| 20 | 223-mum-2006-form 2(title page)-(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 21 | 223-mum-2006-form 13(17-1-2007).pdf | 2018-08-09 |
| 21 | 223-mum-2006-form 2(title page)-(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 22 | 223-mum-2006-form 13(19-2-2009).pdf | 2018-08-09 |
| 22 | 223-mum-2006-form 2(title page)-(complete)-(15-2-2007).pdf | 2018-08-09 |
| 23 | 223-MUM-2006-FORM 2 (TITAL PAGE)(31-7-2013).pdf | 2018-08-09 |
| 23 | 223-MUM-2006-FORM 2(TITLE PAGE)-(21-6-2012).pdf | 2018-08-09 |
| 24 | 223-mum-2006-form 2(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 24 | 223-MUM-2006-FORM 2(31-7-2013).pdf | 2018-08-09 |
| 25 | 223-mum-2006-form 2(complete)-(15-2-2007).pdf | 2018-08-09 |
| 25 | 223-mum-2006-form 2(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 26 | 223-mum-2006-form 2(complete)-(15-2-2007).pdf | 2018-08-09 |
| 26 | 223-mum-2006-form 2(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 27 | 223-MUM-2006-FORM 2(31-7-2013).pdf | 2018-08-09 |
| 27 | 223-mum-2006-form 2(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 28 | 223-MUM-2006-FORM 2 (TITAL PAGE)(31-7-2013).pdf | 2018-08-09 |
| 28 | 223-MUM-2006-FORM 2(TITLE PAGE)-(21-6-2012).pdf | 2018-08-09 |
| 29 | 223-mum-2006-form 13(19-2-2009).pdf | 2018-08-09 |
| 29 | 223-mum-2006-form 2(title page)-(complete)-(15-2-2007).pdf | 2018-08-09 |
| 30 | 223-mum-2006-form 13(17-1-2007).pdf | 2018-08-09 |
| 30 | 223-mum-2006-form 2(title page)-(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 31 | 223-MUM-2006-FORM 1(21-6-2012).pdf | 2018-08-09 |
| 31 | 223-mum-2006-form 2(title page)-(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 32 | 223-mum-2006-form 1(17-2-2006).pdf | 2018-08-09 |
| 32 | 223-mum-2006-form 26(16-1-2007).pdf | 2018-08-09 |
| 33 | 223-mum-2006-form 1(14-3-2006).pdf | 2018-08-09 |
| 33 | 223-mum-2006-form 3(17-2-2006).pdf | 2018-08-09 |
| 34 | 223-MUM-2006-DRAWING-(31-7-2013).pdf | 2018-08-09 |
| 34 | 223-MUM-2006-FORM 3(27-1-2012).pdf | 2018-08-09 |
| 35 | 223-mum-2006-form 3(29-5-2007).pdf | 2018-08-09 |
| 35 | 223-mum-2006-drawing(15-2-2007).pdf | 2018-08-09 |
| 36 | 223-MUM-2006-DESCRIPTION-(31-7-2013).pdf | 2018-08-09 |
| 37 | 223-mum-2006-description(provisional)-(17-2-2006).pdf | 2018-08-09 |
| 37 | 223-mum-2006-form 5(14-3-2006).pdf | 2018-08-09 |
| 38 | 223-mum-2006-description(provisional)-(14-3-2006).pdf | 2018-08-09 |
| 38 | 223-mum-2006-form 5(15-2-2007).pdf | 2018-08-09 |
| 39 | 223-mum-2006-description(complete)-(15-2-2007).pdf | 2018-08-09 |
| 39 | 223-MUM-2006-FORM PCT-IB-373(27-1-2012).pdf | 2018-08-09 |
| 40 | 223-MUM-2006-CORRESPONDENCE(31-7-2013).pdf | 2018-08-09 |
| 40 | 223-MUM-2006-FORM PCT-ISA-237(27-1-2012).pdf | 2018-08-09 |
| 41 | 223-MUM-2006-CORRESPONDENCE(27-1-2012).pdf | 2018-08-09 |
| 41 | 223-MUM-2006-REPLY TO EXAMINATION REPORT(21-6-2012).pdf | 2018-08-09 |
| 42 | 223-MUM-2006-CORRESPONDENCE(19-2-2009).pdf | 2018-08-09 |
| 42 | 223-MUM-2006-SPECIFICATION(AMENDED)-(21-6-2012).pdf | 2018-08-09 |
| 43 | 223-mum-2006-correspondence 1(29-5-2007).pdf | 2018-08-09 |
| 43 | 223-MUM-2006-SPECIFICATION(MARKED COPY)-(21-6-2012).pdf | 2018-08-09 |
| 44 | 223-mum-2006-claims(complete)-(15-2-2007).pdf | 2018-08-09 |
| 44 | 223-MUM-2006_EXAMREPORT.pdf | 2018-08-09 |
| 45 | 223-MUM-2006 -CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(14-03-2016).pdf | 2016-03-14 |
| 45 | 223-MUM-2006-CLAIMS(AMENDED)-(21-6-2012).pdf | 2018-08-09 |
| 46 | 223-mum-2006-claims(14-3-2006).pdf | 2018-08-09 |
| 46 | 223-MUM-2006-CORRESPONDENCE-(12-03-2015).pdf | 2015-03-12 |
| 47 | 223-MUM-2006-CORRESPONDENCE(10-12-2008).pdf | 2008-12-10 |
| 47 | 223-MUM-2006-CLAIM-(31-7-2013).pdf | 2018-08-09 |
| 48 | 223-MUM-2006-FORM 18(10-12-2008).pdf | 2008-12-10 |
| 48 | 223-MUM-2006-ABSTRACT-(31-7-2013).pdf | 2018-08-09 |
| 49 | 223-mum-2006-correspondence(ipo)-(12-12-2006).pdf | 2006-12-12 |
| 49 | 223-mum-2006-abstract(15-2-2007).pdf | 2018-08-09 |
| 50 | 223-mum-2006-abstract(14-3-2006).pdf | 2018-08-09 |
| 50 | 223-mum-2006-correspondence 2(24-11-2006).pdf | 2006-11-24 |