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SAGM (saline-adenine-dextrose-monitor) solution is the most widely used preservative solution for storage of RBCs after separation form whole blood. Even though the permitted period of storage of RBCs in SAGM solution is 35 days, there is a steady and progressive deterioration in the quality of the quality of the cells, which increases with storage time. Some of most harmful changes are a drastic decrease in the level of 2,3 diphosphogiycerate (which is essential for delivery of oxygen to the tissues), increased haemolysis (which releases Hob and K+ from the RBCIs Into the SAGM; both of which are harmful) and progressive volatilization of di-(2-ethyl hexyl) phthalates (DEHP) [the plasticizer commonly used in the bag] in the medium containing RBCs, which is also harmful. The present formulation prevents the extent of these changes in the RBCs during storage, particularly the drastic decrease in 2,3 DPG.
Notices, Deadlines & Correspondence
Patent Information
Applicants
TERUMO PENPOL LTD
Inventors
1. PARAMESWARA ACHUTHA KURUP
2. PEETHAMBARAN ARUN
3. CHANDRASEKHAR BALAGOPAL
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | Drawings_Granted 193608_18-04-2005.pdf | 2005-04-18 |
| 2 | Description_Granted 193608_18-04-2005.pdf | 2005-04-18 |
| 3 | Claims_Granted 193608_18-04-2005.pdf | 2005-04-18 |
| 4 | Abstract_Granted 193608_18-04-2005.pdf | 2005-04-18 |
| 5 | 994-mas-2001 form-9.pdf | 2011-09-03 |
| 6 | 994-mas-2001 form-5.pdf | 2011-09-03 |
| 7 | 994-mas-2001 form-26.pdf | 2011-09-03 |
| 8 | 994-mas-2001 form-1.pdf | 2011-09-03 |
| 9 | 994-mas-2001 drawing.pdf | 2011-09-03 |
| 10 | 994-mas-2001 description (complete).pdf | 2011-09-03 |
| 11 | 994-mas-2001 correspondence po.pdf | 2011-09-03 |
| 12 | 994-mas-2001 correspondence others.pdf | 2011-09-03 |
| 13 | 994-mas-2001 claims.pdf | 2011-09-03 |
| 14 | 994-mas-2001 abstract.pdf | 2011-09-03 |