The present invention relates to a red aloe vera based transdermal base composition and formulationthereof. Particularly, the present invention relates to a transdermal base composition comprising a plurality of chemical penetration enhancing components/compounds at an effective concentration range, thereby providing synergistic effect i.e. significantly enhancing skin permeability and bioavailability of the components/compounds applied to skin or hair. More particularly, the present invention relates to formulation comprising the base composition and aromatherapy based topical cosmetic products, thereby providing an effective skin care formulation.
BACKGROUND OF THE INVENTION
[002] Nowadays, a plurality of topical formulations have been developed in order to provide beneficial effects on skin by enhancing appearance of skin and treat various skin diseases. Despite of the availability of numerous topical formulations, desired effects are still not achieved, as skin possess a complex structure and does not absorb all the components of the formulation instead functions as a barrier to entry of foreign substances into the skin. After applying topical formulation, molecules of the formulation first needs to penetrate stratum corneum i.e. theoutermost layer of skin, which acts as highly resistant lipid barrier to the penetration of such molecules into the skin. To overcome this barrier, various efforts have been made. Various transdermal delivery systems have been developed and intensively used to overcome the skin barrier for more effective application in pharmaceutical and cosmetic industry. In cosmeceutical industry, even after significant progress in their products,the skin remains a barrier factor in the penetration and absorption of such products. Some of the conventional technology in order to overcome the barrier include iontophoresis, sonophoresis, and use of chemical penetration enhancers (CPE). Amongst these technologies, CPEs are known to provide effective response including design flexibility with formulation chemistry. However, CPEs formulation is limited to transdermal patches for a specific drug delivery.
[003] Although the chemical penetration enhancers have been known for their use in the transdermal technology for cosmetic aromatherapy, however, conventionally available skin care formulation involving the use of chemical penetration enhancers mixed with the creams based products may not be effective enough in enhancing permeability of enhancers into the skin and may have adverse side effects on skin of the user.
[004] Therefore, keeping in view the problems associated with the above state of art, there is a need

for skin friendly base composition capable of enhancing skin permeability and bioavailability of components/compounds applied to skin with any irritation/side effects.
OBJECTIVES OF THE INVENTION
[005] A primary objective of the invention is to provide a red aloe-vera based transdermal base composition and formulation thereof.
[006] Another objective of the present invention is to provide a base composition that enhances enhancing permeability and bioavailability of the active ingredients into skin or hair.
[007] Yet another objective of the present invention is to provide a formulation comprising a base composition and aromatherapy based topical cosmetic products, thereby providing an effective skin care formulation.
[008] Other objects and advantages of the present invention will become apparent from the following description taken in connection with the accompanying drawings, wherein, by way of illustration and example, the aspects of the present invention are disclosed.
SUMMARY OF THE INVENTION
[009] The present invention relates to a red aloe vera based transdermal base composition and formulation thereof. The transdermal base composition comprises of a plurality of chemical penetration enhancing components/compounds that enhances skin permeability and bioavailability of the components/compounds applied to skin or hair. The transdermal composition comprises of 0.01% to 2.5% of fatty acid; 1.0%-10.0% of five-membered cyclic amide pyrrolidone; 0.1%-20.0% of monoalkyl ether; 0.1%-1.0% of polyol; 0.1%-1.1% of surfactant; 0.01%-0.1% of essential oil; 0.01%-0.1% of plant extract; optionally, excipients/additives, or a combination thereof, and 60%-80%) of water. The present invention also relates to a formulation comprising a base composition in a range of 30-90 wt%> and a cosmetic product in a range of 20-40 wt%. The cosmetic product is selected from a group consisting of, sunscreen lotion, moisturizing cream, scrub, face pack, red aloe vera gel, body lotion, body wash, hair oil, hair serum, conditioner, shampoo and face wash. The transdermal base composition is based on Star (Stress Free-Skin with Transdermal and Aromatherapy Based Reagents) Technology.

SOURCES OF BIOLOGICAL MATERIAL USED IN THE PRESENT INVENTION
[010] The plant extract used in the present invention such as red aloe vera is procured from Lipra Nutriscience, Gujarat. The essential oils used in the present invention including Neoli oil, Patchouli oil, Black Pepper oil, Geranium oil, Tea Tree oil, Palmarosa oil, Mir oil, Lavender oil, Helicalum oil and Eucalyptus oil are procured from A.G. Industries, Uttar Pradesh.
DETAILED DESCRIPTION OF THE INVENTION
[Oil] The following description describes various features and functions of the disclosed systemwith reference to the accompanying figures. The illustrative aspects described herein are not meantto be limiting. It may be readily understood that certain aspects of the disclosed system can be arranged and combined in a wide variety of different configurations, all of which have not been contemplated herein.
[012] The terms and words used in the following description are not limited to the bibliography meaning, but, are merely used to enable a clear and consistent understanding of the invention. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope of invention. In addition, descriptions of well-known functions and constructions are omitted for clarity and conciseness.
[013] It is to be understood that the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.
[014] It should be emphasized that the term "comprises/comprising" when used in this specification is taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.
[015] Accordingly, the present invention relates to a transdermal base composition and formulation thereof based on Star (Stress Free-Skin with Transdermal and Aromatherapy Based Reagents) Technology. Particularly, the present invention relates to a transdermal base composition comprising a plurality of chemical penetration enhancing components/compounds at an effective concentration range, thereby providing synergistic effect i.e. significantly enhancing skin permeability and bioavailability of the components/compounds applied to skin or hair. More particularly, the present invention relates to formulation comprising the base composition and aromatherapy based topical cosmetic products, thereby providing an effective skin care formulation.

[016] In an embodiment, the transdermal base composition based on Star (Stress Free-Skin with Transdermal and Aromatherapy Based Reagents) Technology comprises of at least one compound selected from the following categories:
a. C12-C30 fatty acid;
b. five-membered cyclic amide pyrrolidone;
c. monoalkyl ether;
d. polyol;
e. plant extract;
f. surfactant;
g. essential oil;
h. excipient/other additives or a combination thereof; and
h. water.
[017] The fatty acid used in the present invention acts as penetration enhancer, thereby interacting with outermost layer of skin i.e. stratum corneum and increasing permeability thereof. The fatty acid preferable contains 12-30 carbon atoms, more preferably 16-22 carbon atoms, and most preferably 16-20 carbon atoms. In an exemplary embodiment, the fatty acid is selected from a group consisting of, such as, but not limited to, lauric acid, myristic acid, palmiticacid, stearic acid, behenic acid, arachidic acid, oleic acid, linoleic acid, palmitoleic acid, linolenic acid and arachidonic acid, or a combination thereof. In a preferred embodiment, fatty acid used in the present invention is oleic acid. Oleic acid is suitable for dry and aging skin as it penetrates the skin deeply and locks in the moisture, thereby preventing the skin from developing fine lines, and wrinkles. Oleic acid also acts as an anti¬inflammatory acid andhelps in restoring skin's natural oil without clogging pores. Oleic acid is highly beneficial in healing wounds and skin diseases like psoriasis, eczema, and rosacea, and helps skin repair itself. In an exemplary embodiment, amount of fatty acid used in the present invention is in a range of 0.01% to 2.5% by total weight of the transdermal base composition.
[018] The five-membered cyclic amide pyrrolidone used in the present invention acts as chemical penetration enhancers, which interacting with outermost layer of skin i.e. stratum corneum and increases permeability thereof. In an exemplary embodiment, the five-membered cyclic amide pyrrolidone are selected from a group consisting of, such as, but not limited to, l-methyl-2-

pyrrolidone, 2-pyrrolidone, l-laurly-2-pyrrolidone, l-methyl-4-carboxy-2-pyrrolidone, l-hexyl-4-
carboxy-2-pyrrolidone, 1 -lauryl-4-carboxy-2-pyrrolidone, 1 -methyl-4-methoxycarbonyl-2
pyrrolidone, 1 -hexyl-4-methoxycarbonyl -2 -pyrrolidone, 1 -lauryl-4-methoxycarbonyl-2
pyrrolidone,N-methyl-pyrrolidone, N-cyclohexyl pyrrolidone and N-dimethyl amino propyl-pyrrolidone, or a combination thereof. In a preferred embodiment, the five-membered cyclic amide pyrrolidone used in the present invention is N-methyl-2-pyrrolidone (NMP), which is a polar aprotic solvent and forms a homogenous solution with solvents such as water and alcohol. In an exemplary embodiment, the amount of five-membered cyclic amide pyrrolidone used in the present invention is in a range of 1.0%-10.0% by total weight of the transdermal base composition.
[019] The monoalkyl ether used in the present invention acts as skin permeation enhancer. In an exemplary embodiment, the monoalkyl ether is selected from a group consisting of, such as, but not limited to, the mono diethylene glycol monoethyl ether, diethylene glycol monomethyl ether or a combination thereof. In an exemplary embodiment, amount of monoalkyl ether used in the present invention is in a range of 0.1%-20.0% by total weight of the transdermal base composition.
[020] The polyol used in the present invention may be selected from a group consisting of, such as, but not limited to, propylene glycol, glycerin and Polyethylene glycol, or a combination thereof. In an exemplary embodiment, the amount of polyol used in the present invention is in a range of 0.1%-1.0% by total weight of the transdermal base composition.
[021] The surfactant used in the present invention may belong to a class of nonionic, anionic, cationic, or amphoteric surfactant. In an exemplary embodiment, the surfactant is selected from a group consisting of, such as, but not limited to, sorbitan esters, polysorbates, sarcosinates, taurate, ethoxylated castor oil, ethoxylated fatty alcohols, ethoxylated glycerides, caprylocaproyl macrogol-8 glycerides and polyglyceryl-6 dioleate, or a combination thereof. In an exemplary embodiment, the amount of surfactant used in the present invention is in a range of 0.1%-l.l%by total weight of the composition.
[022] The essential oils used in the present invention are natural, less toxic/allergic, and capable of enhancing skin penetration of both lipophilic and hydrophilic products. The skin penetration of the essential oils is facilitated by hydrophilic nature of the dermis, where lipophilic essential oils easily cross the epidermal cell membranes. The essential oils also act as accelerators, thereby helping in percutaneous absorption and penetration of other chemical substances and bioactive components. In

an exemplary embodiment, the essential oils are selected from a group consisting of, such as, but not limited to, Neoli oil, Patchouli oil, Black Pepper oil, Geranium oil, Tea Tree oil, Palmarosa oil, Mir oil, Lavender oil, Helicalum oil and Eucalyptus oilor a combination thereof. In an exemplary embodiment, the amount of essential oils used in the present invention is in a range of 0.01%-0.1% by total weight of the composition. In a preferred embodiment, commercially available essential oils are used in the present invention.
[023] The plant extract used in the present invention aids in enhancing skin penetration. The plant extracts may be extracted from such as, but not limited to, succulent plants. In an exemplary embodiement, the plant extract may be selected from a group consisting of, such as, but not limited to, Aloe cameronii extract (red aloe vera extract), Ocimum kilimandscharicum x Ocimum basilicum extract (blue basil extract), Cynara cardunculus extract (Artichoke extract), Centella asiatica (Gotu Kola extract), or a combination thereof. In an alternate embodiment, the plant extract may include commercially available essential oils. In a preferred embodiment, red aloe vera extract is used as a plant extract in the present invention. The plant extracts exhibit medicinal properties, and thus provide relief from skin rashes/diseases/infections. . In an exemplary embodiment, the amount of plant extract used in the present invention is in a range of 0.01%-0.1% by total weight of the composition.
[024] In an embodiment, the excipients/other additives used in the present invention may be selected from a group consisting of, such as, but not limited to, preservatives, pH stabilizer, colorant and fragrance, or a combination thereof. The amount the excipients/additives may vary depending on the requirement and the final formulation prepared.
[025] In an exemplary embodiment, the amount of water may be in a range of 60%-80% by total weight of the composition.
[026] In an embodiment, the combination of red aloe vera extract and essential oils provides the synergistic effects.
[027] In an embodiment, the base composition serve as chemical penetration enhancer and exerts its effect through a range of mechanisms such as disrupting the lipid bilayer to increase permeability of the molecules, fluidization of the structurallipids of the subcutaneous, increasing water content of the skin, increasing thermodynamic activity of the subcutaneous tissues, decreasing the barrier function of the lipophilic membrane, modification of the lipid structure, and providing pretreatment of the skin.

[028] In an embodiment, the present invention relates to a formulation comprising a base composition in a range of 30-90 wt% and a cosmetic product in a range of 20-40 wt%. In an exemplary embodiment, the cosmetic product is selected from a group consisting of, such as, but not limited to, sunscreen lotion, moisturizing cream, scrub, face pack, red aloe vera gel, body lotion, body wash, hair oil, hair serum, conditioner, shampoo and face wash.
[029] While this invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the scope of the appended claims.

WE CLAIM:

1. A transdermal base composition, comprising:
• 0.01% to 2.5% of fatty acid;
• 1.0%-10.0% of five-membered cyclic amide pyrrolidone;
• 0.1 %-20.0% of monoalkyl ether;
• 0.1%-1.0%ofpolyol;
• 0.1%-1.1% of surfactant;
• 0.01%-0.1% of essential oil;
• 0.01%-0.1% of plant extract;
• optionally, excipients/additives, or a combination thereof; and
• 60%-80% of water.

2. The base composition as claimed in claim 1, wherein the fatty acid is selected from a group consisting of lauric acid, myristic acid, palmiticacid, stearic acid, behenic acid, arachidic acid, oleic acid, linoleic acid, palmitoleic acid, linolenic acid and arachidonic acid, or a combination thereof.
3. The base composition as claimed in claim 1, wherein the five-membered cyclic amide pyrrolidone is selected from a group consisting of l-methyl-2-pyrrolidone, 2-pyrrolidone, 1 -laurly-2-pyrrolidone, 1 -methyl-4-carboxy -2-pyrrolidone, 1 -hexyl-4-carboxy-2-pyrrolidone, 1 - lauryl-4-carboxy-2-pyrrolidone, 1 -methyl-4-methoxycarbonyl-2-pyrrolidone, 1 -hexyl-4-methoxy carbonyl-2-pyrrolidone, 1 -lauryl-4-methoxycarbonyl-2-pyrrolidone,N-methyl-pyrrolidone, N-cyclohexyl pyrrolidone and N-dimethyl amino propyl-pyrrolidone, or a combination thereof.
4. The base composition as claimed in claim 1, wherein the monoalkyl ether is selected from a group consisting of mono diethylene glycol monoethyl ether, diethylene glycol monomethyl ether or a combination thereof.

5. The base composition as claimed in claim 1, wherein the polyol is selected from group
consisting of propylene glycol, glycerin and polyethylene glycol, or a combination thereof.
5
6. The base composition as claimed in claim 1, wherein the surfactant belongs to class of
nonionic, anionic, cationic, or amphoteric surfactant.
7. The base composition as claimed in claim 1 and claim 6, wherein the surfactant is
0 selected from a group consisting of sorbitan esters, polysorbates, sarcosinates, taurate,
ethoxylated castor oil, ethoxylated fatty alcohols, ethoxylated, or a combination thereof.
8. The base composition as claimed in claim 1, wherein the essential oil is selected from
a group consisting of Neoli, Patchouli, Black Pepper, Geranium, Tea Tree, Palmarosa,
Mir, Lavender, Helicalum and Eucalyptus or a combination thereof.
5 9. The base composition as claimed in claim 1, wherein the plant extract is selected from
a group consisting of Aloe cameronii extract (red aloe vera extract), Ocimum kilimandscharicum x Ocimum basilicum extract (blue basil extract), Cynara cardunculus extract (Artichoke extract), Centella asiatica (Gotu Kola extract), or a combination thereof.
10. The base composition as claimed in claim 1, wherein the excipients/additive may be
!0 selected from a group of preservatives, pH stabilizer, colorant and fragrance, or a
combination thereof.
11. The base composition as claimed in claim 1, wherein the excipients/additives may
vary in amount depending on the requirement and the final formulation prepared.
12. A formulation comprising: a base composition as claimed in claim 1 in a range of
!5 30-90 wt% and a cosmetic product in a range of 20-40 wt%.

13. The formulation as claimed in claim 11, wherein the cosmetic product is selected from a group consisting of, sunscreen lotion, moisturizing cream, scrub, face pack, red aloe vera gel, body lotion, body wash, hair oil, hair serum, conditioner, shampoo and face wash.