FIELD OF THE INVENTION
Embodiments of the present invention generally relate to the field of pesticidal formulations, and, more particularly, to a synergistic and stable pesticidal granular formulation.
BACKGROUND OF THE INVENTION
Generally, it is well known in the art that pesticides are substances meant to control pests or weeds. Also, the Food and Agriculture Organization (FAO) has defined a pesticide as, "any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or substances that may be administered to animals for the control of insects, arachnids, or other pests in or on their bodies". In addition, the term further includes substances intended for use as a plant growth regulator, defoliant, desiccant, or agent for thinning fruit or preventing the premature fall of fruit. Pesticides are also used as substances that are applied to crops either before or after harvest to protect the commodity from deterioration during storage and transport.
Generally, Emamectin benzoate is widely used in the United States of America and Canada as an insecticide because of its chloride channel activation properties. Emamectin benzoate works as a chloride channel activator by binding gamma amino butyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods. The compound stimulates the release of GABA from the synapses between nerve cells and while additionally increasing GABA's affinity for its receptor on the post-junction membrane of muscle cells in insects and arthropods. The stronger binding of GABA increases the cells permeability to chloride ions within the cell due to the hypotonic

concentration gradient. Neurotransmission is thereby reduced by subsequent hyperpolarization and the elimination of signal transduction. Moreover, Profenofos can be used on a variety of crops including cotton and vegetables such as maize, potato, soybean, and sugar beet. In the United States, it is used exclusively on cotton and is primarily used against lepidopteran insects.
Generally, Profenofos is available in market as emulsifiable concentrate (EC) formulation and ultra-low volume liquid (UL) formulation. Profenofos is also available in mixture with cypermethrin, beta-cypermethrin, phoxim, imidacloprid and deltamethrin. Profenofos is a non-systemic insecticide. Profenofos can be used against cotton mealybug, cabbage caterpillar, plutella xylostella and asparagus caterpillars, as well as against wheat and cabbage aphids.
Additionally, like other organophosphates, Profenofos mechanism of action is via the inhibition of the acetyl cholinesterase enzyme. Although it is used in the form of a racemate, the S (-) isomer is a more potent inhibitor. In use, when an active substance is in a liquid state at ambient temperatures, then it has been formulated in a number of ways that to varying extents, so that formulated products are adapted for ease of transport, handling and application. It is generally desirable with these various formulations that the active substance be delivered in the form of an aqueous spray. Examples of types of formulations that may be applied in this manner are emulsifiable concentrates (EC), suspension concentrates (SC) and oil dispersion (OD) etc. Limitations of EC and OD formulations include the dangers in packaging, storing and handling highly flammable solvents. SC formulations can have storage problems and are difficult to clean up after spillage. Furthermore, Wettable granule (WG) or Water dispersible granule (WDG) formulations offer significant advantages in packaging, ease of handling and safety. Typically, these consist of small granules and preferably of uniform size and which are free flowing, low dusting and readily disperse in water to form homogenous suspension of very small particles that may pass through conventional spray nozzles. Ideally wettable granule or water dispersible granule formulations when dispersed in water under gentle agitation for few

minutes have residues of less than 0.01% on a 150 pm sieve screen and less than 0.5% on a 53 pm screen. The granules can usually be measured accurately by volume which is convenient for the end user. As disclosed hereinbelow, some documents are available as prior art which suggest the use of Emamectin benzoate and Profenofos, in various formulation for controlling the insects. For example, Indian Patent 206677, discloses the combination of Emamectin benzoate and one or more of the compound(s) selected from the group consisting of Profenofos as one of the group members. In this prior art, the amount of any of the second compound selected from the group with Emamectin benzoate is present between 5%-21% in the granules as represented by the general method of preferred example along with Kaolin, highly dispersed silicic acid and/or attapulgite. Further, this prior art is claiming specifically azamethiphos, cypermethrin high-cis and fenoxycarb in combination with Emamectin benzoate. Therefore, this prior art is not specifically for Profenofos in combination with Emamectin benzoate. Also, liquid active ingredient like Profenofos in the synergistic, stable and safe wettable granule formulation of the instant invention is present in higher amount in comparison to this prior art. Even due to presence of higher amount of liquid active ingredient like Profenofos, the granules of present invention are dustless and free flow with other advanced quality of formulation, which is a technically advanced step in comparison to this prior art.
In addition to above, US patent application US 2006/0093637 A1, discloses an insecticidal composition comprising insecticide and phosphonates or derivatives thereof. An insecticidal composition according to claim 1 wherein the insecticide is selected from chlorpyrifos, profenofos, pirimicarb, imidacloprid, acetamiprid, nitenpyram, clothianidin, thiacloprid, thiamethoxam, MTI-446, spinosad, abamectin, Emamectin benzoate, fipronil, lambdacyhalothrin, gamma-cyhalothrin, indoxacarb, fenpyroximate, tebufenpyrad, chlorfenapyr, lufenuron, cyromazine, diafenthiuron and pymetrozine.
Also, Australian Patent Application No. AU 2007230693 B2 discloses a dry spreadable or broadcast granule comprising:

i) a solid carrier;
ii) at least one substantially water-insoluble active chemical agent; and iii) an emulsifier system capable of forming a microemulsion of the at least one substantially water-insoluble active chemical agent (ii) upon dilution in water.
Moreover, Chinese Patent Application No. CN 102047905A discloses emulsion in water (EW) formulation having the mass percent of the Emamectin benzoate to the Profenofos is (0.1-20): (5-80). The present invention has advantages over this prior art in the form of efficacy, stability and safety by wettable granule formulation comprising liquid active ingredient Profenofos and Emamectin benzoate. Additionally, Chinese Patent Application No. CN 101601406 A, discloses about water dispersible granule formulation comprising Pymetrozine and Profenofos, wherein in preferred examples maximum amount of Profenofos used is 25%, further this composition is used to control rice planthopper. The drawback of this prior art is that it is not used in broad spectrum against pest and in various crops.
Indian Patent Application No. IN 705/DEL/2013 discloses an insecticidal composition of Emamectin benzoate amount ranging from 0.5 to 3% by weight and thiamethoxam amount ranging from 10-15% by weight of the composition, here both active ingredients are in solid form, thus it is easy to prepare granular formulation of solid active ingredients, rather this document is not specifically describing synergistic and stable wettable granule formulation comprising Emamectin benzoate and Profenofos, having water content less than 3.0%. Also, one of the active ingredient Profenofos, of present invention is in liquid form, thus it is a technically advance step to prepare its granular formulation having its broader synergistic amount in comparison to prior art.
Indian Patent IN 263280, discloses the process for the preparation of water dispersible granular formulation where suspension concentrate or dispersion of solid active ingredient was done which then be granulated. Further on this granule, the emulsifiable solution of liquid active ingredient is absorbed i.e. sprayed. This whole process is lengthy and also even

spraying of emulsifiable solution of liquid active ingredient is not environmentally friendly. The formulation of this document had two agrochemically acceptable excipients, whereas present invention is specifically for synergistic and stable wettable granule formulation comprising Emamectin benzoate and Profenofos. Even also the process for the preparation of present invention formulation is economical and commercially viable.
PCT Patent Application No. WO/2016/180658 A1 discloses EC formulations (emulsifiable concentrate) comprising 10-40% by weight of one or more actives among the organophosphates. Profenofos is not disclosed in the specification of this document. Further, due to use of organic solvent EC formulation causes environmental pollution and phytotoxicity to plants. Accordingly, there exists a need in the art for developing a suitable wettable granule composition comprising two or more active ingredients, because the use of instant granular formulation is less risky for farmers then the corresponding liquid formulation, as the exposure to hazardous chemicals gets reduced. However, the solid pesticidal composition such as wettable granule (WDG or WG) containing combination of agriculture actives with different mode of action can be difficult to produce. Many factors play a role in the ability to provide an active ingredient in a specific form or composition. For example, solid formulation such as wettable granule typically requires the active ingredients to be in the form of appropriate dispersed particle in order to achieve optimal suspensibility in water. Further, when using an active ingredient having low melting temperature or liquid active ingredient, direct grinding of the discrete solid of that active ingredient can be difficult due to melting or softening of the active ingredient itself during grinding when subject to range of temperature and shear stress which is normally encountered during processing and storage.
The storage stability of granule formulation containing low melting active ingredient or liquid active ingredient in the form of solid particles can be negatively impacted by the tendency of the solid particles to soften and then coalesce or agglomerate into large particles. Such physical instability can

lead to granule formulation that does not disperse well in water and forms unstable suspension that delivers substandard biological efficacy due to poor delivery on target locus of the pests after application. Accordingly, there remains a need in the art for synergistic and stable pesticidal granular formulations, which overcome the shortcomings of the prior art.
SUMMARY OF THE INVENTION
Multiple embodiments of the present invention relate to a synergistic and stable pesticidal wettable granule formulation having excellent insecticidal property comprising an effective amount of Emamectin benzoate and Profenofos as active ingredients. The present invention also relates to process for preparing the said stable granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation.
Yet another aspect of the present invention is to make a safe, free flowing, dustless dispersible granular formulation along with inactive excipients. The present invention also related to process for preparing synergistic water dispersible granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation.
Yet another aspect of the present invention is that it synergistically acts to have excellent pesticidal utility in control of several Coleopteran and Lepidopteran species like Armyworm ( Spodoptera fugiperda), Fruit Borer (Helicoverpa armigera), Tobacco caterpillar (Spodoptera litura), Semilooper (Agrotis ipsilon), Bihar hairy Caterpillar (Spilosoma obliqua), Spotted Pod borer (Earias vittella), Bollworm complex-Fruit borer (Helicoverpa armigera), Pink Bollworm (Pectinophora gossypiella), Spotted bollworm (Earias vittella), Spiny bollworm (Earias insulana ), Fruit and shoot borer(l_eucinodes orbonalis), Diamond back moth (Plutella xylostella), Pod Borer (Helicoverpa armigera), Looper caterpillar (Biston supressaria) and American bollworm (Spodoptera litura).

Embodiments of the present invention disclose a synergistic and stable
pesticidal granule formulation includes, an effective amount of a first
ingredient and a liquid active ingredient. In use, the first ingredient is
Emamectin benzoate and the liquid active ingredient is an
organothiophosphate. In further use, the liquid active ingredient is an
organophosphate insecticide. Specifically, the liquid active ingredient is
Profenofos.
In accordance with an embodiment of the present invention, the synergistic
and stable pesticidal granule formulation is a synergistic and stable water
dispersible granular formulation (WDG or WG).
In accordance with an embodiment of the present invention, Emamectin
benzoate is present in a range of approximately 1% to 3% by weight of
formulation. In use, Profenofos is present in a range of approximately 32%
to 40% by weight of formulation.
Other aspects of the invention will be set forth in the description which
follows, and in part will be apparent from the description, or may be learnt
by the practice of the invention.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is related to a synergistic and stable pesticidal wettable granule formulation comprising an effective amount of Emamectin benzoate and Profenofos. The present invention also relates to process for preparing the said stable granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation. An adjuvant used in the present invention to make it a stable, safe, free flowing, dustless dispersible granular formulation comprises inert fillers, surfactant, emulsifier, binder and wetting agent. The term "pesticide" or "pesticidal" is similar to "insecticide" or "insecticidal" and is used interchangeably in this whole specification. Also, the term "pesticidal formulation" or "insecticidal formulation" or "agrochemical formulation" is used interchangeably in this whole specification. The phrase "pesticidally effective amount" or "effective amount" means the amount of a pesticide needed to achieve an observable effect on a pest

and/or activity of a pest in a locus; this effect may come about when pest
populations are repulsed from a locus, pests are incapacitated in or around
a locus and/or pests are exterminated in or around a locus. Of course, a
combination of these effects can occur. Generally, pest populations or
activity or both are desirably reduced more than fifty percent, preferably
more than 90 percent and most preferably more than 99 percent. The
formulation of present invention synergistically acts to have excellent effect
on pests thus it has excellent pesticidal utility in control of pest.
Synergism is the interaction or cooperation of two or more organizations,
substances, or other agents to produce a combined effect greater than the
sum of their separate effects.
As described in the Herbicide Handbook of the Weed Science Society of
America, Ninth Edition, 2007, p. 429, "synergism" [is] an interaction of two
or more factors such that the effect when combined is greater than the
predicted effect based on the response to each factor applied separately.
Colby's formula is applied to determine synergistic effect, as provided in
WEEDS 1967, 15,22
E = (X + Y)-((Xx Y)/100)
For Synergy, O/E > 1
wherein;
X= individual response of (a) Emamectin benzoate
Y= individual response of (b) Profenofos
E= expected (or predicted) response of combination of (a) + (b) when
applied
0= observed response of combination of (a) + (b) when applied
The phrase "synergistically effective amount" of the formulation means a
sufficient amount of the formulation to provide the desired pesticidal effect.
In general, the formulation is employed in amounts that do not cause
phytotoxic damage to any part of the plant and also it is safe to natural
enemies. The amount of the formulation may vary depending on specific
crops and other factors.
The formulation of present invention acts synergistically to control pest in
various crops. The pesticidal utility of present invention in excellent control

of pest of several Coleopteran and Lepidopteran species in various crops is
given in Table 1. Table 1

Crop Crop Family Pest
Maize (Zea mays) Poaceae Armyworm ( Spodoptera fugiperda)
Tomato (Solanum lycopersicum) Solanaceae Fruit Borer (Helicoverpa armigera)
Urd (Vigna mungo) Leguminaceae Tobacco caterpillar (Spodoptera litura)
Mung (Vigna radiata) Leguminaceae Tobacco caterpillar (Spodoptera litura)
Soybean (Glycine max) Leguminaceae Tobacco caterpillar (Spodoptera litura), Semilooper (Agrotis ipsilon)ar\d Bihar hairy Caterpillar (Spilosoma obliqua)
Okra( Abelmoschus esculentus) Malvaceae Fruit borer (Helicoverpa armigera), Spotted Pod borer (Earias vittella)
Cotton (Gossipium spp) Malvaceae Bollworm complex- Fruit borer (Helicoverpa armigera), Tobacco caterpillar (Spodoptera liura), Pink Bollworm (Pectinophora gossypiella), Spotted bollworm (Earias vittella), Spiny bollworm (Earias insulana)
Brinjal (Solanum melongena) Solanaceae Fruit and shoot borer(Leucinodes orbonalis)
Wheat (Triticum aestivum) Poaceae Armyworm (Spodoptera fugiperda)
Chiili (Capsicum annuum and Capsicum frutescens) Solanaceae Fruit Borer (Helicoverpa armigera)

Cabbage (Brassica oleracea) Brassicaceae Diamond back moth (Plutella xylostella)
Pigeon pea (Cajanus cajan) Fabaceae Pod Borer (Helicoverpa armigera)
Chickpea (Cicer arietinum) Fabaceae Pod Borer (Helicoverpa armigera)
Tea (Camellia sinensis) Theaceae Looper caterpillar (Biston supressaria)
Black gram (Vigna mungo) Fabaceae Pod Borer(Helicoverpa armigera)
Bitter gourd ( Momordica charantia) Cucurbitaceae Fruit borers & Caterpillars
Ground nut (Arachis hypogaea) Leguminosae American bollworm (Spodoptera litura), Bihar hairy caterpillar (Spilosoma obliqua)
An adjuvant used in the present invention is any material that is added to an agrochemical formulation to enhance or modify the performance of the formulation. An adjuvant used in the present invention to make it a stable, safe, free flowing, dustless dispersible granular formulation comprises inert fillers, surfactant, emulsifier, binder and wetting agent. The term "adjuvants" is similar to "inactive excipients" and used interchangeably in this whole specification. In accordance with the present invention, the synergistic composition further comprises one or more agriculturally acceptable adjuvants.
One or more inert fillers used herein can be selected from the group comprising of Water, Precipitated silica, Fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof. Emulsifier used in the present invention is selected from the group comprising of Linear dodecylbenzene sulfonate calcium salt in 2-ethylhexanol solution, Benzenesulfonic acid, 4-C10-14-alkyl derivatives, calcium salts, Sodium dioctyl sulfosuccinate, Ethoxylated propoxylated polyarylphenol, Thiophospharyl succinate salt, Taurine derivatives (in

particular alkyl taurate), Polyoxyethylene alcohol or Phenol phosphoric acid ester, Fatty acid esters of polyols.
Surfactant used in the present invention is selected from the group comprising of Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), 2,5-Furandione, polymer with 2,4,4-trimethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof.
One or more binder used in the present invention is selected from the group comprising of Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a mixture thereof. Optionally, titanium dioxide as whitening agent may be used in the present invention. The synergistic and stable granular formulation of present invention is wettable granule formulation (WG) or water dispersible granular formulation (WDG). The synergistic granular formulation of present invention is stable, safe, free flowing and dustless formulation. Various embodiments of the present invention are aimed at providing synergistic and stable pesticidal granular formulations having an effective amount of Emamectin benzoate and Profenofos. As disclosed hereinbelow, Emamectin benzoate is present in the rage of 1 to 3% by weight of formulation and Profenofos is in the range of 32% to 40% by weight of formulation. Additionally, embodiments of the instant invention also relate to a process for preparing the said stable granular formulation and its pesticidal utility. Those of ordinary skills in the art will appreciate that mechanism of action of active ingredient Emamectin benzoate and mechamism of action of active ingredient Profenofos have been discussed hereinabove.
In order to provide the solution of long felt need of efficacious, stable and safe wettable granule formulation, the inventors of the present invention conducted extensive study and comes up with suitable composition comprising active ingredients Emamectin benzoate and Profenofos in

wettable granule form without much complex manufacturing process which is economically efficient. The formulation of present invention is stable and synergistically acts to have excellent pesticidal utility in control of Armyworm ( Spodoptera fugiperda), Fruit Borer (Helicoverpa armigera), Tobacco caterpillar (Spodoptera litura), Semilooper (Agrotis ipsilon), Bihar hairy Caterpillar (Spilosoma obliqua), Spotted Pod borer (Earias vittella), Bollworm complex- Fruit borer (Helicoverpa armigera), Pink Bollworm (Pectinophora gossypiella), Spotted bollworm (Earias vittella), Spiny bollworm (Earias insulana ), Fruit and shoot borer(l_eucinodes orbonalis), Diamond back moth (Plutella xylostella), Pod Borer (Helicoverpa armigera), Looper caterpillar (Biston supressaria) and American bollworm (Spodoptera litura). The present invention has excellent use in various crop family such as Poaceae, Solanaceae, Leguminaceae, Malvaceae, Brassicaceae, Fabaceae, Theaceae and Cucurbitaceae without causing harm to natural enemies.
In accordance with an embodiment of the present invention, a synergistic and stable pesticidal granule formulation includes, an effective amount of a first ingredient and a liquid active ingredient. In use, the first ingredient is Emamectin benzoate and the liquid active ingredient is an organothiophosphate. In further use, the liquid active ingredient is an organophosphate insecticide. Specifically, the liquid active ingredient is Profenofos.
In accordance with an embodiment of the present invention, the synergistic and stable pesticidal granule formulation is a synergistic and stable water dispersible granular formulation (WDG).
In accordance with an embodiment of the present invention, Emamectin benzoate is present in a range of approximately 1% to 3% by weight of formulation. In use, Profenofos is present in a range of approximately 32% to 40% by weight of formulation.
In accordance with an embodiment of the present invention, the formulation further includes multiple adjuvants for making the formulation a stable, safe, free flowing, dustless and dispersible granular formulation. In use, the adjuvants are selected from a group including one or more inert fillers, one

or more surfactants, one or more emulsifiers, one or more binders and one or more wetting agents. In further use, the adjuvants are selected from a group including one or more agriculturally acceptable adjuvants. In accordance with an embodiment of the present invention, the one or more inert fillers are selected from a group including of water, precipitated silica, fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof.
In accordance with an embodiment of the present invention, the one or more emulsifiers are selected from a group including of Linear dodecylbenzene sulfonate calcium salt in 2-ethylhexanol solution, Benzenesulfonic acid, 4-C10-14-alkyl derivatives, calcium salts, Sodium dioctyl sulfosuccinate, Ethoxylated propoxylated polyarylphenol, Thiophospharyl succinate salt, Taurine derivatives (in particular alkyl taurate), Polyoxyethylene alcohol or Phenol phosphoric acid ester, Fatty acid esters of polyols. In accordance with an embodiment of the present invention, the one or more surfactants are selected from a group including of Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), 2,5-Furandione, polymer with 2,4,4-thmethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof. In accordance with an embodiment of the present invention, the one or more binders are selected from a group including of Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a blend thereof.
In accordance with an embodiment of the present invention, the formulation further includes a whitening agent. In use, the whitening agent is titanium dioxide. Those of ordinary skills in the art will appreciate that in alternate embodiments, other whitening agents may also be employed depending upon the specific requirements.

In accordance with an embodiment of the present invention, the formulation as disclosed herein is a synergistic and stable wettable granule formulation (WDGorWG).
In accordance with an embodiment of the present invention, the formulation as disclosed herein by way of one or more embodiments is capable of being employed in an amount that does not cause phytotoxic damage to any part of a plant and wherein the formulation is safe to multiple natural enemies. The following examples are intended to illustrate, but in no way limit the scope of the present invention.
EXAMPLES
Table A and B are depicting the specification of Profenofos and Emamectin benzoate technicals used for the preparation of desired wettable granule (WDG or WG) formulation: Table A: Profenofos technical

S.No. Test Parameter Specification Result
1. Description Yellowish to brown clear liquid Complies
2. Active Content % w/w 89.0 % min. 95.08 %
3. Acidity % w/w 0.5 % max. 0.012 %
4. Moisture Content % w/w 0.20 max. 0.002%
Table B: Emamectin benzoate technical

S.No. Test Parameter Specification Result
1. Description Off white to brownish homogenous powder Complies
2. Active Content % w/w 68.0% min. 70.05 %
3. Moisture Content % w/w 2.0 % max. 0.001 %

Example-1
Composition of Wettable Granule (WDG or WG) formulation

Ingredients Quantity % w/w
Profenofos technical 35.00
Emamectin benzoate technical 1.50
Lactose 20.00
Precipitated Silica 20.00
Geropon SA 5.00
Sodium lignosulfonate QS to make 100% w/w
Total 100% w/w
The stable synergistic wettable granule (WDG or WG) formulation with
above desired composition can be prepared by following procedure:
Step -1: Preparation of active ingredient micronized mixture
1.5 parts by weight of Emamectin benzoate technical was charged in pre-
mixer blender. Add ppt. silica 20 parts under stirring to Emamectin benzoate
technical followed by addition of lactose 20 parts at 30°C to 35°C. Stir the
mixture for further 30 minutes. After completion of mixing, the grinding of
mixture was done through jet mill to obtain micronized mass.
To this obtained micronized mass add 35 parts by weight of Profenofos
technical under stirring at 30°C to 35°C, mixing was continued for further 30
minutes to get homogenous active ingredients mass of particle size less
than 75 microns.
Step-2: Preparation of surfactants slurry
In another vessel 18-20 parts by weight of Sodium lignosulfonate, 5 parts of
Geropon SA and 32-42 parts of DM water was mixed under stirring at 35°C
to 50°C to get homogeneous surfactants slurry.

Step-3: Preparation of granules
Micronized powder of Step-1 was transferred into the bowl of FBD (Fluidized Bed Dryer cum processor), where it was fluidized by air under temperature 70°C to 80°C. Surfactant slurry of Step-2 was sprayed on micronized active ingredients mass at the flow rate of 5 ml to 10 ml per minute. Temperature of FBD was gradually increased up to 90°C under air flow for maximum granulation. Finally, obtained dry granules was sieved to get wettable granules in the size rage of 0.1 mm to 1.0 mm (moisture content < 3.0%).
Example-2
Composition of Wettable Granule (WDG or WG) formulation

Ingredients Quantity % w/w
Profenofos technical 35.00
Emamectin benzoate technical 1.50
Lactose 15.00
Precipitated Silica 22.00
Geropon T-36 5.00
PVK-30 2.0
Titanium dioxide (optionally) 0.25
Sodium lignosulfonate QS to make 100% w/w
Total 100% w/w
The stable synergistic wettable granule (WDG or WG) formulation with above desired composition can be prepared by the following procedure: Step -1: Preparation of active ingredient micronized mixture
At this step, 1.5 parts by weight of Emamectin benzoate technical was charged in pre-mixer blender. Subsequently, ppt. silica 22 parts were added under stirring to Emamectin benzoate technical followed by addition of lactose 15 parts at 30°C to 35°C. Subsequently, the mixture was stirred for

further 30 minutes. After completion of mixing, the grinding of mixture was done through jet mill to obtain micronized mass.
Thereafter, to this obtained micronized mass, 35 parts by weight of Profenofos technical were added under stirring at 30°C to 35°C, and, 0.25 parts of Titanium dioxide were optionally added and mixing was continued for further 30 minutes to get homogenous active ingredients mass. Step-2: Preparation of surfactants slurry
In another vessel, 19-22 parts by weight of Sodium lignosulfonate, 5 parts of Geropon T-36 and 40-60 parts of DM water and 2 parts of PVK-30 were mixed under stirring at 35°C to 50°C to get homogeneous surfactants slurry. Step-3: Preparation of granules
Subsequently, micronized powder of Step-1 was transferred into the bowl of FBD (Fluidized Bed Dryer cum processor), where it was fluidized by air under temperature 70°C to 80°C. Thereafter, surfactant slurry of Step-2 was sprayed on micronized active ingredients mass at the flow rate of 5 ml to 10 ml per minute. Temperature of FBD was gradually increased up to 90°C under air flow for maximum granulation. Finally, obtained dry granules were sieved to get wettable granules in the size rage of 0.1 mm to 1.0 mm (moisture content < 3.0%).
Example-3: Stability Study
Result of storage stability study, done by CIPAC method F MT46.1 of In-house developed wettable granule (WDG or WG), is tabulated in Table 2. Table-2

Test Parameter Initial (0 days) Result of storage stability study done by CIPAC method FMT46.1 at 54°C for 7 Days
Physical Description Beige color free flowing spherical granules Beige color free flowing spherical granules Beige color free flowing spherical granules

Active Content % w/w Emamectin Benzoate 1.5% 1.5%

Profenofos 35.0% 34.5%
Suspensibility % w/w Emamectin Benzoate 85.58% 84.54

Profenofos 77.89% 76.52%
pH 1 % Aq. Solution 6.12 5.85
BIO-EFFICACY STUDY
Insects are the most diverse species of animals living on earth. Herbivorous insects are said to be responsible for destroying one fifth of the world's total crop production annually. Several Coleopteran and Lepidopteran species attack crops both in the field and in store. This causes major problem to plants. This problem has resolved by the present invention in excellent synergistic manner. In accordance with an embodiment of the present invention, R&D study was performed with Emamectin 1.5% + Profenofos 35% WDG for studying the effect of the combination on Lepidopteran, Coleopteran and other pests.
Laboratory Bio-efficacv Study
The preliminary testing and dose selection of the test molecule was done in laboratory. The studies were initiated on Spodoptera litura and Helicoverpa armigera.
Methodology
The experiment was conducted at Plant Protection Laboratory, Bio efficacy Lab Ambala. The test molecule was evaluated against two major lepidopteron pest larvae in controlled lab conditions. Spodoptera litura (Tobacco caterpillar) and Helicoverpa armigera (American bollworm) were artificially reared for in House study purpose.

The experiment was laid out in CRD (Completely Randomized Design) fashion, with 9 treatments and 3 replications each. One replication comprised of 10 test insects each. Thus a total of 30 insects were tested for, in each treatment. Separate studies were initiated for Spodoptera litura and Helicoverpa armigera.
30 Healthy larvae were selected for each treatment and left in starvation for 12 hrs. Subsequently they were fed the treated cotton leaves. The mortality was then assessed over a period of 24 hrs.
The study was done via Leaf dip method. The cotton leaf was used for the study. Selected leaves were properly washed and shade dried and then dipped in the stock solution (different stock solutions were made for each treatment depending on the dose to be tested) and then fed to the test insect.
Example-4: Study on Spodoptera litura
The study was conducted via leaf dip method. Cotton leaves were dipped in the test stock solution and then fed to 2nd instar larvae of Spodoptera litura that had been kept under starvation for 12 hrs. The details of experimental parameter are as follows

S.N.O Parameter Detail
1 Test Insect Spodoptera
2 Stage 2nd Instar
3 Test method Leaf dip
4 Plant used Cotton
Result of laboratory experiment on 2nd Instar of Spodoptera litura are
tabulated in Table-3

Table-3

Effect on 2nd Instar of Spodoptera litura 24 hrs after treatment
Treatments Observed Value Expected value Ratio Synergy
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre 36.66 99.34 0.37 NO
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 53.33 99.34 0.54 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 100 99.34 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 100 99.34 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 100 99.34 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 100 99.34 1.01 Yes
Emamectin benzoate 90
Profenofos 93.33
Control 0
Example-5: Study on Helicoverpa armiqera
The study was conducted via leaf dip method. Cotton leaves were dipped in the test stock solution and then fed to 2nd instar larvae of Helicoverpa armigera that had been kept under starvation for 12 hrs. The details of experimental parameter are as follows

S.N.O Parameter Detail
1 Test Insect Helicoverpa
2 Stage 2nd Instar
3 Test method Leaf dip

4 Plant used Cotton
Result of laboratory experiment on 2nd Instar of Helicoverpa armigera are tabulated in Table-4
Table-4

Effect on 2nd Instar of Helicoverpa armigera 48 hrs after treatment
Treatments Observed Value Expected value Ratio Synergy
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre 40 99.12 0.40 NO
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 63.33 99.12 0.64 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 96.66 99.12 0.98 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 100 99.12 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 100 99.12 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 100 99.12 1.01 Yes
Emamectin benzoate 86.66
Profenofos 93.33
Control 0
Conclusion
Thus, by the experiments conducted in laboratory conditions, it is evident that the test molecule controls the 2nd instar stages of both Spodoptera litura and Helicoverpa armigera. However, there exists a slight dose variation in terms of control with both the insects. In case of Spodoptera litura, a synergy

was observed at the dose of 250 gm/Acre. However in case of Helicoverpa armigeraz, synergy was observed at 280 gm/Acre. The data also portrays that up to 100 percent control was achieved in case of both the insects, under lab conditions, after 24 hrs of application.
Field Bio-efficacv Study
In accordance with an embodiment of the present invention, a field study was performed. Any study however successful in lab needs to be validated in field for the actual results in natural conditions.
Methodology
The Experiment in field was conducted in the Randomized block design fashion. The pests considered for this experiment were Army worm (Spodoptera fugiperda) in Maize, Fruit borer (Helicoverpa armigera) in Tomato and Tobacco caterpillar (Spodoptera litura) on Soybean. The studies were conducted in different locations for validation purposes.
Observation Methodology: Observed values (O) are the Percent Control
values and Formula used = [(Insect count before spray - Insect Count After
spray) / Insect Count before spray]* 100
Colby's formula is applied to determine synergistic effect, as provided in
WEEDS 1967, 15,22
E = (X + Y)-((Xx Y)/100)
For Synergy, O/E > 1
wherein;
X= individual response of (a) Emamectin benzoate
Y= individual response of (b) Profenofos
E= expected (or predicted) response of combination of (a) + (b) when
applied
0= observed response of combination of (a) + (b) when applied

Example-6: Experiment on Maize {Zea mays)
The experiment was conducted at Karnataka. Experiment was laid out with
a set of 9 treatments having 3 replications each.
The spray was conducted in Maize against Army worm at the emergence of
pest. 200 lit of water was used to spray 1 Acre area. The spray was
conducted with the help of Battery operated Knapsack sprayer.
The details of experimental parameter are as follows

S.N.O Parameter Detail
1 Variety VNR4226
2 Spacing 60 cm X 30 cm
3 Seed Rate 6 Kg/Acre
4 Duration 120 Days
5 Yield 35 - 40 Quintal /Acre
Result of field bio-efficacv on Maize Armyworm are tabulated in Table-5
Table-5

Treatments Observed Value Expected value Ratio Synergy
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre -50.00 98.75 -0.51 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 3.70 98.75 0.04 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 70.00 98.75 0.71 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 99.57 98.75 1.01 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 100.00 98.75 1.01 Yes

Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 100.00 98.75 1.01 Yes
Emamectin benzoate 86.36
Profenofos 90.77
Control 0
* The observed negative values are indicative that the treatment was not successful in controlling the pest population and instead of control there was an increase in population. Thus, the Percent control (Observed values) turned out to be negative.
Example-7: Experiment on Fruit borer (Helicoverpa armiqera) in Tomato
The experiment was conducted at Research Farm Ambala. Experiment was
laid out with a set of 9 treatments having 3 replications each.
The spray was conducted in Tomato against Fruit Borer at the emergence
of pest. 200 lit of water was used to spray 1 Acre area. The spray was
conducted with the help of Battery operated Knapsack sprayer.
The details of experimental parameter are as follows

S.N.O Parameter Detail
1 Variety Himsona
2 Spacing 90 x 30 cm
3 Seed Rate 150-200 g/ha
4 Duration 120 days
5 Yield 350- 400 Quintal/Ha
Result of field bio-efficacv on Fruit borer (Helicoverpa armiqera) are tabulated in Table-6
Table-6
Treatments Observed Value Expected value Ratio Synergy
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre -10.77 95.3 -0.11 No

Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre -13.08 95.3 -0.14 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre -15.38 95.3 -0.16 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 64.71 95.3 0.68 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 95.71 95.3 1.00 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 100.00 95.3 1.05 Yes
Emamectin benzoate 82.86
Profenofos 81.25
Control 0
* The observed negative values are indicative that the treatment was not successful in controlling the pest population and instead of control there was an increase in population. Thus, the Percent control (Observed values) turned out to be negative.
Example-8: Experiment on Tobacco caterpillar (Spodoptera Litura) in Soybean
The experiment was conducted in Madhya Pradesh, where experiment was laid out with a set of 9 treatments having 3 replications each. The spray was conducted in Soybean against Tobacco Caterpillar, at the emergence of pest. 200 lit of water was used to spray 1 Acre area. The spray was conducted with the help of Battery operated Knapsack sprayer. The details of experimental parameter are as follows

S.N.O Parameter Detail
1 Variety JS 95-60
2 Spacing 45X5 Cm
3 Seed Rate 70- 75 Kg/ Ha

4 Duration 110 Days
5 Yield 14-15 Quintal/Ha
Result of field bio-efficacv on Tobacco Caterpillar (Spodoptera Litura) are tabulated in Table-7
Table-7

Treatments Observed Value Expected Value Ratio Synergy
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre -18.33 91.36 -0.20 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 15.07 91.36 0.16 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 44.62 91.36 0.49 No
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 92.86 91.36 1.02 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 93.94 91.36 1.03 Yes
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 96.67 91.36 1.06 Yes
Emamectin benzoate 70.15
Profenofos 71.01
Control 0
* The observed negative values are indicative that the treatment was not
successful in controlling the pest population and instead of control there was an increase in population. Thus, the Percent control (Observed values) turned out to be negative.
Example-9: Phvtotoxicitv study
The standard testing and result tabulated in Table-8 shows that no phytotoxicity was observed with the use of formulation of present invention.

Table-8

S.N.O Treatments Hvoonastv Necrosis Vein Clearinq Wiltina
1 Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre 0 0 0 0
2 Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 0 0 0 0
3 Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 0 0 0 0
4 Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 0 0 0 0
5 Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 0 0 0 0
6 Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 0 0 0 0
7 Emamectin benzoate 0 0 0 0
8 Profenofos 0 0 0 0
The formulation of present invention was safe to natural enemies present in plant eco-system. The result was taken from 1 meter2 area of sampling and tabulated in Table 9. Table 9

Treatments No. of Chrysoperla carnea No. of Coccinela Septumpunctata

Pre- 5 10 15 Pre- 5 10 15
count Days Day s Days count Days Days Days

Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre 0 0 1 1 2 2 1 2
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 0 1 0 1 3 2 2 2
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 1 1 1 1 3 2 2 3
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 0 1 0 1 2 3 3 2
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 0 0 1 1 2 3 3 2
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 1 1 1 0 3 2 2 3

Emamectin benzoate 2 1 0 1 0 2 3 3
Profenofos 1 1 1 1 2 2 1 2
Control 1 2 1 0 2 0 1 1
Crop Yield data recorded in field bio-efficacv study

Treatments Yield

Maize Tomato Soybean

Kg / Acre Kg / Acre Kg/Ha
Emamectin benzoate 1.5% + Profenofos 35% WDG @100gm/Acre 3211 1600 1800
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 200 gm/Acre 3210 1605 1825
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 250 gm/Acre 3212 1608 1835
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 280 gm/Acre 3215 1610 18 51
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 300 gm/Acre 3222 1614 1850
Emamectin benzoate 1.5% + Profenofos 35% WDG @ 350 gm/Acre 3225 1618 1855
Emamectin benzoate 3195 1605 1838
Profenofos 3190 1605 1836
In accordance with an embodiment of the present invention, a method for preparing a synergistic and stable pesticidal granule formulation comprises

the steps of: adding an effective amount of Emamectin benzoate in a range of approximately 1% to 3% by weight of formulation; and, adding a liquid active ingredient as Profenofos in a range of approximately 32% to 40% by weight of formulation. In use, this formulation is, a synergistic and stable water dispersible granular formulation (WDG) or wettable granule formulation (WG).
In accordance with an embodiment of the present invention, the method further comprises the step of adding a plurality of adjuvants for making said formulation a stable, safe, free flowing, dustless and dispersible granular formulation.
In accordance with an embodiment of the present invention, the method further comprises the step of adding a whitening agent. In use, the whitening agent is titanium dioxide.
Therefore, as may be seen, multiple embodiments of the instant invention, as disclosed hereinabove, provide significant advantages over prior art. Specifically, in comparison to the prior art, embodiments of the present invention as disclosed hereinbelow disclose a stable and synergistic agrochemical wettable granule formulation having effective amount of high concentration of Profenofos, wherein the amount of liquid ingredient Profenofos is in the range of 32% to 40% by weight of formulation, along with adjuvants like inert fillers, surfactant, binder and wetting agent, wherein the preparation of stable, safe and efficacious granular formulation with more amount of liquid active ingredient by economically efficient and ecologically safe route is making the present invention not obvious to person skilled in the art. Further, the present invention provides the enhanced efficacious synergistic effect against various pest and has broad pesticidal utility in many crops.
Moreover, there does not exist any prior art disclosure that specifically discloses stable wettable granule formulation comprising synergistic amount of Emamectin benzoate and Profenofos with excellent pesticidal utility, as per the embodiments of the instant invention. Some prior art references disclose the formation of microemulsion but do not specifically relate to Emamectin benzoate and Profenofos synergistic wettable granule

formulation.
In addition, certain prior art disclosures disclose the combination of Emamectin benzoate and one or more of the compound(s) selected from the group consisting of Profenofos as one of the group members. In the general method of prior art for granules prepared with Kaolin, highly dispersed silicic acid and/or attapulgite, the amount of any of the second compound selected from the group in combination with Emamectin benzoate is present in between 5%-21%. Further, this prior art is claiming specifically azamethiphos, cypermethrin high-cis and fenoxycarb in combination with Emamectin benzoate. Therefore, in comparison to this prior art, the embodiments of present invention are specifically for Profenofos in combination with Emamectin benzoate in the synergistic, stable and safe wettable granule formulation present in higher amount in comparison to this prior art. Also, liquid active ingredient like Profenofos has lower melting point in comparison to azamethiphos, cypermethrin high-cis and fenoxycarb as claimed in prior art. Further, even due to presence of higher amount of liquid active ingredient like Profenofos, the granules of present invention are dustless and free flow with other advanced quality of formulation like not phytotoxic and safer to natural enemies along with synergistic pesticidal utility against coleopteran and lepidopteran species which are the major problematic pest of present scenario, therefore the present invention is a technically advanced step in comparison to prior art also it is not obvious to a person skilled in the art. Further, the present invention is fulfilling the long felt need.
In addition, certain prior art disclosures disclose EW formulation but not specifically describe stable wettable granule formulation comprising Emamectin benzoate and Profenofos in synergistic amount. Furthermore, in comparison to the prior art, the water content in present invention formulation is less than 3.0%.
As compared to prior art, embodiments of the present invention disclose the formulation comprising high percentage of liquid active ingredient Profenofos along with Emamectin benzoate, which is difficult to prepare as

per the disclosures of the prior art. Also, the formulation of the present invention is stable and has broad pesticidal utilities. The embodiments of the present invention disclose synergistic and stable wettable granule formulations comprising Emamectin benzoate and Profenofos as active ingredients with other inactive excipients, having excellent pesticidal utility with the following advantages:
1) Granular formulation is stable, safe, free flowing, dustless dispersible granular formulation comprising Profenofos a liquid active ingredient in 32% to 40% by weight of formulation and can be prepared without much complex manufacturing process.
2) Granular formulation of present invention synergistically acts in wider aspect in control of pest in various crops.
3) The granules of the present invention typically have an average particle size in the range between about 0.1 mm to about 1.0 mm.
4) The granules of present invention virtually can be in any desired shape, for example, spheres, cylinders, ellipses, rods, cones, discs, needles and irregular shapes. Ideally, the granules are approximately spherical and cylinders, which lends to desired flow characteristics of the granules in bulk form.
5) Granular formulation have significant advantages in packaging, ease of handling and safety and phytotoxicity relative to liquid formulations
6) Granular formulation of present invention results in significant grain yield after crop treatment.
7) Granular formulation of present invention is safe by having no harmful effects on natural enemies.
While this invention has been described in detail with reference to certain preferred embodiments, it should be appreciated that the present invention is not limited to those precise embodiments rather, in view of the present disclosure, which describes the current best mode for practicing the invention, many modifications and variations would present themselves to those skilled in the art without departing from the scope and spirit of this invention. This invention is susceptible to considerable variation in its practice within the spirit and scope of the appended claims.

We Claim:
1. A synergistic and stable pesticidal wettable granule formulation
comprising an effective amount of a first active ingredient and a liquid active
ingredient, wherein said first active ingredient is Emamectin benzoate and
said liquid active ingredient is an organothiophosphate, wherein
organothiophosphate is present in the range of 32% to 40% by weight of
formulation and wherein said granule has particle size in the range between
about 0.1 mm to about 1.0 mm.
2. The synergistic and stable pesticidal granule formulation as claimed in
Claim 1, wherein said liquid active ingredient is Profenofos.
4. The synergistic and stable pesticidal granule formulation as claimed in Claim 1, wherein said formulation is a synergistic and stable water dispersible granular formulation (WDG) or wettable granule formulation (WG).
5. The synergistic and stable pesticidal granule formulation as claimed in Claim 1, wherein Emamectin benzoate is present in a range of approximately 1% to 3% by weight of formulation.
6. The synergistic and stable pesticidal granule formulation as claimed in Claim 1, wherein said formulation further comprises a plurality of agriculturally acceptable adjuvants for making said formulation a stable, safe, free flowing, dustless and dispersible granular formulation.
7. The synergistic and stable pesticidal granule formulation as claimed in Claim 6, wherein said plurality of adjuvants are selected from a group comprising at least one inert filler, at least one surfactant, at least one binder and at least one wetting agent.

8. The synergistic and stable pesticidal granule formulation as claimed in Claim 7, wherein said at least one inert filler is selected from a group comprising water, precipitated silica, fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof is present in a range of approximately 18% to 25% by weight of formulation.
9. The synergistic and stable pesticidal granule formulation as claimed in Claim 7, wherein said at least one surfactant is selected from a group comprising Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), Furandione, polymer with 2,4,4-trimethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof is present in a range of approximately 5% to 30% by weight of formulation.

10. The synergistic and stable pesticidal granule formulation as claimed in Claim 7, wherein said at least one binder is selected from a group comprising Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a blend thereof is present in a range of approximately 1% to 25% by weight of formulation.
11. The synergistic and stable pesticidal granule formulation as claimed in Claim 1, wherein said formulation further comprises a whitening agent.
12. The synergistic and stable pesticidal granule formulation as claimed in Claim 11, wherein said whitening agent is titanium dioxide which is present in a range of approximately 0.1% to 1% by weight of formulation.
13. The synergistic and stable pesticidal granule formulation as claimed in Claim 1, wherein said formulation is capable of being employed in an synergistically effective amount dose in ranging from 250 gm/Acre to 350

gm/Acre, wherein that dose does not cause phytotoxic damage to any part of a plant and wherein said formulation is safe to a plurality of natural enemies.
14. The synergistic and stable pesticidal granule formulation as claimed in
Claim 1, wherein said formulation is effective against coleopteran and
lepidopteran species.
15. A method for preparing a synergistic and stable pesticidal granule
formulation as claimed in claim 1, said method comprising the steps of:
adding an effective amount of Emamectin benzoate in a range of approximately 1% to 3% by weight of formulation; and
adding a liquid active ingredient as Profenofos in a range of approximately 32% to 40% by weight of formulation,
wherein said formulation is, a synergistic and stable water dispersible granular formulation (WDG or WG), wherein granulation is done in Fluidized Bed Dryer cum processor at temperature ranging from 70 °C - 90 °C, wherein said granule has particle size in the range between about 0.1 mm to about 1.0 mm and wherein said formulation is effective against coleopteran and lepidopteran species.
16. The method as claimed in Claim 15, wherein said method further comprises the step of adding a plurality of adjuvants for making said formulation a stable, safe, free flowing, dustless and dispersible granular formulation.
17. The method as claimed in Claim 15, wherein said plurality of adjuvants are selected from a group comprising at least one inert filler, at least one surfactant, at least one binder and at least one wetting agent.
18. The method as claimed in Claim 16, wherein said plurality of adjuvants are selected from a group comprising at least one agriculturally acceptable adjuvant.

19. The method as claimed in Claim 17, wherein said at least one inert filler is selected from a group comprising of water, precipitated silica, fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof.
20. The method as claimed in Claim 17, wherein said at least one surfactant is selected from a group comprising Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), Furandione, polymer with 2,4,4-thmethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof.
21. The method as claimed in Claim 17, wherein said at least one binder is selected from a group comprising Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a blend thereof.
22. The method as claimed in Claim 15, wherein said method further comprises the step of adding a whitening agent.
23. The method as claimed in Claim 22, wherein said whitening agent is titanium dioxide.