Abstract:
The purpose of the present invention is to provide an adsorption carrier packed column which enables a reduction in short pass and an improvement in the performance of an adsorption carrier. The present invention provides an adsorption carrier packed column provided with a center pipe an adsorption carrier a plate (A) and a plate (B) wherein an insertion material (C) is inserted between the adsorption carrier and the plate (A) an insertion material (D) is inserted between the adsorption carrier and the plate (B) the ratio between the deformation rate (C) of the insertion material (C) and the deformation rate (E) of the adsorption carrier is 1=C/E=10 the ratio between the deformation rate (D) of the insertion material (D) and the deformation rate (E) of the adsorption carrier is 1=D/E=10 the ratio between the thickness (T) of the insertion material (C) and the distance (L) of a gap between the adsorption carrier and the plate (A) is 1.1=T/L=4 and the ratio between the thickness (T) of the insertion material (D) and the distance (L) of a gap between the adsorption carrier and the plate (B) is 1.1=T/L=4.
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Notices, Deadlines & Correspondence
1 1 Nihonbashi Muromachi 2 chome Chuo ku Tokyo
1038666
Inventors
1. TOMITA Naotoshi
c/o Shiga Plant Toray Industries Inc. 1 1 Sonoyama 1 chome Otsu shi Shiga
5208558
2. SHIMADA Kaoru
c/o Shiga Plant Toray Industries Inc. 1 1 Sonoyama 1 chome Otsu shi Shiga
5208558
3. UENO Yoshiyuki
c/o Shiga Plant Toray Industries Inc. 1 1 Sonoyama 1 chome Otsu shi Shiga
5208558
Specification
ADSORPTION CARRIER-PACKED COLUMN
TECHNICAL FIELD [0001]
The present invention relates to an adsorption carrier-packed column which reduces bypassing. BACKGROUND ART [0002]
y A variety of columns packed with adsorption carriers have been devised for removal/recovery of unnecessary components from liquids and gases. The structures of the columns can be divided, based on the flow of the medium, into two large groups: the axial flow and the radial flow. The axial flow is used mainly for analysis and fractionation by GC, HPLC, GPC, or the like, and the radial flow is use< for body fluid processing columns and the like (Patent Document 1). The radial flow is thought to be especially efficient from the viewpoint of contacting with the carrier, and products in which an adsorption carrier is wound around a central pipe are widely used in the field of extracorporeal circulation (Patent Document 2). PRIOR ART DOCUMENTS [Patent Documents] [0003],
[Patent Document 1] JP 2004:41527 A
[Patent Document 2] WO 2000/38763 SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED BY THE INVENTION [0004] '
However, in the conventional radial flow columns described in Patent
Documents 1 and 2, gaps are generated at the inlet and outlet plates arranged above and below the adsorption carrier, and the medium preferentially flows through the gaps, which show no resistance. This causes bypassing, resulting in insufficient exertion of the capacity of the adsorption carrier in-some cases. In order to avoid the bypassing, there are limitations, for example, that each pore on the central pipe cannot be provided in the vicinities of the plates. A countermeasure for the gaps is filling of the gaps with a resin, and urethane resins and epoxy resins are mainly used therefor (CELLSORBA (registered trademark), manufactured by Asahi Kasei Medical Co., Ltd.). Uniform application of urethane resins and epoxy resins requires a technique. Moreover, since .they are in the forms of pastes, their operability under clean circumstances is poor, and, in cases where the adsorption carrier is wet, use of such resins is restricted, so that the resins lack versatility. Furthermore, since a reactive base reshxand a curing agent need to be mixed together for producing a resin immediately before the application, there is a possibility that the base resin or the curing agent reacts with the adsorption carrier to cause deterioration of the adsorption carrier, and there are also safety problems such as the irritant nature and harmfulness to operators, so that a simpler method has been demanded. [0005]
The present invention aims to prepare a radial flow column in which an adsorption carrier is packed, wherein the adsorption carrier-packed radial flow 'column enables maximal exertion of the performance of the adsorption carrier contained therein by reducing bypassing and allowing uniform flow of the flowing liquid.
MEANS FOR SOLVING THE PROBLEMS [0006]
As a result of intensive study to solve the problems described above, the.
present inventors discovered that, in cases where insertion materials having
deformation rates of not less than the deformation rate of the adsorption carrier and
having thicknesses suitable for the gaps between the absorption carrier and the plates
are inserted in the gaps, the gaps between the absorption carrier and the plates can be
eliminated, so that bypassing can be avoided and the adsorption carrier can be
uniformly used. ' This eliminates the limitation oftheposition(s) ofthepore(s) on
the central pipe, thereby completing the present invention.
[0007] ;
That is, the present invention provides the adsorption carrier-packed columns described in (1) to (5) below.
(1) An adsorption carrier-packed column which is a radial flow type adsorption carrier-packed column, comprising:
a central pipe in which a pore(s) provided for allowing outflow of a supplied
liquid is/are formed on a longitudinal side surface(s); .
an adsorption carrier packed in the circumference of the central pipe, for allowing adsorption of a target molecule(s) or a target cell(s) contained in the liquid;
a plate A communicating with the upstream end of the central pipe such that
the inflowing liquid passes through the central pipe, the plate A being arranged such
that contacting of the liquid with the adsorption carrier without passing through the
central pipe is prevented; and •
a plate B arranged such that the downstream end of the central pipe is sealed and the adsorption carrier is immobilized in the space in the circumference of the central pipe; wherein
an insertion material C is inserted between the adsorption carrier and the plate
A; '
an insertion material D is inserted between the adsorption carrier and the plate
the ratio (Ci/E0) of the deformation rate of the insertion material C (Ci) to the deformation rate of the adsorption carrier (E0) is li) to the deformation rate of the adsorption carrier (E0) is l