Amorphous Atorvastatin Calcium

Abstract: Amorphous atorvastain calcium having an enhanced stability contains about 2 to about 8 percent by weight water. A process preparing the amorphous atorvastatin calcium and a packaging system for maintaining the stability are described.

Patent Information

Application #

Filing Date

28 September 2005

Publication Number

40/2007

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

DR. REDDY LABORATORIES LIMITED

7-1-27, AMEERPET, HYDERABAD ANDHRA PRADESH INDIA-500 016

DR. REDDY LABORATORIES INC.,

20, SOMERSET CORPORATE, BOULEVARD, SEVENTH FLOOR, BRIDGEWATER, NEW JERSERY-08807 USA

Inventors

1. GUDIPATI SRINIVASULU

H.NO:15-21-107 BALLAJINAGAR KUKKATPALLY, HYDERABAD ANDHRAPREDESH

2. KATKAM SRINIVAS

H.NO.13-1/32/3 SAI PURI COLONY, MALKAJGIRI, SECUNDARABAD, ANDHRA PRADESH

3. KOMATI SATYANARAYANA

H.NO:5-105/1 VENKATRAMANNA COLONY NEAR BHEL HYDERABAD, ANDHRAPRADESH

4. KUDAVALLI JAYA SATYANNNARAYANNA

2ND WARD, TADEPALLIGUDEM, WEST GODDHAVARI DISTRICT, ANDHRA PREDESH

Specification

INTRODUCTION TO THE INVENTION The invention relates to a stable amorphous form of atorvastatin calcium and to packaging procedures that maintain stability of the compound during storage. Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, for treating hypercholestrolemia. The compound has the chemical name [R-(R*,R*)]-2-(4-fluorophenyl)-/ff,