FIELD OF THE INVENTION:
The present invention relates to synergistic pesticidal compositions comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.
BACKGROUND OF THE INVENTION:
Combination of insecticides and plant health additives are used to broaden the spectrum of control of insect-pests and mites, to improve the pest control with synergistic effect, reduce dosage, thereby reducing environmental impact, to broaden the spectrum of control, decrease chances of resistance development and to enhance residual control so lesser the number of sprays for crop protections and minimizing the pesticidal load in ecosystem. The combination of insecticides and fungicides at times demonstrate an additive or synergistic effect that results in an improved control on the insect-pests and disease.
Insecticides and plant health additives in combination or pesticides are used widely and very frequently in commercial agriculture and have enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in term of economic advantage as well as ease of farming activities.
There are many combinations of Flupyrimin along with other insecticide known in the art for the control of soil borne pests. For example, CN108849961A relates to a kind of composition pesticides containing pyridine quinazoline, it is A and B containing active constituent, wherein A is selected from pyridine quinazoline, B is selected from one of dinotefuran, Diacloden, Flupyrimin, Ivermectin HCL, composition includes usual auxiliaries, active components A and B, A and B has synergistic effect to target after compounding in certain proportion, suitable for preventing and treating insects pest.

WO2018052136A1 relates to a pesticide composition characterized by comprising a condensed heterocyclic compound comprising insecticidal compounds such Flupyrimin, ipronil, brofuranilide and other insecticides from various groups.
CN109645002A relates to a synergetic pesticide compositions containing D- limonene, and other agent is selected from one or more of compounds such as dinotefuran, Diacloden, clothianidin, fluorine pyrrole furanone, flonicamid, Flupyrimin, pymetrozine, trifluoro-benzene pyrimidine, Nitenpyram, bromine cyanogen insect amide, Rynaxypyr, four chlorantraniliproles, fluorobenzene insect amide, and composition includes usual auxiliaries.
There is however a need for improvement of these combinations. Single active combinations used over a long period of time has resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of control over insect-pests and mites.
However still there is a need for a composition comprises Flupyrimin; an insecticide selected from various groups or mixture thereof; and a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the pesticide actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism, such as plants, fungi and insects. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.

Therefore, one object of the present invention is to provide improved combinations of insecticides and plant health additives for the control of insect-pests and mites. Another object of the present invention is to provide a method and a composition for controlling insect-pests and mites.
Yet another object of the present invention is to provide improved combinations of insecticides and plant health additives that promote plant health and to increase plant or crop yield.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
Inventors of the present invention have surprisingly found that the novel synergistic pesticidal composition of Flupyrimin; an insecticide selected from various groups or mixture thereof; and a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof as described herein which can provide solution to the above mentioned problems.
SUMMARY OF THE INVENTION
Therefore an aspect of the present invention provides a synergistic pesticidal composition comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof.
Further aspect of the present invention provides a synergistic pesticidal compositions comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from fipronil, nicofluprole, bifenthrin, lambda-cyhalothrin, clothianidin, dinotefuran, thiamethoxam, triflumezopyrim, dichloromezotiaz, emamectin benzoate, pyriproxyfen, pymetrozine, pyrifluquinazon; afidopyropen, flonicamid, bensultap, monosultap, cartap hydrochloride, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, novaluron, methoxyfenozide, spiropidion, tyclopyrazoflor, azadirechtin, benzpyrimoxan, oxazosulfyl, dimpropyridaz or mixture thereof; and (C) a plant health

additive from class of bio-stimulant is selected from humic acid, fulvic acid, amino acids, protein hydrolysates, carboxylic acid, jasmonic acid, chitosan, chitin, seaweed extract (Ascophyllum nodosum), salicylic acid, silicic acid (Orth silicic acid (H4Si04)); from class of plant growth regulator is selected from gibberellic acid (GA3), alpha-naphthyl acetic acid, mepiquat chloride, paclobutrazol, uniconazole-p, chlormequat chloride, trinexapac ethyl, aminoethoxyvinylglycine (AVG), prohexadione calcium, brassinolide, triacontanol, nitrobenzene, nitrophenolate (sodium para-nitrophenolate); from class of microbial agent is selected from Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp., Bacillus megaterium var. phosphaticum, Bacillus polymyxa, Bacillus licheniformis, Frateuria aurantia, Thiobacillus thiooxidans, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), Acinetobacter calcoaceticus, Bacillus subtilis, Bacillus thuringiensis var. kurstaki, Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae, Varticillium lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp.; and from the class of micronutrient is selected from zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ) and sulphur (elemental sulphur, boronated sulphur) or mixture thereof.
Accordingly, in a further aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage by applying to the plant propagation material a composition comprising a pesticidal composition defined in the first aspect.
As per one embodiment formulation for the pesticidal composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible

granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR), and and one or more customary formulation adjuvants such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides e) anti-freezing agent f) suspending agent g) thickener h) coating agent and i) buffering agent.
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.
Accordingly, in a first aspect, the present invention provides a synergistic pesticidal compositions comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from fipronil, nicofluprole, bifenthrin, lambda-cyhalothrin, clothianidin, dinotefuran, thiamethoxam, triflumezopyrim, dichloromezotiaz, emamectin benzoate, pyriproxyfen, pymetrozine, pyrifluquinazon; afidopyropen, flonicamid, bensultap, monosultap, cartap hydrochloride, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, novaluron, methoxyfenozide, spiropidion, tyclopyrazoflor, azadirechtin, benzpyrimoxan, oxazosulfyl, dimpropyridaz or mixture thereof; and (C) a plant health additive from class of bio-stimulant is selected from humic acid, fulvic acid, amino acids, protein hydrolysates, carboxylic acid, jasmonic acid, chitosan, chitin, seaweed extract (Ascophyllum nodosum), silicyclic acid, silicic acid (Orth silicic acid (H4Si04)); from class of plant growth regulator is selected from gibberellic acid (GA3), alpha-naphthyl acetic acid, mepiquat chloride, paclobutrazol, uniconazole-p, chlormequat chloride, trinexapac ethyl, aminoethoxyvinylglycine (AVG), prohexadione calcium, brassinolide, triacontanol, nitrobenzene, nitrophenolate (sodium para-nitrophenolate); from class of microbial agent is selected from Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp., Bacillus megaterium var. phosphaticum, Bacillus polymyxa, Bacillus licheniformis, Frateuria aurantia, Thiobacillus thiooxidans, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), Acinetobacter calcoaceticus, Bacillus subtilis, Bacillus thuringiensis var. kurstaki, Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae,

Varticillium lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp.; and from the class of micronutrient is selected from zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax,) and sulphur (elemental sulphur, boronated sulphur) or mixture thereof; and one or more customary formulation adjuvants; shows synergistic activity.
DETAILED DESCRIPTION OF THE INVENTION:
The term "synergistic", as used herein, refers the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.
"Bioactive amounts" as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
Therefore an aspect of the present invention provides a synergistic pesticidal composition comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof.
Further aspect of the present invention provides a synergistic pesticidal compositions comprising bioactive amounts of (A) Flupyrimin; (B) an insecticide selected from fipronil, nicofluprole, bifenthrin, lambda-cyhalothrin, clothianidin, dinotefuran, thiamethoxam, triflumezopyrim, dichloromezotiaz, emamectin benzoate, pyriproxyfen, pymetrozine, pyrifluquinazon; afidopyropen, flonicamid, bensultap, monosultap, cartap hydrochloride, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, novaluron, methoxyfenozide, spiropidion, tyclopyrazoflor, azadirechtin, benzpyrimoxan, oxazosulfyl, dimpropyridaz or mixture thereof; and (C) a plant health additive from class of bio-stimulant is selected from humic acid, fulvic acid, amino acids, protein hydrolysates, carboxylic acid, jasmonic acid, chitosan, chitin, seaweed extract (Ascophyllum nodosum), silicyclic acid, silicic acid (Orth silicic acid (H4Si04)); from class of plant growth regulator is selected from gibberellic acid (GA3), alpha-naphthyl

acetic acid, mepiquat chloride, paclobutrazol, uniconazole-p, chlormequat chloride, trinexapac ethyl, aminoethoxyvinylglycine (AVG), prohexadione calcium, brassinolide, triacontanol, nitrobenzene, nitrophenolate (sodium para-nitrophenolate); from class of microbial agent is selected from Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp., Bacillus megaterium var. phosphaticum, Bacillus polymyxa, Bacillus licheniformis, Frateuria aurantia, Thiobacillus thiooxidans, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), Acinetobacter calcoaceticus, Bacillus subtilis, Bacillus thuringiensis var. kurstaki, Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae, Varticillium lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp.; and from the class of micronutrient is selected from zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ) and sulphur (elemental sulphur, boronated sulphur) or mixture thereof.
In an embodiment of the present invention an insecticide is fipronil, nicofluprole, bifenthrin, lambda-cyhalothrin, clothianidin, dinotefuran, thiamethoxam, triflumezopyrim, dichloromezotiaz, emamectin benzoate, pyriproxyfen, pymetrozine, pyrifluquinazon; afidopyropen, flonicamid, bensultap, monosultap, cartap hydrochloride, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, novaluron, methoxyfenozide, spiropidion, tyclopyrazoflor, azadirechtin, benzpyrimoxan, oxazosulfyl, dimpropyridaz or mixture thereof.
In an embodiment of the present invention a plant health additive from class of bio-stimulant is selected from humic acid, fulvic acid, amino acids, protein hydrolysates, carboxylic acid, jasmonic acid, chitosan, chitin, seaweed extract (Ascophyllum nodosum), silicyclic acid, silicic acid (Orth silicic acid (H4Si04)).
In an embodiment of the present invention a plant health additive from class of plant growth regulator is selected from gibberellic acid (GA3), alpha-naphthyl acetic acid, mepiquat chloride, paclobutrazol, uniconazole-p, chlormequat chloride, trinexapac ethyl,

aminoethoxyvinylglycine (AVG), prohexadione calcium, brassinolide, triacontanol, nitrobenzene, nitrophenolate (sodium para-nitrophenolate).
In an embodiment of the present invention a plant health additive from class of microbial agent is selected from Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp., Bacillus megaterium var. phosphaticum, Bacillus polymyxa, Bacillus licheniformis, Frateuria aurantia, Thiobacillus thiooxidans, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), Acinetobacter calcoaceticus, Bacillus subtilis, Bacillus thuringiensis var. kurstaki, Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae, Varticillium lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp.
In an embodiment of the present invention a plant health additive from the class of micronutrient is selected from zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ) and sulphur (elemental sulphur, boronated sulphur) or mixture thereof.
Flupyrimin is a novel chemotype insecticide flupyrimin has unique biological properties, including outstanding potency to imidacloprid (EVII)-resistant rice pests together with superior safety toward pollinators. Intriguingly, FLP acts as a nicotinic antagonist in American cockroach neurons, and [3FTJFLP binds to the multiple high-affinity binding components in house fly nicotinic acetylcholine (ACh) receptor (nAChR) preparation. One of the [3FTJFLP receptors is identical to the EVII receptor, and the alternative is IMI-insensitive subtype. Furthermore, FLP is favorably safe to rats as predicted by the very low affinity to the rat a4p2 nAChR. Structure-activity relationships of FLP analogues in terms of receptor potency, featuring the pyridinylidene and trifluoroacetyl pharmacophores, were examined, thereby establishing the FLP molecular recognition at the Aplysia californica ACh-binding protein, a suitable structural surrogate of the insect nAChR. These FLP pharmacophores account for the excellent receptor affinity, accordingly revealing differences in its binding mechanism from EVIL

Lambda-cyhalothrin is an insecticide of (lS)-cis-(alphaR)-cyhalothrin is a
cyclopropanecarbo xylate ester. It has an IUPAC name as [(R)-cyano-(3
phenoxyphenyl)methyl] (lS,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-l-enyl]-2,2-
dimethylcyclopropane-1-carboxylate.
Clothianidin is an insecticide similar to thiamethoxam and imidacloprid, it is a neonicotinoid. Neonicotinoids are a class of insecticides that are chemically similar to nicotine. Clothianidin and other neonicotinoids act on the central nervous system of insects as an agonist of acetylcholine, the neurotransmitter that stimulates nAChR, targeting the same receptor site (AChR) and activating post-synaptic acetylcholine receptors but not inhibiting AChE.
Triflumezopyrim is an extremely effective hopper insecticide with low impact on non-target organisms including pollinators. This unique class of mesoionic chemistry targets the nicotinic acetylcholine receptor, inducing a physiological action which is distinct from that of neonicotinoids.
Dichloromezotiaz, a novel class of mesoionic compounds has been discovered, with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera. These compounds bind to the orthosteric site of the nicotinic acetylcholine receptor and result in a highly potent inhibitory action at the receptor with minimal agonism. The synthesis, biological activity, optimization and mode of action will be discussed. Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests.
Pymetrozine, is a member of the class of 1,2,4-triazines that is 4,5-dihydro-l,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4. It has a role as an antifeedant, an environmental contaminant, a xenobiotic and a TRPV channel modulator. It is a member of 1,2,4-triazines and a member of pyridines. It hasan RJPAC name as 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-l,2,4-triazin-3-one.

Cartap hydrochloride is a broad spectrum, systemic insecticide with contact and stomach action. Effected Insects discontinue feeding and dies due to starvation. It is used to control of chewing and sucking insects at almost all the stages of development, on many crops. It has an IUPAC name as S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate; hydro chloride.
Thiocyclam hydrogen oxalate is an oxalate salt resulting from the formal reaction of equimolar amounts of thiocyclam and oxalic acid. A nicotinic acetylcholine receptor agonist, it was used as a broad-spectrum insecticide. It is not approved for use within the European Union. It has a role as an agrochemical, a nicotinic acetylcholine receptor agonist and an insecticide. It contains a thiocyclam(l+) and an oxalate(l-).
Tyclopyrazoflor, is a member of the class of pyrazoles that is lH-pyrazole which is substituted at positions 1, 3 and 4 by a pyridin-3-yl group, chloro group and an ethyl{3 [(3,3,3-trifluoropropyl)sulfanyl]propanoyl}nitrilo group, respectively. It is an insecticide from Dow AgroSciences LLC. It has a role as an insecticide. It is an organofluorine compound, a member of pyrazoles, a member of pyridines, a tertiary carboxamide, an organic sulfide and an organochlorine compound. It has an IUPAC name as N-(3-chloro-l-pyridin-3-ylpyrazol-4-yl)-N-ethyl-3-(3,3,3-trifluoro propyl sulfanyl)propanamide.
Benzpyrimoxan has a unique chemical structure which contains benzyloxy and cyclic acetal groups on pyrimidine moiety (5-(l,3-dioxan-2-yl)-4-[4 (trifluorom ethyl) benzyloxy] pyrimidine). It has an IUPAC name as 5-(l,3-dioxan-2-yl)pyrimidin-4-yl 4-(trifluoromethyl)benzyl ether.
Oxazosulfyl is a newly developed insecticide. It has an IUPAC name as 2-(3 -ethyl sulfonyl pyridin-2-yl)-5-(trifluoromethylsulfonyl)-l,3-benzoxazole.
Dimpropyridaz chemically is a pyrazole carboxamide insecticide that has a pyridin-3-yl group, as in tyclopyrazoflor. Dimpropyridaz is effective against aphids. Dimpropyridaz mechanism of action is unknown. The polymorphic form-A is prior art form, which can be obtained by following process disclosed in compound patent of dimpropyridaz as

glassy melt, which contains the crystalline form A. Polymorphic Form-B of dimpropyridaz is more stable than polymorphic Form-A.
Plant growth regulators:
Biostimulants:
Humic acid is a group of molecules that bind to, and help plant roots receive, water and nutrients. It has an IUPAC name as 2-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid. High humic acid levels can dramatically increase yields. Humic acid deficiency can prevent farmers and gardeners from growing crops with optimum nutrition. Humic acids are vital for increasing cell wall permeability in plants. When cell membranes become more permeable, nutrients can more easily enter through the plant
Silicic acid (Orth silicic acid (H4SW4)) is important, very important. It acts as a bio-stimulant for the growth of the plant and helps the plant to overcome infections and stress factors like heat, drought and salinity. So, when bio-active silicic acid is added, plants show an improved growth, higher yield, reduced mineral toxicities and better disease and insect resistance. Moreover, silicon stimulates the beneficial micro-organisms in the (top) soil resulting in synergistic effects for the uptake of nutrients by the plant. Moreover, application of silicic acid along with half dose of recommended pesticide as foliar spray increased the grain and straw yield.
Plant Growth Additives are defined as small, simple chemicals produced naturally by
plants to regulate their growth and development.
Plant Growth Regulators can be of a diverse chemical composition such as gases
(ethylene), terpenes (gibberellic acid) or carotenoid derivatives (abscisic acid). They are
also referred to as plant growth substances, phytohormones or plant hormones.
Plant growth hormones are organic compounds which are either produced naturally
within the plants or are synthesized in laboratories. They profoundly control and modify
the physiological processes like the growth, development, and movement of plants.

Gibberellic acid is a simple gibberellin, a pentacyclic diterpene acid promoting growth and elongation of cells. It affects decomposition of plants and helps plants grow if used in small amounts, but eventually plants develop tolerance to it. Gibberellic acid is a very potent hormone whose natural occurrence in plants controls their development. Since GA regulates growth, applications of very low concentrations can have a profound effect while too much will have the opposite effect. Gibberellins have a number of effects on plant development. They can stimulate rapid stem and root growth, induce mitotic division in the leaves of some plants, and increase seed germination rates. Moreover oral toxicity of Gibberellic acid (GA3) has been evaluated in S. littoralis and L.migratoria insect species. Researchers observed that GA3 caused significant reduction in food consumption in both insect species which led to larval weight loss. GA3 toxicity was also demonstrated by larval mortality due to exuviation difficulties.
Mepiquat chloride is a quaternary ammonium salt consisting of equimolar amounts of mepiquat cations and chloride anions. It is having IUPAC name as 1,1 -dimethylpiperidin-1-ium;chloride. A plant growth regulator, it is used in agriculture to reduce vegetative growth including sprout suppression in garlic, leeks and onions. It has a role as a plant growth retardant and an agrochemical. It is a quaternary ammonium salt and a chloride salt. It contains a mepiquat.
Brassinolide is a plant hormone. The first isolated brassinosteroid, it was discovered when it was shown that pollen from rapeseed (Brassica napus) could promote stem elongation and cell division. The biologically active component was isolated and named brassinolide.
Triacontanol is a fatty alcohol of the general formula C30H62O, also known as melissyl alcohol or myricyl alcohol. It is found in plant cuticle waxes and in beeswax. Triacontanol has been reported to increase the growth of plants by enhancing the rates of photosynthesis, protein biosynthesis, the transport of nutrients in a plant and enzyme activity, reducing complex carbohydrates among many other purposes. The fatty alcohol appears to increase the physiological efficiency of plant cells and boost the potential of the cells responsible for the growth and maturity of a plant.
Nitrobenzene is a plant energiser and flower stimulant. The main advantages of nitrobenzene it helps the plant to increase CN ratio significantly, it increases plant size

and helps for flowering, it enhances the plant canopy and induces flowering and increases the yield, it can be used in all major agriculture crops through foliar application, it is compatible with pesticide and fungicides. It is applicable in foliar spray and other forms of applications also as a plant nutrient. Micronutrients
Zinc is an essential micronutrient which means it is essential for plant growth and development, but is required in very small quantities. Although zinc requirements vary among crops, zinc leaf concentrations (on a dry matter basis) in the range 20 to 100 mg/kg are adequate for most crops.
Zinc occurs in plants as a free ion, as a complex with a variety of low molecular weight compounds, or as a component of proteins and other macromolecules. In many enzymes, zinc acts as a functional, structural, or regulatory cofactor; a large number of zinc-deficiency disorders are associated with the disruption of normal enzyme activity (including that of key photosynthetic enzymes). Zinc deficiency also increases membrane leakiness as zinc-containing enzymes are involved in the detoxification of membrane-damaging oxygen radicals. Zinc may be involved in the control of gene expression; it appears important in stabilizing RNA and DNA structure, in maintaining the activity of DNA-synthesizing enzymes and in controlling the activity of RNA-degrading enzymes.
Application of zinc may not correct zinc deficiency in alkaline soils because even with the addition of zinc, it may remain unavailable for plant absorption. Foliar applications of zinc as zinc sulphate or as zinc chelate (or other organic complexes) are also widely used, especially with fruit trees and grape vines. Zinc can also be supplied as a seed treatment, or by root-dipping of transplant
Sulphur is one of the essential plant nutrients. It is essential for the growth and development of all crops, without exception. Sulphur also has some key functions in plants as Formation of chlorophyll that permits photosynthesis through which plants produce starch, sugars, oils, fats, vitamins and other compounds. Protein production: Sulphur is a constituent of three S-containing amino acids (cysteine, cystine and methionine), which are the building blocks of protein. About 90% of plant S is present in these amino acids. Synthesis of oils: This is why adequate sulphur is so crucial for oilseeds. Activation of enzymes: which aid in biochemical reactions in the plant.

Increases crop yields and improves produce quality, both of which determine the market price a farmer would get for his produce. With reference to crop quality, S improves protein and oil percentage in seeds, cereal quality for milling and baking, marketability of dry coconut kernel (copra), quality of tobacco, nutritive value of forages, etc. It is associated with special metabolisms in plant and the structural characteristics of protoplasm.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of insect pest and mites control and has surprisingly improved plant vigour and yield. Also providing residual control, i.e. longer duration of control and thereby reducing the number of applications. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
Therefor the aspect of the present invention provides the pesticide composition of active ingredients comprising (A) Flupyrimin; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof; are present in following different preferred combination in present pesticidal composition as below:

Compound A

Compound B

Compound C

Flupyrimin

Clothianidin

Humic acid

Flupyrimin

Thiamethoxam

Humic acid

Flupyrimin

Triflumezopyrim

Humic acid

Flupyrimin

Pymetrozine

Humic acid

Flupyrimin

Cartap hydrochloride

Humic acid

Flupyrimin

Thiocyclam hydrogen oxalate

Humic acid

Flupyrimin

Tyclopyrazoflor

Humic acid

Flupyrimin

Benzpyrimoxan

Humic acid

Flupyrimin

Oxazosulfyl

Humic acid

Flupyrimin

Dimpropyridaz

Humic acid

Flupyrimin

Clothianidin

Fulvic acid

Flupyrimin

Thiamethoxam

Fulvic acid

Flupyrimin

Triflumezopyrim

Fulvic acid

Flupyrimin

Pymetrozine

Fulvic acid

Flupyrimin

Cartap hydrochloride

Fulvic acid

Flupyrimin

Thiocyclam hydrogen oxalate

Fulvic acid

Flupyrimin

Tyclopyrazoflor

Fulvic acid

Flupyrimin

Benzpyrimoxan

Fulvic acid

Flupyrimin

Oxazosulfyl

Fulvic acid

Flupyrimin

Dimpropyridaz

Fulvic acid

Flupyrimin

Clothianidin

Chitosan

Flupyrimin

Thiamethoxam

Chitosan

Flupyrimin

Triflumezopyrim

Chitosan

Flupyrimin

Pymetrozine

Chitosan

Flupyrimin

Cartap hydrochloride

Chitosan

Flupyrimin

Thiocyclam hydrogen oxalate

Chitosan

Flupyrimin

Tyclopyrazoflor

Chitosan

Flupyrimin

Benzpyrimoxan

Chitosan

Flupyrimin

Oxazosulfyl

Chitosan

Flupyrimin

Dimpropyridaz

Chitosan

Flupyrimin

Clothianidin

Brassinolide

Flupyrimin

Thiamethoxam

Brassinolide

Flupyrimin

Triflumezopyrim

Brassinolide

Flupyrimin

Pymetrozine

Brassinolide

Flupyrimin

Cartap hydrochloride

Brassinolide

Flupyrimin

Thiocyclam hydrogen oxalate

Brassinolide

Flupyrimin

Tyclopyrazoflor

Brassinolide

Flupyrimin

Benzpyrimoxan

Brassinolide

Flupyrimin

Oxazosulfyl

Brassinolide

Flupyrimin

Dimpropyridaz

Brassinolide

Flupyrimin

Clothianidin

Triacontanol

Flupyrimin

Thiamethoxam

Triacontanol

Flupyrimin

Triflumezopyrim

Triacontanol

Flupyrimin

Pymetrozine

Triacontanol

Flupyrimin

Cartap hydrochloride

Triacontanol

Flupyrimin

Thiocyclam hydrogen oxalate

Triacontanol

Flupyrimin

Tyclopyrazoflor

Triacontanol

Flupyrimin

Benzpyrimoxan

Triacontanol

Flupyrimin

Oxazosulfyl

Triacontanol

Flupyrimin

Dimpropyridaz

Triacontanol

Flupyrimin

Clothianidin

Ortho silicic acid

Flupyrimin

Thiamethoxam

Ortho silicic acid

Flupyrimin

Triflumezopyrim

Ortho silicic acid

Flupyrimin

Pymetrozine

Ortho silicic acid

Flupyrimin

Cartap hydrochloride

Ortho silicic acid

Flupyrimin

Thiocyclam hydrogen oxalate

Ortho silicic acid

Flupyrimin

Tyclopyrazoflor

Ortho silicic acid

Flupyrimin

Benzpyrimoxan

Ortho silicic acid

Flupyrimin

Oxazosulfyl

Ortho silicic acid

Flupyrimin

Dimpropyridaz

Ortho silicic acid

Flupyrimin

Clothianidin

Sulphur

Flupyrimin

Thiamethoxam

Sulphur

Flupyrimin

Triflumezopyrim

Sulphur

Flupyrimin

Pymetrozine

Sulphur

Flupyrimin

Cartap hydrochloride

Sulphur

Flupyrimin

Thiocyclam hydrogen oxalate

Sulphur

Flupyrimin

Tyclopyrazoflor

Sulphur

Flupyrimin

Benzpyrimoxan

Sulphur

Flupyrimin

Oxazosulfyl

Sulphur

Flupyrimin

Dimpropyridaz

Sulphur

Flupyrimin

Clothianidin

Zinc

Flupyrimin

Thiamethoxam

Zinc

Flupyrimin

Triflumezopyrim

Zinc

Flupyrimin

Pymetrozine

Zinc

Flupyrimin

Cartap hydrochloride

Zinc

Flupyrimin

Thiocyclam hydrogen oxalate

Zinc

Flupyrimin

Tyclopyrazoflor

Zinc

Flupyrimin

Benzpyrimoxan

Zinc

Flupyrimin

Oxazosulfyl

Zinc

Flupyrimin

Dimpropyridaz

Zinc

Flupyrimin

Lambda cyhalothrin

Gibberellic acid

Flupyrimin

Clothianidin

Gibberellic acid

Flupyrimin

Dinotefuran

Gibberellic acid

Flupyrimin

Triflumezopyrim

Gibberellic acid

Flupyrimin

Dichloromezotiaz

Gibberellic acid

Flupyrimin

Pymetrozine

Gibberellic acid

Flupyrimin

Flonicamid

Gibberellic acid

Flupyrimin

Methoxyfenozi de

Gibberellic acid

Flupyrimin

Tyclopyrazoflor

Gibberellic acid

Flupyrimin

Benzpyrimoxan

Gibberellic acid

Flupyrimin

Oxazosulfyl

Gibberellic acid

Flupyrimin

Dimpropyridaz

Gibberellic acid

Flupyrimin

Lambda cyhalothrin

Amino acid

Flupyrimin

Clothianidin

Amino acid

Flupyrimin

Dinotefuran

Amino acid

Flupyrimin

Triflumezopyrim

Amino acid

Flupyrimin

Dichloromezotiaz

Amino acid

Flupyrimin

Pymetrozine

Amino acid

Flupyrimin

Flonicamid

Amino acid

Flupyrimin

Methoxyfenozi de

Amino acid

Flupyrimin

Tyclopyrazoflor

Amino acid

Flupyrimin

Benzpyrimoxan

Amino acid

Flupyrimin

Oxazosulfyl

Amino acid

Flupyrimin

Dimpropyridaz

Amino acid

The synergistic agrochemical composition of specific active ingredient has the special advantage of being highly active against insect pests and mites. The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combinations of the present invention allow for a broad spectrum of pest control and has surprisingly improved plant vigour and yield. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic composition has very advantageous pesticidal properties for protecting cultivated plants against insect-pests and mites. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the insect-pests and mites that occur on plants or parts of plants of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such insect-pests and mites. Active ingredient composition has the special advantage of being highly active against diseases in the soil that mostly occurs due to insect-pests and mites in the early stages of plant development.
The synergistic composition of pesticide are used to protect the crops and plants from insect-pests and mites. The lists of the major crops includes but are not limited to GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard

(Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus), vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf

grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc. , trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.
The synergistic combination of the present invention used to control the insects-pests and mites.
The major insects pests are belongs to the order Hemiptera, for example, rice leafhopper Nephotettix nigropictus, rice brown plant hopper Nilaparvata lugen, rice white backed plant hopper, Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, cotton aphid Aphis gossypii, cotton jassid Amrasca biguttula biguttla, cotton mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, cotton whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp. ; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar AcheaJanata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer

Diatraea saccharalis, tobacco budworm Heliothis virescens, tomato fruitworm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza novella, Tuta absoluta. from the order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp. ; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp., from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, Tetranychus cinnabarinus.

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.
In an especially preferred embodiment of the invention, the yield of the treated plant is increased.
In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.
Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain

yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.
According to the present invention, the yield is increased by at least 5%, preferable by 5 to 10 %, more preferable by 10 to 20 %, or even 20 to 30 % compared to the untreated control plants or plants treated with pesticides in a way different from the method according to the present invention. In general, the yield increase may even be higher.
A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive

tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.
The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).
Another indicator for the condition of the plant is the "quality" of a plant and/or its products.
In an especially preferred embodiment of the invention, the quality of the treated plant is increased.
In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product: increased nutrient content, increased protein content, increased content of fatty acids, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher processability of the harvested products.
Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms,

can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means (1.) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.
Formulation of the present invention can be in any of the formulations selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).
One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the "free" active ingredient and the "release rate" are relevant properties of a specific product.
Further pesticidal composition comprising (A) Flupyrimin; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, microbial agents and micronutrients or mixture thereof are present in the said composition in specific fixed ratio.

In further aspect the present invention relates to the synergistic insecticidal composition comprising bioactive amounts of (A) is 0.01 to 30% w/w of the composition; (B) is 0.01 to 50 % w/w of the composition; and (C) is 0.001 to 20 % w/w of the composition.

Compounds Compound A Compound B Compound C
Composition Flupyrimin One or more insecticides Plant health additives
% Ratio
(w/w) 0.01 to 30% w/w 0.01 to 50% w/w 0.001 to 20% w/w
The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to wetting agents, wetting-spreading-penetrating agent, dispersant or dispersing agent, anti-freezing agent, anti-foam agent, preservatives, solvents, carriers, suspension aid, thickener, and buffering agent.
A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules.
Examples of wetting agent used herein for SC (Suspension concentrate) formulation include but not limited to ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl

trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of wetting agent used herein for WDG (Water Dispersible Granule) formulation includes but not limited to sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
Examples of wetting agent used herein for Granule Slow release (GR-SL) formulation includes but not limited to Mono C2-6 alkyl ether of a poly C2-4alkylene oxide block copolymer, condensation product of castor oil and polyC2-4alkylene oxide, alkoxylated castor oil is available under the trade name Agnique CSO-36, a mono- or di-ester of a C12-24fatty acid and polyC2-4alkylene oxide, carboxylates, sulphates, sulphonates, alcohol ethoxylates, alkyl phenol ethoxylates, fatty acid ethoxylates, sorbitan esters, ethoxylated fats or oils, amine ethoxylates, phosphate esters, ethylene oxide - propylene oxide copolymers, fluorocarbons,alkyd-polyethylene glycol resin, polyalkylene glycol ether, apolyalkoxylated nonyl phenyl, alkoxylated primary alcohol, ethoxylated distyrylphenol, ethoxylated distyryl phenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts,alkyd-polyethylene glycol resin, polyalkylene

glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt.
A dispersant or a dispersing agent is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lingo sulphonates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic 'backbones' and a large number of ethylene oxide chains forming the 'teeth' of a 'comb' surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces.
Examples of dispersants or dispersing agent used herein for SC (Suspension concentrate) formulation include but not limited to alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium ploycarboxylate,EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.
Examples of dispersants or dispersing agent used herein for WDG (Water Dispersible Granule) formulation includes but not limited to alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde

condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt.
Examples of dispersants or dispersing agent used herein for Granule Slow release (GR-SL) formulation include but not limited to Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), ethoxylated tristyrene phenol is alpha-[2,4,6-tris[l-(phenyl)ethyl] phenyl]-omega-hydroxy poly(oxyethylene, poly(oxy-l,2-ethanediyl)-alpha-C10-15alkyl-omega-hydroxy phosphate or sulphate and/or a C10-13alkylbenzenesulfonic acid, tristyrylphenols, nonylphenols, dinonylphenol and octylphenols, styrylphenol polyethoxyester phosphate, alkoxylated C14-20fatty amines.
Antifoaming agent for the present formulation is selected from various compounds and selectively used according to the formulation. Generally, there are two types of antifoam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl poly siloxane while the non-silicone anti-foam agents are water- insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.
Examples of Antifoaming agent used herein for SC (Suspension concentrate), Oil dispersion (OD) formulation, SE (Suspo Emulsion) formulation and Capsule suspension (CS)) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, poly dimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkylene oxide modified polydimethylsiloxane.
Examples of Antifoaming agent used herein for WDG (Water Dispersible Granule) formulation includes but not limited to polydimethylsiloxane.
Examples of Anti-freezing agent used herein for SC (Suspension concentrate) and Oil dispersion (OD) formulation, SE (Suspo Emulsion) formulation and Capsule suspension (CS)) formulation include but not limited to ethylene glycol, propane diols, glycerine or

the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.
Preservative used herein for the SC (Suspension concentrate) formulation include but not limited to l,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-l,3-diol, Formaldehyde, Sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspo-emulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers.
Examples of thickeners used herein for SC (Suspension concentrate) formulation include but not limited to xanthan gum, PVK, carboxymethylcelluloses, polyvinyl alcohols, gelatin, sodium carboxy methylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch.
Suspension aid or the suspending agent in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).
Examples of suspending agent used herein for SC (Suspension concentrate) formulation, SE (Suspo Emulsion) formulation and Capsule suspension (CS)) formulation include but not limited to Aluminium Magnesium Silicate, Bentonite clay, Silica, Attapulgite clay.
Examples of Carrier used herein for WDG (Water Dispersible Granule) formulation includes but not limited to china clay, silica, lactose anhydrous, ammonium sulfate,

sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
Examples of Carrier used herein for Granule Slow release (GR-SL) formulation includes but not limited to Diatomaceous earth, attapulgite or zeolites, dolomite, limestone, silica, fly ash, hydrated lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, attapulgite, diatomaceous earth, calcium carbonate, talc, muscovite mica, fused sodium potassium, aluminum silicate , perlite, talc and muscovite mica, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple superphosphate, phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and a combination of these. Calcium, magnesium, sulfur, iron, manganese, copper, zinc; oxides, humic acid, Wood floor, Calcium silicate, Cellulose granules, Magnesium stearate.
Examples of Solvent used herein for Granule Slow release (GR-SL) formulation includes but not limited to Fatty acid methyl ester, cyclohexane, xylene, mineral oil or kerosene, mixtures or substituted naphthalenes, mixtures of mono- and polyalkylated aromatics, dibutyl phthalate or dioctyl phthalate, ethylene glycol monomethyl or monoethyl ether, butyrolactone, octanol, castor oil, soybean oil, cottonseed oil, epoxidised coconut oil or soybean oil, aromatic hydrocarbons, dipropyleneglycol monomethylether, polypropylene glycol [M.W. 2000-4000], polyoxyethylene polyoxypropylene glycols, polyoxypropylene polyoxyethylene glycols, diethyleneglycol, polyethylene glycol [M.W. 200-4000 amu], methoxy polyethylene glycols 350, 550, 750, 2000, 5000;

glycerol, methyl oleate, n-octanol, alkyl phosphates such as tri-n-butyl phosphate, propylene carbonate and isoparaffinic, tetrahydrofurfuryl alcohol, gamma-butyrolactone, N-methyl-2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide, Diacetone alcohol, Polybutene, Propylene carbonate, Dipropylene glycol isomer mixture.
Examples of Disintegrating agent used herein for WDG (Water Dispersible Granule) formulation includes but not limited to citric acid, succinic acid or the sodium bicarbonate.
Examples of Humectant used herein for SC (Suspension concentrate) formulation, WDG (Water Dispersible Granule) formulation includes but not limited to urea, humic acid, glycerol, lactose.
Examples of Colouring agent used herein for Granule Slow release (GR-SL) formulation includes but not limited to Crystal violet, Thalocyano dye chlorinated, Aerosol green FFB dye, Rodamine, Azo compound.
Examples of Controlled release agent used herein for Granule Slow release (GR-SL) formulation includes but not limited to Xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethylcellulose, Sodium Polyacrylate, modified starch, Paraffin wax, Polyvinyl acetate,Montan wax and vinyl acetate, Polyethylene Glycol 6000, Cationic hydrosoluble polymer, C4 alkylated Polyvinyl pyrrolidone.
Examples of Other innert agents used herein for Granule Slow release (GR-SL) formulation includes but not limited to Nano polysaccharide.
While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than

limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.
These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.
EXAMPLE 1:
GR-SL (Granule-Slow release) Flupyrimin 0.8%+Thiocyclam hydrogen oxalate
3%+Zinc 2%

Ingredients content %
(w/w) Function
River sand (Silica) 76.10 carrier/filler
Thiocyclam hydrogen oxalate a.i. 3.00 active ingredient 1
Tri-styryl Phenol Ethoxylate 3.00 emulsifier
Phosphoric acid 0.10 buffering agent
Polyvinyl alcohols 2.00 controlled release agent-1
Nano polysaccharide 2.50 innert 1
Flupyrimin a.i. 0.80 active ingredient 2
N-methyl-2-pyrrolidone 3.00 solvent
Copolymer of propylene oxide (PO) and ethylene oxide (EO) 1.00 dispersing agent
Paraffin wax 5.00 controlled release agent-2
Zinc lactate gluconate a.i. 2.00 active ingredient 3
Rhodamine 0.50 colourant
Precipitated silica 1.00 innert 2
Total 100.00
Storage stability-
Flupyrimin 0.8%+Thiocyclam hydrogen oxalate 3%+Zinc 2% GR-SL (Granule-Slow release) formulation.

Laboratory storage stability
Parameters Specification (in house) Initial At
54+2 °C At 0+2
°C
Flupyrimin content percent by mass 0.76 to 0.88 0.85 0.82 0.84
Thiocyclam hydrogen oxalate content percent by mass 2.85 to 3.30 3.20 3.10 3.16

Zinc lactate gluconate content percent by mass 1.90 to 2.20 2.15 2.05 2.12
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness <20mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.5 99.2 99.3
Attrition Resistance (<100 micron) <5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.50
Room temperature storage stability
Parameters specification (in house) 1 month 6 months 12 months
Flupyrimin content percent by mass 0.76 to 0.88 0.85 0.84 0.82
Thiocyclam hydrogen oxalate content percent by mass 2.85 to 3.30 3.20 3.16 3.10
Zinc lactate gluconate content percent by mass 1.90 to 2.20 2.15 2.15 2.12
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness <20mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.50 96.35 96.25
Attrition Resistance (<100 micron) <5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.40
Manufacturing process for Flupyrimin 0.8%+Thiocyclam hydrogen oxalate 3%+Zinc 2% GR-SL (Granule-Slow release):

Preparation of GR-SL (Granule-Slow release) formulation:
Step 1- Add Thiocyclam hydrogen oxalate into Tri-styryl Phenol Ethoxylate, then add phosphoric acid and polyvinyl alcohols and homogenize the mixture.
Step 2- Now spray this mixture on River sand granules and blend it till homogeneity
Step 3- Add nano polysaccharide into these granules and blend it till homogeneity.
Step 4- Mix Flupyrimin into N-methyl-2-pyrrolidone and mix Copolymer of propylene oxide (PO) and ethylene oxide (EO) and paraffin wax and homogenize.
Step 5- Now spray on treated granules and homogenize it till homogeneity

Step 6- Now add zinc lactate gluconate and Rhodamine dye onto these granules so that it can coat on these sand granules
Step 7- Finally add silica to make granules free flowing and free of moisture
Step 8- Final product is sent for QC approval.
Step 9- After approval, material is packed in required pack sizes.
EXAMPLE 2:
GR-SL (Granule-Slow release) Flupyrimin 0.6%+Clothianidin 0.5%+Triacontanol
0.125%

Ingredients content %
(w/w) Function
River sand (silica) 81.28 carrier/filler
Flupyrimin a.i. 0.60 active ingredient 1
N-methyl-2-pyrrolidone 3.00 solvent
Copolymer of propylene oxide (PO) and ethylene oxide (EO) 1.00 dispersing agent
Paraffin wax 5.00 controlled release agent 1
Nano polysaccharide 2.50 innert 1
Clothianidin a.i. 0.50 active ingredient 2
Trisiloxane ethoxylate 2.50 wetting agent
Polyvinyl alcohols 2.00 controlled release agent 2
Triacontanol a.i. 0.125 active ingredient 3
Rhodamine Dye 0.50 colourant/Dye
Precipitated silica 1.00 innert 2
Total 100.00
Storage stability- Flupyrimin 0.6%+Clothianidin 0.5%+Triacontanol 0.125% GR-SL (Granule-Slow release) formulation.

Laboratory storage stability
Parameters Specification (in house) Initial At
54+2 °C At 0+2
°C
Flupyrimin content percent by mass 0.57 to 0.66 0.65 0.61 0.64
Clothianidin content percent by mass 0.48 to 0.55 0.55 0.51 0.54
Triacontanol content percent by mass 0.12 to 0.14 0.14 0.13 0.14

pH range (1% aq. Suspension)
4.0 to 7.0 6.50 6.50 6.50
Dustiness <20mg 10 12 10
Dry sieve (300 micron) percent by mass min. > 90% 98.5 97.2 98.2
Attrition Resistance (<100 micron) <5% 2.4 2.8 2.4
Bulk density (g/ml) 1.25 to 1.50 1.4 1.4 1.4
Moisture content percent by mass max. Max. 2% 1.2 1.2 1.2
Room temperature storage stability
Parameters specification (in house) 1 month 6 months 12 months
Flupyrimin content percent by mass 0.57 to 0.66 0.65 0.63 0.61
Clothianidin content percent by mass 0.48 to 0.55 0.55 0.53 0.51
Triacontanol content percent by mass 0.12 to 0.14 0.14 0.13 0.13
pH range (1% aq. Suspension) 4.0 to 7.0 6.50 6.40 6.20
Dustiness <20mg 10 11 12
Dry sieve (300 micron) percent by mass min. > 90% 98.5 97.0 96.0
Attrition Resistance (<100 micron) <5% 2.4 2.5 2.8
Bulk density (g/ml) 1.25 to 1.50 1.4 1.4 1.4
Moisture content percent by mass max. Max. 2% 1.2 1.2 1.3
Manufacturing process for Flupyrimin 0.6%+Clothianidin 0.5%+Triacontanol 0.125% GR-SL (Granule-Slow release)
Preparation of GR-SL (Granule-Slow release) formulation:

Step 1-

Add Flupyrimin into N-methyl-2-pyrrolidone and mix Copolymer of propylene oxide (PO) and ethylene oxide (EO) and paraffin wax and homogenize.

Step 2-

Now spray this on River sand granules and blend it till homogeneity.

Step 3-

Add Nano polysaccharide on to these granules.

Step 4-
Step 5-

Mix Clothianidin, trisiloxane ethoxylate and polyvinyl alcohol and then spray on treated granules and homogenize it till homogeneity.
Now add Triacontanol and Rhodamine dye onto these granules so that it can coat on these sand granules.

Step 6-

Finally add silica to make granules free flowing and free of moisture.

Step 7-

Final product is sent for QC approval.

Step 8-

After approval, material is packed in required pack sizes.

EXAMPLE 3:
SC (Suspension Concentrate) formulation of Flupyrimin 10%+Triflumezopyrim
4%+Fulvic acid 2%

Ingredients content
% (w/w) Function
Flupyrimin a.i. 10.00 Active Ingredient
Triflumezopyrim a.i. 4.00 Active Ingredient
Fulvic acid a.i. 2.00 Active Ingredient
Trisiloxane ethoxylate 5.00 Wetting-spreading-penetrating agent
Naphthalenesulfonic acid, sodium salt condensated with formaldehyde 2.00 Dispersing agent 1
Tri-styrylphenole with 16 moles EO 3.00 Dispersing agent 2
Bentonite clay 1.50 Suspending agent
Polydimethyl siloxane 0.50 Antifoaming agent
2-bromo-2-nitropropane-l,3-diol 0.20 Preservative
Polypropylene glycol 5.00 Antifreezing agent
Xanthan gum 0.20 Thickner
Water 66.60 Diluent Water
Total 100.00
Storage stability- Flupyrimin 10%+Triflumezopyrim 4%+Fulvic acid 2% SC (Suspension Concentrate)
Storage stability study in laboratory (at 54+2 C & At 0+2 C temp, for 14 days) and at room temperature (for 12 months) shows that Flupyrimin 10%+Triflumezopyrim 4%+Fulvic acid 2% SC (Suspension concentrate) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming.

Procedure: Manufacturing process for Flupyrimin 10%+Triflumezopyrim 4%+Fulvic acid 2% SC:

Preparation of Suspension Concentrate (SC) formulation:
Step 1 2% Gel Preparation: Charged water (96 kg) to a vessel, equipped with a high shear stirrer and started the agitation and added 2 kg 2-bromo-2-nitropropane-l,3-diol. The ingredients were mixed to obtain homogenous mixture. To the homogenous mixture, added 2 kg of Xanthan gum and mixed vigorously to fully wet.
Step 2 Charged water (62 kg) to a vessel, equipped with bulk agitator and a high shear homogenizer and start agitation. Added 5 kg of polypropylene glycol and mixed until uniform solution. 0.25 kg Polydimethyl siloxane was added to the uniform solution. Added trisiloxane ethoxylate (5.0 kg), naphthalene sulfonic acid, sodium salt condensated with formaldehyde (2kg), bentonite clay (1.5 kg) and 3 kg of Tristyrylphenole with 16 moles EO to the uniform solution and mixed well until the dispersing agent is fully dispersed.
Step 3 Added Flupyrimin (10 kg), Triflumezopyrim (4 kg) and Fulvic acid (2 kg) to the vessel and continued the agitating until all components were dissolved to obtain pre-mix solution. The pre-mix solution was milled through colloid mill and subsequently through a dyno mill to obtain SC mill.
Step 4 The remaining 0.25 kg of polydimethyl siloxane was added to the SC mill base in a vessel, equipped with bulk agitator and mixed well until uniform solution. Added the required amount of 2% aqueous pre-gel (5kg) and continued agitation until the formulation is homogeneous and has the target viscosity is reached.
EXAMPLE 4:
WG (Water Dispersible Granule) formulation of Flupyrimin 10%+Pymetrozine 20%+Triacontanol 0.05%.

Chemical composition % (w/w) Function
Flupyrimin a.i. 10.00 Active Ingredient
Pymetrozine a.i. 20.00 Active Ingredient
Triacontanol a.i. 0.05 Active Ingredient
Trisiloxane ethoxylate 5.00 Wetting-spreading-penetrating agent
Alkylnaphthalene sulfonate sodium salt 6.00 Dispersing agent I
Sodium Polycarboxylate 3.00 Dispersing agent II

Sodium sulphate anhydrous 8.00 Disintegrating agent
Polydimethyl siloxane 0.50 Antifoaming agent
Nano polysaccharide 2.50 Humactant
Lactose anhydrous 44.95 Carrier
Total 100.0 0
Storage stability- Flupyrimin 10%+Pymetrozine 20%+Triacontanol 0.05% WG (Water Dispersible Granule) formulation
Storage stability study in laboratory (at 54+2 C & At 0+2 C temp, for 14 days) and at room temperature (for 12 months) shows that Flupyrimin 10%+Pymetrozine 20%+Triacontanol 0.05% WG formulation complies all the in-house parameters like active ingredients content, suspensibility, wettability, wet sieve percent by mass, pH range and moisture content.
Procedure: Manufacturing Process for Flupyrimin 10%+Pymetrozine 20%+Triacontanol 0.05% WG (Wettable Granule):

Preparation of WG (Water Dispersible Granule) formulation:
Step 1: The active ingredients, Flupyrimin (10 kg), Pymetrozine (20 kg) and Triacontanol (0.05 kg) were weighed and added in blender. Added required quantity of Trisiloxane ethoxylate (5 kg), Alkylnaphthalene sulfonate sodium salt (6 kg), Sodium Polycarboxylate (3 kg), Sodium sulphate anhydrous (8 kg), Polydimethyl siloxane (0.5 kg), Nano polysaccharide (2.5 kg) & Lactose anhydrous (44.95 kg) and mix it till its complete homogenization.
Step 2: Mill this homogenized Mixture till required wet sieve and post blend again for homogeneity.
Step 3: Make dough of this material by spraying 5 kg of water and mix till water
get uniformly distributed into the powder to make dough
Pass the above homogenous material through Extruder for granulation.
Step 4: Now transfer the granules through Fluid Bed Dryer to remove excess 5 kg of moisture added during dough making.
Step 5: Transfer these granules to vibro shifter.
Step 6: Collect the final material from the vibro shifter into drum.
EXAMPLE 5:
Lists of preferred combinations and formulations:

Compou ndA Compound B Compou ndC Active ingredients (%) Formul ation
Strengt h (%) Formul ation Type

Compo und A Compo undB Compo undC

Flupyrim in Clothianidi n Triacont anol 0.6 0.5 0.125 1.23 GR-SL
Flupyrim in Thiamethox am Triacont anol 0.6 0.5 0.125 1.23 GR-SL
Flupyrim in Fipronil Triacont anol 0.6 0.3 0.125 1.03 GR-SL
Flupyrim in Clothianidi n Humic acid 0.6 0.5 2.5 3.60 GR-SL
Flupyrim in Thiamethox am Humic acid 0.6 0.5 2.5 3.60 GR-SL
Flupyrim in Fipronil Humic acid 0.6 0.3 2.5 3.40 GR-SL
Flupyrim in Cartap
hydrochlori
de Zinc 0.8 3 2 5.80 GR-SL
Flupyrim in Thiocyclam
hydrogen
oxalate Zinc 0.8 3 2 5.80 GR-SL
Flupyrim in Emamectin benzoate Zinc 0.8 0.2 2 3.00 GR-SL
Flupyrim in Clothianidi n Sulphur 0.6 0.5 20 21.10 GR-SL
Flupyrim in Thiamethox am Sulphur 0.6 0.5 20 21.10 GR-SL
Flupyrim in Fipronil Sulphur 0.6 0.3 20 20.90 GR-SL
Flupyrim in Cartap
hydrochlori
de Sulphur 0.8 3 20 23.80 GR-SL
Flupyrim in Thiocyclam
hydrogen
oxalate Sulphur 0.8 3 20 23.80 GR-SL
Flupyrim in Emamectin benzoate Sulphur 0.8 0.2 20 21.00 GR-SL
Flupyrim in Cartap
hydrochlori
de Paclobut razol 0.8 3 0.25 4.05 GR-SL
Flupyrim in Thiocyclam
hydrogen
oxalate Paclobut razol 0.8 3 0.25 4.05 GR-SL
Flupyrim in Emamectin benzoate Paclobut razol 0.8 0.2 0.25 1.25 GR-SL

Flupyrim in Cartap
hydrochlori
de Brassino lide 0.8 3 0.02 3.82 GR-SL
Flupyrim in Thiocyclam
hydrogen
oxalate Brassino lide 0.8 3 0.02 3.82 GR-SL
Flupyrim in Emamectin benzoate Brassino lide 0.8 0.2 0.02 1.02 GR-SL
Flupyrim in Clothianidi n Humic acid 0.6 0.5 3 4.10 GR
Flupyrim in Thiamethox am Humic acid 0.6 0.5 3 4.10 GR
Flupyrim in Imidaclopri d Humic acid 0.6 0.6 3 4.20 GR
Flupyrim in Triflumezo pyrim Humic acid 0.5 0.5 3 4.00 GR
Flupyrim in Pymetrozin e Humic acid 0.5 2 3 5.50 GR
Flupyrim in Tyclopyraz oflor Humic acid 0.5 0.5 3 4.00 GR
Flupyrim in Benzpyrim oxan Humic acid 0.5 0.5 3 4.00 GR
Flupyrim in Oxazosulfy 1 Humic acid 0.5 0.5 3 4.00 GR
Flupyrim in Dimpropyri daz Humic acid 0.5 0.5 3 4.00 GR
Flupyrim in Clothianidi n Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Thiamethox am Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Imidaclopri d Fulvic acid 0.5 0.6 3 4.10 GR
Flupyrim in Triflumezo pyrim Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Pymetrozin e Fulvic acid 0.5 2 3 5.50 GR
Flupyrim in Tyclopyraz oflor Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Benzpyrim oxan Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Oxazosulfy 1 Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Dimpropyri daz Fulvic acid 0.5 0.5 3 4.00 GR
Flupyrim in Clothianidi n Amino acid 0.5 0.5 3 4.00 GR

Flupyrim in Thiamethox am Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Imidaclopri d Amino acid 0.5 0.6 3 4.10 GR
Flupyrim in Triflumezo pyrim Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Pymetrozin e Amino acid 0.5 2 3 5.50 GR
Flupyrim in Tyclopyraz oflor Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Benzpyrim oxan Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Oxazosulfy 1 Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Dimpropyri daz Amino acid 0.5 0.5 3 4.00 GR
Flupyrim in Clothianidi n Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Thiamethox am Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Triflumezo pyrim Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Pymetrozin e Chitosan 0.6 2 2.5 5.10 GR
Flupyrim in Cartap
hydrochlori
de Chitosan 0.6 4 2.5 7.10 GR
Flupyrim in Thiocyclam
hydrogen
oxalate Chitosan 0.6 4 2.5 7.10 GR
Flupyrim in Tyclopyraz oflor Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Benzpyrim oxan Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Oxazosulfy 1 Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Dimpropyri daz Chitosan 0.6 0.5 2.5 3.60 GR
Flupyrim in Clothianidi n Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Thiamethox am Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Triflumezo pyrim Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Pymetrozin e Brassino lide 0.6 2 0.02 2.62 GR

Flupyrim in Cartap
hydrochlori
de Brassino lide 0.8 3 0.02 3.82 GR
Flupyrim in Thiocyclam
hydrogen
oxalate Brassino lide 0.8 3 0.02 3.82 GR
Flupyrim in Tyclopyraz oflor Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Benzpyrim oxan Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Oxazosulfy 1 Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Dimpropyri daz Brassino lide 0.6 0.5 0.02 1.12 GR
Flupyrim in Clothianidi n Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Thiamethox am Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Triflumezo pyrim Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Pymetrozin e Triacont anol 0.6 2 0.125 2.73 GR
Flupyrim in Cartap
hydrochlori
de Triacont anol 0.8 3 0.125 3.93 GR
Flupyrim in Thiocyclam
hydrogen
oxalate Triacont anol 0.8 3 0.125 3.93 GR
Flupyrim in Tyclopyraz oflor Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Benzpyrim oxan Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Oxazosulfy 1 Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Dimpropyri daz Triacont anol 0.6 0.5 0.125 1.23 GR
Flupyrim in Clothianidi n Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Thiamethox am Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Triflumezo pyrim Ortho silicic acid 0.6 0.5 0.25 1.35 GR

Flupyrim in Pymetrozin e Ortho silicic acid 0.6 2 0.25 2.85 GR
Flupyrim in Cartap
hydrochlori
de Ortho silicic acid 0.8 3 0.25 4.05 GR
Flupyrim in Thiocyclam
hydrogen
oxalate Ortho silicic acid 0.8 3 0.25 4.05 GR
Flupyrim in Tyclopyraz oflor Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Benzpyrim oxan Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Oxazosulfy 1 Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Dimpropyri daz Ortho silicic acid 0.6 0.5 0.25 1.35 GR
Flupyrim in Triflumezo pyrim Sulphur 0.6 0.5 20 21.10 GR
Flupyrim in Pymetrozin e Sulphur 0.6 2 20 22.60 GR
Flupyrim in Cartap
hydrochlori
de Sulphur 0.8 3 20 23.80 GR
Flupyrim in Thiocyclam
hydrogen
oxalate Sulphur 0.8 3 20 23.80 GR
Flupyrim in Tyclopyraz oflor Sulphur 0.6 0.5 20 21.10 GR
Flupyrim in Benzpyrim oxan Sulphur 0.6 0.5 20 21.10 GR
Flupyrim in Oxazosulfy 1 Sulphur 0.6 0.5 20 21.10 GR
Flupyrim in Dimpropyri daz Sulphur 0.6 0.5 20 21.10 GR
Flupyrim in Triflumezo pyrim Zinc 0.6 0.5 2 3.10 GR
Flupyrim in Pymetrozin e Zinc 0.6 2 2 4.60 GR
Flupyrim in Tyclopyraz oflor Zinc 0.6 0.5 2 3.10 GR
Flupyrim in Benzpyrim oxan Zinc 0.6 0.5 2 3.10 GR

Flupyrim in Oxazosulfy 1 Zinc 0.6 0.5 2 3.10 GR
Flupyrim in Dimpropyri daz Zinc 0.6 0.5 2 3.10 GR
Flupyrim in Triflumezo pyrim Fulvic acid 10 4 2 16.00 SC
Flupyrim in Benzpyrim oxan Fulvic acid 10 10 2 22.00 SC
Flupyrim in Dinotefuran Fulvic acid 10 5 2 17.00 SC
Flupyrim in Lambda cyhalothrin Gibberel lie acid 10 4 0.2 14.20 ZC
Flupyrim in Clothianidi n Gibberel lie acid 10 4 0.2 14.20 SC
Flupyrim in Dinotefuran Gibberel lie acid 10 4 0.2 14.20 SC
Flupyrim in Triflumezo pyrim Gibberel lie acid 10 4 0.2 14.20 SC
Flupyrim in Dichlorome zotiaz Gibberel lie acid 10 6 0.2 16.20 SC
Flupyrim in Pymetrozin e Gibberel lie acid 10 20 0.2 30.20 WG
Flupyrim in Flonicamid Gibberel lie acid 10 10 0.2 20.20 WG
Flupyrim in Methoxyfe nozide Gibberel lie acid 5 12 0.1 17.10 SC
Flupyrim in Tyclopyraz oflor Gibberel lie acid 10 10 0.2 20.20 SC
Flupyrim in Benzpyrim oxan Gibberel lie acid 10 10 0.2 20.20 SC
Flupyrim in Oxazosulfy 1 Gibberel lie acid 10 10 0.2 20.20 SC
Flupyrim in Dimpropyri daz Gibberel lie acid 10 10 0.2 20.20 SC
Flupyrim in Lambda cyhalothrin Mepiqua
t
chloride 10 4 5 19.00 ZC
Flupyrim in Clothianidi n Mepiqua
t
chloride 10 4 5 19.00 SC
Flupyrim in Dinotefuran Mepiqua
t
chloride 10 4 5 19.00 SC
Flupyrim in Triflumezo pyrim Mepiqua
t
chloride 10 4 5 19.00 SC

Flupyrim in Dichlorome zotiaz Mepiqua
t
chloride 10 6 5 21.00 sc
Flupyrim in Pymetrozin e Mepiqua
t
chloride 10 20 5 35.00 WG
Flupyrim in Flonicamid Mepiqua
t
chloride 10 10 5 25.00 WG
Flupyrim in Methoxyfe nozide Mepiqua
t
chloride 5 12 2.5 19.50 SC
Flupyrim in Tyclopyraz oflor Mepiqua
t
chloride 10 10 5 25.00 SC
Flupyrim in Benzpyrim oxan Mepiqua
t
chloride 10 10 5 25.00 SC
Flupyrim in Oxazosulfy 1 Mepiqua
t
chloride 10 10 5 25.00 SC
Flupyrim in Dimpropyri daz Mepiqua
t
chloride 10 10 5 25.00 SC
Flupyrim in Lambda cyhalothrin Paclobut razol 10 4 6 20.00 ZC
Flupyrim in Clothianidi n Paclobut razol 10 4 6 20.00 SC
Flupyrim in Dinotefuran Paclobut razol 10 4 6 20.00 SC
Flupyrim in Triflumezo pyrim Paclobut razol 10 4 6 20.00 SC
Flupyrim in Dichlorome zotiaz Paclobut razol 10 6 6 22.00 SC
Flupyrim in Pymetrozin e Paclobut razol 10 20 6 36.00 WG
Flupyrim in Flonicamid Paclobut razol 10 10 6 26.00 WG
Flupyrim in Methoxyfe nozide Paclobut razol 5 12 3 20.00 SC
Flupyrim in Tyclopyraz oflor Paclobut razol 10 10 6 26.00 SC
Flupyrim in Benzpyrim oxan Paclobut razol 10 10 6 26.00 SC
Flupyrim in Oxazosulfy 1 Paclobut razol 10 10 6 26.00 SC

Flupyrim in Dimpropyri daz Paclobut razol 10 10 6 26.00 SC
Flupyrim in Lambda cyhalothrin Triacont anol 10 4 0.05 14.05 zc
Flupyrim in Clothianidi n Triacont anol 10 4 0.05 14.05 SC
Flupyrim in Dinotefuran Triacont anol 10 5 0.05 15.05 SC
Flupyrim in Triflumezo pyrim Triacont anol 10 4 0.05 14.05 SC
Flupyrim in Dichlorome zotiaz Triacont anol 10 6 0.05 16.05 SC
Flupyrim in Pymetrozin e Triacont anol 10 20 0.05 30.05 WG
Flupyrim in Flonicamid Triacont anol 10 10 0.05 20.05 WG
Flupyrim in Methoxyfe nozide Triacont anol 5 12 0.025 17.03 SC
Flupyrim in Tyclopyraz oflor Triacont anol 10 10 0.05 20.05 SC
Flupyrim in Benzpyrim oxan Triacont anol 10 10 0.05 20.05 SC
Flupyrim in Oxazosulfy 1 Triacont anol 10 10 0.05 20.05 SC
Flupyrim in Dimpropyri daz Triacont anol 10 10 0.05 20.05 SC
SC Suspension Concentrate, WG (Water Dispersible Granule), GR-SL (Granule-Slow release) formulation. GR (Granule) formulation.
Biological Examples:
A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.
In the field of agriculture, it is often understood that the term "synergy" is as defined by Colby S.R. in an article entitled " Calculation of the synergistic and antagonistic responses of herbicide combinations" published in the journal Weeds, 1967, 15, p.20-22,

incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:
Colby's formula for calculating synergism between three active ingredients
E = ( X+Y+ Z ) - (XY + XZ + YZ) + (X Y Z)
100 10000
Where, E=Expected percent (%) control by mixture or combination of Compound A, Compound B and Compound C in a defined dose X=Observed percent (°b) control by Compound A Y=Observed percent (%) control by CompoundB Z=Observed percent (%) control by Compound C
Observed percent (%) control
Colby's Ratio =
Expected percent (° o) control
If ratio of O/E >1, means synergism observed, O/E < 1, means antagonism, O/E = 1, means additive reaction. Higher the ratio means stronger the synergism
Colby's formula for calculating synergism between two active ingredient
XY
E = X + Y -
100 Where,
E=Expected percent (%) control by mixture or combination of Compound A and Compound B
in a defined dose X=Observed percent (%) control by Compound A Y=Observed percent (%) control by CompoundB
Observed percent (%) control
Ratio =
Expected percent (°'o) control
Ratio of O/E > 1. means synergism observed. 0/E>l, means antagonism, O/E =1, means additive effect. Higher the ratio means stronger the synergism
The field studies have been conducted to evaluate the synergism and other benefits of innovative ready-mix combinations in comparison to conventional combinations. Experiment 1: Control of insect-pests of paddy/rice crop
Crop : Paddy
Variety : Swarna
Location : Kurud, Dhamtari, Chattishgarh
Plot size : 30 sq. mt. (6m x 5m)
Number of Treatments: 24
Application Time : 20 DATP (Days after transplanting)
Method of Application: Soil application. The required quantity of ready-mix granules
and other prior art treatments were mixed with sand (bulked out and to ensure uniform
coverage) and manually broadcasted in the respective plot.

Agronomic Practices : All other agronomic practices followed as per the crop requirement for weed control and disease control. Observation Methods:
Stem borer (Scirpophaga incertulas) control:
The stem borer infestation in paddy crop causes dead heart (DH) symptoms during vegetative stage and white earhead (WE) symptoms during reproductive stage. The observation on dead heart symptoms were recorded on 50 DATP (days after transplanting, i.e. 30 days after treatment application) by counting the number of dead heart (DH) and healthy (non infested) tiller per hill. Record such observations from 10 hills per plot and calculate % dead heart incidence and recalculate % reduction in dead heart (indirectly % stem borer contro) by formula given below. The white earhead observation were recorded at 90 DATP (at grain filling and ripening stage) by counting the number of white earhead and healthy panicle per hill. Record such observations from 10 hills per plot. Calculate % white earhead incidence and recalculate % white earhead reduction (indirectly % stem borer control) by formula give below.
Number of dead heart per 10 hills
Dead Heart (DH%) Incidence = X 100
Total number of tillers per 10 hills
Dead heart (%) in treatment
% Stem borer control (Dead Heart symptoms) = 100 x 100
Dead heart(%) in untreated
Number of white ears per 10 hills
White ear(WE%) Incidence = X 100
Total number of panicle per 10 hills
White ear(%) in treatment
% Stem borer control (White ear symptoms) = 100 x 100
White ear(%) in untreated
% Brown Plant Hopper (BPH), Nilaparvata lugens control:
Count the number of hoppers (BPH) per hill, observe 10 hills per plot. Record the observations when moderate infestation noticed in untreated plot. Calculate the % Hoppers (BPH) control (observed value) as below formula.

Number of live BPH in treated plot
% Hoppers (BPH) control = 100 X 100
Number of live BPH in untreated plot
The calculated value of % control was used to worked out the Colby's formula to judge the synergism.
Productive tiller count : Count the number of productive tillers per hill. Record observations from 10 hills per plot at the time of harvesting.
Table 1: Treatment details

Treatme
nt number Treatment details gai/h
Tl Flupyrimin 0.6%+Clothianidin 0.5%+Triacontanol 0.125% GR-SL 60+50+12.5
T2 Flupyrimin 0.6%+Thiamethoxam 0.5%+Triacontanol 0.125% GR-SL 60+50+12.5
T3 Flupyrimin 0.6%+Fipronil 0.3%+Triacontanol 0.125% GR-SL 60+30+12.5
T4 Flupyrimin 0.6%+Clothianidin 0.5%+Humic acid 2.5% GR-SL 60+50+250
T5 Flupyrimin 0.6%+Thiamethoxam 0.5%+Humic acid 2.5% GR-SL 60+50+250
T6 Flupyrimin 0.6%+Fipronil 0.3%+Humic acid 2.5% GR-SL 60+30+250
T7 Flupyrimin 2% GR+Clothianidin 50% WDG 60+50
T8 Flupyrimin 2% GR+Thiamethoxam 25% WG 60+50
T9 Flupyrimin 2% GR+Fipronil 0.3% GR 60+30
T10 Flupyrimin 2% GR+Triacontanol 0.05% GR 60+12.5
Til Flupyrimin 2% GR+Humic acid 90% WP 60+250
T12 Clothianidin 50% WDG+Triacontanol 0.05% GR 50+12.5
T13 Thiamethoxam 25% WG+Triacontanol 0.05% GR 50+12.5
T14 Fipronil 0.3% GR+Triacontanol 0.05% GR 30+12.5
T15 Clothianidin 50% WDG+Humic acid 90% WP 50+250
T16 Thiamethoxam 25% WG+Humic acid 90% WP 50+250
T17 Fipronil 0.3% GR+Humic acid 90% WP 30+250
T18 Flupyrimin 2% GR 60
T19 Clothianidin 50% WDG 50
T20 Thiamethoxam 25% WG 50
T21 Fipronil 0.3% GR 30
T22 Triacontanol 0.05% GR 12.5
T23 Humic acid 90% WP 250
T24 UTC (Untreated Control) -

GR-SL-Slow releasing granule. GR-Granule, WP Wettable powder, WDG Water dispersible granules, WG Wettable granule, Tl to T6 were ready mix innovative slow release granules, T7 to T17 were conventional combinations.
Table 2: Stem borer control

Treatment number Stem borer control

Dead heart reduction (%) White earhead reduction (%)

50 DATP 90 DATP

Obs.
value Exp. value Colby's ratio Synergism
(Y/N) Obs.
value Exp. value Colby's ratio Synergism
(Y/N)
Tl 95.2 86.37 1.10 Y 90.4 84.35 1.07 Y
T2 93.6 85.93 1.09 Y 88.8 83.87 1.06 Y
T3 95.8 87.42 1.10 Y 91.6 85.50 1.07 Y
T4 94.8 86.20 1.10 Y 90.0 84.22 1.07 Y
T5 93.2 85.76 1.09 Y 89.2 83.73 1.07 Y
T6 96.2 87.26 1.10 Y 91.2 85.38 1.07 Y
T7 85.2 85.72 0.99 N 81.2 83.90 0.97 N
T8 84.6 85.25 0.99 N 80.8 83.40 0.97 N
T9 85.2 86.81 0.98 N 82.6 85.09 0.97 N
T10 71.4 72.52 0.98 N 67.8 69.67 0.97 N
Til 70.8 72.18 0.98 N 68.8 69.42 0.99 N
T12 51.8 52.68 0.98 N 47.6 49.84 0.95 N
T13 50.8 51.16 0.99 N 46.4 48.29 0.96 N
T14 55.8 56.31 0.99 N 50.6 53.54 0.95 N
T15 51.4 52.09 0.99 N 48.2 49.43 0.98 N
T16 49.6 50.54 0.98 N 45.2 47.86 0.94 N
T17 54.8 55.76 0.98 N 51.4 53.16 0.97 N
T18 71.2 68.8
T19 50.4 48.4
T20 48.8 46.8
T21 54.2 52.2
T22 4.6 2.8
T23 3.4 2.0
T24 0.0 0.0
All the ready mix innovative slow releasing granules provides synergistic control of stem borer by reducing dead heart symptoms during vegetative stage and by reducing white ear head symptoms in reproductive stage.

Table 3: Brown Plan Hoppers (BPH) control

Treatment number BPH Control (%) Productive
tillers/hill,
Before harvest % increase in
productive
tillers

90 DATP

Obs.
value Exp. value Colby's ratio Synergism
(Y/N)

Tl 92.4 87.81 1.05 Y 26.8 83.56
T2 91.6 87.09 1.05 Y 26.4 80.82
T3 89.6 84.63 1.06 Y 27.2 86.30
T4 92.2 87.54 1.05 Y 27.0 84.93
T5 91.4 86.81 1.05 Y 26.6 82.19
T6 89.2 84.29 1.06 Y 27.4 87.67
T7 86.4 86.69 1.00 N 24.2 65.75
T8 85.4 85.91 0.99 N 25.8 76.71
T9 82.8 83.22 0.99 N 24.6 68.49
T10 66.6 67.57 0.99 N 24.0 64.38
Til 65.2 66.87 0.98 N 23.6 61.64
T12 64.4 65.56 0.98 N 23.4 60.27
T13 62.4 63.54 0.98 N 22.8 56.16
T14 55.8 56.58 0.99 N 23.6 61.64
T15 63.4 64.81 0.98 N 22.2 52.05
T16 61.8 62.75 0.98 N 21.8 49.32
T17 54.6 55.63 0.98 N 22.8 56.16
T18 64.6 20.4 39.73
T19 62.4 19.8 35.62
T20 60.2 18.8 28.77
T21 52.6 20.0 36.99
T22 8.4 16.8 15.07
T23 6.4 15.6 6.85
T24 0.0 14.6 0.00
The slow release granules (Tl to T6) also provides excellent synergistic control of BPH and also produces higher number of productive tiller which are directly contributing to the grain yield. The slow release granules residual control i.e. with single application, farmer can get season long control of both the important pests of paddy crop.
Experiment 2: Control of insect-pests of paddy/rice crop
Crop : Paddy
Variety : MTU 7029
Location : Burdwan, West Bengal
Plot size : 24 sq. mt. (6m x 4m)

Number of Treatments: 24
Application Time : 28 DATP (Days after transplanting)
Method of Application: Soil application. The required quantity of ready-mix granules
and other prior art treatments were mixed with sand (bulked out and to ensure uniform
coverage) and manually broadcasted in the respective plot.
Agronomic Practices : All other agronomic practices followed as per the crop
requirement for weed control and disease control.
Observation Methods:
Stem borer control (%): same as given in experiment 1.
Table 4: Treatment details

Treatme
nt number Treatment details gai/h
Tl Flupyrimin 0.8%+Cartap Hydrochloride 3%+Paclobutrazol 0.25% GR-SL 80+300+25
T2 Flupyrimin 0.8%+Thiocyclam hydrogen oxalate 3%+Paclobutrazol 0.25% GR-SL 80+300+25
T3 Flupyrimin 0.8%+Emamectin benzoate 0.2%+Paclobutrazol 0.25% GR-SL 80+20+25
T4 Flupyrimin 0.8%+Cartap Hydrochloride 3%+Zinc 2% GR-SL 80+300+200
T5 Flupyrimin 0.8%+Thiocyclam hydrogen oxalate 3%+Zinc 2% GR-SL 80+300+200
T6 Flupyrimin 0.8%+Emamectin benzoate 0.2%+Zinc 2% GR-SL 80+20+200
T7 Flupyrimin 2% GR+Cartap hydrochloride 4% GR 80+300
T8 Flupyrimin 2% GR+Thiocyclam hydrogen oxalate 4% GR 80+300
T9 Flupyrimin 2% GR+Emamectin benzoate 5% SG 80+20
T10 Flupyrimin 2% GR+Paclobutrazol 23% SC 80+25
Til Flupyrimin 2% GR+Zinc 33% WP 80+200
T12 Cartap Hydrochloride 4% GR+Paclobutrazol 23% SC 300+25
T13 Thiocyclam hydrogen oxalate 4% GR+Paclobutrazol 23% SC 300+25
T14 Emamectin benzoate 5% SG+Paclobutrazol 23% SC 20+25
T15 Cartap Hydrochloride 4% GR+Zinc 33% WP 300+200
T16 Thiocyclam hydrogen oxalate 4% GR+Zinc 33% WP 300+200
T17 Emamectin benzoate 5% SG+Zinc 33% WP 20+200
T18 Flupyrimin 2% GR 80
T19 Cartap hydrochloride 4% GR 300
T20 Thiocyclam hydrogen oxalate 4% GR 300
T21 Emamectin benzoate 5% SG 20
T22 Paclobutrazol 23% SC 25
T23 Zinc 33% WP 200
T24 UTC (Untreated Control) -

Zinc as Zinc lactate gluconate. Tl to T6 were ready-mix innovative slow release granule.
Table 5: Stem borer control

Treatment number Stem borer control Productive
tillers/hill,
Before
harvest % increase
in
productive
tillers

Dead heart reduction (%) White earhead reduction (%)

50 DATP 90 DATP

Obs.
value Exp. value Colby's ratio Obs.
value Exp. value Colby's ratio

Tl 97.4 92.21 1.06 94.4 88.48 1.07 28.2 123.81
T2 99.2 92.56 1.07 95.8 88.72 1.08 28.8 128.57
T3 96.4 91.34 1.06 94.0 87.55 1.07 26.6 111.11
T4 96.8 91.98 1.05 94.8 88.36 1.07 27.8 120.63
T5 98.8 92.34 1.07 95.4 88.60 1.08 28.6 126.98
T6 95.6 91.08 1.05 85.4 87.42 0.98 26.8 112.70
T7 90.4 91.69 0.99 86.2 88.20 0.98 24.2 92.06
T8 91.4 92.07 0.99 85.4 88.44 0.97 24.4 93.65
T9 89.4 90.77 0.98 84.4 87.25 0.97 23.6 87.30
T10 77.4 78.24 0.99 68.2 70.92 0.96 22.2 76.19
Til 76.2 77.59 0.98 67.8 70.62 0.96 21.8 73.02
T12 65.8 66.42 0.99 59.2 61.35 0.96 21.4 69.84
T13 66.6 67.92 0.98 58.8 62.13 0.95 22.6 79.37
T14 61.4 62.67 0.98 56.4 58.23 0.97 21.0 66.67
T15 64.8 65.42 0.99 57.4 60.95 0.94 20.2 60.32
T16 64.4 66.96 0.96 58.6 61.74 0.95 20.6 63.49
T17 60.2 61.55 0.98 55.2 57.80 0.96 18.8 49.21
T18 76.8 70.2 19.4 53.97
T19 64.2 60.4 18.4 46.03
T20 65.8 61.2 18.8 49.21
T21 60.2 57.2 17.6 39.68
T22 6.2 2.4 15.2 20.63
T23 3.4 1.4 14.2 12.70
T24 0.0 0.0 12.6 0.00
All the ready mix innovative slow releasing granules provides synergistic control of
stem borer by reducing dead heart symptoms during vegetative stage and by reducing
white ear head symptoms in reproductive stage and also produces higher number of
productive tillers.
Experiment 3: Control of Brown Plant Hopper (BPH) in paddy/rice crop
Crop : Paddy
Variety : Swarna
Location : Rajim, Chattishgarh

Plot size : 36 sq. mt. (6m x 6m)
Number of Treatments: 20
Application Time : 64 DATP (Days after transplanting)
Method of Application: Foliar spray with knap sack sprayer fitted with hollow cone
nozzle.
Water volume : 500 liter per hectare
Agronomic Practices : All other agronomic practices followed as per the crop
requirement for weed control and disease control.
Observation Methods:
BPH control (%): same as given in experiment 1.
Grain yield : Record the grain yield per plot at harvest.
Table 6: Treatment details

Treatment number Treatment details gai/h
Tl Flupyrimin 10%+Dinotefuran 5%+Fulvic acid 2% SC 50+25+10
T2 Flupyrimin 10%+Triflumezopyrim 4%+Fulvic acid 2% SC 50+20+10
T3 Flupyrimin 10%+Pymetrozine 20%+Fulvic acid 2% WG 50+100+1 0
T4 Flupyrimin 10%+Benzpyrimoxan 10%+Fulvic acid 2% SC 50+50+10
T5 Flupyrimin 10% SC+Dinotefuran 20% SG 50+25
T6 Flupyrimin 10% SC+Triflumezopyrim 10.6 % SC 50+20
T7 Flupyrimin 10% SC+Pymetrozine 50% WG 50+100
T8 Flupyrimin 10% SC+Benzpyrimoxan 10% SC 50+50
T9 Flupyrimin 10% SC+Fulvic acid 80% WP 50+10
T10 Dinotefuran 20% SG+Fulvic acid 80% WP 25+10
Til Triflumezopyrim 10.6 % SC+Fulvic acid 80% WP 20+10
T12 Pymetrozine 50% WG+Fulvic acid 80% WP 100+10
T13 Benzpyrimoxan 10% SC+Fulvic acid 80% WP 50+10
T14 Flupyrimin 10% SC 50
T15 Dinotefuran 20% SG 25
T16 Triflumezopyrim 10.6 % SC 20
T17 Pymetrozine 50% WG 100
T18 Benzpyrimoxan 10% SC 50
T19 Fulvic acid 80% WP 10
T20 UTC (Untreated Control) -
Tl to T4 were ready mix innovative treatments. SC Suspension concentrate, SG soluble
granule.
Table 7: BPH control (%) and grain yield

Treatment number BHP Control (%) % increase

3DAA

Obs.
value Exp. value Colby's ratio Synergism
(Y/N) 7 DAA 14 DAA Grain
Yield
(kg/plot) in grain yield over T20
Tl 98.2 86.48 1.14 Y 90.2 61.4 16.5 111.5
T2 97.4 85.57 1.14 Y 94.6 70.2 17.6 125.6
T3 98.8 89.19 1.11 Y 92.2 63.4 17.3 121.8
T4 97.2 84.02 1.16 Y 93.2 67.4 16.8 115.4
T5 85.4 85.70 1.00 N 78.8 53.4 14.7 88.5
T6 84.4 84.75 1.00 N 84.2 60.8 15.4 97.4
T7 88.2 88.58 1.00 N 80.6 57.4 15.2 94.9
T8 82.8 83.11 1.00 N 83.6 58.2 14.9 91.0
T9 66.8 67.65 0.99 N 59.6 36.4 12.8 64.1
T10 59.8 60.46 0.99 N 49.4 24.8 13.4 71.8
Til 57.2 57.81 0.99 N 62.4 37.6 13.8 76.9
T12 67.8 68.40 0.99 N 55.4 32.2 12.9 65.4
T13 52.8 53.27 0.99 N 62.8 35.8 13.0 66.7
T14 65.8 60.2 40.4 11.8 51.3
T15 58.2 50.4 28.6 11.2 43.6
T16 55.4 64.2 42.2 11.7 50.0
T17 66.6 56.4 34.8 11.6 48.7
T18 50.6 63.8 38.8 11.4 46.2
T19 5.4 3.2 0.4 8.5 9.0
T20 0.0 0.0 0.0 7.8 0.0
All the ready mix innovative combinations (Tl to T4) provides synergistic residual control of BPH and also produces higher grain yield per plot compared to conventional treatments (T5 to T13). Experiment 4: Control of Brown Plant Hopper (BPH) in paddy/rice crop
Crop : Paddy
Variety : Mahamaya 51
Location : Dhamtari, Chattishgarh
Plot size : 40 sq. mt. (8m x 5m)
Number of Treatments: 7
Application Time : 26 DATP (Days after transplanting)
Method of Application: Manual broadcasting
Agronomic Practices : All other agronomic practices followed as per the crop
requirement for weed control and disease control.
Observation Methods:
Stem borer control (%): same as given in experiment 1.

BPH control (%): same as given in experiment 1.
Table 8: Treatment details

Treat
ment
numbe
r Treatment details gai/h
Tl Flupyrimin 0.5%+Thiocyclam hydrogen oxalate 2.5%+Clothianidin 0.4%+Zinc 2% GR 50+250+4 0+200
T2 Flupyrimin 0.5%+Thiocyclam hydrogen oxalate 2.5%+Triflumezopyrim 0.15%+Zinc 2% GR 50+250+1 5+200
T3 Flupyrimin 2% GR 50
T4 Thiocyclam hydrogen oxalate 2.5%+Clothianidin 0.4% GR (ready mix) 250+40
T5 Thiocyclam hydrogen oxalate 2.5%+Triflumezopyrim 0.15% GR (ready mix) 250+15
T6 Zinc 33% WP 200
T7 UTC (Untreated Control) -
Tl and T2 were ready mix innovative granule (GR).
Table 9: Control of stem borer and BPH in paddy

Treatment number Stem borer control % BPH Control at 75 DATP

Dead heart reduction (%) White earhead reduction (%)

50 DAT] 3 90 DAT 3

Obs.
value Exp. value Colby's ratio Obs.
value Exp. value Colby's ratio

Tl 100.0 88.05 1.14 96.4 82.28 1.17 89.8
T2 100.0 87.14 1.15 92.6 81.20 1.14 92.6
T3 60.2 54.2 58.2
T4 68.8 60.6 64.8
T5 66.4 58.2 62.6
T6 3.8 1.8 2.4
T7 0.0 0.0 0.0
Field trials results shows that ready mix innovative GR treatments (Tl and T2) provides excellent residual control of paddy stem borer and BPH.
Summery of field studies:
The field trials results shows many benefits/advantages of innovative ready mix combinations.

• Synergistic control of insect pests observed.
• Increase in level of insect-pests control (higher % control)
• Residual control
• The slow release granules provides the season long control of key insects of paddy.
• Increase in yield (increase in healthy and productive tillers, grain yield)
• Increases plant growth, vigor, leaf size, root biomass.

CLAIMS

We claim;

[CLAIM 1]. A synergistic agrochemical composition comprising:
a. an insecticide Flupyrimin present in amount of 0.01 to 30%
w/w;
b. an insecticide selected from an insecticide selected from
fipronil, nicofluprole, bifenthrin, lambda-cyhalothrin,
clothianidin, dinotefuran, thiamethoxam, triflumezopyrim,
dichloromezotiaz, emamectin benzoate, pyriproxyfen,
pymetrozine, pyrifluquinazon; afidopyropen, flonicamid,
bensultap, monosultap, cartap hydrochloride, thiocyclam
hydrogen oxalate, thiocyclam hydrochloride, thiosultap
sodium, novaluron, methoxyfenozide, spiropidion,
tyclopyrazoflor, azadirechtin, benzpyrimoxan, oxazosulfyl,
dimpropyridaz or mixture thereof present in amount of 0.01 to
50%,
c. a Plant Health Additives selected from biostimulants, plant
growth regulators, microbial agents and micronutrients or
mixtures thereof present in amount of 0.001 to 20%.
d. Inactive formulation excipients.
[CLAIM 2]. The synergistic agrochemical composition as claimed in claim 1, wherein plant health additives from class of bio-stimulant is selected from humic acid, fulvic acid, amino acids, protein hydrolysates, carboxylic acid, jasmonic acid, chitosan, chitin, seaweed extract (Ascophyllum nodosum), salicylic acid, silicic acid (Orth silicic acid (H4Si04)); from class of plant growth regulator is selected from gibberellic acid (GA3), alpha-naphthyl acetic acid, mepiquat chloride, paclobutrazol, uniconazole-p, chlormequat chloride, trinexapac ethyl, aminoethoxyvinylglycine (AVG), prohexadione calcium,

brassinolide, triacontanol, nitrobenzene, nitrophenolate (sodium para-nitrophenolate); from class of microbial agent is selected from Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp., Bacillus megaterium var. phosphaticum, Bacillus polymyxa, Bacillus licheniformis, Frateuria aurantia, Thiobacillus thiooxidans, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), Acinetobacter calcoaceticus, Bacillus subtilis, Bacillus thuringiensis var. kurstaki, Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae, Varticillium lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp.; and from the class of micronutrient is selected from zinc (zinc sulphate heptahydrate ZnS047H20, zinc sulphate mono hydrate ZnS04.H20, chelated zinc as Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), boron (borax-sodium tetraborate, boric acid (H3B03), di-sodium octa borate tetra hydrate (Na2B8013.4H20), di-sodium tetra borate penta hydrate, anhydrous borax, ) and sulphur (elemental sulphur, boronated sulphur) or mixture thereof.
[CLAIM 3]. The synergistic agrochemical composition as claimed in claim 1, wherein the formulation for the said composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule

(GR) / Soil Applied Granules (SAG), Controlled release granules (CR) or GR-SL (Granule-Slow release).
[CLAIM 4]. The synergistic agrochemical composition as claimed in claim 1-claim
3, wherein the preferred combinations of active ingredients in the
composition of the GR-SL (Granule-Slow release) formulation
comprises:
i. Flupyrimin0.6%+Clothianidin0.5%+Triacontanol0.125%;
ii. Flupyrimin0.6%+Thiamethoxam0.5%+Triacontanol0.125%;
iii. Flupyrimin0.6%+Fipronil0.3%+Triacontanol0.125%;
iv. Flupyrimin0.6%+Clothianidin0.5%+Humic acid2.5%;
v. Flupyrimin0.6%+Thiamethoxam0.5%+Humic acid2.5%;
vi. Flupyrimin0.6%+Fipronil0.3%+Humic acid2.5%;
vii. Flupyrimin0.8%+Cartap hydrochloride 3%+Zinc2%;
viii. Flupyrimin0.8%+Thiocyclam hydrogen oxalate 3%+Zinc2%;
ix. Flupyrimin0.8%+Emamectin benzoate 0.2%+Zinc2%;
x. Flupyrimin0.6%+Clothianidin 0.5%+Sulphur20%;
xi. Flupyrimin0.6%+Thiamethoxam0.5%+Sulphur20 %;
xii. Flupyrimin0.6%+Fipronil0.3%+Sulphur20%;
xiii. Flupyrimin0.8%)+Cartap hydrochloride 3%+Sulphur20%;
xiv. FlupyriminO.8%o+Thiocyclam hydrogen oxalate3%+Sulphur 20%;
xv. FlupyriminO.8%+Emamectin benzoate 0.2%+Sulphur20%;
xvi. FlupyriminO.8%o+Cartap hydrochloride 3%+Paclobutrazol 0.25%;
xvii. FlupyriminO. 8%+Thiocyclam hydrogen oxalate 3% +
Paclobutrazol 0.25%;
xviii. FlupyriminO.8%+Emamectin benzoate 0.2% + Paclobutrazol
0.25%;
xix. FlupyriminO.8%+Cartap hydrochloride 3%+Brassinolide 0.02%;
xx. FlupyriminO.8%+Thiocyclam hydrogen oxalate 3%+ Brassinolide
0.02%;
xxi. FlupyriminO.8%+Emamectin benzoate0.2%+Brassinolide0.02%.
[CLAIM 5]. The synergistic agrochemical composition as claimed in claim 1 -claim
3, wherein the GR-SL (Granule-Slow release) formulation comprises:
i. an insecticide Flupyrimin present in amount of 0.01 to 30%
w/w;

ii. an insecticide selected from Clothianidin, Thiamethoxam,
Fipronil, Cartap hydrochloride, Thiocyclam hydrogen oxalate,
Emamectin benzoate or mixture thereof present in amount of
0.01 to50%w/w; iii. a plant health additive selected from Triacontanol, Humic acid,
Zinc, Sulphur, Paclobutrazol, Brassinolideor mixture thereof
present in amount of 0.001 to 20%w/w; iv. Emulsifier in an amount of 0.25 to 6 % by weight; v. Controlled release agent-1 in an amount of 0.5 to 4 % by
weight; vi. Controlled release agent-2 in an amount of 0.5 to 8 % by
weight; vii. Dispersing agent in an amount of 0.5 to 2 % by weight; viii. Colourant in an amount of 0.25 to 2 % by weight; ix. Innerts agent in an amount of 0.5 to 6 % by weight; x. Solvent in an amount of 2 to 6 % by weight; xi. Carrier in an amount of 60 to 80 % by weight.
[CLAIM 6]. The synergistic agrochemical composition as claimed in claim 5, wherein dispersing agent is selected from Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), ethoxylated tristyrene phenol is alpha-[2,4,6-tris[l-(phenyl)ethyl] phenyl]-omega-hydroxy poly(oxyethylene, poly(oxy-l,2-ethanediyl)-alpha-Cl 0-15 alkyl-omega-hydroxy phosphate or sulphate and/or a C10-13alkylbenzenesulfonic acid, tristyrylphenols, nonylphenols, dinonylphenol and octylphenols, styrylphenol polyethoxyester phosphate, alkoxylated C14-20fatty amines,
[CLAIM 7]. The synergistic agrochemical composition as claimed in claim 5, wherein Solvent is selected from Fatty acid methyl ester, cyclohexane,

xylene, mineral oil or kerosene, mixtures or substituted naphthalenes, mixtures of mono- and polyalkylated aromatics, dibutyl phthalate or dioctyl phthalate, ethylene glycol monomethyl or monoethyl ether, butyrolactone, octanol, castor oil, soybean oil, cottonseed oil , epoxidised coconut oil or soybean oil, aromatic hydrocarbons, dipropyleneglycol monomethylether, polypropylene glycol [M.W. 2000-4000], polyoxyethylene polyoxypropylene glycols, polyoxypropylene polyoxyethylene glycols, diethyleneglycol, polyethylene glycol [M.W. 200-4000 amu], methoxy polyethylene glycols 350, 550, 750, 2000, 5000; glycerol, methyl oleate, n-octanol, alkyl phosphates such as tri-n-butyl phosphate, propylene carbonate and isoparaffinic, tetrahydrofurfuryl alcohol, gamma-butyrolactone, N-methyl-2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide , Diacetone alcohol, Polybutene, Propylene carbonate, Dipropylene glycol isomer mixture.
[CLAIM 8]. The synergistic agrochemical composition as claimed in claim 5, wherein Solvent Controlled release agent is selected from Xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethylcellulose, Sodium Polyacrylate, modified starch, Paraffin wax, Polyvinyl acetate,Montan wax and vinyl acetate, Polyethylene Glycol 6000, Cationic hydrosoluble polymer, C4 alkylated Polyvinyl pyrrolidone.
[CLAIM 9]. The synergistic insecticidal composition as claimed in claim 5, wherein Carrier or Filler is selected from Diatomaceous earth, attapulgite or zeolites, dolomite, limestone, silica, fly ash, hydrated lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, attapulgite, diatomaceous earth, calcium carbonate, talc, muscovite mica, fused sodium potassium, aluminum silicate , perlite, talc and muscovite mica, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate,

ammonium phosphate, triple super phosphate, phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and a combination of these, calcium, magnesium, sulfur, iron, manganese, copper, zinc; oxides, humic acid, Wood floor, Calcium silicate, Cellulose granules, Magnesium stearate.
[CLAIM 10]. The synergistic insecticidal composition as claimed in claim 5, wherein inert agent is Nano polysaccharide.
[CLAIM 11]. The synergistic agrochemical composition as claimed in claim 4-claim
10, wherein the GR-SL (Granule-Slow release) formulation
comprises:
i. Flupyrimin present in an amount of 0.80%w/w; ii. Thiocyclam hydrogen oxalate present in an amount of
3.00%w/w; iii. Zinc lactate gluconate present in an amount of 2.00%w/w; iv. River sand (Silica) present in an amount of 76.10%w/w; v. Tri-styryl Phenol Ethoxylate present in an amount of
3.00%w/w; vi. Phosphoric acid present in an amount of 0.10%w/w; vii. Polyvinyl alcohols present in an amount of 2.00%w/w; viii. Nano polysaccharide present in an amount of 2.50%w/w; ix. N-methyl-2-pyrrolidone present in an amount of 3.00%w/w; x. Copolymer of propylene oxide (PO) and ethylene oxide (EO)
present in an amount of 1.00%w/w; xi. Paraffin wax present in an amount of 5.00%w/w; xii. Rhodamine present in an amount of 0.50%w/w; xiii. Precipitated silica present in an amount of 1.00%w/w.
[CLAIM 12]. The synergistic agrochemical composition as claimed in claim 4-claim
10, wherein the GR-SL (Granule-Slow release) formulation
comprises:
i. Flupyrimin present in an amount of 0.60%w/w; ii. Clothianidin present in an amount of 0.50%w/w; iii. Triacontanol present in an amount of 0.125%w/w;

IV.
V.
vi.
vii. viii.
ix.
x.
xi. xii.

River sand (silica) present in an amount of 81.28%w/w;
N-methyl-2-pyrrolidone present in an amount of 3.00%w/w;
Copolymer of propylene oxide (PO) and ethylene oxide (EO)
present in an amount of 1.00%w/w;
Paraffin wax present in an amount of 5.00%w/w;
Nano polysaccharide present in an amount of 2.50%w/w;
Trisiloxane ethoxylate present in an amount of 2.50%w/w;
Polyvinyl alcohols present in an amount of 2.00%w/w;
Rhodamine Dye present in an amount of 0.50%w/w;
Precipitated silica present in an amount of 1.00%w/w.

[CLAIM 13]. The synergistic agrochemical composition as claimed in claim 1 and claim 3, wherein preferred combinations of active ingredients in the composition of the Suspension Concentrate (SC) formulation comprises:

I.
ii.
iii.
iv.
v.
vi.
vii.
viii.
ix.
x.
xi.
xii.
xiii.
xiv.
xv.
xvi.
xvii.
xviii.
xix.
XX.
xxi.
xxii. xxiii. xxiv.
xxv.

FlupyriminlO%+ Triflumezopyrim4%+Fulvic acid2%; FlupyriminlO%+ Benzpyrimoxan 10%+Fulvic acid2%; FlupyriminlO%+ Dinotefuran5%+Fulvic acid2%; FlupyriminlO%+ Clothianidin4%+Gibberellic acidO.2%; FlupyriminlO%+ Dinotefuran4%+Gibberellic acidO.2%; FlupyriminlO%+ Triflumezopyrim4%+Gibberellic acid 0.2%; FlupyriminlO%+ Dichloromezotiaz6%+Gibberellic acid 0.2%; Flupyrimin5%+ Methoxyfenozidel2%+Gibberellic acid 0.1%; FlupyriminlO%+ Tyclopyrazoflor 10%+Gibberellic acidO.2%; FlupyriminlO%+ Benzpyrimoxan 10%+Gibberellic acidO.2%; FlupyriminlO%+ Oxazosulfyl 10%+Gibberellic acidO.2%; FlupyriminlO%+ Dimpropyridaz 10%+Gibberellic acidO.2%; FlupyriminlO%+ Clothianidin4%+Mepiquat chloride5%; FlupyriminlO%)+ Dinotefuran4%+Mepiquat chloride5%); FlupyriminlO%+ Triflumezopyrim4%+Mepiquat chloride5%; FlupyriminlO%+ Dichloromezotiaz6%+Mepiquat chloride5%; Flupyrimin5%+ Methoxyfenozidel2%+Mepiquat chloride2.5%; FlupyriminlO%)+ Tyclopyrazoflor 10%+Mepiquat chloride5%; FlupyriminlO%+ Benzpyrimoxan 10%+Mepiquat chloride5%; FlupyriminlO%)+ Oxazosulfyl 10%+Mepiquat chloride5%); FlupyriminlO%)+ Dimpropyridaz 10%+Mepiquat chloride5%; Flupyrimin5 %+ Methoxy fenozi del 2%+Pacl obutrazol 3 %; FlupyriminlO%+ Tyclopyrazoflor 10%+Paclobutrazol6%; FlupyriminlO%+ Benzpyrimoxan 10%+Paclobutrazol6%; Flupyrimin 10%+ Oxazosulfyl 10%+Pacl obutrazol 6%;

XXVI.
xxvii.
xxviii.
xxix.
XXX.
xxxi.
xxxii.
xxxiii.
xxxiv.
xxxv.
xxxvi.
xxxvii.
xxxviii.
xxxix.

FlupyriminlO%+Dimpropyridaz 10%+Paclobutrazol 6%; Flupyrimin5%+Methoxyfenozidel2%+Triacontanol0.025%; FlupyriminlO%+ Tyclopyrazoflor 10%+Triacontanol0.05%; FlupyriminlO%+ Benzpyrimoxan 10%+Triacontanol0.05%; Flupyriminl0%+Oxazosulfyll0%+Triacontanol0.05%; FlupyriminlO%+ Dimpropyridaz 10%+Triacontanol0.05%; Flupyriminl0%+Clothianidin4%+Triacontanol0.05%; FlupyriminlO%+ Dinotefuran5%+Triacontanol0.05%; FlupyriminlO%+ Triflumezopyrim4%+Triacontanol0.05%; Flupyrimin 10%+ Di chl oromezoti az6%+Tri acontanol 0.05%; Flupyrimin 10%+ Clothianidin4%+Paclobutrazol6%; Flupyrimin 10%+ Dinotefuran4%+Paclobutrazol6%. Flupyrimin 10%+ Triflumezopyrim4%+Paclobutrazol6% Flupyrimin 10%+ Di chl oromezoti az6%+Pacl obutrazol 6%

I. ii.
[CLAIM 14]. The synergistic agrochemical composition as claimed in claim 1 and claim 13, wherein the Suspension Concentrate (SC) formulation comprises:
in.
an insecticide Flupyrimin present in amount of 0.01 to 30% w/w; an insecticide selected from Triflumezopyrim, Benzpyrimoxan, Dinotefuran, Clothianidin, Dichloromezotiaz, Methoxyfenozide, Tyclopyrazoflor, Oxazosulfyl, Dimpropyridaz, Clothianidin or mixture thereof present in amount of 0.01 to 50% w/w; a plant health additive selected from Fulvic acid, Gibberellic acid, Mepiquat chloride, Paclobutrazol, Triacontanol or mixture thereof present in amount of 0.001 to 20%w/w;
IV.
v.
vi.
vii.
viii.
ix.
x.
xi.
Wetting-spreading-penetrating agent in an amount of 2 to 6 % by weight;
Dispersing agent 1 in an amount of 2 to 8 % by weight; Dispersing agent 2 in an amount of lto 3 % by weight; Suspending agent in an amount of 0.2 to 4.0 % by weight; Antifoaming agent in an amount of 0.1 to 1.5 % by weight; Preservative in an amount of 0.1 to 0.5 % by weight; Antifreezing agent in an amount of 2 to 6 % by weight; Thickner in an amount of 0.1 to 1.0 % by weight;

xii. Diluent Water in an amount of 40 to 70 % by weight.
[CLAIM 15]. The synergistic agrochemical composition as claimed in claim 14, wherein Wetting agent is selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate; organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
[CLAIM 16]. The synergistic agrochemical composition as claimed in claim 14, wherein dispersing agent is selected from alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyryl phenol-polyglycol ether-phosphate, tristyryl phenole with 16 moles EO, tristyryl phenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.
[CLAIM 17]. The synergistic agrochemical composition as claimed in claim 13, wherein suspending agent is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 18]. The synergistic agrochemical composition as claimed in claim 14, wherein anti-freezing agent is selected from ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.
[CLAIM 19]. The synergistic agrochemical composition as claimed in claim 1 and claim 4, wherein preferred combinations of active ingredients in the composition of the Water Dispersible Granules (WG) formulation comprises:
i. FlupyriminlO% +Pymetrozine20% +Triacontanol0.05%;
ii. FlupyriminlO% +FlonicamidlO% +Triacontanol0.05%;
iii. FlupyriminlO% +Pymetrozine20% +Paclobutrazol6%;
iv. FlupyriminlO% +FlonicamidlO% +Paclobutrazol6%;
v. FlupyriminlO% +Pymetrozine20% +Mepiquat chloride5%;
vi. FlupyriminlO% +FlonicamidlO% +Mepiquat chloride5%;
vii. FlupyriminlO% +Pymetrozine20% +Gibberellic acid 0.2%;
viii. FlupyriminlO% +FlonicamidlO% +Gibberellic acid 0.2%.
[CLAIM 20]. The synergistic agrochemical composition as claimed in claim 1 and claim 19, wherein the Water Dispersible Granules (WG) formulation comprises: i. an insecticide Flupyrimin present in amount of 0.01 to 30% w/w; ii. an insecticide selected from Pymetrozine, Flonicamid or mixture
thereof present in amount of 0.01 to 50% w/w; iii. a plant health additive selected from Gibberellic acid, Mepiquat chloride, Paclobutrazol, Triacontanol or mixture thereof present in amount of 0.001 to 20%w/w; iv. Wetting-spreading-penetrating agent in an amount of 2 to 8 % by
weight; v. Dispersing agent I in an amount of 2 to 8 % by weight; vi. Dispersing agent II in an amount of 1 to 5 % by weight; vii. Disintegrating agent in an amount of 0.2 to 0.8 % by weight;

viii. Antifoaming agent in an amount of 0.1 to 1.5 % by weight; ix. Carrier in an amount of 30 to 80 % by weight.
[CLAIM 21]. The synergistic agrochemical composition as claimed in claim 20, wherein dispersing agent is selected from alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt.
[CLAIM 22]. The synergistic agrochemical composition as claimed in claim 20, wherein Wetting-spreading-penetrating agent is selected from Organo silicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, modified heptamethyl trisiloxane, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
[CLAIM 23]. The synergistic agrochemical composition as claimed in claim 20, wherein Antifoaming agent is polydimethylsiloxane.
[CLAIM 24]. The synergistic agrochemical composition as claimed in claim 20, wherein carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride,

gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
[CLAIM 25]. The synergistic agrochemical composition as claimed in claim 20, wherein Disintegrating agent is selected from citric acid, succinic acid or the sodium bicarbonate.
[CLAIM 26]. The synergistic agrochemical composition as claimed in claim 20, wherein Humectant is selected from Nano polysaccharide, urea, humic acid, glycerol, lactose