Claims:1. A spray plaster formulation comprising:
a. at least one anaesthtic having weight concentration in the range of 0.5-1% w/w;
b. at least one antiseptic having weight concentration in the range of 0.05-0.1% w/w;
c. at least one film forming agent having weight concentration in the range of 2.5-5% w/w;
d. at least one alcohol having weight concentration in the range of 45.5-55% w/w;
e. at least one ketone having weight concentration in the range of 2-5% w/w; and
f. at least one propellant having weight concentration in the range of 30-60% w/w.
2. The formulation as claimed in claim 1, wherein said at least one anaesthetic is selected from the group consisting of lidocaine, tetracaine, benzocaine, prilocaine, and combinations thereof.
3. The formulation as claimed in claim 1, wherein said at least one antiseptic is selected from the group consisting ofcetrimide, benzalkonium chloride, benzethonium chloride, cetyl pyridinium chloride, and combinations thereof.
4. The formulation as claimed in claim 1, wherein said at least one film forming agent is selected from the group consisting ofpoly(butyl methacrylate-co-(2- demethylaminoeethyl) methacrylate-co-methyl methacrylate) 1:2:1 (Eudragit), polyvinyl butyryl, and combinations thereof.
5. The formulation as claimed in claim 1, wherein said at least one alcohol is selected from the group consisting of isopropyl alcohol, ethanol, and combinations thereof.
6. The formulation as claimed in claim 1, wherein said at least one ketone is selected from the group consisting of, acetone, butanone, any other ketone, and combinations thereof.
7. The formulation as claimed in claim 1, wherein said at least one propellant is selected from the group consisting of, liquefied petroleum gas, 1 difluoroethane, dimethyl ether, 1,1,1,2-tetrafluoroethane, propane, isobutane, n-butane, isopentane, n-pentane, and combinations thereof.
8. The spray plaster formulation as claimed in claim 1, comprising:
a. lidocaine having weight concentration in the range of 0.5-1%;
b. cetrimide having weight concentration in the range of 0.05-0.1%;
c. poly(butyl methacrylate-co-(2- demethylaminoeethyl) methacrylate-co-methyl methacrylate) 1:2:1 having weight concentration in the range of 2.5-5%;
d. isopropyl alcohol having weight concentration in the range of 45.5-55%;
e. acetone having weight concentration in the range of 2-5%; and
f. liquefied petroleum gas having weight concentration in the range of 30-60%.
9. The spray plaster formulation as claimed in claim 8, comprising:
a. lidocaine having weight concentration of 1%;
b. cetrimide having weight concentration of 0.1%;
c. poly(butyl methacrylate-co-(2- demethylaminoeethyl) methacrylate-co-methyl methacrylate) 1:2:1 having weight concentration of 3%;
d. isopropyl alcohol having weight concentration of 50.896%;
e. acetone having weight concentration of 5%; and
f. liquefied petroleum gas having weight concentration of 40%.
10. The spray plaster formulation as claimed in any of the claims 1, and 8-9, wherein said formulation is characterized in that said formulation is at least 93% water resistant when in contact with water for up to about 30 minutes.
11. The spray plaster formulation as claimed in any of the claims 1, and 8-9, wherein said formulation thickness per actuation is in the range of 40-50µm.
12. A method of making a spray plaster formulation of claim 1, said method comprising:
a. in a first container adding 91-99% (w/w) of total quantity of at least one alcohol, at least one ketone, at least one antiseptic sequentially while continually stirring at about 900-2000rpm for about 1-3 hrs at a temperature in the range of 22-27°C;
b. adding at least one anaesthetic, and at least one film forming agent to first container while continually mixing at about 900-2000rpm until said at least one film forming agent is fully dissolved;
c. adding remaining 1-9% (w/w) of total quantity of at least one alcohol to first container and mixing for about 5-120 minutes to obtain a mixture A; and
d. transferring mixture A into a container of pre-decided volume and adding at least one propellant under pressure in the range of 50-65psi to obtain said spray plaster formulation.
, Description:N/A