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A Self Assembled Nano Architecture

Abstract: The present disclosure discloses a self-assembled peptide nano-architecture comprising: an assembly of peptide-encapsulated drug; and an assembly of peptide-cisplatin conjugate, wherein the peptide is having an amino acid sequence as set forth in SEQ ID NO: 1, and the nano-architecture is in form of a vesicle. Also described in the present disclosure is a method for preparing the nano-architecture as disclosed herein. The present disclosure also discloses a method for treating cancer using the nano-architecture as disclosed herein along with a method for delivering cisplatin in a subject and a method for delivering a drug in a subject using the nano-architecture as disclosed herein.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
08 May 2020
Publication Number
46/2021
Publication Type
INA
Invention Field
BIO-CHEMISTRY
Status
Email
iprdel@lakshmisri.com
Parent Application

Applicants

INDIAN INSTITUTE OF SCIENCE
INDIAN INSTITUTE OF SCIENCE, BANGALORE, KARNATAKA 560012, INDIA
INDIAN ASSOCIATION FOR THE CULTIVATION OF SCIENCE
INDIAN ASSOCIATION FOR THE CULTIVATION OF SCIENCE, 2A & 2B RAJA SC MULLICK ROAD, JADAVPUR, KOLKATA 700032, India

Inventors

1. BHATTACHARYA, Santanu
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India
2. KAMRA, Mohini
Technical Research Centre, Indian Association for the Cultivation of Science, 2A & 2B Raja SC Mullick Road, Jadavpur, Kolkata 700032, India
3. MOITRA, Parikshit
Technical Research Centre, Indian Association for the Cultivation of Science, 2A & 2B Raja SC Mullick Road, Jadavpur, Kolkata 700032, India

Specification

I/We Claim:
1. A self-assembled peptide nano-architecture comprising:
a) an assembly of peptide-encapsulated drug; and
b) an assembly of peptide-cisplatin conjugate,
wherein the peptide is having an amino acid sequence as set forth in SEQ ID NO: 1, and the nano-architecture is in form of a vesicle.
2. The self-assembled peptide nano-architecture as claimed in claim 1, wherein the nano-architecture has a size higher than 100 nm.
3. The self-assembled peptide nano-architecture as claimed in claim 1, wherein the assembly of peptide-encapsulated drug comprises peptide-encapsulated drug having a concentration in a range of 0.01-0.05 mg/ml with respect to the self-assembled peptide nano-architecture.
4. The self-assembled peptide nano-architecture as claimed in claim 1, wherein the assembly of peptide-cisplatin conjugate comprises peptide-cisplatin conjugate having a concentration in a range of 0.01-0.05 mg/ml with respect to the self-assembled peptide nano-architecture.
5. The self-assembled peptide nano-architecture as claimed in claim 1, wherein the drug is at least one selected from doxorubicin, camptothecin, or irinotecan.
6. The self-assembled peptide nano-architecture as claimed in claim 5, wherein the drug is doxorubicin.
7. The self-assembled peptide nano-architecture as claimed in claim 1, wherein in the peptide-cisplatin conjugate, the peptide and cisplatin are covalently linked.
8. A method for preparing the self-assembled peptide nano-architecture as claimed in claim 1, said method comprising:

a) obtaining the drug and the peptide;
b) encapsulating the drug with the peptide, to obtain an assembly of peptide-encapsulated drug;
c) obtaining cisplatin and the peptide;

d) conjugating cisplatin with the peptide, to obtain peptide-cisplatin conjugate;
e) contacting the peptide-cisplatin conjugate with vesicles of the peptide of step (c), to obtain an assembly of peptide-cisplatin conjugate; and
f) mixing the assembly of peptide-encapsulated drug and the assembly of peptide-cisplatin conjugate, to obtain the self-assembled peptide nano-architecture.

9. A composition comprising: (a) a peptide; (b) a drug; and (c) a peptide-cisplatin conjugate to form a drug encapsulating self-assembled peptide nano-architecture in form of a vesicle, wherein the peptide is having an amino acid sequence as set forth in SEQ ID NO: 1.
10. The self-assembled peptide nano-architecture as claimed in claim 1, wherein the nano-architecture is used for treating cancer.
11. A method for delivering a drug in a subject, said method comprising:

a) obtaining the self-assembled peptide nano-architecture as claimed in claim 1; and
b) administering the nano-architecture to the subject for delivering the drug in the subject.
12. A method for delivering cisplatin in a subject, said method comprising:
a) obtaining the self-assembled peptide nano-architecture as claimed in claim 1; and
b) administering the nano-architecture to the subject for delivering cisplatin in the subject.
13. A method for treating cancer in a subject, said method comprises:
a) obtaining the self-assembled peptide nano-architecture as claimed in claim 1; and
b) administering the nano-architecture to the subject for treating cancer in the subject.

14. Use of the self-assembled peptide nano-architecture as claimed in claim 1 for delivering a drug into a subject.
15. Use of the self-assembled peptide nano-architecture as claimed in claim 1 for delivering cisplatin into a subject.

Documents

Application Documents

# Name Date
1 202041019648-FORM 18 [16-12-2021(online)].pdf 2021-12-16
1 202041019648-STATEMENT OF UNDERTAKING (FORM 3) [08-05-2020(online)].pdf 2020-05-08
2 202041019648-FORM 1 [08-05-2020(online)].pdf 2020-05-08
2 202041019648-FORM-26 [05-11-2020(online)].pdf 2020-11-05
3 202041019648-DRAWINGS [08-05-2020(online)].pdf 2020-05-08
3 202041019648-Proof of Right [05-11-2020(online)].pdf 2020-11-05
4 202041019648-FORM-26 [05-08-2020(online)].pdf 2020-08-05
4 202041019648-DECLARATION OF INVENTORSHIP (FORM 5) [08-05-2020(online)].pdf 2020-05-08
5 202041019648-COMPLETE SPECIFICATION [08-05-2020(online)].pdf 2020-05-08
6 202041019648-DECLARATION OF INVENTORSHIP (FORM 5) [08-05-2020(online)].pdf 2020-05-08
6 202041019648-FORM-26 [05-08-2020(online)].pdf 2020-08-05
7 202041019648-DRAWINGS [08-05-2020(online)].pdf 2020-05-08
7 202041019648-Proof of Right [05-11-2020(online)].pdf 2020-11-05
8 202041019648-FORM 1 [08-05-2020(online)].pdf 2020-05-08
8 202041019648-FORM-26 [05-11-2020(online)].pdf 2020-11-05
9 202041019648-FORM 18 [16-12-2021(online)].pdf 2021-12-16
9 202041019648-STATEMENT OF UNDERTAKING (FORM 3) [08-05-2020(online)].pdf 2020-05-08
10 202041019648-FER.pdf 2025-08-07
11 202041019648-FORM 3 [25-08-2025(online)].pdf 2025-08-25

Search Strategy

1 202041019648_SearchStrategyNew_E_searchhistorydoxcisplatinE_06-08-2025.pdf