DESC:FIELD OF THE INVENTION:

The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) Prothioconazole or a salt or adduct thereof and (B) strobilurin fungicide or a salt or adduct thereof and (C) at least one further active compound or a salt or adduct thereof. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops

BACKGROUND OF THE INVENTION

Prothioconazole, having the chemical name 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione (Compound A) and its manufacturing process is described in WO 96/16048.

Fungicides are chemical substances that were developed for controlling fungi, which are the main causative agents of diseases in plants. Owing to the increase in diseases and their intensity, there is a constant need to develop new fungicides, as well as increase their concentration in commercial formulations. This increase in concentration, associated with adverse environmental conditions, may lead to phytotoxicity (collateral effects on the plants), since the disease-causing fungi and the plants parasitized by them share much physiology in common.

The main fungicides used on large-scale crops, such as soya, maize and wheat, have two types of active ingredients in their composition a triazole and a strobilurin. Triazole fungicides which inhibit ergosterol biosynthesis are economically important active compounds and are widely used in crop plants such as wheat, barley, leguminous plants, vegetables and in the cultivation of fruits. However, these fungicides may cause phytotoxic damage to some plants when used at their customary application rates for controlling unwanted fungi. This phytotoxic effect can be observed in particular in stress situations such as drought or when the triazole fungicides are used in combination with penetration promoters.

To minimize the phytotoxic effect, WO 2007/028388 proposes a certain formulation which, in addition to the triazole fungicides as active compound, comprises various further components, such as solvents and surfactants.

WO 2009/000407 discloses a method for reducing the phytotoxicity of triazole fungicides on dicotyledonous plants by using prothioconazole or tebuconazole or a mixture of tebuconzole and trifloxystrobin in combination with sulphosuccinates as additive.

The main concern with the use of fungicide is the development of resistance by the pests for that particular fungicide and at the end one has to apply more concentrated formulation of the fungicide. The high amount of fungicide may results in the toxicity to human beings as well as has bad effect on environment.

Previously people have tried many alternatives and option to overcome this problem and as a result developed poly mixture of pesticide, use of non-toxic ingredients and developing novel formulations which provides effective amount of the fungicide and at the required part only.

However the use of poly mixture containing large number of fungicide poses a problem in many was like preparing formulation of multiple fungicides with different chemical properties and behavior and physical properties. It also creates challenge for formulator in term of compatibility and stability of all the fungicide along with used excipients in the formulation.

Further the environmental and economic requirements imposed on modern-day crop protection compositions are continually increasing, with regard, for example, to the spectrum of action, toxicity, selectivity, application rate, formation of residues, and favourable preparation ability, and since, furthermore, there may be problems, for example, with resistances, a constant task is to develop new compositions, in particular fungicidal agents, which in some areas at least help to fulfil the abovementioned requirements.

SUMMARY OF THE INVENTION

The present invention provides active compound combinations/compositions which in some aspects at least achieve the stated objective.

It is an object of the present invention to provide, with a view to effective resistance management and effective control of phytopathogenic harmful fungi, at application rates which are as low as possible, compositions which, at a reduced total amount of active compounds applied, have improved activity against the harmful fungi (synergistic mixtures) and minimize risk of phytotoxicity.

One of the objective of present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) Prothioconazole and (B) strobirulin fungicide selected from the group consisting of Azoxystrobin , Picoxystrobin, Pyraclostrobin, Trifloxystrobin and (C) a at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph.

Moreover, we have found that simultaneous, or combined, application of (A) Prothioconazole and (B) strobirulin fungicide selected from the group consisting of Azoxystrobin , Picoxystrobin, Pyraclostrobin, Trifloxystrobin and (C) a at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph allows better control of phytopathogenic fungi of plants or crops.

According to the present invention there is provided a synergistic and stable fungicide composition comprising of component (A) Prothioconazole 0.1 to 25% and component (B) strobirulin fungicide 0.1 to 40% selected from the group consisting of Azoxystrobin , Picoxystrobin, Pyraclostrobin, Trifloxystrobin and (C) least one further active compound or a salt or adduct thereof 0.1 to 30% selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph weight of active ingredients, optionally also contains at least one Biocide, dispersant and thickener

DETAILED DESCRIPTION OF THE INVENTION

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure.

Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors.

The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.

In an especially preferred embodiment of the invention, the yield of the treated plant is increased.

In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.

A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance.

In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically.

The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).Another indicator for the condition of the plant is the "quality" of a plant and/or its products.

In an especially preferred embodiment of the invention, the quality of the treated plant is increased.

In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product:
• increased nutrient content
• increased protein content
• increased content of fatty acids
• increased metabolite content
• increased carotenoid content
• increased sugar content
• increased amount of essential amino acids
• improved nutrient composition
• improved protein composition
• improved composition of fatty acids
• improved metabolite composition
• improved carotenoid composition
• improved sugar composition
• improved amino acids composition
• improved or optimal fruit color • improved leaf color
• higher storage capacity
• higher processability of the harvested products.

Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means (1.) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fungicidal or insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.

In another preferred embodiment of the invention relates to fungicide composition comprising, as active components,
1) (A) Prothioconazole;
2) (B) strobirulin fungicide selected from the group consisting of Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin;
3) (C) a at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph; and
4) Optionally one or more inactive excipient.

In another preferred embodiment of the invention relates to a process for preparation mixtures of a (A) Prothioconazole and (B) strobirulin fungicide selected from the group consisting of Azoxystrobin, Picoxystrobin, Pyraclostrobin, Trifloxystrobin and (C) a at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph for preparing such three way mixtures, and also to compositions comprising these mixtures.

In another preferred embodiment of the invention composition of present invention can be in form of Suspension Concentrate (SC), Suspo emulsion (SE), Water dispersible grnules (WDG), Emulsifiable concentrate (EC), Wettable Powders (WP), Oil dispersion (OD), capsule suspension (CS), Zean Concentrate (ZC). Preferably the pesticidal composition of the present invention may be in the form of Suspension Concentrate (SC), Suspo emulsion (SE).

The present invention relates to fungicidal composition comprising component (A) Prothioconazole and component (B) strobirulin fungicide selected from the group consisting of Azoxystrobin , Picoxystrobin, Pyraclostrobin, Trifloxystrobin and component (C) a at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph in ratios by weight of the active ingredients are 0.1 to 30% component (A); 0.1 to 40% component (B) and 0.1 to 30% component (C).

The present invention relates to fungicidal composition comprising ratios by weight:
Active Ingredient I Active Ingredient II Active Ingredient III


Prothioconazole Azoxystrobin Cyproconazole
Picoxystrobin Difenoconazole
Pyraclostrobin Flutriafol
Trifloxystrobin Hexaconazole
Propiconazole
Tebuconazole
Tricyclazole
Mancozeb
Chlorothalonil
Propineb
Folpet
Copper (different salt)
Captan
Dithianon
Fthalide
Fluxapyroxad
Penthiopyrad
Sedaxane
Boscalid
Fluopyram
Thifluzamide
Fluopicolide
Fluazinam
Fenpyrazamine
Dimethomorph
0.1 to 30% 0.1 to 40% 0.1 to 30%

One embodiment of the present invention relates to the use of the above composition, which comprises of component (A) Prothioconazole and component (B) strobirulin fungicide and component (C) a at least one further active compound or a salt or adduct thereof is effective for management of mixed infection of fungal diseases in following crops GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus)

One embodiment of the present invention relates to the use of the above composition. The compositions according to the invention have very good fungicidal properties and can be employed for controlling phytopathogenic fungi such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, and the like. Examples which may be mentioned, but not by limitation, are some pathogens of fungal diseases Which come under the above generic terms:
Diseases caused by pathogens causing powdery mildew such as, for example, Blumeria species such as, for example, Blumeria graminis; Podosphaera species such as, for example, Podosphaera leucotricha;
Sphaerotheca species such as, for example, Sphaerotheca fuliginea; Uncinula species such as, for example, Uncinula necator; Leveillula species such as, for example Leveillula taurica, Erysiphe species such as for example Erysiphe polygoni, diseases caused by pathogens of rust diseases such as, for example, Gymnosporangium species such as, for example, Gymnosporangium sabinae, Hemileia species such as, for example, Hemileia vastatrix; Phakopsora species such as, for example, Phakopsora pachyrhizi and Phakopsora meibomiae; Puccinia species such as, for example, Puccinia graminis, Puccinia recondita or Puccinia triticina, Puccinia striiformis; Uromyces species such as, for example, Uromyces phaseoli; diseases caused by pathogens of smut diseases such as, for example, Sporisorium species such as , for example, Sporisorium scitamineum; Ustilago species such as, for example Ustilago maydis, Tilletia species such as for example Tilletia tritici, Ustilaginoidea species such as , for example Ustilaginoidea virens, diseases caused by pathogens of ergot diseases such as, for example Claviceps species, Claviceps purpurea; diseases caused by pathogens from the group of the Oomycetes such as, for example, Bremia species such as, for example, Bremia lactucae; Peronospora species such as, for example, Peronospora pisi or P. brassicae; Phytophthora species such as, for example, Phytophthora infestans; Plasmopara species such as, for example, Plasmopara viticola; Pseudoperonospora species such as, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis; Pythium species such as, for example, Pythium ultimum; leaf spot diseases and leaf wilt caused by, for example, Alternaria species such as, for example, Alternaria solani; Cercospora species such as, for example, Cercospora beticola; Cladiosporum species such as, for example, Cladiosporium cucumerinum; Cochliobolus species such as, for example, Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium);
Colletotrichum species such as, for example, Colletotrichum lindemuthanium; Cycloconium species such as, for example, Cycloconium oleaginum; Diaporthe species such as, for example, Diaporthe citri;
Elsinoe species such as, for example, Elsinoe fawcettii; Gloeosporium species such as, for example, Gloeosporium laeticolor; Glomerella species such as, for example, Glomerella cingulata; Guignardia species such as, for example, Guignardia bidwelli; Leptosphaeria species such as, for example, Leptosphaeria maculans; Magnaporthe species such as, for example, Magnaporthe grisea;
Mycosphaerella species such as, for example, Mycosphaerella graminicola; Phaeosphaeria species such as, for example, Phaeosphaeria nodorum; Pyrenophora species such as, for example, Pyrenophora teres;
Ramularia species such as, for example, Ramularia collo-cygni; Rhynchosporium species such as, for example, Rhynchosporium secalis; Septoria species such as, for example, Septoria apii;
Typhula species such as, for example, Typhula incarnata; Venturia species such as, for example, Venturia inaequalis; root and stalk diseases, caused by, for example, Corticium species such as, for example, Corticium graminearum; Fusarium species such as, for example, Fusarium oxysporum;
Gaeumannomyces species such as, for example, Gaeumannomyces graminis; Rhizoctonia species such as, for example, Rhizoctonia solani; Tapesia species such as, for example, Tapesia acuformis;
Thielaviopsis species such as, for example, Thielaviopsis basicola; ear and panicle diseases (including maize cobs), caused by, for example, Alternaria species such as, for example, Alternaria spp.;
Aspergillus species such as, for example, Aspergillus flavus; Cladosporium species such as, for example, Cladosporium spp.; Claviceps species such as, for example, Claviceps purpurea;
Fusarium species such as, for example, Fusarium culmorum; Gibberella species such as, for example, Gibberella zeae; Monographella species such as, for example, Monographella nivalis;
diseases caused by smuts such as, for example, Sphacelotheca species such as, for example, Sphacelotheca reiliana; Tilletia species such as, for example, Tilletia caries; Urocystis species such as, for example, Urocystis occulta; Ustilago species such as, for example, Ustilago nuda;
fruit rot caused by, for example, Aspergillus species such as, for example, Aspergillus flavus;
Botrytis species such as, for example, Botrytis cinerea; Penicillium species such as, for example, Penicillium expansum; Sclerotinia species such as, for example, Sclerotinia sclerotiorum;
Verticilium species such as, for example, Verticilium alboatrum; seed- and soil-borne rots and wilts, and seedling diseases, caused by, for example, Fusarium species such as, for example, Fusarium culmorum; Phytophthora species such as, for example, Phytophthora cactorum; Pythium species such as, for example, Pythium ultimum; Rhizoctonia species such as, for example, Rhizoctonia solani;
Sclerotium species such as, for example, Sclerotium rolfsii; cankers, galls and witches' broom diseases, caused by, for example, Nectria species such as, for example, Nectria galligena; wilts caused by, for example, Monilinia species such as, for example, Monilinia laxa; deformations of leaves, flowers and fruits, caused by, for example, Taphrina species such as, for example, Taphrina deformans; degenerative diseases of woody species, caused by, for example, Esca species such as, for example, Phaemoniella clamydospora; flower and seed diseases, caused by, for example, Botrytis species such as, for example, Botrytis cinerea; diseases of plant tubers caused by, for example, Rhizoctonia species such as, for example, Rhizoctonia solani; diseases caused by bacterial pathogens such as, for example, Xanthomonas species such as, for example, Xanthomonas campestris pv. oryzae; Pseudomonas species such as, for example, Pseudomonas syringae pv. lachrymans; Erwinia species such as, for example, Erwinia amylovora.

According to the invention, carrier is to be understood as meaning a natural or synthetic, organic or inorganic substance which is mixed or combined with the active compounds for better applicability, in particular for application to plants or plant parts or seeds. The carrier, which may be solid or liquid, is generally inert and should be suitable for use in agriculture.

Suitable solid or liquid carriers are: for example ammonium salts and natural ground minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and natural or synthetic silicates, resins, waxes, solid fertilizers, water, alcohols, especially butanol, organic solvents, mineral oils and vegetable oils, and also derivatives thereof. It is also possible to use mixtures of such carriers. Solid carriers suitable for granules are: for example crushed and fractionated natural minerals, such as calcite, marble, pumice, sepiolite, dolomite, and also synthetic granules of inorganic and organic meals and also granules of organic material, such as sawdust, coconut shells, maize cobs and tobacco stalks.

Suitable liquefied gaseous extenders or carriers are liquids which are gaseous at ambient temperature and under atmospheric pressure, for example aerosol propellants, such as butane, propane, nitrogen and carbon dioxide. Tackifiers, such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules and latices, such as gum arabic, polyvinyl alcohol, polyvinyl acetate, or else natural phospholipids, such as cephalins and lecithins and synthetic phospholipids can be used in the formulations. Other possible additives are mineral and vegetable oils and waxes, optionally modified.

If the extender used is water, it is also possible for example, to use organic solvents as auxiliary solvents. Suitable liquid solvents are essentially: aromatic compounds, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatic compounds or chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example mineral oil fractions, mineral and vegetable oils, alcohols, such as butanol or glycol, and also ethers and esters thereof, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyl sulphoxide, and also water.

The compositions according to the invention may comprise additional further components, such as, for example, surfactants. Suitable surfactants are emulsifiers, dispersants or wetting agents having ionic or nonionic properties, or mixtures of these surfactants. Examples of these are salts of polyacrylic acid, salts of lignosulphonic acid, salts of phenolsulphonic acid or naphthalenesulphonic acid, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (preferably alkylphenols or arylphenols), salts of sulphosuccinic esters, taurine derivatives (preferably alkyl taurates), phosphoric esters of polyethoxylated alcohols or phenols, fatty esters of polyols, and derivatives of the compounds containing sulphates, sulphonates and phosphates. The presence of a surfactant is required if one of the active compounds and/or one of the inert carriers is insoluble in water and when the application takes place in water. The proportion of surfactants is between 5 and 40 per cent by weight of the composition according to the invention.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide, Prussian blue, and organic dyes, such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and trace nutrients, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

If appropriate, other additional components may also be present, for example protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestering agents, complex formers. In general, the active compounds can be combined with any solid or liquid additive customarily used for formulation purposes.

The active compound combinations or compositions according to the invention can be used as such or, depending on their respective physical and/or chemical properties, in the form of their formulations or the use forms prepared therefrom, such as aerosols, capsule suspensions, cold-fogging concentrates, warm-fogging concentrates, encapsulated granules, fine granules, flowable concentrates for the treatment of seed, ready-to-use solutions, dustable powders, emulsifiable concentrates, oil-in-water emulsions, water-in-oil emulsions, macrogranules, microgranules, oil-dispersible powders, oil-miscible flowable concentrates, oil-miscible liquids, foams, pastes, pesticide-coated seed, suspension concentrates, suspoemulsion concentrates, soluble concentrates, suspensions, wettable powders, soluble powders, dusts and granules, water-soluble granules or tablets, water-soluble powders for the treatment of seed, wettable powders, natural products and synthetic substances impregnated with active compound, and also microencapsulations in polymeric substances and in coating materials for seed, and also ULV cold-fogging and warm-fogging formulations.

The formulations mentioned can be prepared in a manner known per se, for example by mixing the active compounds or the active compound combinations with at least one additive. Suitable additives are all customary formulation auxiliaries, such as, for example, organic solvents, extenders, solvents or diluents, solid carriers and fillers, surfactants (such as adjuvants, emulsifiers, dispersants, protective colloids, wetting agents and tackifiers), dispersants and/or binders or fixatives, preservatives, dyes and pigments, defoamers, inorganic and organic thickeners, water repellents, if appropriate siccatives and UV stabilizers, gibberellins and also water and further processing auxiliaries. Depending on the formulation type to be prepared in each case, further processing steps such as, for example, wet grinding, dry grinding or granulation may be required.

The compositions according to the invention do not only comprise ready-to-use compositions which can be applied with suitable apparatus to the plant or the seed, but also commercial concentrates which have to be diluted with water prior to use.

The active compound combinations according to the invention can be present in (commercial) formulations and in the use forms prepared from these formulations as a mixture with other (known) active compounds, such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, fertilizers, safeners and Semiochemicals.

The treatment according to the invention of the plants and plant parts with the active compounds or compositions is carried out directly or by action on their surroundings, habitat or storage space using customary treatment methods, for example by dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, foaming, painting, spreading-on, watering (drenching), drip irrigating and, in the case of propagation material, in particular in the case of seeds, furthermore as a powder for dry seed treatment, a solution for seed treatment, a water-soluble powder for slurry treatment, by incrusting, by coating with one or more layers, etc. It is furthermore possible to apply the active compounds by the ultra-low volume method, or to inject the active compound preparation or the active compound itself into the soil.

The invention furthermore comprises a method for treating seed. The invention furthermore relates to seed treated according to one of the methods described in the preceding paragraph.

The active compounds or compositions according to the invention are especially suitable for treating seed. A large part of the damage to crop plants caused by harmful organisms is triggered by an infection of the seed during storage or after sowing as well as during and after germination of the plant. This phase is particularly critical since the roots and shoots of the growing plant are particularly sensitive, and even small damage may result in the death of the plant. Accordingly, there is great interest in protecting the seed and the germinating plant by using appropriate compositions.

The control of phytopathogenic fungi by treating the seed of plants has been known for a long time and is the subject of continuous improvements. However, the treatment of seed entails a series of problems which cannot always be solved in a satisfactory manner Thus, it is desirable to develop methods for protecting the seed and the germinating plant which dispense with the additional application of crop protection agents after sowing or after the emergence of the plants or which at least considerably reduce additional application. It is furthermore desirable to optimize the amount of active compound employed in such a way as to provide maximum protection for the seed and the germinating plant from attack by phytopathogenic fungi, but without damaging the plant itself by the active compound employed. In particular, methods for the treatment of seed should also take into consideration the intrinsic fungicidal properties of transgenic plants in order to achieve optimum protection of the seed and the germinating plant with a minimum of crop protection agents being employed.

Accordingly, the present invention also relates in particular to a method for protecting seed and germinating plants against attack by phytopathogenic fungi by treating the seed with a composition according to the invention. The invention also relates to the use of the compositions according to the invention for treating seed for protecting the seed and the germinating plant against phytopathogenic fungi. Furthermore, the invention relates to seed treated with a composition according to the invention for protection against phytopathogenic fungi.

The control of phytopathogenic fungi which damage plants post-emergence is carried out primarily by treating the soil and the above-ground parts of plants with crop protection compositions. Owing to the concerns regarding a possible impact of the crop protection composition on the environment and the health of humans and animals, there are efforts to reduce the amount of active compounds applied.

One of the advantages of the present invention is that, because of the particular systemic properties of the compositions according to the invention, treatment of the seed with these compositions not only protects the seed itself, but also the resulting plants after emergence, from phytopathogenic fungi. In this manner, the immediate treatment of the crop at the time of sowing or shortly thereafter can be dispensed with.

It is also considered to be advantageous that the mixtures according to the invention can be used in particular also for transgenic seed where the plant growing from this seed is capable of expressing a protein which acts against pests. By treating such seed with the active compound combinations or compositions according to the invention, even by the expression of the, for example, insecticidal protein, certain pests may be controlled. Surprisingly, a further synergistic effect may be observed here, which additionally increases the effectiveness of the protection against attack by pests.

The fungicidal composition of the present invention in addition to component (A) first fungicide and component (B) second fungicide further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol.

Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates or mixtures thereof.

Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).

Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.

Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agentcan be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tri-calcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

The solvent for the formulation of the present invention may include water, water-soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxyalcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

List of inactive excipients which may be used in the present invention are listed below but not limited to:
Inactive excipients used in SC (Suspension Concentrate) formulation:
Excipients Function
Acrylic graft copolymer Dispersing agent
Alkylated naphthalene sulfonate, sodium salt Dispersing agent
Sodium salt of naphthalene sulfonate condensate Dispersing agent
Sodium ligno sulfonate Dispersing agent
Polyalkoxy alkyl ether Dispersing agent, Emulsifier
Ethylene oxide/propylene oxide block copolymer Dispersing agent, Emulsifier
Polyarylphenyl ether phosphate Dispersing agent & Wetting agent
Ethoxylated Fatty Alcohol Dispersing agent & Wetting agent
Trisiloxane ethoxylate Wetting agent & Spreader
Sodium dioctyl sulfosuccinate Wetting agent & Emulsifier
Silicone antifoam emulsion Antifoam
Polysaccharide Rheology Modifier, Thickener
Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol) Antifreezing Agent
Glycerene Antifreezing Agent
1,2-benzisothiazolin-3(2H)-one, sodium salt Biocide/Preservative
Sodium benzoate Biocide/Preservative
2-bromo-2-nitropropane-1,3-diol Biocide/Preservative
Formaldehyde Biocide/Preservative
Sodium o-phenylphenate Biocide/Preservative
5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one Preservative
Aluminum Magnesium Silicate Suspending aid
Silicone dioxide Suspending aid, Anticaking agent
Polydimethyl siloxane Antifoaming agent
Organo modified Trisiloxane Spreader
Poly glycerol ester Sticker, Penetrant
Poly ether Deposition aid

Inactive excipients used in SE (Suspo emulsion) formulation:
Excipients Function
n- Octanol Solvent
Octyl Phenol Ethoxylate Wetting agent & Emulsifier
Polyoxyethylene (8) nonyl phenol Wetting agent & Emulsifier
Acrylic graft copolymer Dispersing agent
Ethoxylated Fatty Alcohol Co-dispersant/Wetting agent
Polyalkoxy alkyl ether Dispersing agent & Emulsifier
Ethylene oxide/propylene oxide block copolymer Dispersing agent & Emulsifier
Sodium salt of naphthalene sulfonate condensate Dispersing agent
Trisiloxane ethoxylate Spreader & Wetting agent
Silicone antifoam emulsion Antifoam
Silicone dioxide Suspending aid, Ant caking agent
Polysaccharide Rheology Modifier, Thickener
Sodium dioctyl sulfosuccinate Wetting agent & Emulsifier
Polyarylphenyl ether phosphate Dispersing agent & Wetting agent
Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol) Antifreezing Agent
1,2-benzisothiazolin-3-one Biocide/Preservative
Sodium benzoate Biocide/Preservative
2-bromo-2-nitropropane-1,3-diol Biocide/Preservative
Formaldehyde Biocide/Preservative

Inactive excipients used in WG (Wettable Granules/ Water Dispersible Granules) formulation
Excipients Function
Sodium salt of naphthalene sulfonate condensate Dispersing Agent
Modified polyacrylate copolymer Dispersing Agent
Sodium polycarboxylate Dispersing Agent
Sodium Ligno sulfonate Dispersing Agent
Alkyl naphthalene sulfonate condensate, sodium salt Dispersing Agent
Polyacrylate co-polymer Dispersing Agent, Stabilizer, Emulsifier
Alcohol block co-polymer Co-dispersant
Blend of naphthalene sulfonate condensate & phenol sulfonate condensate Wetting Agent & Dispersing Agent
blend of naphthalene sulfonate condensate Wetting Agent
Sodium dodecylbenzene sulfonate Wetting Agent
Sodium lauryl sulfate Wetting Agent
Blend of alkyl naphthalene sulfonate and anionic wetting agent Wetting Agent
Sodium n-butyl naphthalene sulfonate Wetting Agent
Sodium isopropyl naphthalene sulfonate Wetting Agent
Blend of sodium alkyl aryl sulfonates Wetting Agent
Corn starch Binder, Filler
Silicon dioxide Suspending agent, Anti-caking Agent, Filler
Urea formaldehyde resin / Urea-methanol Anti-caking agent
Lactose Filler
China clay/ Kaolin Filler
Titanium dioxide Filler
Talcum powder Filler
Diatomaceous earth Filler
Polyvinylpyrrolidone Binder
Silicone antifoam emulsion Defoaming agent
Fatty amine ethoxylate Wetting agent, Dispersing agent, Stabilizers, Sanitizers, Defoaming agent

Inactive excipients used in WP (Wettable Powder) formulation:
Excipients Function
Sodium salt of naphthalene sulfonate condensate Dispersing Agent
blend of naphthalene sulfonate condensate Wetting Agent
Sodium dodecylbenzene sulfonate Wetting Agent
Blend of naphthalene sulfonate condensate & phenol sulfonate condensate Wetting Agent & Dispersing Agent
Sodium lauryl sulfate Wetting Agent
Corn starch Binder, Filler
Lactose Filler
Polyvinylpyrrolidone Binder
Modified polyacrylate copolymer Dispersing Agent
Sodium polycarboxylate Dispersing Agent
Sodium Ligno sulfonate Dispersing Agent
China clay/ Kaolin Filler
Silicone antifoam emulsion Defoamer
Silicon dioxide Suspending agent, Anti-caking Agent, Filler
Titanium dioxide Filler
Talcum powder Filler
Urea formaldehyde resin / Urea-methanol Anti-caking agent
Diatomaceous earth Filler
Blend of alkyl naphthalene sulfonate and anionic wetting agent Wetting Agent
Sodium n-butyl naphthalene sulfonate Wetting Agent
Sodium isopropyl naphthalene sulfonate Wetting Agent
Blend of sodium alkyl aryl sulfonates Wetting Agent
Alkyl naphthalene sulfonate condensate, sodium salt Dispersing Agent
Polyacrylate co-polymer Dispersing Agent

Inactive excipients used in OD (Oil Dispersion) formulation:
Excipients Function
N,N-Dimethyldecanamide Solvent
Unsaturated Fatty alcohol, Ethoxylated Non Ionic Emulsifier
Calcium Alkyl Benzen Sulphonate Anionic Emulsifier
Ethoxylated TristyrylPhenol Dispersing Agent, Emulsifier
2-Pyrrolidinone, 1-ethenylhexadecyl-,homopolymer Emulsifier and anti-flocculant
Polyamide Rheology Modifier, Thickener
fatty acid methyl ester Green solvent & carrier
Trisiloxane ethoxylate Spreader & Wetting agent
Polyacrylate co-polymer Dispersing agent
Polyarylalkylphenol polyethylene glycol phosphoric acid ester Dispersing agent
Polyether phosphate Dispersing agent
Nonionic modified polyether Dispersing agent

Inactive excipients used in EC (Emulsifiable Concentrate) formulation:
Excipients Function
Mixture of heavy aromatic hydrocarbons / C IX, Xylene, n-Butanol (NBA), Solvent - C-9, N-Methyl-2-pyrrolidone Solvent
Polyaryl Phenol Ethoxylate Emulsifiers, Wetting agents, Dispersants, Stabilizers
Calcium Dodecyl Benzene Sulphonate, Blend of Polyaryl phenol ethoxylate & calcium dodecyl benzene sulfonate Emulsifier
Alkyl polyethylene glycol ether Spreader, Sticker, Penetrant, Surface tension reducer
Polyvinylpyrrolidone Sticker, Surface tension reducer, Binder

The process for preparing the present novel composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.

EXAMPLES

Example 1: Prothioconazole 10%+Azoxystrobin 15%+ Difenoconazole 7.5% SC (suspension concentrate)

Chemical composition % (w/w)
Prothioconazole a.i. 10.00
Azoxystrobin a.i. 15.00
Difenoconazole a.i. 7.50
Ethoxylated fatty alcohol 2.00
Acrylic graft copolymer 3.00
Alkylated napthalene sulfonate, sodium salt 0.50
Precipitated Silica 0.50
Polydimethyl siloxane 0.30
1,2-benzisothiazol-3-one 0.05
Glycol 5.00
Xanthan gum 0.15
D.M. Water q.s.
TOTAL 100.00

Procedure:
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenize, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Suspension concentrate production.
Step 3 Add required quantity of Wetting agent, antifreeze, dispersing agent & suspending agents and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 4 Then add technical and other remaining adjuvants excluding ‘thickener’ are added to it and homogenized to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6 Half quantity of the antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check.

Example 2: Prothioconazole 10%+Azoxystrobin 12%+ Thifluzamide 7.5% SC (suspension concentrate)
Chemical composition % (w/w)
Prothioconazole a.i. 10.00
Azoxystrobin a.i. 12.00
Thifluzamide a.i. 7.50
Ethoxylated fatty alcohol 2.00
Acrylic graft copolymer 3.00
Alkylated napthalene sulfonate, sodium salt 0.50
Precipitated Silica 0.50
Polydimethyl siloxane 0.30
1,2-benzisothiazol-3-one 0.05
Glycol 5.00
Xanthan gum 0.15
D.M. Water q.s.
TOTAL 100.00

Procedure: as per Example 1
Example 3: Prothioconazole 10%+Trifloxystrobin 15%+ Difenoconazole 7.5% SC (suspension concentrate)
Chemical composition % (w/w)
Prothioconazole a.i. 10.00
Trifloxystrobin a.i. 15.00
Difenoconazole a.i. 7.50
Ethoxylated fatty alcohol 2.00
Acrylic graft copolymer 3.00
Alkylated napthalene sulfonate, sodium salt 0.50
Precipitated Silica 0.50
Polydimethyl siloxane 0.30
1,2-benzisothiazol-3-one 0.05
Glycol 5.00
Xanthan gum 0.15
D.M. Water q.s.
Total 100.00

Procedure: as per Example 1
Example 4: Prothioconazole 10%+Trifloxystrobin 12%+ Thifluzamide 7.5% SC (suspension concentrate)
Chemical composition % (w/w)
Prothioconazole a.i. 10.00
Trifloxystrobin a.i. 12.00
Thifluzamide a.i. 7.50
Ethoxylated fatty alcohol 2.00
Acrylic graft copolymer 3.00
Alkylated napthalene sulfonate, sodium salt 0.50
Precipitated Silica 0.50
Polydimethyl siloxane 0.30
1,2-benzisothiazol-3-one 0.05
Glycol 5.00
Xanthan gum 0.15
D.M. Water q.s.
TOTAL 100.00

Procedure: as per Example 1
Example 5: Prothioconazole 5%+Azoxystrobin 7.5%+ Mancozeb 30% WDG (Water Dispersible Granules)
Chemical composition % (w/w)
Prothioconazole a.i. 5.00
Azoxystrobin a.i. 7.50
Mancozeb a.i. 30.00
Sodium Lauryl Sulfate 2.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalene sulfonate, formaldehyde condensate 7.00
Silicone based antifoam 1.00
Starch 15.00
PPT silica 5.00
China clay q.s.
TOTAL 100.00

Procedure A: Water Dispersible Granules (WG) by extrusion method
Step 1 Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2 Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx.. 1.5 hr)
Step 3 Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 4 Dough is passed through extruder to get granules of required size.
Step 5 Wet granules are passed through Fluidized bed drier and further graded using vibrating screens.
Step 6 Final product is sent for QC approval.
Step 7 After approval material is packed in required pack sizes.

Procedure B: Water Dispersible Granules (WG) by spray dried method

Step 1 Charge required quantity of DM water need to be taken in designated vessel for production.
Step 2 Add required quantity of Wetting agent, dispersing agent, antifoam & suspending agents and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 3 Add required quantity technical and homogenized to get uniform slurry ready for grinding.
Step 4 Now material is subjected to grinding in Bead mill till desired particle size is achieved.
Step 5 After grinding process completes the material is sprayed at required temperature.
Step 6 After completion of spray drying process material is collected and sent for QC department approval.
Step 7 After approval material is packed in required pack sizes.

Example 6: Prothioconazole 5%+Trifloxystrobin 7.5%+ Mancozeb 30% WDG (Water Dispersible Granules)
Chemical composition % (w/w)
Prothioconazole a.i. 5.00
Trifloxystrobin a.i. 7.50
Mancozeb a.i. 30.00
Sodium Lauryl Sulfate 2.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalene sulfonate, formaldehyde condensate 7.00
Silicone based antifoam 1.00
Starch 10.00
PPT silica 5.00
China clay q.s.
TOTAL 100.00

Procedure: as per Example 5
Example 7 to 34
Most Preferred formulations
Sr no active ingredient 1 active ingredient 2 active ingredient 3 active ingredients in % Formulation Strength (%) Formulation Type Application Rate (g per hectare) g.a.i per hectare
a.i.1 a.i.2 a.i.3 a.i.1 a.i.2 a.i.3
1 Prothioconazole Azoxystrobin Difenoconazole 10 15 7.5 32.5 SC 750 75.00 112.50 56.25
2 Prothioconazole Azoxystrobin Hexaconazole 10 15 5 30 SC 750 75.00 112.50 37.50
3 Prothioconazole Azoxystrobin Propiconazole 10 15 7.5 32.5 ZE 750 75.00 112.50 56.25
4 Prothioconazole Azoxystrobin Tricyclazole 8 12 15 35 WG 1000 80.00 120.00 150.00
5 Prothioconazole Azoxystrobin Mancozeb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
6 Prothioconazole Azoxystrobin Chlorothalonil 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
7 Prothioconazole Azoxystrobin Propineb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
8 Prothioconazole Azoxystrobin Copper Oxychloride 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
9 Prothioconazole Azoxystrobin Thifluzamide 10 15 7.5 32.5 SC 750 75.00 112.50 56.25
10 Prothioconazole Pyraclostrobin Difenoconazole 10 15 7.5 32.5 SC 750 75.00 112.50 56.25
11 Prothioconazole Pyraclostrobin Hexaconazole 10 15 5 30 SC 750 75.00 112.50 37.50
12 Prothioconazole Pyraclostrobin Propiconazole 10 15 7.5 32.5 ZE 750 75.00 112.50 56.25
13 Prothioconazole Pyraclostrobin Tricyclazole 8 12 15 35 WG 1000 80.00 120.00 150.00
14 Prothioconazole Pyraclostrobin Mancozeb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
15 Prothioconazole Pyraclostrobin Chlorothalonil 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
16 Prothioconazole Pyraclostrobin Propineb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
17 Prothioconazole Pyraclostrobin Copper Oxychloride 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
18 Prothioconazole Pyraclostrobin Thifluzamide 10 12 7.5 29.5 SC 750 75.00 90.00 56.25
19 Prothioconazole Trifloxystrobin Difenoconazole 10 15 7.5 32.5 SC 750 75.00 112.50 56.25
20 Prothioconazole Trifloxystrobin Hexaconazole 10 15 5 30 SC 750 75.00 112.50 37.50
21 Prothioconazole Trifloxystrobin Hexaconazole 20 30 10 60 WG 375 75.00 112.50 37.50
22 Prothioconazole Trifloxystrobin Propiconazole 10 15 7.5 32.5 SC 750 75.00 112.50 56.25
23 Prothioconazole Trifloxystrobin Tricyclazole 15 22.5 30 67.5 WG 500 75.00 112.50 150.00
24 Prothioconazole Trifloxystrobin Mancozeb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
25 Prothioconazole Trifloxystrobin Chlorothalonil 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
26 Prothioconazole Trifloxystrobin Propineb 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
27 Prothioconazole Trifloxystrobin Copper Oxychloride 5 7.5 30 42.5 WG 1500 75.00 112.50 450.00
28 Prothioconazole Trifloxystrobin Thifluzamide 10 12 7.5 29.5 SC 750 75.00 90.00 56.25

Thus, the present invention provides above compositions containing incompatible ingredients, and particularly active ingredients, with improved stability and methods of improving stability thereto in a simple and cost effective manner.

Biological Examples: 35
The synergistic fungicidal action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) of active ingredient is greater than the sum of the action of each of the components alone. Therefore a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components. In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two active components can be calculated as follows:
Colby’s Formula:

To study the synergistic effect of Prothioconazole+Azoxystrobin+Mancozeb, Prothioconazole+Pyraclostrobin+Mancozeb, Prothioconazole+Trifloxystrobin+Difenoconazole and Prothioconazole+Trifloxystrobin+Mancozeb, a laboratory bioassay were carried out in laboratory condition.

Example: A
Laboratory screening of mixtures of Prothioconazole + Azoxystrobin + Mancozeb, Prothioconazole + Pyraclostrobin + Mancozeb, were carried out to evaluate their efficacy against various fungi causing fungal diseases in crop plants. The synergistic effect of Prothioconazole + Azoxystrobin + Mancozeb, Prothioconazole + Pyraclostrobin+Mancozeb, Prothioconazole + Trifloxystrobin+ Difenoconazole and Prothioconazole + Trifloxystrobin + Mancozeb on growth of the pathogen in vitro were studied by poison food technique. Different concentration of active ingredient were prepared by dissolving the requisite quantity of each active ingredient in warm potato dextrose agar medium before autoclaving. After autoclaving the medium was then dispensed uniformly into 90 mm diameter petriplate and inoculated at the 2 mm mycelial discs of pathogen taken from 7 to 10 days old culture. Pathogen inoculated in unamended medium served as control. Each treatment was maintained in four replications. The inoculated plates were incubated at 30+/- 2 C for 3 days and the diameter of the fungal colony was measured by measuring the two opposite circumference of the colony growth at 3 days interval for 15 days. The growth of fungus was monitored by measuring the radial growth (in mm) every 72 h till the fungus covers the plate completely in control plates. The percent inhibition (PI) of the fungus over the control was calculated using the following formula:
PI = A-B X 100/A
Where A= Colony diameter of fungus in control plates (mm)
B= Colony diameter of fungus in treated plates (mm)
The synergistic pesticidal action of the inventive mixtures calculated as per the Colby’s formula given above by using percent inhibition (PI) data.
Table 1: Effect on mycelial growth of Alternaria solani
Active Ingredient Concentrations (ppm) Alternaria solani
Mycelial growth (mm) % Inhibition over control
Prothioconazole+Azoxystrobin+Mancozeb 75+112.5+450 0.0 100.00
Prothioconazole+Pyraclostrobin+Mancozeb 75+112.5+450 0.0 100.00
Prothioconazole+Azoxystrobin 75+112.5 37.4 57.79
Prothioconazole+Pyraclostrobin 75+112.5 42.6 51.92
Prothioconazole+Mancozeb 75+450 45.2 48.98
Azoxystrobin+Mancozeb 112.5+450 33.2 62.53
Pyraclostrobin+Mancozeb 112.5+450 35.6 59.82
Prothioconazole 75 51.2 42.21
Azoxystrobin 112.5 45.6 48.53
Pyraclostrobin 112.5 48.8 44.92
Mancozeb 450 56.4 36.34
Untreated Check (UTC) 0 88.6 0.00

Table 2: Synergistic activity on mycelial growth of Alternaria solani
Active Ingredient Concentrations (ppm) % Growth Inhibition of Alternaria solani
Obs. Value Exp. Value Ratio O/E
Prothioconazole+Azoxystrobin+Mancozeb 75+112.5+450 100.00 81.07 1.23
Prothioconazole+Pyraclostrobin+Mancozeb 75+112.5+450 100.00 79.74 1.25
Prothioconazole+Azoxystrobin 75+112.5 57.79 70.26 0.82
Prothioconazole+Pyraclostrobin 75+112.5 51.92 68.17 0.76
Prothioconazole+Mancozeb 75+450 48.98 63.21 0.77
Azoxystrobin+Mancozeb 112.5+450 62.53 67.24 0.93
Pyraclostrobin+Mancozeb 112.5+450 59.82 64.94 0.92
Prothioconazole 75 42.21
Azoxystrobin 112.5 48.53
Pyraclostrobin 112.5 44.92
Mancozeb 450 36.34
Untreated Check (UTC) 0 0.00

In vitro studies indicated the suppressive effect of Prothioconazole + Azoxystrobin + Mancozeb, Prothioconazole + Pyraclostrobin + Mancozeb fungicide mixtures on the radial growth of the mycelium of Alternaria solani (Table 1). It can be seen that the synergism was observed between Prothioconazole + Azoxystrobin + Mancozeb, Prothioconazole + Pyraclostrobin + Mancozeb in terms of excellent suppressive effect on radial growth of Alternaria solani (Table 2).
Example: B
Laboratory bioassay to study the synergism between Prothioconazole + Trifloxystrobin + Difenoconazole and Prothioconazole + Trifloxystrobin + Mancozeb.
Table 3: Effect on mycelial growth of Alternaria solani
Active Ingredient Concentrations (ppm) Alternaria solani
Mycelial growth (mm) % Inhibition over control
Prothioconazole+Trifloxystrobin+Difenoconazole 75+112.5+56.25 0.0 100.00
Prothioconazole+Trifloxystrobin+Mancozeb 75+112.5+450 0.0 100.00
Prothioconazole+Trifloxystrobin 75+112.5 43.2 54.14
Prothioconazole+Difenoconazole 75+56.25 44.6 52.65
Prothioconazole+Mancozeb 75+450 55.4 41.19
Trifloxystrobin+Difenoconazole 112.5+56.25 40.8 56.69
Trifloxystrobin+Mancozeb 112.5+450 61.4 34.82
Prothioconazole 75 52.4 44.37
Trifloxystrobin 112.5 55.8 40.76
Difenoconazole 56.25 50.6 46.28
Mancozeb 450 42.4 54.99
Untreated Check (UTC) 0 94.2 0.00

Table 4: Synergistic activity on mycelial growth of Alternaria solani
Active Ingredient Concentrations (ppm) % Growth Inhibition of Alternaria solani
Obs. Value Exp. Value Ratio O/E
Prothioconazole+Trifloxystrobin+Difenoconazole 75+112.5+56.25 100.00 82.30 1.22
Prothioconazole+Trifloxystrobin+Mancozeb 75+112.5+450 100.00 85.17 1.17
Prothioconazole+Trifloxystrobin 75+112.5 54.14 67.05 0.81
Prothioconazole+Difenoconazole 75+56.25 52.65 70.12 0.75
Prothioconazole+Mancozeb 75+450 41.19 74.96 0.55
Trifloxystrobin+Difenoconazole 112.5+56.25 56.69 68.18 0.83
Trifloxystrobin+Mancozeb 112.5+450 34.82 73.34 0.47
Prothioconazole 75 44.37
Trifloxystrobin 112.5 40.76
Difenoconazole 56.25 46.28
Mancozeb 450 54.99
Untreated Check (UTC) 0 0.00

The mixture of Prothioconazole + Trifloxystrobin + Difenoconazole and Prothioconazole + Trilfoxystrobin + Mancozeb shows synergism in terms of their efficacy against Alternaria solani.
,CLAIMS:We claim;
[CLAIM 1]. A synergistic composition comprising
(A) Prothioconazole;
(B) strobirulin fungicide selected from the group consisting of Azoxystrobin , Picoxystrobin, Pyraclostrobin, Trifloxystrobin; and
(C) at least one further active compound or a salt or adduct thereof selected from the group consisting of Cyproconazole, Difenoconazole, Flutriafol, Hexaconazole, Propiconazole, Tebuconazole, Tricyclazole, Mancozeb, Chlorothalonil, Propineb, Folpet, Copper (different salt), Captan, Dithianon, Fthalide, Fluxapyroxad, Penthiopyrad, Sedaxane, Boscalid, Fluopyram, Thifluzamide, Fluopicolide, Fluazinam, Fenpyrazamine, Dimethomorph; and
(D) optionally, one or more inactive excipients.

[CLAIM 2]. The synergistic composition as claimed in claim 1 wherein the component (A) Prothioconazole is in ratio of 0.1 to 25%, component (B) strobirulin fungicide is in ratio of 0.1 to 40% and component (C) further active compound is in ratio of 0.1 to 30%.

[CLAIM 3]. The synergistic composition as claimed in claim 1-2, wherein inactive excipients are selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents and buffering agent.

[CLAIM 4]. The synergistic composition as claimed in claim 1-3, wherein the formulations comprises of Suspension Concentrate (SC), Suspo emulsion (SE), Water dispersible grnules (WDG), Emulsifiable concentrate (EC), Wettable Powders (WP), Oil dispersion (OD), capsule suspension (CS), Zeon Concentrate (ZC), preferably Suspension Concentrate (SC), and Suspo emulsion (SE).

[CLAIM 5]. The formulation comprising the synergistic composition as claimed in claim 4, wherein the SC (Suspension Concentrate) formulation comprises:
a) Dispersing agent selected from Acrylic graft copolymer, Alkylated naphthalene sulfonate, sodium salt, Sodium salt of naphthalene sulfonate condensate, Sodium ligno sulfonate, Polyalkoxy alkyl ether, Ethylene oxide/propylene oxide block copolymer, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol;
b) Emulsifier selected from Polyalkoxy alkyl ether, Ethylene oxide, propylene oxide block copolymer Sodium dioctyl sulfosuccinate;
c) Wetting agent selected from Trisiloxane ethoxylate, Sodium dioctyl sulfosuccinate;
d) Antifoam is Silicone antifoam emulsion;
e) Rheology Modifier, Thickener is Polysaccharide;
f) Anti-freezing Agent selected from Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), Glycerene;
g) Biocide Preservative selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde, Sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
[CLAIM 6]. The formulation comprising synergistic composition as claimed in claim 4, wherein the SE (Suspo emulsion) formulation comprises:
a) Wetting agent selected from Octyl Phenol Ethoxylate, Polyoxyethylene (8) nonyl phenol, Ethoxylated Fatty Alcohol, Trisiloxane ethoxylate, Sodium dioctyl sulfosuccinate;
b) Dispersing agent selected from Acrylic graft copolymer, Ethoxylated Fatty Alcohol, Polyalkoxy alkyl ether Ethylene oxide propylene oxide block copolymer, Sodium salt of naphthalene sulfonate condensate, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol;
c) Anti-freezing Agent selected from Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol);
d) Biocide Preservative 1,2-benzisothiazolin-3-one, Sodium benzoate,
e) 2-bromo-2-nitropropane-1,3-diol, Formaldehyde

[CLAIM 7]. The formulation comprising synergistic composition as claimed in claim 4, wherein the WG (Wettable Granules/ Water Dispersible Granules) comprises:
a) Wetting agent Blend of naphthalene sulfonate condensate & phenol sulfonate condensate, blend of naphthalene sulfonate condensate, Sodium dodecylbenzene sulfonate, Sodium lauryl sulfate, Blend of alkyl naphthalene sulfonate and anionic wetting agent, Sodium n-butyl naphthalene sulfonate, Sodium isopropyl naphthalene sulfonate, Blend of sodium alkyl aryl sulfonates,
b) Dispersing agent selected from Sodium salt of naphthalene sulfonate condensate, Modified polyacrylate copolymer, Sodium polycarboxylate, Sodium Ligno sulfonate; Alkyl naphthalene sulfonate condensate, sodium salt, Polyacrylate co-polymer, Alcohol block co-polymer;
c) Suspending agent is Silicon dioxide;
d) Filler selected from Lactose, China clay/ Kaolin, Titanium dioxide, Talcum powder, Diatomaceous earth.

[CLAIM 8]. The formulation comprising of synergistic composition as claimed in claim 4, wherein the WP (Wettable Powder) formulation comprises:
a) Wetting agent selected from Blend of naphthalene sulfonate condensate & phenol sulfonate condensate, blend of naphthalene sulfonate condensate, Sodium dodecylbenzene sulfonate, Sodium lauryl sulfate, Sodium lauryl sulfate Blend of alkyl naphthalene sulfonate and anionic wetting agent, Sodium n-butyl naphthalene sulfonate, Sodium isopropyl naphthalene sulfonate, Blend of sodium alkyl aryl sulfonates;
b) Dispersing agent selected from Sodium salt of naphthalene sulfonate condensate, Modified polyacrylate copolymer, Sodium polycarboxylate, Sodium Ligno sulfonate; Alkyl naphthalene sulfonate condensate, sodium salt, Polyacrylate co-polymer, Alcohol block co-polymer, Alkyl naphthalene sulfonate condensate, sodium salt;
c) Suspending agent is Silicon dioxide;
d) Defoamer is Silicone antifoam emulsion
e) Filler selected from Lactose, China clay/ Kaolin, Titanium dioxide, Talcum powder, Diatomaceous earth.

[CLAIM 9]. The formulation comprising of synergistic composition as claimed in claim 4, wherein the OD (Oil Dispersion) formulation comprises:
a) Emulsifier is Unsaturated Fatty alcohol, Ethoxylated; Calcium Alkyl Benzen Sulphonate; Ethoxylated TristyrylPhenol;
b) Anti-flocculant is 2-Pyrrolidinone, 1-ethenylhexadecyl-,homopolymer;
c) Rheology Modifier,Thickner is Polyamide;
d) Solvent is N,N-Dimethyldecanamide;
e) Carrier is fatty acid methyl ester
f) Dispersing agent are selected from Polyacrylate co-polymer, Polyarylalkylphenol polyethylene glycol phosphoric acid ester, Polyether phosphate, Non-ionic modified polyether;
g) Spreader & Wetting agent is Trisiloxane ethoxylate.

[CLAIM 10]. The formulation comprising of synergistic composition as claimed in claim 4, wherein the EC (Emulsifiable Concentrate) formulation comprises:
a) Solvent selected from aromatic hydrocarbons, Xylene, n-Butanol, N-Methyl-2-pyrrolidone and mixture thereof;
b) Emulsifiers selected from Calcium Dodecyl Benzene Sulphonate, Blend of Polyaryl phenol ethoxylate & calcium dodecyl benzene sulfonate;
c) Wetting agent is Polyaryl Phenol Ethoxylate;
d) Spreader, is Alkyl polyethylene glycol ether;
e) Binder is Polyvinylpyrrolidone.

[CLAIM 11]. The synergistic composition as claimed in any of the preceding claims, wherein the said composition is to be used to manage or control insects in crops selected from GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).

[CLAIM 12]. The synergistic composition as claimed in any of the preceding claims, wherein the said composition is active against normally sensitive and resistant species phytopathogenic fungi such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, Blumeria graminis; Podosphaera species such as, for example, Podosphaera leucotricha, Sphaerotheca fuliginea; Uncinula. Uncinula necator, Leveillula taurica, Erysiphe, Erysiphe polygoni, Gymnosporangium, Gymnosporangium sabinae, Hemileia vastatrix, Phakopsora pachyrhizi, Phakopsora meibomiae, Puccinia graminis, Puccinia recondita or Puccinia triticina, Puccinia striiformis; Uromyces species such as, for example, Uromyces phaseoli; diseases caused by pathogens of smut diseases such as, for example, Sporisorium species such as , for example, Sporisorium scitamineum; Ustilago species such as, for example Ustilago maydis, Tilletia species such as for example Tilletia tritici, Ustilaginoidea species such as , for example Ustilaginoidea virens, diseases caused by pathogens of ergot diseases such as, for example Claviceps species, Claviceps purpurea; diseases caused by pathogens from the group of the Oomycetes such as, for example, Bremia species such as, for example, Bremia lactucae; Peronospora species such as, for example, Peronospora pisi or P. brassicae; Phytophthora species such as, for example, Phytophthora infestans; Plasmopara species such as, for example, Plasmopara viticola; Pseudoperonospora species such as, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis; Pythium species such as, for example, Pythium ultimum; leaf spot diseases and leaf wilt caused by, for example, Alternaria species such as, for example, Alternaria solani; Cercospora species such as, for example, Cercospora beticola; Cladiosporum species such as, for example, Cladiosporium cucumerinum; Cochliobolus species such as, for example, Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium); Colletotrichum species such as, for example, Colletotrichum lindemuthanium; Cycloconium species such as, for example, Cycloconium oleaginum; Diaporthe species such as, for example, Diaporthe citri; Elsinoe species such as, for example, Elsinoe fawcettii; Gloeosporium species such as, for example, Gloeosporium laeticolor; Glomerella species such as, for example, Glomerella cingulata; Guignardia species such as, for example, Guignardia bidwelli; Leptosphaeria species such as, for example, Leptosphaeria maculans; Magnaporthe species such as, for example, Magnaporthe grisea; Mycosphaerella species such as, for example, Mycosphaerella graminicola; Phaeosphaeria species such as, for example, Phaeosphaeria nodorum; Pyrenophora species such as, for example, Pyrenophora teres; Ramularia species such as, for example, Ramularia collo-cygni; Rhynchosporium species such as, for example, Rhynchosporium secalis; Septoria species such as, for example, Septoria apii; Typhula species such as, for example, Typhula incarnata; Venturia species such as, for example, Venturia inaequalis; root and stalk diseases, caused by, for example, Corticium species such as, for example, Corticium graminearum; Fusarium species such as, for example, Fusarium oxysporum; Gaeumannomyces species such as, for example, Gaeumannomyces graminis; Rhizoctonia species such as, for example, Rhizoctonia solani; Tapesia species such as, for example, Tapesia acuformis; Thielaviopsis species such as, for example, Thielaviopsis basicola; ear and panicle diseases (including maize cobs), caused by, for example, Alternaria species such as, for example, Alternaria spp.; Aspergillus species such as, for example, Aspergillus flavus; Cladosporium species such as, for example, Cladosporium spp.; Claviceps species such as, for example, Claviceps purpurea; Fusarium species such as, for example, Fusarium culmorum; Gibberella species such as, for example, Gibberella zeae; Monographella species such as, for example, Monographella nivalis; diseases caused by smuts such as, for example, Sphacelotheca species such as, for example, Sphacelotheca reiliana; Tilletia species such as, for example, Tilletia caries; Urocystis species such as, for example, Urocystis occulta; Ustilago species such as, for example, Ustilago nuda; fruit rot caused by, for example, Aspergillus species such as, for example, Aspergillus flavus; Botrytis species such as, for example, Botrytis cinerea; Penicillium species such as, for example, Penicillium expansum; Sclerotinia species such as, for example, Sclerotinia sclerotiorum; Verticilium species such as, for example, Verticilium alboatrum; seed- and soil-borne rots and wilts, and seedling diseases, caused by, for example, Fusarium species such as, for example, Fusarium culmorum; Phytophthora species such as, for example, Phytophthora cactorum; Pythium species such as, for example, Pythium ultimum; Rhizoctonia species such as, for example, Rhizoctonia solani; Sclerotium species such as, for example, Sclerotium rolfsii; cankers, galls and witches' broom diseases, caused by, for example, Nectria species such as, for example, Nectria galligena; wilts caused by, for example, Monilinia species such as, for example, Monilinia laxa; deformations of leaves, flowers and fruits, caused by, for example, Taphrina species such as, for example, Taphrina deformans; degenerative diseases of woody species, caused by, for example, Esca species such as, for example, Phaemoniella clamydospora; flower and seed diseases, caused by, for example, Botrytis species such as, for example, Botrytis cinerea; diseases of plant tubers caused by, for example, Rhizoctonia species such as, for example, Rhizoctonia solani; diseases caused by bacterial pathogens such as, for example, Xanthomonas species such as, for example, Xanthomonas campestris pv. oryzae; Pseudomonas species such as, for example, Pseudomonas syringae pv. lachrymans; Erwinia species such as, for example, Erwinia amylovora.