DESC:FIELD OF THE INVENTION:
The present invention relates to synergistic pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and ( C) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients. The present invention also relates to process for preparing the said synergistic pesticidal composition.

BACKGROUND OF THE INVENTION

Paclobutrazol was first disclosed in US 4243405. Paclobutrazol chemically known as (aR,bR)-rel-b-[(4-Chlorophenyl)methyl]-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol and having chemical structure as below;

Paclobutrazol (PBZ) is a plant growth retardant and triazole fungicide. It is a known antagonist of the plant hormone gibberellin. It acts by inhibiting gibberellin biosynthesis, reducing internodial growth to give stouter stems, increasing root growth, causing early fruitset and increasing seedset in plants such as tomato and pepper. PBZ has also been shown to reduce frost sensitivity in plants. Moreover, paclobutrazol can be used as a chemical approach for reducing the risk of lodging in cereal crops (Kamran et al 2017). PBZ is used by arborists to reduce shoot growth and has been shown to have additional positive effects on trees and shrubs. Among those are improved resistance to drought stress, darker green leaves, higher resistance against fungi and bacteria, and enhanced development of roots. Cambial growth, as well as shoot growth, has been shown to be reduced in some tree species.

Mancozeb is a dithiocarbamate non-systemic agricultural fungicide with multi-site, protective action on contact. It is a combination of two other dithiocarbamates: maneb and zineb. The mixture controls many fungal diseases in a wide range of field crops, fruits, nuts, vegetables, and ornamentals. It is marketed as Penncozeb, Trimanoc, Vondozeb, Dithane, Manzeb, Nemispot, and Manzane.

Propineb is a dithiocarbamate fungicide. It has been evaluated several times by the JMPR, the initial evaluation being in 1977 and the latest residues evaluation being in 1993 for residues and toxicology. It is a contact fungicide based used as a foliar spray for the control of fungal diseases in different crops Apple, Potato, Chilli, Tomato, Grapes, Grapes and Pomegranate.

Chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) is an organic compound mainly used as a broad spectrum, nonsystemic fungicide, with other uses as a wood protectant, pesticide, acaricide, and to control mold, mildew, bacteria, algae. Chlorothalonil-containing products are sold under the names Bravo, Echo, and Daconil. Chlorothalonil chemically reduces fungal intracellular glutathione molecules to alternate chemicals that cannot participate in essential enzymeatic reactions, ultimately leading to cell death, similar to the mechanism of trichloromethyl sulfenyl fungicidessuch as captan and folpet.

Folpet is a protective leaf-fungicide. Its mode of action inhibits normal cell division of a broad spectrum of microorganisms. It is used to control cherry leaf spot, rose mildew, rose black spot, and apple scab. Used on berries, flowers, ornamentals, fruits and vegetables, and for seed- and plant- bed treatment. Also used as a fungicide in paints and plastics, and for treatment of internal and external structural surfaces of buildings. Incompatible with strongly alkaline preparations, such as lime sulfur.

Captan is man-made fungicide used to control a range of fungal diseases. The pesticide was first registered in 1951. Captan can be used to control plant diseases such as black rot, early and late blight, and downy mildew, among others.. Captan works by coming into contact with a fungus and interrupting a key process in its life cycle. It can be toxic to many different fungal diseases. Captan is non-systemic, which means it is not expected to move through plants.

Dithianon is a synthetic compound of the quinine family. It acts as a conventional, protective, broad spectrum fungicide in apples, pears and many other fruits. Dithianon is applied as a foliar spray, and is surface acting. Dithianon adheres well to the surface of the leaves, and once dried gives good persistence and is relatively rainfast. It is also possible for the compound to be reactivated on the surface of the plant by rain and run off, resulting in a certain level of protection to new growth. The mode of action of dithianon is that it is a multi-site inhibitor of protein formation that acts by modifying the sulfydryl groups found in the cysteine residues of many proteins. This protein inhibition prevents spore germination and germ tube growth.

Fthalide which is also known as Pthlaide is an organic chemical compound with the molecular formula C8H6O2. It is a lactone that serves as the core chemical structure for a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).

Metiram is an excellent protective fungicide. Its active ingredient metiram affects the activity of the complex enzyme contained in the fungal cell and thus prevents crops from fungal infections.

Azoxystrobin (brand name Amistar, Syngenta) is a systemic fungicide commonly used in agriculture. The substance is used as an active agent protecting plants and fruit/vegetables from fungal diseases. Azoxystrobin possesses the broadest spectrum of activity of all known antifungals. It is the only counteragent that has the ability to protect against the four big groups of fungal and fungal-like diseases.

Picoxystrobin is the new strobilurin fungicide developed specifically by Syngenta to control cereal diseases in early season. It differs from the existing strobilurins thanks to its complete biokinetic properties, such as a rapid uptake, systemic and translaminar movements vapour phase activity, strong affinity with the wax layer, a protection of newly formed organs and also a curative activity. Picoxystrobin will deliver better disease control and yield within a cereal fungicide programme. It is developed as a straight product or in a ready-to-use mixture with hexaconazole, a well-known fungicide from the triazole group, and will be recommended in early season applications.

Isoprothiolane is a malonate ester that is diisopropyl malonate in which the two methylene hydrogens at position 2 are replaced by a 1,3-dithiolan-2-ylidene group. An insecticide and fungicide used to control a range of diseases including Pyricularia oryzae, Helminthosporium sigmoideum and Fusarium nivale. It has a role as an insecticide, an environmental contaminant, a phospholipid biosynthesis inhibitor and an antifungal agrochemical. It is a malonate ester, a member of dithiolanes and an isopropyl ester. It derives from a malonic acid.

Difenoconazole is a broad spectrum fungicide that controls a wide variety of fungi – including members of the Aschomycetes, Basidomycetes and Deuteromycetes families. It acts as a seed treatment, foliar spray and systemic fungicide. It is taken up through the surface of the infected plant and is translocated to all parts of the plant. It has a curative effect and a preventative effect. Difenoconazole can be applied to winter wheat, oilseed rape, Brussels sprouts, cabbage, broccoli/calabrese and cauliflower. It controls various fungi including Septoria tritici, Brown Rust, Light Leaf Spot, Leaf Spot, Pod Spot, Ring Spot and Stem canker. It also prevents Ear Discolouration in winter wheat. The mode of action of difenoconazole is that it is a sterol demethylation inhibitor which prevents the development of the fungus by inhibiting cell membrane ergosterol biosynthesis.

Tricyclazole (5-methyl-1,2,4-triazolo[3,4-b]benzothiazole) is a unique fungicide for control of Pyricularia oryzae on rice. Tricyclazole is systemic in rice and will control rice blast disease in any stage of plant development by a variety of application methods. Tricyclazole protects plants from infection by P. oryzae by preventing penetration of the epidermis by the fungus. The compound acts by inhibiting melanization within the appressorium, thus causing a lack of rigidity in the appressorial wall. Tricyclazole has no apparent effect on spore germination although sporulation is reduced. Tricyclazole is not curative but is protective in its activity.

Hexaconazole is a Broad-spectrum systemic triazole fungicide used for the control of many fungi particularly Ascomycetes and Basidiomycetes. Major consumption is in Asian countries and it is used mainly for the control of rice sheath blight in China, India, Vietnam and parts of East Asia. It is also used for control of diseases in various fruits & vegetables.

Cyproconazole is an azole fungicide used to control a wide range of fungi on cereal crops, coffee,
sugar beet, fruit trees, grapes, including rust on cereal crops, powdery mildew on cereal crops, fruit tree and grapes, and scab on apple. It is both a prevention and treatment fungicide.

Isoprothiolane has been developed as a fungicide showing eradicant as well as protectant activities against the most important fungal disease of rice plant caused by Pyvioutavia oryzae Cav. (Taninaka et al., 1976). It acts on the fungus at the penetration and growth stages of the infecting hyphae rather than at those of conidial germination and appressorium formation (Araki and Miyagi, 1977). Besides being applied as a foliar spray, a submerging technique has been developed in which isoprothiolane is applied to the irrigation water as granules containing 12% active ingredient.

Propiconazole is a systemic foliar fungicide with a broad range of activity. It is used on grasses grown for seed, mushrooms, corn, wild rice, peanuts, almonds, sorghum, oats, pecans, apricots, peaches, nectarines, plums and prunes. On cereals it controls diseases caused by Erysiphe graminis, Leptosphaeria nodorum, Pseudocerosporella herpotrichoides, Puccinia spp., Pyrenophora teres, Rhynchosporium secalis, and Septoria spp. Propiconazole's mode of action is demethylation of C-14 during ergosterol biosynthesis, and leading to accumulation of C-14 methyl sterols. The biosynthesis of these ergosterols is critical to the formation of cell walls of fungi. This lack of normal sterol production slows or stops the growth of the fungus, effectively preventing further infection and/or invasion of host tissues. Therefore, propiconazole is considered to be fungistatic or growth inhibiting rather than fungicidal or killing.

Prothioconazole is a synthetic compound of the triazolinthione family of compounds. It is a broad spectrum systemic fungicide, with curative, preventative and eradicative action. It can be used as both a seed treatment and a foliar treatment. After absorption it moves into cells of the target organisms, effecting sterol biosynthesis and thereby disrupting membrane structure. This ultimately effects hyphal growth and germ tube elongation. Fungi susceptible to prothioconazole include Early leaf spot (Mycosphaerella arachidis), eyespot, Fusarium spp., powdery mildew, net blotch, phoma leaf spot, Rhynchosporium secalis, Sclerotinia sclerotiorum, Sclerotium rolfsii, Septoria tritici, Septoria nodorum, rust and tan spot. Prothioconazole is approved for use on barley, durum wheat, oats, oilseed rape (winter), rye (winter), and wheat. Prothioconazole is sold in combination with numerous other fungicides, including bifaxen, spiroxamine, tebuconazole, fluoxastrobin, trifloxystrobin and floupyram. It is a broad spectrum systemic Triazole fungicide with protective, curative and eradicative mode of action. It is effective against wide range of diseases. It is very effective against brown rust, leaf blotch, Net blotch, septoria leaf spot& Yellow rust of cereals; Soybean-Asian rust, brown spot/Septoria leaf spot, Powdery mildew; Rice-Dirty panicle & grain discoloration.

Thiophanate-methyl is a curative, preventive and systemic broad-spectrum fungicide, used for plant diseases on various crops. Thiophanate-methyl is a preventive and systemic fungicide with contact action. It is absorbed through the plant’s leaves and roots and provides a very good protective and curative effect against a wide range of fungal pathogens responsible of surface plant infection as eyespot, powdery mildew, blight or gray mold apple scab and other diseases of cereals, vegetables, fruit, leaf spot diseases and many diseases in floriculture.

The main concern with the use of fungicide is the development of resistance by the pests for that particular fungicide and at the end one has to apply more concentrated formulation of the fungicide. The high amount of fungicide may results in the toxicity to human beings as well as has bad effect on environment.

Previously people have tried many alternatives and option to overcome this problem and as a result developed poly mixture of pesticide, use of non-toxic ingredients and developing novel formulations which provides effective amount of the fungicide and at the required part only.

However the use of poly mixture containing large number of fungicide poses a problem in many was like preparing formulation of multiple fungicide with different chemical properties and behavior and physical properties. It also creates challenge for formulator in term of compatibility and stability of all the fungicide along with used excipients in the formulation.

CN101569304A relates to a paclobutrazol suspension concentrate and a preparation method thereof, which are suitable to the manufacture technology of farm chemical preparation and belong to the chemical technical field. Paclobutrazol is mainly in a way of 15 percent of wettable powder in China market. Because the wettable powder is easy to produce dust pollution during processing and use and the suspension rate of the wettable powder is lower than that of the suspension concentrate, the product is easy to produce the chemical injury. The paclobutrazol suspension concentrate is prepared by the following components of paclobutrazol, wetting agent, dispersing agent, thickening agent, antifoaming agent, antifreeze agent, preservative, and the like according to a certain weight percent and a special preparation method.

CN102524265B describes a MET preparing nanoscale dispersion agent to suspension, mass ratio weighed paclobutrazol, disintegrating agents, surface active agents, stabilizers, and distilled water, standby; first surfactant is added to distilled water after stirring for 2 min, paclobutrazol added thereto, stabilizing and disintegrating agents, stirring was continued for 13 min; the solution obtained above was placed in an ultrasonic cleaning machine ultrasonic removed after 45 min, paclobutrazol obtain nanoscale dispersion of the present invention suspended glue .
CN102450268A discloses paclobutrazol effervescent granules/or effervescent tablets and a preparation method thereof, wherein the paclobutrazol effervescent granules/or effervescent tablets comprise the following raw materials by mass percent: 0.1-80% of paclobutrazol, 0.5-15% of dispersant, 0.5-8% of wetting agent, 4-60% of disintegrating agent, 0-10% of binding agent and balance of padding. The preparation method is as follows: mixing the raw materials for forming the paclobutrazol effervescent granules/or effervescent tablets; after the paclobutrazol effervescent granules/or effervescent tablets are smashed by ultra-micro flow, pelleting, drying, finishing granules/tabletting, precisely selecting, detecting and obtaining the paclobutrazol effervescent granules/or effervescent tablets. The paclobutrazol effervescent granules/or effervescent tablets provided in the invention are safe for environment, people and livestock and other beneficial organisms, not easy to generate phytotoxicity, accurately measured and convenient to use and have no dust and quick granules disintegrating speed; and with better storage stability and simple preparation technology, the paclobutrazol effervescent granules/or effervescent tablets are suitable for industrial production and agricultural big area promotion.

CN102204543B relates to a containing brassinolide-MET complex soybean growth regulators, comprising the following weight percentages: 1% -65% of brassinolide and plant growth active ingredient, the balance and auxiliaries; Yun wherein MET-BR moss and a weight ratio of 1: 500-1: 10,000. The present invention employs the field of pesticides customary auxiliaries emulsifiers, solvents, defoaming agents, modifiers composite EC can be made, which can be used as growth regulators for controlling the soybean plant height and reduced lodging soybeans.

Hence there is a need in the society to have a composition or formulation with fungicidal effect with combination of one more active ingredient which provided synergistic effect and easy to manufacture.

Inventors of the present invention have surprisingly found that the synergistic pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and ( C) another ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients. described herein in can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide, with a view to effective resistance management and effective control of phytopathogenic harmful fungi, at application rates which are as low as possible, compositions which, at a reduced total amount of active compounds applied, have improved activity against the harmful fungi (synergistic mixtures).

We have accordingly found that this objective is achieved by the compositions, defined herein, comprising novel synergistic pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and (C ) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients.

According to another aspect of present invention also relates to process for preparing the novel pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and (C) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients.

DETAILED DESCRIPTION OF THE INVENTION

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure.

Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors.

The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.

In an especially preferred embodiment of the invention, the yield of the treated plant is increased.

In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.

A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance.
In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention is increased synergistically.

The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).Another indicator for the condition of the plant is the "quality" of a plant and/or its products.

In an especially preferred embodiment of the invention, the quality of the treated plant is increased.

In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product:
• increased nutrient content
• increased protein content
• increased content of fatty acids
• increased metabolite content
• increased carotenoid content
• increased sugar content
• increased amount of essential amino acids
• improved nutrient composition
• improved protein composition
• improved composition of fatty acids
• improved metabolite composition
• improved carotenoid composition
• improved sugar composition
• improved amino acids composition
• improved or optimal fruit color • improved leaf color
• higher storage capacity
• higher processability of the harvested products.

Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fungicidal or insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.

In another preferred embodiment of the invention relates to a novel pesticidal composition comprising, as active components,
1) Paclobutrazol;
2) at least one active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper; and
3) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl and
4) one or more inactive ingredient.

In another preferred embodiment of the invention relates to a method for controlling harmful fungi using composition comprising Paclobutrazol and one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients.

In another preferred embodiment of the invention relates to a process for preparation of novel pesticidal composition comprising Paclobutrazol and one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients.

In another preferred embodiment of the invention, pesticidal composition of present invention can be in form of Suspension Concentrate (SC), Flowable Suspension (FS), Suspo emulsion (SE), Capsule Suspension (CS), Oil Dispersion (OD), Micro emulsion (ME), Dispersal concentrate (DC), Soluble liquid (SL), Emusifiable concentrate (EC), Emulsion in water (EW), Soluble liquid (SL), mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granules (Soil Applied Granules), Controlled Release Granules (CR Granules), Slow release and Fast release microsphere Granules (MS Granules), Water Soluble Granules (SG), Water dispersible granule (WDG or WG), Capsulated dry flowable (CDF), Dry flowalbe (DF), Jumbo ball formulation, Water soluble bag formulation, Wettable Powder (WP), Soluble Powder (SP), Dusting Powder (DP).

The present invention relates to novel pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and (C ) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole and Thiophanate methyl are present in ratios by weight of the active ingredients as below;

Active Ingredient I Active Ingredient II Active Ingredient III
Paclobutrazol Mancozeb
Propineb
Chlorothalonil
Folpet
Captan
Dithianon
Fthalide, Metiram, Sulphur
Different salts of copper Azoxystrobin
Picoxystrobin
Pyraclostrobin Trifloxystrobin Difenoconazole Cyproconazole Expoxiconazole
Flusilazole
Hexaconazole
Isoprothiolane
Propiconazoe Prothioconazole Tebuconazole
Tricyclazole
Thiophanate methyl
0.1 to 10% 0.1 to 60% 0.1 to 30%

The novel pesticidal composition comprising (A) Paclobutrazol and (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and (C ) another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients is effective for management or control or regulate crop (plant) growth and to manage or control fungal diseases in the crops selected from GMO (Genetically Modified Organism/crops) and Non GMO varieties of Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut/Groundnut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).
The novel pesticidal composition of present invention have very good fungicidal properties and can be employed for controlling phytopathogenic fungi such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, and the like.Examples which may be mentioned, but not by limitation, are some pathogens of fungal diseases which come under the above generic terms: Diseases caused by pathogens causing powdery mildew such as, for example, Blumeria species such as, for example, Blumeriagraminis; Podosphaera species such as, for example, Podosphaeraleucotricha;Sphaerotheca species such as, for example, Sphaerothecafuliginea; Uncinula species such as, for example, Uncinulanecator; Leveillula species such as, for example Leveillulataurica, Erysiphe species such as for example Erysiphepolygoni, diseases caused by pathogens of rust diseases such as, for example, Gymnosporangium species such as, for example, Gymnosporangiumsabinae, Hemileia species such as, for example, Hemileiavastatrix; Phakopsora species such as, for example, Phakopsorapachyrhizi and Phakopsorameibomiae; Puccinia species such as, for example, Pucciniagraminis, Pucciniarecondita or Pucciniatriticina, Pucciniastriiformis; Uromyces species such as, for example, Uromycesphaseoli; diseases caused by pathogens of smut diseases such as, for example, Sporisorium species such as , for example, Sporisoriumscitamineum; Ustilago species such as, for example Ustilagomaydis, Tilletia species such as for example Tilletiatritici, Ustilaginoidea species such as , for example Ustilaginoideavirens, diseases caused by pathogens of ergot diseases such as, for example Claviceps species, Clavicepspurpurea; leaf spot, leaf blight and leaf wilt diseases caused by, for example, Alternaria species such as, for example, Alternariasolani; Cercospora species such as, for example, Cercosporabeticola; Cladiosporum species such as, for example, Cladiosporiumcucumerinum; Cochliobolus species such as, for example, Cochliobolussativus (conidial form: Drechslera, syn: Helminthosporium); Colletotrichum species such as, for example, Colletothrichum capsici- Die back of chillies Colletotrichum lindemuthanium; Cycloconium species such as, for example, Cycloconiumoleaginum; Diaporthe species such as, for example, Diaporthecitri; Elsinoe species such as, for example, Elsinoefawcettii; Gloeosporium species such as, for example, Gloeosporiumlaeticolor; Glomerella species such as, for example, Glomerellacingulata; Guignardia species such as, for example, Guignardiabidwelli; Leptosphaeria species such as, for example, Leptosphaeriamaculans; Magnaporthe species such as, for example, Magnaporthegrisea;Mycosphaerella species such as, for example, Mycosphaerellagraminicola; Phaeosphaeria species such as, for example, Phaeosphaerianodorum; Pyrenophora species such as, for example, Pyrenophorateres;Ramularia species such as, for example, Ramulariacollo-cygni; Rhynchosporium species such as, for example, Rhynchosporiumsecalis; Septoria species such as, for example, Septoriaapii;Typhula species such as, for example, Typhulaincarnata; Venturia species such as, for example, Venturiainaequalis; root and stalk diseases, caused by, for example, Corticium species such as, for example, Corticiumgraminearum; Fusarium species such as, for example, Fusariumoxysporum;Gaeumannomyces species such as, for example, Gaeumannomycesgraminis; Rhizoctonia species such as, for example, Rhizoctoniasolani; Tapesia species such as, for example, Tapesiaacuformis;Thielaviopsis species such as, for example, Thielaviopsisbasicola; ear and panicle diseases (including maize cobs), caused by, for example, Alternaria species such as, for example, Alternaria spp.;Aspergillus species such as, for example, Aspergillusflavus; Cladosporium species such as, for example, Cladosporium spp.; Claviceps species such as, for example, Clavicepspurpurea; Fusarium species such as, for example, Fusariumculmorum; Gibberella species such as, for example, Gibberellazeae; Monographella species such as, for example, Monographellanivalis;Smut diseases caused by, for example, Sphacelotheca species such as, for example, Sphacelothecareiliana; Tilletia species such as, for example, Tilletia caries; Urocystis species such as, for example, Urocystisocculta; Ustilago species such as, for example, Ustilagonuda; fruit rot caused by, for example, Aspergillus species such as, for example, Aspergillusflavus; Botrytis species such as, for example, Botrytis cinerea; Penicillium species such as, for example, Penicilliumexpansum; Sclerotinia species such as, for example, Sclerotiniasclerotiorum; Verticilium species such as, for example, Verticiliumalboatrum; seed- and soil-borne rots and wilts, and seedling diseases, caused by, for example, Fusarium species such as, for example, Fusariumculmorum; Phytophthora species such as, for example, Phytophthoracactorum; Pythium species such as, for example, Pythiumultimum; Rhizoctonia species such as, for example, Rhizoctoniasolani; Sclerotium species such as, for example, Sclerotiumrolfsii; cankers, galls and witches' broom diseases, caused by, for example, Nectria species such as, for example, Nectriagalligena; wilts caused by, for example, Monilinia species such as, for example, Monilinialaxa; deformations of leaves, flowers and fruits, caused by, for example, Taphrina species such as, for example, Taphrinadeformans; degenerative diseases of woody species, caused by, for example, Esca species such as, for example, Phaemoniellaclamydospora; flower and seed diseases, caused by, for example, Botrytis species such as, for example, Botrytis cinerea; diseases of plant tubers caused by, for example, Rhizoctonia species such as, for example, Rhizoctoniasolani; diseases caused by bacterial pathogens such as, for example, Xanthomonas species such as, for example, Xanthomonascampestrispv. oryzae; Pseudomonas species such as, for example, Pseudomonas syringaepv. lachrymans; Erwinia species such as, for example, Erwinia amylovora etc.

The present invention can be widely used to protect the agricultural, horticultural and forest plant species from the diseases caused by pathogens from the group of the Oomycetes, such as, for example, Pythium species such as, Pythium blight (high temperature) by Pythiumaphanidermatum, Pythium blight (low temperature) by Pythiumgraminicola, Pythiumultimum, Pythium damping off diseases in nurseries of tobacco, tomato, chillies, egg-plant; Phytophthora species such as, Phytophthora capsici causing Fruit rot in chillies, Phytophthorainfestans causing late blight in potato and tomato, Gummosis and Root rot in citrus by Phytophthora spp., seed rot, seedling blight, fruit rot in chilli and cucurbits by Phytophthoracapsici, downy mildew of cucurbits by Pseudoperonosporacubensis, downy mildew of millets by Sclerosporagraminicola, downy mildew of maize by Peronosclerosporasroghi, white rust of crucifers by Albugo candida, downy mildew of grape by Plasmoparaviticola.

The novel pesticidal composition of the present invention comprising Paclobutrazol and one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl with one or more inactive ingredients offers various advantages and benefits as listed below;
• Increase in yield of treated plants (cereals, pulses, oilseeds, fiber crop, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamentals etc.)
• Increase in yield due to protection against fungal diseases
• Increase in yield due to plant growth regulation, check vegetative growth and increase in reproductive parts of plant.
• Increase in yield due to more number of tillers, more branches and sub branches, more number of flowers, more number of fruits
• Increase plant vigor
• Increase tolerance to insect-pests damage
• Increase tolerance to the weather stress, moisture stress
• Prevents lodging in susceptible plants (lodging due to biotic and abiotic factors, like heavy rains, winds, insects and diseases damage.
• Improves quality (means visual appearance, color, size, shape etc.) in grains, fruits, fiber, flowers, tuber, bulb, rhizomes, straw, leaves and other plant parts and plant products
• Improves keeping quality of produce, increase post-harvest life, storage life, protection from post-harvest diseases
• Uniform sizing in tuber, bulb, rhizome and root crops.

The novel pesticidal composition of the present invention comprising Paclobutrazol and one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper and another active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl may further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol.

Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates or mixtures thereof.

Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).

Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.

Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tri-calcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

The solvent for the formulation of the present invention may include water, water-soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxyalcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

Sr.No. AI-1 AI-2 AI-3 Formulation strength A.I.(%) in formulation Formulation per Hectare (g or ml) Active Ingredient/Hectare
1 AI1 AI2a Azoxystrobin 46% 1.2% 40.0% 5.0% 2500 30 1000 125
2 AI1 AI2a Pyraclostrobin 45% 1.2% 40.0% 4.0% 2500 30 1000 100
3 AI1 AI2a Trifloxystrobin 45% 1.2% 40.0% 4.0% 2500 30 1000 100
4 AI1 AI2a Difenoconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
5 AI1 AI2a Propiconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
6 AI1 AI2a Prothioconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
7 AI1 AI2a Tebuconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
8 AI1 AI2a Tricyclazole 49% 1.2% 40.0% 8.0% 2500 30 1000 200
9 AI1 AI2a Thiophanate methyl 57% 1.2% 40.0% 16.0% 2500 30 1000 400
10 AI1 AI2b Azoxystrobin 58% 1.5% 50.0% 6.25% 2000 30 1000 125
11 AI1 AI2b Pyraclostrobin 57% 1.5% 50.0% 5.0% 2000 30 1000 100
12 AI1 AI2b Trifloxystrobin 57% 1.5% 50.0% 5.0% 2000 30 1000 100
13 AI1 AI2b Difenoconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
14 AI1 AI2b Propiconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
15 AI1 AI2b Prothioconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
16 AI1 AI2b Tebuconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
17 AI1 AI2b Tricyclazole 62% 1.5% 50.0% 10.0% 2000 30 1000 200
18 AI1 AI2b Thiophanate methyl 72% 1.5% 50.0% 20.0% 2000 30 1000 400
19 AI1 AI2c Azoxystrobin 58% 1.5% 50.0% 6.25% 2000 30 1000 125
20 AI1 AI2c Pyraclostrobin 57% 1.5% 50.0% 5.0% 2000 30 1000 100
21 AI1 AI2c Trifloxystrobin 57% 1.5% 50.0% 5.0% 2000 30 1000 100
22 AI1 AI2c Difenoconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
23 AI1 AI2c Propiconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
24 AI1 AI2c Prothioconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
25 AI1 AI2c Tebuconazole 57% 1.5% 50.0% 5.0% 2000 30 1000 100
26 AI1 AI2c Tricyclazole 62% 1.5% 50.0% 10.0% 2000 30 1000 200
27 AI1 AI2c Thiophanate methyl 72% 1.5% 50.0% 20.0% 2000 30 1000 400
28 AI1 AI2d Azoxystrobin 56% 1.2% 50.0% 5.0% 2500 30 1250 125
29 AI1 AI2d Pyraclostrobin 55% 1.2% 50.0% 4.0% 2500 30 1250 100
30 AI1 AI2d Trifloxystrobin 55% 1.2% 50.0% 4.0% 2500 30 1250 100
31 AI1 AI2d Difenoconazole 55% 1.2% 50.0% 4.0% 2500 30 1250 100
32 AI1 AI2d Propiconazole 55% 1.2% 50.0% 4.0% 2500 30 1250 100
33 AI1 AI2d Prothioconazole 55% 1.2% 50.0% 4.0% 2500 30 1250 100
34 AI1 AI2d Tebuconazole 55% 1.2% 50.0% 4.0% 2500 30 1250 100
35 AI1 AI2d Tricyclazole 59% 1.2% 50.0% 8.0% 2500 30 1250 200
36 AI1 AI2d Thiophanate methyl 67% 1.2% 50.0% 16.0% 2500 30 1250 400
37 AI1 AI2e Azoxystrobin 46% 1.2% 40.0% 5.0% 2500 30 1000 125
38 AI1 AI2e Pyraclostrobin 45% 1.2% 40.0% 4.0% 2500 30 1000 100
39 AI1 AI2e Trifloxystrobin 45% 1.2% 40.0% 4.0% 2500 30 1000 100
40 AI1 AI2e Difenoconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
41 AI1 AI2e Propiconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
42 AI1 AI2e Prothioconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
43 AI1 AI2e Tebuconazole 45% 1.2% 40.0% 4.0% 2500 30 1000 100
44 AI1 AI2e Tricyclazole 49% 1.2% 40.0% 8.0% 2500 30 1000 200
45 AI1 AI2e Thiophanate methyl 57% 1.2% 40.0% 16.0% 2500 30 1000 400
46 AI1 AI2f Azoxystrobin 37% 1.2% 30.0% 6.3% 2000 24 600 125
47 AI1 AI2f Pyraclostrobin 36% 1.2% 30.0% 5.0% 2000 24 600 100
48 AI1 AI2f Trifloxystrobin 36% 1.2% 30.0% 5.0% 2000 24 600 100
49 AI1 AI2f Difenoconazole 36% 1.2% 30.0% 5.0% 2000 24 600 100
50 AI1 AI2f Propiconazole 36% 1.2% 30.0% 5.0% 2000 24 600 100
51 AI1 AI2f Prothioconazole 36% 1.2% 30.0% 5.0% 2000 24 600 100
52 AI1 AI2f Tebuconazole 36% 1.2% 30.0% 5.0% 2000 24 600 100
53 AI1 AI2f Tricyclazole 41% 1.2% 30.0% 10.0% 2000 24 600 200
54 AI1 AI2f Thiophanate methyl 51% 1.2% 30.0% 20.0% 2000 24 600 400
Active Ingredient ; AI1= Paclobutrazol; AI2a=Chlorothalonil;AI2b= Mancozeb; AI2c= Propineb; AI2d= Metiram; AI2e= Folpet; AI2f= Copper

EXAMPLES
The present invention will now be explained in detail by reference to the following formulation examples and a test example, which should not be construed as limiting the scope of the present invention.

Example 1: WG (Water dispersible granules) formulation of Paclobutrazol 1.2%+Chlorothalonil 40%+Azoxystrobin 5%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.20
Chlorothalonil a.i. 40.00
Azoxystrobin a.i. 5.00
Sodium salt of Phenol sulphonic acid condensate 5.00
Polyacrylate co-polymer 8.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
Corn Starch 32.30
TOTAL 100.00

Manufacturing process for Water Dispersible Granules (WG) by extrusion method:
Step 1-Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2-Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx.. 1.5 hr.)
Step 3-Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 4-Dough is passed through extruder to get granules of required size.
Step 5-Wet granules are passed through Fluidized bed drier and further graded using vibrating screens.
Step 6-Final product is sent for QC approval.
Step 7-After approval material is packed in required pack sizes.

Example 2: WG (Water dispersible granules) formulation of Paclobutrazol 1.2%+Chlorothalonil 40%+Difenoconazole 4%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.20
Chlorothalonil a.i. 40.00
Difenoconazole a.i. 4.00
Sodium salt of Phenol sulphonic acid condensate 5.00
Polyacrylate co-polymer 9.50
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
Corn Starch 31.80
TOTAL 100.00

Manufacturing process for Water Dispersible Granules (WG) by spray dried method:
Step 1-Charge required quantity of DM water need to be taken in designated vessel for production.
Step 2-Add required quantity of Wetting agent, dispersing agent, antifoam & suspending agents and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 3-Add required quantity technical and homogenized to get uniform slurry ready for grinding.
Step 4-Now material is subjected to grinding in Bead mill till desired particle size is achieved.
Step 5-After grinding process completes the material is sprayed at required temperature.
Step 6-After completion of spray drying process material is collected and sent for QC department approval.
Step 7-After approval material is packed in required pack sizes.

Example 3: WG (Water dispersible granules) formulation of Paclobutrazol 1.5%+Mancozeb 50% + Azoxystrobin 6.25%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.50
Mancozeb a.i. 50.00
Azoxystrobin a.i. 6.25
Modified sodium lignosulphonate 15.00
Polyacrylate co-polymer 2.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
China Clay 16.75
TOTAL 100.00

Process of preparation: as per example 2
Example 4: WG (Water dispersible granules) formulation of Paclobutrazol 1.5%+ Manoczeb 50% + Pyraclostrobin 5%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.50
Mancozeb a.i. 50.00
Pyraclostrobin a.i. 5.00
Modified sodium lignosulphonate 15.00
Polyacrylate co-polymer 2.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
China Clay 18.00
TOTAL 100.00

Process of preparation: as per example 1
Example 5: WG (Water dispersible granules) formulation of Paclobutrazol 1.5%+Mancozeb 50%+Trifloxystrobin 5%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.50
Mancozeb a.i. 50.00
Trifloxystrobin a.i. 5.00
Modified sodium lignosulphonate 15.00
Polyacrylate co-polymer 2.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
China Clay 18.00
TOTAL 100.0

Process of preparation: as per example 2

Example 6: WG (Water dispersible granules) formulation of Paclobutrazol 1.5%+Mancozeb 50%+Difenoconazole 5%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.50
Mancozeb a.i. 50.00
Difenoconazole a.i. 5.00
Modified sodium lignosulphonate 15.00
Polyacrylate co-polymer 2.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
China Clay 18.00
TOTAL 100.0

Process of preparation: as per example 1

Example 7: WG (Water dispersible granules) formulation of Paclobutrazol 1.5%+Mancozeb 50%+Tebuconazole 5%
Composition Contents (% w/w)
Paclobutrazol a.i. 1.50
Mancozeb a.i. 50.00
Tebuconazole a.i. 5.00
Modified sodium lignosulphonate 15.00
Polyacrylate co-polymer 2.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 3.00
Silicone based antifoam 0.50
Sodium Sulfate Anhydrous 5.00
China Clay 18.00
TOTAL 100.00

Process of preparation: as per example 2

Example 8: Storage stability-WG (Water dispersible granule) of Paclobutrazol 1.2%+Chlorothalonil 40%+Azoxystrobin 5%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.14-1.32 1.22 1.21 1.2
Paclobutrazol Suspensibility Mini 80% 99 98 99
Chlorothalonil Content 38.0-42.0 40.2 40.15 40.18
Chlorothalonil Suspensibility Mini 80% 98 98 99
Azoxystrobin Content 4.75-5.5 5.2 5.15 5.19
Azoxystrobin Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 5.0-8.0 7 7.1 7
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 month 12 months
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.14-1.32 1.22 1.21 1.21
Paclobutrazol Suspensibility Mini 80% 99 99 99
Chlorothalonil Content 38.0-42.0 40.2 40.2 40.18
Chlorothalonil Suspensibility Mini 80% 99 99 99
Azoxystrobin Content 4.75-5.5 5.2 5.19 5.18
Azoxystrobin Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 5.0-8.0 7 7 7.05
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Bulk density 0.45 -0.55 0.5 0.5 0.5
Moisture Content Max 2.0% 1.5 1.5 1.49
Wettability Max 30 s 5 5 6

Example 9: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.2%+Chlorothalonil 40%+Difenoconazole 4%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.14-1.32 1.22 1.21 1.2
Paclobutrazol Suspensibility Mini 80% 99 98 99
Chlorothalonil Content 38.0-42.0 40.2 40.15 40.18
Chlorothalonil Suspensibility Mini 80% 98 98 99
Difenoconazole Content 3.8-4.4 4.1 4 4
Difenoconazole Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 5.0-8.0 7 7 7
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 month 12 months
Paclobutrazol Content 1.14-1.32 1.22 1.21 1.21
Paclobutrazol Suspensibility Mini 80% 99 99 99
Chlorothalonil Content 38.0-42.0 40.2 40.2 40.18
Chlorothalonil Suspensibility Mini 80% 99 99 99
Difenoconazole Content 3.8-4.4 4.1 4.08 4.05
Difenoconazole Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 5.0-8.0 7 7 7.05
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Example 10: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.5%+Mancozeb 50%+Azoxystrobin 6.25%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.5 1.5
Paclobutrazol Suspensibility Mini 80% 99 98 99
Mancozeb Content 47.5-52.5 50.1 50 50
Mancozeb Suspensibility Mini 80% 98 98 99
Azoxystrobin Content 5.937-6.875 6.3 6.25 6.25
Azoxystrobin Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 5.0-8.0 7 7 7
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 months 12 months
Paclobutrazol Content 1.425-1.650 1.51 1.51 1.5
Paclobutrazol Suspensibility Mini 80% 99 99 99
Mancozeb Content 47.5-52.5 50.1 50.1 50
Mancozeb Suspensibility Mini 80% 99 99 99
Azoxystrobin Content 5.937-6.875 6.3 6.3 6.3
Azoxystrobin Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 5.0-8.0 7 7 7.05
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Example 11: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.5%+Mancozeb 50%+Pyraclostrobin 5.0%
Laboratory storage stability for 14 days
parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.5 1.5
Paclobutrazol Suspensibility Mini 80% 99 98 99
Mancozeb Content 47.5-52.5 50.1 50 50
Mancozeb Suspensibility Mini 80% 98 98 99
Pyraclostrobin Content 4.75-5.5 5.1 5 5.05
Pyraclostrobin Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 5.0-8.0 7 7 7
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 months 12 months
Paclobutrazol Content 1.425-1.650 1.51 1.51 1.5
Paclobutrazol Suspensibility Mini 80% 99 99 99
Mancozeb Content 47.5-52.5 50.1 50.1 50
Mancozeb Suspensibility Mini 80% 99 99 99
Pyraclostrobin Content 4.75-5.5 5.1 5.1 5.08
Pyraclostrobin Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 5.0-8.0 7 7 7.05
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Example 12: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.5% +Mancozeb 50%+Trifloxystrobin 5.0%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.5 1.5
Paclobutrazol Suspensibility Mini 80% 99 98 99
Mancozeb Content 47.5-52.5 50.1 50 50
Mancozeb Suspensibility Mini 80% 98 98 99
Trifloxystrobin Content 4.75-5.5 5.1 5 5.05
Trifloxystrobin Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 5.0-8.0 7 7 7
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 months 12 months
Paclobutrazol Content 1.425-1.650 1.51 1.51 1.5
Paclobutrazol Suspensibility Mini 80% 99 99 99
Mancozeb Content 47.5-52.5 50.1 50.1 50
Mancozeb Suspensibility Mini 80% 99 99 99
Trifloxystrobin Content 4.75-5.5 5.1 5.1 5.08
Trifloxystrobin Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 5.0-8.0 7 7 7.05
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Example 13: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.5%+Mancozeb 50%+Difenoconazole 5.0%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.5 1.5
Paclobutrazol Suspensibility Mini 80% 99 98 99
Mancozeb Content 47.5-52.5 50.1 50 50
Mancozeb Suspensibility Mini 80% 98 98 99
Difenoconazole Content 4.75-5.5 5.1 5 5.05
Difenoconazole Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 6.0-9.0 7.5 7.7 7.5
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 months 12 months
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.51 1.5
Paclobutrazol Suspensibility Mini 80% 99 99 99
Mancozeb Content 47.5-52.5 50.1 50.1 50
Mancozeb Suspensibility Mini 80% 99 99 99
Difenoconazole Content 4.75-5.5 5.1 5.1 5.08
Difenoconazole Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 6.0-9.0 7.5 7.5 7.5
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Example 14: Storage stability-WG (Water dispersible granules) of Paclobutrazol 1.5%+Mancozeb 50%+Tebuconazole 5.0%
Laboratory storage stability for 14 days
Parameters specification (in house) initial heat stability at 54±2 0C cold stability at 0±2 0C
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.5 1.5
Paclobutrazol Suspensibility Mini 80% 99 98 99
Mancozeb Content 47.5-52.5 50.1 50 50
Mancozeb Suspensibility Mini 80% 98 98 99
Tebuconazole Content 4.75-5.5 5.1 5 5.05
Tebuconazole Suspensibility Mini 80% 98 98 99
pH (1% in DM Water) 6.0-9.0 7.5 7.7 7.5
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.7 99.7
Moisture Content Max 2.0% 1.5 1.48 1.45
Wettability Max 30 s 5 6 6
Bulk density 0.45 -0.55 0.5 0.5 0.5
Room temperature storage stability up to 12 months
Parameters Specification Study Duration
In House 1 month 6 months 12 months
Description Off-white to Beige liquid Complies Complies Complies
Paclobutrazol Content 1.425-1.650 1.51 1.51 1.5
Paclobutrazol Suspensibility Mini 80% 99 99 99
Mancozeb Content 47.5-52.5 50.1 50.1 50
Mancozeb Suspensibility Mini 80% 99 99 99
Tebuconazole Content 4.75-5.5 5.1 5.1 5.08
Tebuconazole Suspensibility Mini 80% 99 99 99
pH (1% in DM Water) 6.0-9.0 7.5 7.5 7.5
Wet-sieve(45 micron sieve) Mini 99.5% 99.8 99.8 99.7
Moisture Content Max 2.0% 0.5 0.5 0.5
Wettability Max 30 s 1.5 1.5 1.49
Bulk density 0.45 -0.55 5 5 6

Biological Examples:
The synergistic pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) of active ingredient is greater than the sum of the action of each of the components alone. Therefore a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components. In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two active components can be calculated as follows:
Colby’s Formula:

To study the synergistic effect of paclobutrazol, fungicide and one more fungicide, various sets of experiments were conducted in different crops like chilli.
Example 1:
The synergistic mixture of Paclobutrazol+Chlorothalonil+Azoxystrobin and Paclobutrazol+Chlorothalonil+Difenoconazole were evaluated on chilli (Capsicum annuum) crop.
Details of Experiment:
a) Experiment design : Randomized Block Design
b) Replication : Three
c) Treatments : Twelve
d) Plot size : 30 sq. m.
e) Spacing : 100 cm x 50 cm
f) Test Crop & Variety : Chilli, Rani (Green fruit purpose)
g) Time of application : Two spray, 1st at 50 days, 2nd at 60 days after transplanting
h) Spray Volume : 1st spray- 475 l/h and 2nd spray-525 l/h
i) Method of application : Foliar spray with knap sack sprayer
The chilli nursery was raised and transplanted in the main field at row to row 100 cm and plant to plant 50 cm spacing. Rest of the agronomic practices like fertilizer applications, weeding, irrigation (drip irrigation) were as per the standard agronomic practices. The spraying was done at 50 and 60 days after transplanting with the help of knapsack sprayer. The observations on severity and incidence of various diseases and fruit counts were taken as follow:
1) Die back disease:
Observations recorded at 15 days after 2nd application by observing 25 plant per plot. The disease severity recorded by following 0-9 scale described as below;
Grade Percent branches & foliage infected per plant
0 No infection to branches and leaves
1 1-10% Branches or leaves infected
3 11-25% Branches or leaves infected
5 26-50% Branches or leaves infected
7 51-75% Branches or leaves infected
9 >75% Branches or leaves infected.

% Disease Incidence= No. of plants infected X 100.
No. of plants observed

Die back PDI= .___________Sum of numerical disease rating X 100
Total no. of samples X Maximum of disease rating scale

2) Fruit rot disease:
The fruit rot disease severity and incidence recorded in similar way as die-back. Record the number of infected fruits and healthy fruits per plant to calculate disease incidence and rate the infected fruits in 0 to 9 Grade for severity and calculate % fruit rot incidence and % fruit rot severity.
3) Green fruit:
Count the no. of green fruits per plant at 15 days after 2nd spray. Take the counting from 25 plants per plot.

Table 1: Treatment composition
Sample Code Treatment Compositions
GSP-18-F10 PCB 1.2%+Chlorothalonil 40%+Azoxystrobin 5% WG,30+1000+125 gai/h
GSP-18-F11 PCB 1.2%+Chlorothalonil 40%+Difenoconazole 4% WG,30+1000+100 gai/h
Prior Art 1 PCB 1.2%+Chlorothalonil 40% WG,30+1000 gai/h
Prior Art 2 PCB 1.2%+Azoxystrobin 5% WG, 30+125 gai/h
Prior Art 3 PCB 1.2%+Difenoconazole 4% WG, 30+100 gai/h
Prior Art 4 Chlorothalonil 40%+Azoxystrobin 5% WG, 1000+125 gai/h
Prior Art 5 Chlorothalonil 40%+Difenoconazole 4% WG, 1000+100 gai/h
Prior Art 6 PCB 23% SC, 30 gai/h
Prior Art 7 Chlorothalonil 75% WP,1000 gai/h
Prior Art 8 Azoxystrobin 23% SC,125 gai/h
Prior Art 9 Difenoconazole 25% EC, 100 gai/h
Untreated Check (UTC)
PCB- Paclobutrazol, gai/h- Gram active ingredient per hectare

Table 2: Effect of novel synergistic composition on chilli fruit yield
Treatment details Number of Healthy fruits per plant
Observed Value Expected value Ratio
GSP-18-F10 125.2 91.89 1.36
GSP-18-F11 117.8 89.96 1.31
Prior Art 1 58.5 66.77 0.88
Prior Art 2 83.2 84.29 0.99
Prior Art 3 77.8 80.55 0.97
Prior Art 4 85.4 87.41 0.98
Prior Art 5 82.8 84.42 0.98
Prior Art 6 35.6
Prior Art 7 48.4
Prior Art 8 75.6
Prior Art 9 69.8
Untreated Check (UTC) 25.2

Table 3: Efficacy of novel synergistic composition against fungal diseases of chilli
Treatment details Chilli disease incidence and severity
Die back disease, Colletotrichum capsici Fruit rot disease, Phytophthora capsici
Severity (%) Incidence (%) Severity (%) Incidence (%)
GSP-18-F10 0.00 0.00 0.00 0.00
GSP-18-F11 0.00 0.00 0.00 0.00
Prior Art 1 15.84 28.74 14.28 11.73
Prior Art 2 12.26 16.82 10.29 8.28
Prior Art 3 14.82 18.38 12.38 10.28
Prior Art 4 8.25 10.83 6.28 4.28
Prior Art 5 9.82 12.63 8.38 3.96
Prior Art 6 28.64 46.28 30.62 30.29
Prior Art 7 20.64 30.26 22.83 22.38
Prior Art 8 15.52 24.85 16.38 14.72
Prior Art 9 17.80 35.28 18.20 18.39
Untreated Check (UTC) 33.65 60.62 40.28 52.38

The inventive mixture of Paclobutrazol+Chlorothalonil+Azoxystrobin and Paclobutrazol+Chlorothalonil+Difenoconazol provides excellent control of fungal diseases like die back caused by Colletotrichum capsici and fruit rot caused by Phytophthora capsici. Both inventive mixtures tested also shows synergism (Ration of O/E > 1) in terms of number of green fruits per plant which contributes to the higher fruit yield.
,CLAIMS:CLAIMS
We claim;
[CLAIM 1]. An synergistic pesticidal composition comprising
a. Paclobutrazol;
b. one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper;
c. one more active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl; and
d. one or more other inactive excipients.

[CLAIM 2]. The synergistic pesticidal composition as claimed in claim 1 wherein the component (A) Paclobutrazol is in ratio of 0.1 to 10%, component (B) one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper is in ratio of 0.1 to 60% (C) one more active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl 0.1 to 30%.

[CLAIM 3]. The synergistic pesticidal composition as claimed in claim 1 or 2, wherein inactive excipients are selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

[CLAIM 4]. The synergistic pesticidal composition as claimed in claim 1-3, wherein the preferred formulation is Water dispersible granule (WDG or WG).

[CLAIM 5]. The synergistic pesticidal composition as claimed in claim 1 or 4, wherein the Water dispersible granule (WG) formulation comprises:
a) component (A) Paclobutrazol is in ratio of 0.1 to 10%;
b) component (B) at least one more active ingredient selected from Mancozeb, Propineb, Chlorothalonil, Folpet, Captan, Dithianon, Fthalide, Metiram, Sulphur and different salts of copper is in ratio of 0.1 to 60%;
c) active ingredient selected from Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Difenoconazole, Cyproconazole, Expoxiconazole, Flusilazole, Hexaconazole, Isoprothiolane, Propiconazoe, Prothioconazole, Tebuconazole, Tricyclazole, Thiophanate methyl is in ratio of 0.1 to 30%;
d) Modified sodium lignosulphonate;
e) Polyacrylate co-polymer;
f) Sodium alkylnaphthalenesulfonate, formaldehyde condensate;
g) Silicone based antifoam;
h) Sodium Sulfate Anhydrous;
i) China Clay.
[CLAIM 6]. The synergistic pesticidal composition as claimed in any of the preceding claims, wherein the said composition is effective for management or control or regulate crop (plant) growth and to manage or control fungal diseases in the crops selected from GMO (Genetically Modified Organism/crops) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Soybean (Glycin max), Peanut/Groundnut (Arachis hypogaea), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum).

[CLAIM 7]. The synergistic pesticidal composition as claimed in any of the preceding claims, wherein the said composition controls phytopathogenic fungi such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, and the like.Examples which may be mentioned, but not by limitation, are some pathogens of fungal diseaseswhich come under the above generic terms: Diseases caused by pathogens causing powdery mildew such as, for example, Blumeria species such as, for example, Blumeriagraminis; Podosphaera species such as, for example, Podosphaeraleucotricha;Sphaerotheca species such as, for example, Sphaerothecafuliginea; Uncinula species such as, for example, Uncinulanecator; Leveillula species such as, for example Leveillulataurica, Erysiphe species such as for example Erysiphepolygoni, diseases caused by pathogens of rust diseases such as, for example, Gymnosporangium species such as, for example, Gymnosporangiumsabinae, Hemileia species such as, for example, Hemileiavastatrix; Phakopsora species such as, for example, Phakopsorapachyrhizi and Phakopsorameibomiae; Puccinia species such as, for example, Pucciniagraminis, Pucciniarecondita or Pucciniatriticina, Pucciniastriiformis; Uromyces species such as, for example, Uromycesphaseoli; diseases caused by pathogens of smut diseases such as, for example, Sporisorium species such as , for example, Sporisoriumscitamineum; Ustilago species such as, for example Ustilagomaydis, Tilletia species such as for example Tilletiatritici, Ustilaginoidea species such as , for example Ustilaginoideavirens, diseases caused by pathogens of ergot diseases such as, for example Claviceps species, Clavicepspurpurea; leaf spot, leaf blight and leaf wilt diseases caused by, for example, Alternaria species such as, for example, Alternariasolani; Cercospora species such as, for example, Cercosporabeticola; Cladiosporum species such as, for example, Cladiosporiumcucumerinum; Cochliobolus species such as, for example, Cochliobolussativus (conidial form: Drechslera, syn: Helminthosporium); Colletotrichum species such as, for example, Colletothrichum capsici- Die back of chillies, Colletotrichumlindemuthanium; Cycloconium species such as, for example, Cycloconiumoleaginum; Diaporthe species such as, for example, Diaporthecitri; Elsinoe species such as, for example, Elsinoefawcettii; Gloeosporium species such as, for example, Gloeosporiumlaeticolor; Glomerella species such as, for example, Glomerellacingulata; Guignardia species such as, for example, Guignardiabidwelli; Leptosphaeria species such as, for example, Leptosphaeriamaculans; Magnaporthe species such as, for example, Magnaporthegrisea;Mycosphaerella species such as, for example, Mycosphaerellagraminicola; Phaeosphaeria species such as, for example, Phaeosphaerianodorum; Pyrenophora species such as, for example, Pyrenophorateres;Ramularia species such as, for example, Ramulariacollo-cygni; Rhynchosporium species such as, for example, Rhynchosporiumsecalis; Septoria species such as, for example, Septoriaapii;Typhula species such as, for example, Typhulaincarnata; Venturia species such as, for example, Venturiainaequalis; root and stalk diseases, caused by, for example, Corticium species such as, for example, Corticiumgraminearum; Fusarium species such as, for example, Fusariumoxysporum;Gaeumannomyces species such as, for example, Gaeumannomycesgraminis; Rhizoctonia species such as, for example, Rhizoctoniasolani; Tapesia species such as, for example, Tapesiaacuformis;Thielaviopsis species such as, for example, Thielaviopsisbasicola; ear and panicle diseases (including maize cobs), caused by, for example, Alternaria species such as, for example, Alternaria spp.;Aspergillus species such as, for example, Aspergillusflavus; Cladosporium species such as, for example, Cladosporium spp.; Claviceps species such as, for example, Clavicepspurpurea; Fusarium species such as, for example, Fusariumculmorum; Gibberella species such as, for example, Gibberellazeae; Monographella species such as, for example, Monographellanivalis;Smut diseases caused by, for example, Sphacelotheca species such as, for example, Sphacelothecareiliana; Tilletia species such as, for example, Tilletia caries; Urocystis species such as, for example, Urocystisocculta; Ustilago species such as, for example, Ustilagonuda; fruit rot caused by, for example, Aspergillus species such as, for example, Aspergillusflavus; Botrytis species such as, for example, Botrytis cinerea; Penicillium species such as, for example, Penicilliumexpansum; Sclerotinia species such as, for example, Sclerotiniasclerotiorum; Verticilium species such as, for example, Verticiliumalboatrum; seed- and soil-borne rots and wilts, and seedling diseases, caused by, for example, Fusarium species such as, for example, Fusariumculmorum; Phytophthora species such as, for example, Phytophthora capsici causing Fruit rot in chillies Phytophthoracactorum; Pythium species such as, for example, Pythiumultimum; Rhizoctonia species such as, for example, Rhizoctoniasolani; Sclerotium species such as, for example, Sclerotiumrolfsii; cankers, galls and witches' broom diseases, caused by, for example, Nectria species such as, for example, Nectriagalligena; wilts caused by, for example, Monilinia species such as, for example, Monilinialaxa; deformations of leaves, flowers and fruits, caused by, for example, Taphrina species such as, for example, Taphrinadeformans; degenerative diseases of woody species, caused by, for example, Esca species such as, for example, Phaemoniellaclamydospora; flower and seed diseases, caused by, for example, Botrytis species such as, for example, Botrytis cinerea; diseases of plant tubers caused by, for example, Rhizoctonia species such as, for example, Rhizoctoniasolani; diseases caused by bacterial pathogens such as, for example, Xanthomonas species such as, for example, Xanthomonascampestrispv. oryzae; Pseudomonas species such as, for example, Pseudomonas syringaepv. lachrymans; Erwinia species such as, for example, Erwinia amylovora.