The present invention relates to synergistic agrochemical composition comprising herbicide(s) or mixture thereof; and Insecticide as a safener for reducing phytotoxicity in crops treated with herbicide. More particularly, the present invention relates to a herbicidal composition for weeds control in post emergence conditions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline or mixture thereof for reducing phytotoxicity in crops treated with a herbicide. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.
BACKGROUND OF THE INVENTION:
Weeds are a nuisance in most agricultural crops, orchards, plantation crops, landscapes and sometimes the herbicides used to control the weeds end up injuring crops, useful plants, some of ornamental plants. Herbicides are pesticides useful for killing or controlling unwanted plants. Generally, there are two kinds of herbicides- selective and non-selective. Selective herbicides kill certain target weeds while leaving the desired crop relatively unharmed while non-selective herbicides kill both the weeds and crops. Profitable crop production depends on effective weed control. The weeds can reduce field crop yields by competing for water, sunlight and nutrients. In today’s crop production systems, starting off with a good burn-down program is a must as it helps to achieve maximum initial crop growth and reduce weed interference during early stages of the crop cycle. Since the weed-crop competition is critical during the early stages of crop cycle, the weed interference at early stage has a direct impact on the yield of the crop.
Herbicide injury is observed after application of herbicide in terms of stunting, yellowing, scorching, epinasty, hyponasty, germination loss, poor plant population stand in field and even loss of crop or plant yield. It normally happens while not following the directions on the label as carefully as one should. Farmers tend to use more herbicide than the label instructs or can be careless and spray during windy conditions or wave the wand around so that the spray drifts onto non-target plants.
The term for plant damage is “phytotoxicity” and it can be caused by pesticides, nutrients, or physical and environmental damage (wind, sun, hail, etc.). Often the identity of the herbicide can be determined by the injury symptoms on the plants.
Symptoms can be divided into 5 main categories: leaf and shoot malformations, root and shoot stunting, leaf spotting, leaf chlorosis (yellowing), and leaf necrosis (death).
An effective weed control can be achieved by usage of herbicides appropriately. The activity of herbicides can be enhanced in various ways to achieve the maximum benefit. One of the ways is to use combinations. However, identifying appropriate combinations, which will reduce the toxicity at the same time due to the application of herbicides on crop, their agrochemical application rates and ratio of the combinations is essential to achieve efficacious control, which is not straight forward. The selection of a particular formulation type is more cumbersome for an agrochemical combination.
The efficacy of these herbicides against harmful weeds in the crop plants depends on the application rate, the formulation ingredients, the harmful weeds to be controlled, the climatic conditions and the soil conditions.
Farmers are applying more than one active ingredient or applying high use rate to control different types of weeds at a time, to control multiple generations of weeds in fields, to control troublesome weeds and to get residual control. Such practices increase the chances of herbicidal injury or phytotoxicity to the target crops.
There are many herbicides which used in combination creates characteristic phytotoxic injuries in plants like malformed, distorted leaves and shoots, stunted shoots and roots, chlorotic, necrotic, or spotted leaves.
However, there remains a great need for improved broadleaf and grassy weed control compositions and a method of controlling such noxious vegetation in pre and post emergence without adversely affecting desirable plants and which reduces the amount of chemical herbicidal agent necessary to obtain the acceptable weed control along with reducing the undesirable post treatment toxic effect or injury of the herbicides on crops.
The compound 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone, also known as "clomazone", is a potent herbicide as evidenced by its ability to control, for full growing seasons and at low application rates. However, clomazone is phytotoxic to other crops when applied at rates effective to control undesired vegetation, such contact resulting from drift to adjacent fields planted with low tolerance crops or from carryover when soybean fields treated with clomazone are rotated to a crop sensitive to clomazone.
It has been known that certain insecticides act as a safener against injury inflicted by herbicide application. Article titled“Evaluation of Safening Effects to Herbicides Conferred via Insecticide Seed Treatments in Soybean (Glycine max) and Grain Sorghum (Sorghum bicolor)” by Nicholas Robert Steppig discloses that applications of some organophosphate insecticides at planting can reduce cotton injury following applications of the soil-applied herbicide clomazone.
There are many combinations of herbicides known in the art for the control of weeds further comprising an insecticides used as a safener. For example, US9629366B2 relates to a herbicidal composition which comprises pyroxasulfone along with any one or more of glyphosate, glufosinate, or their salts. The herbicidal composition futher discloses composition comprising one or more of an ALS inhibitor, a PPO inhibitor, an auxine, an HPPD inhibitor, a PDS inhibitor, a PSII inhibitor, a microtublin inhibitor or a VLCFA inhibitors.
US20180368400A1 relates to a synergistic herbicidal composition and a method of controlling the growth of undesirable plants. A synergistic herbicidal composition comprising Pyroxasulfone, Topramezone and Atrazine as the active components, wherein the weight ratio of Pyroxasulfone, Topramezone and Atrazine ranges from 1 to 10:1 to 10:1 to 100, is provided. Use of the synergistic herbicidal composition for controlling the growth of undesirable plants is also provided. A method of controlling the growth of undesirable plants, which comprises applying the active components Pyroxasulfone, Topramezone and Atrazine of the synergistic herbicidal composition to the undesirable plants or their growing locus or separately is also provided.
AU2010334815B2 to nucleic acid sequences encoding a hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, abbreviated herein as HPPD) obtained from bacteria belonging to the genus Kordia, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to HPPD inhibitor herbicides. The patent further claims herbicides Topramezone, Bicyclopyrone along with other group of herbicides.
There is however a need for improvement of these combinations. Further there is a need of a safener in the herbicidal composition which will reduce the unwanted phytotoxic effect on crops treated with the herbicides. An insecticide plays a significant role in development of crop and reduces the phytotoxic effect. Single active combinations used over a long period of time have resulted in resistance. With the onset of resistance to certain weeds, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of controlling grassy, broad leaf weeds and sedges with pre-emergence and post-emergence application.
Even though use of insecticide as safener to herbicide is known, the present invention provides an alternative composition for safening crops to the phytotoxic effects of herbicides in agriculture which will act as useful agronomic tool to farmers.
However still there is a need of herbicidal composition comprises of a herbicide Topramezone; a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof, which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the herbicidal actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target weed. However, most active herbicidal compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating herbicidal compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved herbicidal combination for weeds control in pre and post emergence conditions along with an insecticide acting as a safener in the herbicidal composition which will reduce the unwanted phytotoxic effect on crops treated with the herbicides. Another object of the present invention is to provide a method and a composition for controlling weeds in pre and post emergence conditions.
Yet another object of the present invention is to provide improved combinations of improved broadleaf and grassy weed control without adversely affecting desirable plants and reducing the unwanted effect by using an insecticide(s) as a safener.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
Inventors of the present invention have surprisingly found that the novel synergistic herbicidal composition of a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof as described herein which can provide solution to the above mentioned problems.
SUMMARY OF THE INVENTION
Therefore an aspect of the present invention provides composition comprises with herbicidal compound or mixture thereof along with insecticide as safener for reducing phytotoxicity in crops treated with a herbicide.
Another aspect of the present invention provides a synergistic herbicidal composition comprising an insecticide(s) selected from the class of diamide, metadiamide or isoxazoline used as safener for reducing phytotoxicity in crops treated with a herbicide.
Therefore an aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof.
Further aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof.
In present aspect of the invention to provide a synergistic herbicidal composition comprising an insecticide selected from the class of diamide, metadiamide or isoxazoline as a safener in composition for reducing phytotoxicity in crops treated with a herbicide present in the present herbicidal composition.
In further aspect of the present invention provides a synergistic herbicidal composition comprising an insecticide(s) as a safener to promote speedy recovery of the crop or plant from herbicidal injury. Thus accordingly reduces the stress due to abiotic factors and thus promotes overall plant or crop health and there by plant or crop yield.
Accordingly, in a further aspect, the present invention to provide a combination and a method of controlling pre-emergence and post-emergence weeds and provide a herbicidal combination for improved broadleaf and grassy weed control without adversely affecting desirable plants by reducing phytotoxicity in crops treated with a herbicide present in the present herbicidal composition.
Yet another aspect, the present invention provides to provide a herbicidal combination which reduces the amount of chemical herbicidal agent necessary to obtain the acceptable weed control.
Accordingly, the present invention relates to method which provides a broader spectrum of controlling weeds that helps in resistance management, thus preventing the weed from becoming resistant to either of the herbicides while providing a broader spectrum of control at lower use rates.
As per one embodiment formulation for the herbicidal composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR); and and one or more customary formulation adjuvants such as a) dispersant, b) wetting agent, c) anti-foaming agent, d) biocides, e) anti-freezing agent, f) suspending agent, g) thickener, h) coating agent and i) buffering agent.
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.
Accordingly, in a first aspect, the present invention provides a synergistic herbicidal compositions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof and one or more customary formulation adjuvants; shows synergistic activity.
DETAILED DESCRIPTION OF THE INVENTION:
The term "synergistic", as used herein, refers the combined action of two or more active
agents blended together and administered conjointly that is greater than the sum of their
individual effects.
"Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
For the purposes of the present invention, an insecticide(s) insecticide selected from the class of diamide, metadiamide or isoxazoline or mixture thereof is used as a ‘safener’ and the term ‘safener’ in present context is defined as substances which reduce or prevent the phytotoxic effect of crop protectants specifically herbicide, on plants treated therewith and/or on plants whose seeds and/or growth substrate have been treated or are treated therewith.
The term ‘herbicide’ is used herein to mean an active ingredient that kills, controls or otherwise adversely modifies the growth of unwanted plants. An herbicidally effective or vegetation controlling amount is an amount of active ingredient which causes an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation, and the like.
The term “phytotoxicity” as used herein means unintended herbicidal effect on a plant of interest resulting in significant damage to the plant. In an embodiment the present invention relates to use of a pyrethroid insecticide for reducing phytotoxicity in crops treated with a herbicide.
Therefore an aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof.
Further aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof.
In an embodiment of the present invention herbicide of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Sulfonylurea group is selected from chlorimuron ethyl, flazasulfuron, halosulfuron methyl, metsulfuron mehtyl, nicosufulfuron, primisulfuron methyl, pyrazosulfuron ehtyl, rimsulfuron, thifensulfuron-methyl, tribenuron methyl.
In an embodiment of the present invention herbicide from Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Pyrimidinyl(thio)benzoate group is pyrithiobac sodium; from Triazolopyrimidine group selected from diclosulam, florasulam, flumetsulam,
In an embodiment of the present invention herbicide from Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor of Sulfonylaminocarbonyl group is selected from thiencarbazone-methyl; from Imidazolinone group such as imazamox, imazapic, imazapyr, imazaquin, imazethapyr; from Sulfonanilides group is triafamone.
In an embodiment of the present invention herbicide from Synthetic Auxin of Phenoxy carboxylic acid group is selected from 2,4-D, MCPA, MCPB; of Pyridine carboxylic acid group is selected from aminopyralid, clopyralid, florpyrauxifen benzyl, fluroxypyr, picloram, triclopyr; of Benzoic acid group is dicamba; of Quinoline carboxylic acid group is quinclorac; and halauxifen methyl.
In an embodiment of the present invention herbicide from Inhibitor of photosynthesis at photosystem II site A of Triazine group is selected from ametryn, atrazine, simazine; of Triazinone group is selected from hexazinone, metamitron, metribuzin.
In an embodiment of the present invention herbicide from Inhibitor of photosynthesis at photosystem II site B of Benzothiadiazinone group is bentazone; of Nitrile group is selected from bromoxynil, ioxynil; of Phenyl-pyridazine group is pyridate.
In an embodiment of the present invention herbicide from Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase) of Isoxazolidinone group is clomazone.
In an embodiment of the present invention herbicide from Inhibitor of protoporphyrinogen oxidase (Protox, PPO) of Dipheylether group is selected from aclifluorfen, bifenox, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; of Triazolinone group is selected from azafenidin, carfentrazone-ethyl, flufenpyr-ethyl, sulfentrazone; of Pyrimidinedione group is selected from butafenacil, saflufenacil; of N-phenylphthalimide group is selected from flumiclorac, flumioxazin; of N-Phenyl-imide group is trifludimoxazin; of Thiadiazole group is fluthiacet-methyl; of Oxadiazole group is selected from oxadiargyl, oxadiazon; of Phenylpyrazole group is pyraflufen-ethyl, of other group is pyraclonil; of Uracil group is tiafenacil; of Pyrazole group is cyclopyranil.
In an embodiment of the present invention herbicide from Mitosis Inhibitor of Chloroacetamide group is selected from acetochlor, alachlor, butachlor, dimethenamid, metazachlor, pretilachlor, propachlor, S-metolachlor; of Tetrazolinone group is fentrazamide; of Oxyacetamide group is selected from flufenacet, mefenacet; of Acetamide group is napropamide; of Carbamate group is carbetamide.
In an embodiment of the present invention herbicide from Inhibitor of 7,8-dihydro-preroate synthetase (DHP) of Carbamate group is asulam.
In an embodiment of the present invention herbicide from Inhibitor of indoleacetic acid transport of Phthalamate semicarbazone group is selected from diflufenzopyr, naptalam.
In an embodiment of the present invention herbicide from Inhibitor of cell wall synthesis site C of Alkylazines group is selected from indaziflam, triaziflam.
In an embodiment of the present invention herbicide from Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD) of Pyrazole group is selected from benzofenap, pyrasulfotole, pyrazolynate, pyrazoxyfen, tolpyralate; of Benzoylbicyclooctanedione group is benzobicyclon; Triketone group is selected from mesotrione, tembotrione, sulcotrione, tefuryltrione, fenquinotrione, lancotrione sodium; of Isoxazoles group is selected from isoxaflutole; bicyclo ring compound group is bicyclopyrone.
In an embodiment of the present invention herbicide from Inhibitors of dihydroorotate dehydrogenase (DHODH) is tetflupyrolimet.
In an embodiment of the present invention herbicide from HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD is cyclopyrimorate.
In an embodiment of the present invention herbicide from VLCAFE inhibitors of Isoxazoline group is pyroxasulfone, of Triazolinone group is ipfencarbazone, of Trifluoromethansulfonanilides group is dimesulfazet, and other compounds such as fenoxasulfone.
In an embodiment of the present invention herbicide from Inhibitors of Solanesyl Diphosphate Synthase (SDS) is aclonifen.
In an embodiment of the present invention herbicide with unknown mode of action is selected from diphenamid, naproanilide, napropamide, cacodylic acid, cloquintocet mexyl, epyrifenacil, bixzolone.
In an embodiment of the present invention an insecticide for reducing phytotoxicity in crops treated with a herbicides of diamides class is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor; of class of metadiamides is broflanilide; of class of isoxazolines is selected from fluxametamide, isocycloseram.
I. Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor:
Halosulfuron methyl is a herbicide used on maize, sugarcane and rice. It has IUPAC name as methyl-3-chloro-5-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-1-methyl pyrazole-4-carboxylate.
Pyrazosulfuron-ethyl is a member of pyrazoles. It has IUPAC name as ethyl 5-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-1-methylpyrazole-4-carboxylate.
Imazipic is 5-methyl-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylic acid is a pyridinemonocarboxylic acid that is 5-methylpyridine-3-carboxylic acid which is substituted at position 2 by a 4,5-dihydro-imidazol-2-yl group, which in turn is substituted at positions 4, 4, and 5 by isopropyl, methyl, and oxo groups, respectively. It is a pyridinemonocarboxylic acid, an imidazolone, a member of imidazolines and a member of methylpyridines. It has IUPAC name as 5-methyl-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid. classified as imidazolinone (IMI) herbicides and their mode of action is to inhibit acetohydroxyacid synthase (AHAS), an enzyme involved in the biosynthesis of the amino acids leucine, isoleucine and valine.
II. Synthetic Auxin:
Phenoxy carboxylic acid: 2, 4-D is a member of the phenoxy family of herbicides, which include:; 2, 4-D is a synthetic auxin, which is a class of plant hormones. It is absorbed through the leaves and is translocated to the meristems of the plant. Uncontrolled, unsustainable growth ensues, causing stem curl-over, leaf withering, and eventual plant death. 2, 4-D is typically applied as an amine salt, but more potent ester versions exist as well. 2, 4-Dichlorophenoxyacetic acid (usually referred to by its abbreviation, 2, 4-D) is a common systemic pesticide/herbicide used in the control of broadleaf weeds. It is one of the most widely used herbicide in the world, and the third most commonly used in North America. 2, 4-D is a synthetic auxin (plant hormone), and as such it is often used in laboratories for plant research and as a supplement in plant cell culture media such as MS medium. It was a major ingredient in Agent Orange alongside its chemically similar relative, 2, 4, 5-T (2, 4, 5-trichlorophenoxyacetic acid).
Halauxifen methyl is a methyl ester resulting from the formal condensation of the carboxy group of halauxifen with methanol. It is a proherbicide used for the control of broad-leaved weeds in cereals and oilseed rape. It has a role as a synthetic auxin and a proherbicide. It is a member of monofluorobenzenes, a member of monochlorobenzenes, a monomethoxybenzene, an aminopyridine, a methyl ester, a chloropyridine and a biaryl. It derives from a halauxifen. It has IUPAC name as methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate.
III. Inhibitor of photosynthesis at photosystem II site A:
Atrazine is an herbicide that does not occur naturally. Pure atrazine is an odorless, white powder that is not very volatile, reactive, or flammable and that will dissolve in water. Atrazine is used to kill weeds, primarily on farms, but has also been used on highway and railroad rights-of-way. The EPA now restricts how atrazine can be used and applied; only trained people are allowed to spray it.
Ametryn is a methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by an ethylamino and an isopropylamino group at positions 4 and 6 respectively. It has a role as a herbicide and an environmental contaminant. It is a diamino-1,3,5-triazine and a methylthio-1,3,5-triazine. It has an IUPAC name as 4-N-ethyl-6-methylsulfanyl-2-N-propan-2-yl-1,3,5-triazine-2,4-diamine. Ametryn inhibits photosynthesis and other enzymatic processes. It is a selective systemic herbicide, absorbed by the leaves and roots, with translocation acropetally in the xylem, and accumulation in the apical meristems.
Metribuzin is a member of the class of 1,2,4-triazines that is 1,2,4-triazin-5(4H)-one substituted by an amino group at position 4, tert-butyl group at position 6 and a methylsulfanyl group at position 3. It has a role as a xenobiotic, an environmental contaminant, a herbicide and an agrochemical. It is a member of 1,2,4-triazines, an organic sulfide and a cyclic ketone. It has an IUPAC name as 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one. It acts as a photosynthesis inhibitor.
IV. Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD):
Tolpyralate is 1-({1-ethyl-4-[3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl) benzoyl]-1H-pyrazol-5-yl}oxy)ethyl methyl carbonate, that is 1H-pyrazole substituted by an ethyl, 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl, and 1-[(methoxycarbonyl) oxy] ethoxy groups at positions 1, 4 and 5, respectively. It is an aromatic ether, a benzoylpyrazole, a carbonate ester, a member of toluenes, an aromatic ketone and a sulfone.
Mesotrione is an aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group. It has a role as a herbicide, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a xenobiotic, an environmental contaminant and a carotenoid biosynthesis inhibitor. It is a sulfone, a C-nitro compound, an aromatic ketone and a beta-triketone. It derives from a benzophenone. It has IUPAC name as 2-(4-methylsulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione. Mechanistic studies show that the toxic effects of /mesotrione/ are largely attributable to increased plasma tyrosine levels following 4-hydroxyphenyl pyruvate dioxygenase (HPPD) inhibition. Tyrosine levels are increased to a greater extent in rats (particularly males) due to differences in the activity of enzymes in the tyrosine catabolic pathway.
Tembotrione is an aromatic ketone that is 2-benzoylcyclohexane-1,3-dione in which the phenyl group is substituted at positions 2, 3, and 4 by chlorine, (2,2,2-trifluoroethoxy)methyl, and methylsulfonyl groups, respectively. It is a post-emergence herbicide used (particularly in conjunction with the herbicide safener cyprosulfamide) for the control of a wide range of broad-leaved and grassy weeds in corn and other crops. It has a role as a herbicide, an agrochemical, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor and a carotenoid biosynthesis inhibitor. It is a sulfone, a cyclic ketone, an aromatic ketone, a member of monochlorobenzenes, an organofluorine compound, an ether and a beta-triketone. It has IUPAC name as 2-[2-chloro-4-methylsulfonyl-3-(2,2,2-trifluoroethoxymethyl)benzoyl]cyclohexane-1,3-dione. Tembotrione is a broad-spectrum early and mid-postemergence herbicide that belongs to the triketone class of herbicides. It acts by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), which leads to chlorophyll destruction by photooxidation and causes bleaching of emerging foliar tissue. In mammals, HPPD is a key enzyme in the catabolism of tyrosine. It catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) to homogentisate. Inhibition of HPPD leads to a reconversion of HPP to tyrosine and a consequent increase in blood tyrosine concentrations (tyrosinemia).
Isoxaflutole is a member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane. It has a role as an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a proherbicide and an agrochemical. It is a member of cyclopropanes, a member of isoxazoles, an aromatic ketone, a member of (trifluoromethyl)benzenes and a sulfone. It has IUPAC name as (5-cyclopropyl-1,2-oxazol-4-yl)-[2-methylsulfonyl-4-(trifluoromethyl) phenyl]methanone.
V. VLCAFE inhibitors:
Pyroxasulfone is a Isoxazoline group of VLCFA inhibitors. It has IUPAC name as 3-[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl) pyrazol-4-yl]methylsulfonyl]-5,5-di methyl -4H-1,2-oxazole.
VI. Insecticides from the class of diamides:
Chlorantraniliprole is a carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes. It has a role as a ryanodine receptor agonist. It is an organobromine compound, a member of pyridines, a member of pyrazoles, a pyrazole insecticide, a member of monochlorobenzenes and a secondary carboxamide. It has an IUPAC name as 5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carb oxamide.
Cyantraniliprole is a carboxamide that is chlorantraniliprole in which the chlorine atom attached to the phenyl ring has been replaced by a cyano group. A ryanodine receptor agonist, it is used as insecticide for the control of whitefly, thrips, aphids, fruitflies, and fruit worms in crops such as onions, potatoes and tomatoes. It is highly toxic to honeybees. It has a role as a ryanodine receptor agonist. It is a pyrazole insecticide, a nitrile, an organochlorine compound, an organobromine compound, a member of pyridines and a secondary carboxamide. It has an IUPAC name as 5-bromo-2-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]pyrazole-3-carboxamide.
Tetraniliprole is a carboxamide that is cyantraniliprole in which the bromine atom has been replaced by a [5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl group. It has a role as a ryanodine receptor agonist. It is a nitrile, an organochlorine compound, a pyrazole insecticide, a member of pyridines, a member of tetrazoles, an organofluorine compound and a secondary carboxamide. It has 2-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-5-[[5-(trifluoro methyl)tetrazol-2-yl]methyl]pyrazole-3-carboxamide.
VII. Insecticides from the class of metadiamides:
Broflanilide is a benzamide obtained by formal condensation of the carboxy group of 3-[benzoyl(methyl)amino]-2-fluorobenzoic acid with the amino group of 2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)aniline. An insecticide that exhibits high larvicidal activity against Spodoptera litura and is effective against pests with resistance to cyclodienes and fipronil It has a role as an agrochemical and a GABA antagonist. It is a member of benzamides, a member of monofluorobenzenes, an organofluorine insecticide, a member of bromobenzenes and a member of (trifluoromethyl)benzenes. It has an IUPAC name as 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluoro benz amide.
VIII. Insecticide from the class of Isoxazolines:
Isocycloseram is a member of the isoxazoline class of insecticides.It has an IUPAC name as 4-[(5RS)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl]-N-[(4RS)-2-ethyl-3-oxoisoxazolidin-4-yl]-o-toluamide. Isocycloseram acts as a non-competitive GABA-gated chloride channel antagonist at a site different from known antagonists such as fiproles and cyclodienes.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of weed control and hence has surprisingly improved plant vigour and yield. The broad spectrum of the present combination of controlling weeds that also provides a solution for in resistance management, thus preventing the weed from becoming resistant to either of the herbicides while providing a broader spectrum of control at lower use rates.
The synergistic composition has very advantageous curative, preventive herbicidal properties for protecting cultivated plants. As has been mentioned, said active ingredient composition can be used to inhibit or destroy and effective management of the controlling pre-emergence and post-emergence weeds. The synergistic composition comprising herbicidal compounds for management and control of broad-leaved weeds and grasses in crops of useful plants.
The present synergistic herbicidal composition further comprises of an insecticide(s), play a very crucial role in protection of plant or crops of interest. An insecticide(s) in present composition reduces the phytotoxicity in crops treated with herbicides and promotes speedy recovery of the crop or plant from herbicidal injury. Thus accordingly reduces the stress due to abiotic factors and thus promotes overall plant or crop health and there by plant or crop yield.
Therefor the aspect of the present invention provides the herbicidal compositions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof; are present in most preferred combinations as below:
Compound A Compound B Herbicide(s) Compound C An Insecticide from the class of diamide, metadiamide, isoxazoline as safener
Topramezone - Chlorantraniliprole
Topramezone - Cyantraniliprole
Topramezone - Cyclaniliprole
Topramezone - Cyhalodiamide
Topramezone - Cyproflanilide
Topramezone - Flubendiamide
Topramezone - Tetraniliprole
Topramezone - Tetrachlorantraniliprole
Topramezone - Tyclopyrazoflor
Topramezone - Broflanilide
Topramezone - Fluxametamide
Topramezone - Isocycloseram
Topramezone Halosulfuron methyl Chlorantraniliprole
Topramezone Pyrazosulfuron ethyl Chlorantraniliprole
Topramezone Nicosulfuron Chlorantraniliprole
Topramezone Rimsulfuron Chlorantraniliprole
Topramezone 2,4-D Chlorantraniliprole
Topramezone Clopyralid Chlorantraniliprole
Topramezone Fluroxypyr Chlorantraniliprole
Topramezone Halauxifen methyl Chlorantraniliprole
Topramezone Atrazine Chlorantraniliprole
Topramezone Metribuzin Chlorantraniliprole
Topramezone Clomazone Chlorantraniliprole
Topramezone Carfentrazone ethyl Chlorantraniliprole
Topramezone S-metolachlor Chlorantraniliprole
Topramezone Tolpyralate Chlorantraniliprole
Topramezone Mesotrione Chlorantraniliprole
Topramezone Tembotrione Chlorantraniliprole
Topramezone Sulcotrione Chlorantraniliprole
Topramezone Isoxaflutole Chlorantraniliprole
Topramezone Bicyclopyrone Chlorantraniliprole
Topramezone Pyroxasulfone Chlorantraniliprole
Topramezone Halosulfuron methyl Cyantraniliprole
Topramezone Pyrazosulfuron ethyl Cyantraniliprole
Topramezone Nicosulfuron Cyantraniliprole
Topramezone Rimsulfuron Cyantraniliprole
Topramezone 2,4-D Cyantraniliprole
Topramezone Clopyralid Cyantraniliprole
Topramezone Fluroxypyr Cyantraniliprole
Topramezone Halauxifen methyl Cyantraniliprole
Topramezone Atrazine Cyantraniliprole
Topramezone Metribuzin Cyantraniliprole
Topramezone Clomazone Cyantraniliprole
Topramezone Carfentrazone ethyl Cyantraniliprole
Topramezone S-metolachlor Cyantraniliprole
Topramezone Tolpyralate Cyantraniliprole
Topramezone Mesotrione Cyantraniliprole
Topramezone Tembotrione Cyantraniliprole
Topramezone Sulcotrione Cyantraniliprole
Topramezone Isoxaflutole Cyantraniliprole
Topramezone Bicyclopyrone Cyantraniliprole
Topramezone Pyroxasulfone Cyantraniliprole
Topramezone Halosulfuron methyl Tetraniliprole
Topramezone Pyrazosulfuron ethyl Tetraniliprole
Topramezone Nicosulfuron Tetraniliprole
Topramezone Rimsulfuron Tetraniliprole
Topramezone 2,4-D Tetraniliprole
Topramezone Clopyralid Tetraniliprole
Topramezone Fluroxypyr Tetraniliprole
Topramezone Halauxifen methyl Tetraniliprole
Topramezone Atrazine Tetraniliprole
Topramezone Metribuzin Tetraniliprole
Topramezone Clomazone Tetraniliprole
Topramezone Carfentrazone ethyl Tetraniliprole
Topramezone S-metolachlor Tetraniliprole
Topramezone Tolpyralate Tetraniliprole
Topramezone Mesotrione Tetraniliprole
Topramezone Tembotrione Tetraniliprole
Topramezone Sulcotrione Tetraniliprole
Topramezone Isoxaflutole Tetraniliprole
Topramezone Bicyclopyrone Tetraniliprole
Topramezone Pyroxasulfone Tetraniliprole
Topramezone Halosulfuron methyl Cyclaniliprole
Topramezone Pyrazosulfuron ethyl Cyclaniliprole
Topramezone Nicosulfuron Cyclaniliprole
Topramezone Rimsulfuron Cyclaniliprole
Topramezone 2,4-D Cyclaniliprole
Topramezone Clopyralid Cyclaniliprole
Topramezone Fluroxypyr Cyclaniliprole
Topramezone Halauxifen methyl Cyclaniliprole
Topramezone Atrazine Cyclaniliprole
Topramezone Metribuzin Cyclaniliprole
Topramezone Clomazone Cyclaniliprole
Topramezone Carfentrazone ethyl Cyclaniliprole
Topramezone S-metolachlor Cyclaniliprole
Topramezone Tolpyralate Cyclaniliprole
Topramezone Mesotrione Cyclaniliprole
Topramezone Tembotrione Cyclaniliprole
Topramezone Sulcotrione Cyclaniliprole
Topramezone Isoxaflutole Cyclaniliprole
Topramezone Bicyclopyrone Cyclaniliprole
Topramezone Pyroxasulfone Cyclaniliprole
Topramezone Halosulfuron methyl Broflanilide
Topramezone Pyrazosulfuron ethyl Broflanilide
Topramezone Nicosulfuron Broflanilide
Topramezone Rimsulfuron Broflanilide
Topramezone 2,4-D Broflanilide
Topramezone Clopyralid Broflanilide
Topramezone Fluroxypyr Broflanilide
Topramezone Halauxifen methyl Broflanilide
Topramezone Atrazine Broflanilide
Topramezone Metribuzin Broflanilide
Topramezone Clomazone Broflanilide
Topramezone Carfentrazone ethyl Broflanilide
Topramezone S-metolachlor Broflanilide
Topramezone Tolpyralate Broflanilide
Topramezone Mesotrione Broflanilide
Topramezone Tembotrione Broflanilide
Topramezone Sulcotrione Broflanilide
Topramezone Isoxaflutole Broflanilide
Topramezone Bicyclopyrone Broflanilide
Topramezone Pyroxasulfone Broflanilide
Topramezone Halosulfuron methyl Fluxametamide
Topramezone Pyrazosulfuron ethyl Fluxametamide
Topramezone Nicosulfuron Fluxametamide
Topramezone Rimsulfuron Fluxametamide
Topramezone 2,4-D Fluxametamide
Topramezone Clopyralid Fluxametamide
Topramezone Fluroxypyr Fluxametamide
Topramezone Halauxifen methyl Fluxametamide
Topramezone Atrazine Fluxametamide
Topramezone Metribuzin Fluxametamide
Topramezone Clomazone Fluxametamide
Topramezone Carfentrazone ethyl Fluxametamide
Topramezone S-metolachlor Fluxametamide
Topramezone Tolpyralate Fluxametamide
Topramezone Mesotrione Fluxametamide
Topramezone Tembotrione Fluxametamide
Topramezone Sulcotrione Fluxametamide
Topramezone Isoxaflutole Fluxametamide
Topramezone Bicyclopyrone Fluxametamide
Topramezone Pyroxasulfone Fluxametamide
Topramezone Halosulfuron methyl Isocycloseram
Topramezone Pyrazosulfuron ethyl Isocycloseram
Topramezone Nicosulfuron Isocycloseram
Topramezone Rimsulfuron Isocycloseram
Topramezone 2,4-D Isocycloseram
Topramezone Clopyralid Isocycloseram
Topramezone Fluroxypyr Isocycloseram
Topramezone Halauxifen methyl Isocycloseram
Topramezone Atrazine Isocycloseram
Topramezone Metribuzin Isocycloseram
Topramezone Clomazone Isocycloseram
Topramezone Carfentrazone ethyl Isocycloseram
Topramezone S-metolachlor Isocycloseram
Topramezone Tolpyralate Isocycloseram
Topramezone Mesotrione Isocycloseram
Topramezone Tembotrione Isocycloseram
Topramezone Sulcotrione Isocycloseram
Topramezone Isoxaflutole Isocycloseram
Topramezone Bicyclopyrone Isocycloseram
Topramezone Pyroxasulfone Isocycloseram
Topramezone Mesotrione+Atrazine Chlorantraniliprole
Topramezone Mesotrione+Tolpyralate Chlorantraniliprole
Topramezone Mesotrione+Pyroxasulfone Chlorantraniliprole
Topramezone Mesotrione+Halosulfuron methyl Chlorantraniliprole
Topramezone Mesotrione+Pyrazosulfuron ethyl Chlorantraniliprole
Topramezone Tembotrione+Atrazine Chlorantraniliprole
Topramezone Tembotrione+Tolpyralate Chlorantraniliprole
Topramezone Tembotrione+Pyroxasulfone Chlorantraniliprole
Topramezone Tembotrione+Halosulfuron methyl Chlorantraniliprole
Topramezone Tembotrione+Pyrazosulfuron ethyl Chlorantraniliprole
Topramezone Metribuzin+Pyroxasulfone Chlorantraniliprole
Topramezone Metribuzin+Halosulfuron methyl Chlorantraniliprole
Topramezone Metribuzin+Pyrazosulfuron ethyl Chlorantraniliprole
Topramezone Tolpyralate+Atrazine Chlorantraniliprole
Topramezone Tolpyralate+Metribuzin Chlorantraniliprole
Topramezone Tolpyralate+Halosulfuron methyl Chlorantraniliprole
Topramezone Tolpyralate+Pyrazosulfuron ethyl Chlorantraniliprole

The herbicidal herbicidal combination of the present invention maybe used to control the target weeds among the crops such as GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold (Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera (Gerbera jamesonii), Carnation (Dianthus caryophyllus).
The present invention of synergistic herbicidal combinations can be also used to control unwanted vegetation in plantation crops, orchards, fallow lands, water bodies, field bunds etc.
A herbicidal synergistic composition of present invention controls all kind of monocots, dicots and sedges weeds. The present synergistic herbicidal combinations also controls annual and perennial weeds. The most common weeds controlled by present inventions are Abutilon indicum, Acalypha indica, Acanthospermum hispidum, Achyranthes aspera, Aerva tomentosa, Ageratum conyzoides, Alhagi camelorum, Amaranthus hybridus, Amaranthus spinosus, Amaranthus viridis, Ammannia baccifera, Anagallis arvensis, Argemone mexicana, Artemisia nilagiricia, Asphodelus tenuifolius, Avena fatua, Avena ludoviciana, Bidens pilosa, Boerhaavia diffusa, Boerhavia repanda, Brachiaria mutica, Brassica kaber, Bromus tectorum, Calotropis gigantea, Cannabis sativa, Carthamus axyacantha, Cassia tora, Celosia argentea, Centella asiatica, Chenopodium album, Chenopodium murale, Chloris barbata, Chrozophora rottlerii, Cichorium intybus, Cirsium arvense, Clitoria ternatea, Cnicus arvensis, Commelina benghalensis, Commelina communis, Convolvulus arvensis, Conyza canadensis, Corchorus acutangulus, Coronopus didymus, Crotalaria serice, Cucumis callosus, Cuscuta campestris, Cuscuta chinensis, Cynodon dactylon, Cyanotis axillaris, Cyperus esculenthus, Cyperus iria, Cyperus rotundus, Dactyloctenium aegyptium, Datura stramonium, Daucus carota, Digera arvensis, Digitaria sanguinalis, Dinebra retroflexa, Echinochola colonum, Echinochola crusgalli, Eclipta alba, Eichhornia crassipes, Elephantopus scaber, Eleusine indica, Eragrostis major, Euphorbia geniculata, Euphorbia hirta, Fimbristylis miliacea, Fumaria indica, Gynandropsis gynandra, Heliotropium indicum, Indigofera glandulosa, Ipomea aquatica, Lantana camara, Lathyrus aphaca, Launaea asplenifolia, Launaea nudicaulis, Leucas aspera, Ludwigia parviflora, Marsilea quadrifoliata, Medicago denticulate, Mimosa pudica, Melilotus alba, Melilotus indica, Ocimum canum, Oenothera biennis, Opuntia dillenil, Orobanche ramosa, Oryza longistaminata, Oryza sativa, Oxalis corniculata, Oxalis latifolia, Parthenium hysterophorus, Paspalum sanguinale, Phalaris minor, Phyllanthus niruri, Physalis minima, Polypogon monspeliensis, Portulaca oleracea, Prosopis juliflora, Rumex dentatus, Saccharum spontaneum, Stearia glauca, Seteria viridis, Sida spinosa, Silene antirrhina, Sisymbrium irio, Solanum nigrum, Solanum surattense, Sonchus oleraceous, Sorghum halepense, Spergula arvensis, Sphenocleazeylanica Gaertn, Striga asiatica, Tagetes minuta, Trianthema monogyna, Trianthema portulacastrum, Tribulus terrestris, Trigonelia polycerata, Vernonia cinerea, Vicia sativa and Xanthium strumarium.
Formulation of the present invention can be in any of the formulations selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).
Further formulation for the present synergistic agrochemical composition comprises ‘crop safener’ for use especially in monocotyledonous crops (wheat, paddy/rice, corn/maize, sugarcane, sorghum, pearlmillet).
In an embodiment of the present invention any one of the crop safener for the monocotyledonous crops is selected from the cyprosulfamide, dietholate, isoxadifen / isoxadifen ethyl, dicyclonon, benoxacor, mefenpyr ethyl, fenchlorazole ethyl, cloquintocet / cloquintocet mexyl, oxabetrinil, naphthalic anhydride, mephenate, mefenpyr, furilazole, fluxofenim, flurazole, fenclorim, fenchlorazole, dichlormid, cyometrinil.
One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.
Further herbicidal composition comprising (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener for reducing phytotoxicity in crops treated with a herbicide or mixture thereof; are present in the said composition in specific fixed ratio.
In further aspect the present invention relates to the synergistic herbicidal composition comprising bioactive amounts of (A) is 0.1 to 50% w/w of the composition; (B) is 0.001 to 50% w/w of the composition; and (C) is 0.01 to 20% w/w of the composition.
Active Ingredients Compound A Compound
B Compound
C

Examples
Topramezone
One or more herbicide(s) Insecticide
as safener from the class of diamide, metadiamide or isoxazolines
% of Active Ingredient (w/w, w/v)
0.1 to 50%
0.001 to 50%
0.01 to 20%

The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, antimicrobial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.
A dispersant is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Examples of dispersing agents used in Wettable Granule formulation include, but are not limited to alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt.
Examples of dispersing agents used in Suspension Concentrate formulation include, but are not limited to Naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide; acrylic graft copolymer, ethoxylated tridecyl and/ or isotridecyl alcohol; Block copolymer of polyhydroxystearic acid and polyalkylene glycols.
Examples of dispersing agents used in Oil Dispersion formulation include, but are not limited toalkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, block copolymer of polyhydroxystearic acid and polyalkylene glycols, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.
Anti-freezing agent as used herein suspension concentrate and oil dispersion formulation can be selected from the group consisting of ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), propylene glycol, glycerin, urea, magnesium sulfate heptahydrate, sodium chloride etc.
Examples of wetting-spreading-penetrating agents used in Wettable Granule formulation include, but are not limited to, sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of wetting-spreading-penetrating agents used in Suspension Concentrate formulation include, but are not limited to, trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of wetting-spreading-penetrating agents used in Oil Dispersion formulation include, but are not limited to, Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Emulsifying agent used in oil dispersion formulation is selected from Tristrylphenol with 16 moles EO, castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, polyoxyethylene sorbitan monolaurate etc.
Disintegrating agents as used herein wettable granule formulation include, but are not limited to, citric acid, succinic acid or the sodium bicarbonate, Sodium sulphate anhydrous.
Suspending agent used in oil dispersion formulation include Bentonite clay.
Examples of antifoaming agents used in wettable granule, suspension concentrate, and oil dispersion formulations include, but are not limited to: silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane etc.
Biocides / Microorganisms cause spoilage of formulated products. Therefore antimicrobial agents are used to eliminate or reduce their effect. Examples of such agents used in suspension concentrate and oil dispersion formulations include, but are not limited to: 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
Examples of thickners used in suspension concentrate and oil dispersion formulations include, but are not limited to: xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, Silicon dioxide.
Adjuvant used in suspension concentrate formulation is Methylated seed oil.
Carriers as used herein wettable granule formulation include, but are not limited to, china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.
These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.
EXAMPLE 1:
WG (Wettable Granule) Formulation of Topramezone 10%+Halosulfuron methyl 30%+Chlorantraniliprole 30%
Chemical composition % (w/w)
Topramezone a.i. Active ingredient 10.00
Halosulfuron methyl a.i. Active ingredient 30.00
Chlorantraniliprole a.i. Active ingredient 30.00
Trisiloxane heptamethyl Wetting-spreading-penetrating agent 5.00
Alkylnaphthalene sulfonate sodium salt Dispersing agent 1 4.00
Sodium Polycarboxylate Dispersing agent 2 8.00
Sodium sulphate anhydrous Disintegrating agent 5.00
Polydimethyl siloxane Antifoaming agent 0.50
Corn starch Carrier 7.50
Total 100.00

Procedure: Manufacturing process of WG (Wettable Granule) Formulation
Preparation of WG (Wettable Granule) formulation:
Step 1 Before starting the process, check the cleanliness of all equipment’s in plant and get approval by QC dept.
Step 2 Check the electrical connection and standardize the weighing balance.
Step 3 Take exact weight of active ingredients (technical) in blender and then add required quantity of binder & surfactants and mix it till its complete homogenization.
Step 4 Mill this homogenized Mixture till required wet sieve and post blend again for homogeneity.
Step 5 Pass the above homogenous material through Extruder for granulation.
Step 6 Now transfer the granules through Fluid Bed Dryer to remove excess moisture.
Step 7 Transfer these granules to vibro shifter.
Step 8 Collect the final material from the vibro shifter into drum.
Step 9 Finally send the sample to QC for approval.
Step 10 After approval by QC, transfer the material into different size of drums.

Storage stability- Topramezone 10%+Halosulfuron methyl 30%+Chlorantraniliprole 30% WG
Storage stability study in laboratory (at 54±2 0C & At 0±2 0C for 14 days) and at room temperature (for 12 months) shows that Topramezone 10%+Halosulfuron methyl 30%+Chlorantraniliprole 30% WG formulation complies all the in-house parameters like active ingredients content, suspensibility, wettability, wet sieve percent by mass, pH range and moisture content.
Following table provides more examples of combinations and formulation of Wettable Granule prepared as per EXAMPLE 1.
Compound A (%) Compound B (%) Compound C (%) Formulation Strength (%)
EXAMPLE 2 Topramezone 10% Halosulfuron methyl 30% Chlorantraniliprole 30% 70.00
EXAMPLE 3 Topramezone 10% Pyrazosulfuron ethyl 30% Chlorantraniliprole 30% 70.00
EXAMPLE 4 Topramezone 10% Nicosulfuron 20% Chlorantraniliprole 12% 42.00
EXAMPLE 5 Topramezone 10% Isoxaflutole 40% Chlorantraniliprole 12% 62.00
EXAMPLE 6 Topramezone 10% Halosulfuron methyl 30% Cyantraniliprole 20% 60.00
EXAMPLE 7 Topramezone 10% Pyrazosulfuron ethyl 30% Cyantraniliprole 20% 60.00
EXAMPLE 8 Topramezone 10% Nicosulfuron 20% Cyantraniliprole 20% 50.00
EXAMPLE 9 Topramezone 10% Isoxaflutole 40% Cyantraniliprole 20% 70.00
EXAMPLE 10 Topramezone 2.5% Atrazine 70% Cyantraniliprole 5% 77.50
EXAMPLE 11 Topramezone 2.5% Metribuzin 70% Cyantraniliprole 5% 77.50
EXAMPLE 12 Topramezone 10% Nicosulfuron 20% Broflanilide 4% 34.00
EXAMPLE 13 Topramezone 10% Isoxaflutole 40% Broflanilide 4% 54.00
EXAMPLE 14 Topramezone 2.5% Atrazine 70% Broflanilide 5% 77.50
EXAMPLE 15 Topramezone 2.5% Metribuzin 70% Broflanilide 5% 77.50

EXAMPLE 16:
SC (Suspension concentrate) Formulation of Topramezone 0.7%+Atrazine 20%+Chlorantraniliprole 2.13%
Chemical composition % (w/w)
Topramezone a.i. Active ingredient 0.70
Atrazine a.i. Active ingredient 20.00
Chlorantraniliprole a.i. Active ingredient 2.13
Trisiloxane ethoxylate Wetting-spreading-penetrating agent 5.00
Acrylic graft copolymer Dispersing agent 1 4.50
Ethoxylated tridecyl and/ or isotridecyl alcohol Dispersing agent 2 1.50
Attapulgite clay Suspending agent 0.50
Polydimethyl siloxane Antifoaming agent 0.20
1,2-benzisothazol-3-one Preservative 0.15
Polypropylene glycol Antifreezing agent 5.00
Xanthan gum Thickner 0.20
Water Diluent Water 60.12
Total 100.00

Procedure: Manufacturing process of SC (Suspension concentrate) Formulation
Preparation of SC (Suspension concentrate) formulation:
Step 1 2% Gel Preparation: Charge the required quantity of water to a vessel, equipped with a high shear stirrer and start the agitation. Add the required amount of preservative. Mix until homogenous. Add the required amount of thickener and mix vigorously until it is fully wetted.
Step 2 Charge the required quantity of water to a vessel, equipped with bulk agitator and a high shear homogenizer and start agitation. Add the required amount of ant freezing agent and mix until uniform. Add the antifoaming agent and ensure that it is well dispersed. Add the wetting and dispersing agent and mix until uniform. Ensure that the dispersing agent is fully dispersed.
Step 3 Now add the active ingredient and continue agitating the vessel contents until all components get dissolved. Mill this pre-mix through a Colloid mill and subsequently through a Dyno mill to meet the specified particle size.
Step 4 Now add remaining antifoaming agent to this SC mill base to a vessel, equipped with bulk agitator. Mix until uniform. Add the required amount of 2% aqueous pre-gel and suspending agent and continue agitation until the formulation is homogeneous and has the target viscosity is reached.
Step 5 Final product is sent for QC approval.
Step 6 After approval, material is packed in required pack sizes.

Storage Stability- Topramezone 0.7%+Atrazine 20%+Chlorantraniliprole 2.13% SC
Storage stability study in laboratory (at 54±2 C & At 0±2 C temp. for 14 days) and at room temperature (for 12 months) shows that Topramezone 0.7%+Atrazine 20%+Chlorantraniliprole 2.13% SC (Suspo emulsion) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming.
EXAMPLE 17:
SC (Suspension concentrate) Formulation of Topramezone 2.5%+Tolpyralate 5%+Chlorantraniliprole 7.5%
Chemical composition % (w/w)
Topramezone a.i. Active ingredient 2.50
Tolpyralate a.i. Active ingredient 5.00
Chlorantraniliprole a.i. Active ingredient 7.50
Trisiloxane ethoxylate Wetting-spreading-penetrating agent 5.00
Tristrylphenol with 16 moles EO Dispersing agent 1 10.00
Block copolymer of polyhydroxystearic acid and polyalkylene glycols Dispersing agent 2 5.00
Methylated seed oil Adjuvant 15.00
Polydimethyl siloxane Antifoaming agent 0.30
2-bromo-2-nitropropane-1,3-diol Preservative 0.25
Propylene glycol Antifreezing agent 5.00
Silicon dioxide Thickner 2.50
Water Diluent Water 41.95
Total 100.00

Procedure: Manufacturing process of SC (Suspension concentrate) Formulation
Procedure remains same as that in EXAMPLE 2.
Storage Stability- Topramezone 2.5%+Tolpyralate 5%+Chlorantraniliprole 7.5% SC
Storage stability study in laboratory (at 54±2 C & At 0±2 C temp. for 14 days) and at room temperature (for 12 months) shows that Topramezone 2.5%+Tolpyralate 5%+Chlorantraniliprole 7.5% SC (Suspo emulsion) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming.
Following table provides more examples of combinations and formulation of Suspension Concentrate prepared as per EXAMPLE 17.
Compound A (%) Compound B (%) Compound C (%) Formulation Strength (%)
EXAMPLE 18 Topramezone 2.5% Tolpyralate 5% Chlorantraniliprole 7.5% 15.00
EXAMPLE 19 Topramezone 2.5% Mesotrione 8% Chlorantraniliprole 7.5% 18.00
EXAMPLE 20 Topramezone 2.5% Tembotrione 8% Chlorantraniliprole 7.5% 18.00
EXAMPLE 21 Topramezone 0.7% Atrazine 20% Chlorantraniliprole 2.13% 22.83
EXAMPLE 22 Topramezone 0.7% Metribuzin 20% Chlorantraniliprole 2.13% 22.83

EXAMPLE 23:
OD (Oil Dispersion) Formulation of Topramezone 2.5%+Mesotrione 8%+Cyantraniliprole 5%
Chemical composition % (w/w)
Topramezone a.i. Active ingredient 2.50
Mesotrione a.i. Active ingredient 8.00
Cyantraniliprole a.i. Active ingredient 5.00
Trisiloxane ethoxylate Wetting-spreading-penetrating agent 5.00
Tristrylphenol with 16 moles EO Emulsifying agent 10.00
Block copolymer of polyhydroxystearic acid and polyalkylene glycols Dispersing agent
10.00
Bentonite clay Suspending agent 1.00
Polydimethyl siloxane Antifoaming agent 0.30
2-bromo-2-nitropropane-1,3-diol Preservative 0.25
Propylene glycol Antifreezing agent 5.00
Silicon dioxide Thickner 2.50
Methylated seed oil Diluent 50.45
Total 100.00

Procedure: Manufacturing process of OD (Oil Dispersion) Formulation
Preparation of Oil dispersion (OD) formulation:
Part A Preparation of the liquid premix
Step 1 Charge Vegetable oil or solvent or both into a vessel with anchor stirrer.
Step 2 Under stirring, add the emulsifier and dispersing agent and stir until all ingredients are dissolved completely.
Part B Preparation of the slurry
Step 1 Now, charge the liquid premix into a second vessel, equipped with a cooling and heating device and a high shear stirrer.
Step 2 Add the active ingredient and homogenize thoroughly. Pre-mill this mixture and finally mill it using a bead mill to achieve a particle size distribution as required by the specification.
Part C Preparation of the Thickener gel
Step 1 Charge the vegetable/plant/seed oil or solvent to the vessel, equipped with a high shear stirrer.
Step 2 Add gradually the thickener which is organophilic clay, maintaining high-shear mixing throughout. Stirring is continued until thoroughly mixed.
Step 3 Under stirring, the thickener activating agent is added. Allow the gel to swell whilst maintaining mixing.
Part D Preparation of the final formulation
Step 1 Now add the thickener gel or silica and disperse the mixture by using a high shear stirrer.
Step 2 Finally add the recommended wetting and spreading agent or adjuvants (silicone or non-silicone based) to this formulation and disperse by using high shear stirrer.
Step 3 Check the finished formulation to specification.
Step 4 After approval, material is packed in required pack sizes.

Storage Stability- Topramezone 2.5%+Mesotrione 8%+Cyantraniliprole 5% OD
Storage stability study in laboratory (at 54±2 C & At 0±2 C temp. for 14 days) and at room temperature (for 12 months) shows that Topramezone 2.5%+Mesotrione 8%+Cyantraniliprole 5% OD (Oil Dispersion) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming.

Following table provides more examples of combinations and formulation of Oil Dispersion prepared as per EXAMPLE 23.
Compound A (%) Compound B (%) Compound C (%) Formulation Strength (%)
EXAMPLE 24 Topramezone 2.5% Tolpyralate 5% Cyantraniliprole 5% 12.50
EXAMPLE 25 Topramezone 2.5% Mesotrione 8% Cyantraniliprole 5% 15.50
EXAMPLE 26 Topramezone 2.5% Tembotrione 8% Cyantraniliprole 5% 15.50
EXAMPLE 27 Topramezone 2.5% Sulcotrione 8% Cyantraniliprole 5% 15.50
EXAMPLE 28 Topramezone 2.5% Halosulfuron methyl 7.5% Broflanilide 1% 11.00
EXAMPLE 29 Topramezone 2.5% Pyrazosulfuron ethyl 7.5% Broflanilide 1% 11.00
EXAMPLE 30 Topramezone 2.5% Tolpyralate 5% Broflanilide 5% 12.50
EXAMPLE 31 Topramezone 2.5% Mesotrione 8% Broflanilide 5% 15.50
EXAMPLE 32 Topramezone 2.5% Tembotrione 8% Broflanilide 5% 15.50
EXAMPLE 33 Topramezone 2.5% Sulcotrione 8% Broflanilide 5% 15.50

Biological Examples:
The field experiments were carried out to judge the impact of insecticide (diamide, Metadiamides and Isoxazoline) on crop safety and yield when applied with herbicidal compositions of Topramezone+Herbicide.
Example 34: Crop safety and weed control in maize/corn, Zea mays
Crops: Maize
No. of Treatments: As per treatment details
Plot size: 30 sq. mt.
Application Time: 16 DAS (Days after sowing)
Spray Volume: 375 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Observations:
Phytotoxicity: The observations on crop safety i.e. phytotoxicity or adverse effect of treatments were recorded on 7th 14th and 21st DAA (days after application). All the visual phytotoxicity symptoms like plant yellowing, leaf scorching, bleaching, necrosis, stunting, crinkling, epinasty, hyponasty recorded on the basis of entire plot in comparison with untreated control (UTC) plot. Each individual visual symptoms were recorded on the basis severity of injury i.e. from 0 to 100%.
Weed control: Weed count were recorded at 20 DAA (Days after Application by using (100 cm x 100 cm=1 m2) quadrant treatment wise in minimum 4 places randomly selected in the plot. The weed control (%) calculated by using given formula.
The weed control (%) data used in Colby’s formula to calculate the synergism.
A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.


Table 1: Treatment details
Treatment number Treatment details Rate (gai/h)
T1 Topramezone 2.5%+Halosulfuron methyl 7.5%+Broflanilide 1% OD 25+75+10
T2 Topramezone 2.5%+Pyrazosulfuron ethyl 7.5%+Broflanilide 1% OD 25+75+10
T3 Topramezone 33.6% SC+Halosulfuron methyl 75% WG+MSO-2 ml/l 25+50
T4 Topramezone 33.6% SC+Pyrazosulfuron ethyl 10% WP+MSO-2 ml/l 25+80
T5 Topramezone 33.6% SC+MSO-2 ml/l 25
T6 Halosulfuron methyl 75% WG+NIS-2 ml/l 75
T7 Pyrazosulfuron ethyl 10% WP 75
T8 Broflanilide 30% SC 10
T9 Untreated control (UTC) -
OD Oil Dispersion, WG Wettable Granule, WP Wettable powder, MSO Methylated seed oil, NIS Non-ionic surfactant, g/l gram per liter, ml/l milliliter per liter.
Table 2: Synergistic weed control in maize
Treatment number Weed control (%) on 20 DAA
Observed Value Calculated Value Colby's ratio Synergism (Y/N)
T1 97.4 85.20 1.14 Y
T2 95.8 83.70 1.14 Y
T3 96.8 85.17 1.14 Y
T4 95.2 83.67 1.14 Y
T5 67.2
T6 54.8
T7 50.2
T8 0.2
T9 0.0
Weed flora of trial plot: Grassy weeds (Echinochloa colonum, Eluesine indica), Broad leaf weeds (Digera arvensis, Amaranthus viridis), Sedges (Cyperus rotundus). DAA Days after application.
The treatment number T1 to T4 provides synergistic control of weeds in maize crop.
Table 3: Phytotoxicity and yield parameters in maize crop
Treatment number Yellowing (%) Plant height (cm) 45 DAA Increase(%) in plant height over
7 DAA 14 DAA 21 DAA
T1 5.0 0.0 0.0 76.30 6.27 (over T3)
T2 5.0 0.0 0.0 75.90 8.27 (over T4)
T3 10.0 5.0 0.0 71.80
T4 10.0 5.0 0.0 70.10
T5 5.0 0.0 0.0 71.40
T6 5.0 0.0 0.0 71.80
T7 5.0 0.0 0.0 69.60
T8 0.0 0.0 0.0 72.20
T9 0.0 0.0 0.0 70.00

Both the innovative treatments (T1 and T2) shows better crop safety (mild yellowing symptoms for short time) and also shows increase in plant height in comparison to conventional treatments (T3 and T4).
Example 35: Crop safety and weed control in sugarcane, Saccharum officinarum
Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 50 sq. mt.
Application Time: 4 to 6 leaf stage of weed and crop as 42 DAP (Days after planting)
Spray Volume: 400 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Observations:
Phytotoxicity: Recorded on 7, 14 and 21 DAA (as given in Example 1)
Weed control (%): Recorded on 20th DAA (As given in Example 1)
Table 4: Treatment details for weed control and crop safety study
Treatment number Treatment details Rate (gai/h)
T1 Topramezone 10%+Halosulfuron methyl 30%+Chlorantraniliprole 30% WG+MSO-2 ml/l 25+75+75
T2 Topramezone 10%+Pyrazosulfuron ethyl 30%+Chlorantraniliprole 30% WG+MSO-2 ml/l 25+75+75
T3 Topramezone 0.7%+Atrazine 20%+Chlorantraniliprole 2.13% SC 25+700+75
T4 Topramezone 0.7%+Metribuzine 20%+Chlorantraniliprole 2.13% SC 25+700+75
T5 Topramezone 33.6% SC+Halosulfuron methyl 75% WG+MSO-2 ml/l 25+75
T6 Topramezone 33.6% SC+Pyrazosulfuron ethyl 10% WP+MSO-2 ml/l 25+75
T7 Topramezone 33.6% SC+Atrazine 50% WP+MSO-2 ml/l 25+700
T8 Topramezone 33.6% SC+Metribuzin 70% WP+MSO-2 ml/l 25+700
T9 Topramezone 33.6% SC+MSO-2 ml/l 25
T10 Halosulfuron methyl 75% WG+NIS-2 ml/l 75
T11 Pyrazosulfuron ethyl 10% WP 75
T12 Atrazine 50% WP 700
T13 Metribuzin 70% WP 700
T14 Chlorantraniliprole 18.5% SC 75
T15 Untreated control (UTC) -

WG Wettable Granule, WP Wettable powder, SC Suspension concentrate, MSO Methylated seed oil, NIS Non-ionic surfactant, g/l gram per liter, ml/l milliliter per liter.
Table 5: Synergistic weed control
Treatment number Weed control (%) on 20 DAA
Observed Value Calculated Value Colby's ratio Synergism (Y/N)
T1 98.2 88.50 1.11 Y
T2 95.8 87.15 1.10 Y
T3 92.6 86.04 1.08 Y
T4 93.2 89.23 1.04 Y
T5 98.2 88.48 1.11 Y
T6 95.2 87.13 1.09 Y
T7 92.0 86.01 1.07 Y
T8 93.0 89.21 1.04 Y
T9 75.8
T10 52.4
T11 46.8
T12 42.2
T13 55.4
T14 0.2
T15 0.0

Weed flora of trial plot- Grassy weeds (Dactyloctenium aegyptium, Brachiaria mutica, Panicum spp.), Broad leaf weeds (Trianthema mongyna, Parthenium hysterophorus), Sedges (Cyprus rotundus).
The treatment number T1 to T8 provides synergistic control of weeds in sugarcane crop.
Table 6: Phytotoxicity observations and yield parameters
Treatment number Yellowing (%) Plant height (cm) 45 DAA Increase(%) in plant height over Number of tillers/mrl* Increase(%) in tillers over
7 DAA 14 DAA 21 DAA
T1 5.0 0.0 0.0 86.4 10.49 (over T5) 35.80 15.86 (over T5)
T2 5.0 0.0 0.0 83.5 10.60 (over T6) 36.20 14.92 (over T6)
T3 5.0 0.0 0.0 87.2 12.23 (over T7) 34.90 14.80 (over T7)
T4 5.0 0.0 0.0 86.8 15.12 (over T8) 34.10 16.38 (over T8)
T5 5.0 0.0 0.0 78.2 30.90
T6 5.0 5.0 0.0 75.5 31.50
T7 5.0 0.0 0.0 77.7 30.40
T8 10.0 5.0 5.0 75.4 29.30
T9 0.0 0.0 0.0 76.2 28.40
T10 0.0 0.0 0.0 77.2 29.10
T11 0.0 0.0 0.0 78.2 28.10
T12 0.0 0.0 0.0 79.7 28.70
T13 5.0 5.0 0.0 75.1 27.80
T14 0.0 0.0 0.0 80.4 30.40
T15 0.0 0.0 0.0 72.3 23.70
*Count the number of tillers per 1 meter row length (mrl). DAA Days after application.
The innovative treatments (T1, T2, T3 and T4) shows excellent crop safety and does not causes any adverse effect on sugarcane crop and also produce higher number of productive tillers.
Example 36: Crop safety and weed control in sugarcane, Saccharum officinarum
Table 7: Treatment details for weed control and crop safety study
Treatment number Treatment details Rate (gai/h)
T1 Topramezone 2.5%+Tolpyralate 5%+Chlorantraniliprole 7.5% SC 25+50+75
T2 Topramezone 2.5%+Mesotrione 8%+Chlorantraniliprole 7.5% SC 25+80+75
T3 Topramezone 2.5%+Tembotrione 8%+Chlorantraniliprole 7.5% SC 25+80+75
T4 Topramezone 2.5%+Tolpyralate 5%+Cyantraniliprole 5% OD 25+50+50
T5 Topramezone 2.5%+Mesotrione 8%+Cyantraniliprole 5% OD 25+80+50
T6 Topramezone 2.5%+Tembotrione 8%+Cyantraniliprole 5% OD 25+80+50
T7 Topramezone 33.6% SC+Tolpyralate 40% SC+NIS-2.5 ml/l 25+50
T8 Topramezone 33.6% SC+Mesotrione 40% SC+NIS-2.5 ml/l 25+80
T9 Topramezone 33.6% SC+Tembotrione 34.4% SC+NIS-2.5 ml/l 25+80
T10 Topramezone 33.6% SC+MSO-2 ml/l 25
T11 Tolpyralate 40% SC+NIS-2.5 ml/l 50
T12 Mesotrione 40% SC+NIS-2.5 ml/l 80
T13 Tembotrione 34.4% SC+NIS-2.5 ml/l 80
T14 Chlorantraniliprole 18.5% SC 75
T15 Cyantraniliprole 10.26% OD 50
T16 Untreated control (UTC) -
SC Suspension concentrate, OD Oil Dispersion, MSO Methylated seed oil, NIS Non-ionic surfactant, g/l gram per liter, ml/l milliliter per liter.
Table 8: Synergistic weed control in sugarcane
Treatment number Weed control (%) on 20 DAA
Observed Value Calculated Value Colby's ratio Synergism (Y/N)
T1 98.2 92.67 1.06 Y
T2 97.5 92.03 1.06 Y
T3 97.2 92.43 1.05 Y
T4 97.8 92.67 1.06 Y
T5 98.6 92.03 1.07 Y
T6 97.4 92.43 1.05 Y
T7 97.2 92.66 1.05 Y
T8 97.0 92.01 1.05 Y
T9 96.8 92.42 1.05 Y
T10 73.2
T11 72.6
T12 70.2
T13 71.7
T14 0.2
T15 0.2
T16 0.0
The treatment number T1 to T9 provides synergistic control of weeds in sugarcane crop.
Table 9: Crop safety in sugarcane
Treatment number Yellowing (%) Stunting (%) Number of tillers/mrl Increase(%) in tillers
7 DAA 14 DAA 21 DAA 30 DAA 7 DAA 14 DAA 21 DAA 30 DAA
T1 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 33.80 14.58 (over T7)
T2 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 34.30 18.69 (over T8)
T3 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 34.20 16.72 (over T9)
T4 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 35.10 18.98 (over T7)
T5 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 33.90 17.30 (over T8)
T6 10.0 5.0 0.0 0.0 0.0 5.0 0.0 0.0 34.70 18.43 (over T9)
T7 10.0 10.0 5.0 0.0 5.0 10.0 15.0 15.0 29.50
T8 10.0 10.0 5.0 0.0 5.0 10.0 15.0 15.0 28.90
T9 10.0 10.0 5.0 0.0 5.0 10.0 15.0 15.0 29.30
T10 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.80
T11 5.0 0.0 0.0 0.0 5.0 10.0 10.0 5.0 28.70
T12 5.0 0.0 0.0 0.0 5.0 10.0 10.0 5.0 27.80
T13 5.0 0.0 0.0 0.0 5.0 10.0 10.0 5.0 28.10
T14 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.70
T15 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.80
T16 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.20

The innovative treatments (T1, T2, T3, T4, T5 and T6) shows excellent crop safety and does not causes any adverse effect on sugarcane crop and also produce higher number of productive tillers.

CLAIMS:CLAIMS
We claim;
1) An herbicidal composition comprising topramezone with improved crop safety comprises:
i topramezone in an amount of 0.1 to 50% by weight;
ii one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof in an amount of 0.001 to 50% by weight;
iii an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener thereof in an amount 0.001 to 20% by weight; and
iv inactive formulation excipients.

2) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 wherein, herbicide from:
a) Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Sulfonylurea group is selected from chlorimuron ethyl, flazasulfuron, halosulfuron methyl, metsulfuron mehtyl, nicosufulfuron, primisulfuron methyl, pyrazosulfuron ehtyl, rimsulfuron, thifensulfuron-methyl, tribenuron methyl;
b) acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Pyrimidinyl(thio)benzoate group is pyrithiobac sodium; from Triazolopyrimidine group selected from diclosulam, florasulam, flumetsulam;
c) acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor of Sulfonylaminocarbonyl group is selected from thiencarbazone-methyl; from Imidazolinone group such as imazamox, imazapic, imazapyr, imazaquin, imazethapyr; from Sulfonanilides group is triafamone;
d) synthetic Auxin of Phenoxy carboxylic acid group is selected from 2,4-D, MCPA, MCPB; of Pyridine carboxylic acid group is selected from aminopyralid, clopyralid, florpyrauxifen benzyl, fluroxypyr, picloram, triclopyr; of Benzoic acid group is dicamba; of Quinoline carboxylic acid group is quinclorac; and halauxifen methyl;
e) inhibitor of photosynthesis at photosystem II site A of Triazine group is selected from ametryn, atrazine, simazine; of Triazinone group is selected from hexazione, metamitron, metribuzin;
f) inhibitor of photosynthesis at photosystem II site B of Benzothiadiazinone group is bentazone; of Nitrile group is selected from bromoxynil, ioxynil; of Phenyl-pyridazine group is pyridate;
g) inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase) of Isoxazolidinone group is clomazone;
h) inhibitor of protoporphyrinogen oxidase (Protox, PPO) of Dipheylether group is selected from aclifluorfen, bifenox, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; of Triazolinone group is selected from azafenidin, carfentrazone-ethyl, flufenpyr-ethyl, sulfentrazone; of Pyrimidinedione group is selected from butafenacil, saflufenacil; of N-phenylphthalimide group is selected from flumiclorac, flumioxazin; of N-Phenyl-imide group is trifludimoxazin; of Thiadiazole group is fluthiacet-methyl; of Oxadiazole group is selected from oxadiargyl, oxadiazon; of Phenylpyrazole group is pyraflufen-ethyl, of other group is pyraclonil; of Uracil group is tiafenacil; of Pyrazole group is cyclopyranil;
i) mitosis inhibitor of Chloroacetamide group is selected from acetochlor, alachlor, butachlor, dimethenamid, metazachlor, pretilachlor, propachlor, S-metolachlor; of Tetrazolinone group is fentrazamide; of Oxyacetamide group is selected from flufenacet, mefenacet; of Acetamide group is napropamide; of Carbamate group is carbetamide;
j) inhibitor of 7,8-dihydro-preroate synthetase (DHP) of Carbamate group is asulam;
k) inhibitor of indoleacetic acid transport of Phthalamate semicarbazone group is selected from diflufenzopyr, naptalam;
l) inhibitor of cell wall synthesis site C of Alkylazines group is selected from indaziflam, triaziflam;
m) inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD) of Pyrazole group is selected from benzofenap, pyrasulfotole, pyrazolynate, pyrazoxyfen, tolpyralate; of Benzoylbicyclooctanedione group is benzobicyclon; Triketone group is selected from mesotrione, tembotrione, sulcotrione, tefuryltrione, fenquinotrione, lancotrione sodium; of Isoxazoles group is selected from isoxaflutole; bicyclo ring compound group is bicyclopyrone;
n) inhibitor of dihydroorotate dehydrogenase (DHODH) is tetflupyrolimet;
o) HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD is cyclopyrimorate;
p) VLCAFE inhibitors of Isoxazoline group is pyroxasulfone, of Triazolinone group is ipfencarbazone, of Trifluoromethansulfonanilides group is dimesulfazet;
q) inhibitor of Solanesyl Diphosphate Synthase (SDS) is aclonifen; and
r) herbicide with unknown mode of action is selected from diphenamid, naproanilide, napropamide, cacodylic acid, cloquintocet mexyl, epyrifenacil, bixzolone.

3) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 wherein, insecticide from diamides class is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor; of class of metadiamides is broflanilide; of isoxazolines class is selected from fluxametamide, isocycloseram.

4) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 wherein, safener is selected from the cyprosulfamide, dietholate, isoxadifen / isoxadifen ethyl, dicyclonon, benoxacor, mefenpyr ethyl, fenchlorazole ethyl, cloquintocet / cloquintocet mexyl, oxabetrinil, naphthalic anhydride, mephenate, mefenpyr, furilazole, fluxofenim, flurazole, fenclorim, fenchlorazole, dichlormid or cyometrinil.

5) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1, wherein the formulation for the said composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).

6) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 and claim 5, wherein the preferred composition for Wettable Granule (WG) formulation comprises:
i. Wettable Granule (WG) formulation of Topramezone 10%+ Halosulfuron methyl 30%+ Chlorantraniliprole 30%;
ii. Wettable Granule (WG) formulation of Topramezone 10%+ Pyrazosulfuron ethyl 30%+ Chlorantraniliprole 30%;
iii. Wettable Granule (WG) formulation of Topramezone 10%+ Nicosulfuron 20%+ Chlorantraniliprole 12%;
iv. Wettable Granule (WG) formulation of Topramezone 10%+ Isoxaflutole 40%+ Chlorantraniliprole 12%;
v. Wettable Granule (WG) formulation of Topramezone 10%+ Halosulfuron methyl 30%+ Cyantraniliprole 20%;
vi. Wettable Granule (WG) formulation of Topramezone 10%+ Pyrazosulfuron ethyl 30%+ Cyantraniliprole 20%;
vii. Wettable Granule (WG) formulation of Topramezone 10%+ Nicosulfuron 20%+ Cyantraniliprole 20%;
viii. Wettable Granule (WG) formulation of Topramezone 10%+ Isoxaflutole 40%+ Cyantraniliprole 20%;
ix. Wettable Granule (WG) formulation of Topramezone 2.5%+ Atrazine 70%+ Cyantraniliprole 5%;
x. Wettable Granule (WG) formulation of Topramezone 2.5%+ Metribuzin 70%+ Cyantraniliprole 5%;
xi. Wettable Granule (WG) formulation of Topramezone 10%+ Nicosulfuron 20%+ Broflanilide 4%;
xii. Wettable Granule (WG) formulation of Topramezone 10%+ Isoxaflutole 40%+ Broflanilide 4%;
xiii. Wettable Granule (WG) formulation of Topramezone 2.5%+ Atrazine 70%+ Broflanilide 5%; and
xiv. Wettable Granule (WG) formulation of Topramezone 2.5%+ Metribuzin 70%+ Broflanilide 5%.

7) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 6 wherein, Wettable Granule (WG) formulation comprises:
i topramezone in an amount of 0.1 to 50% by weight;
ii one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof in an amount of 0.001 to 50% by weight;
iii an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener thereof in an amount 0.001 to 20% by weight;
iv wetting-spreading-penetrating agent in an amount of 3 to 8% by weight;
v dispersing agent in an amount of 2 to 10% by weight;
vi disintegrating agent in an amount of 3 to 8% by weight;
vii antifoaming agent in an amount of 0.2 to 1% by weight; and
viii carrier in an amount of 5 to 10% by weight.

8) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 7 wherein, wetting-spreading-penetrating agent is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkylbenzene sulfonates, alpha olefin sulfonate, alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.

9) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 7 wherein, dispersing agent is selected from alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt.

10) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 7 wherein, disintegrating agent is selected from Sodium sulphate anhydrous, citric acid, succinic acid or the sodium bicarbonate.

11) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 7 wherein, antifoaming agent is polydimethylsiloxane.

12) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 7 wherein, carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates, silica gels, ammonium sulphate, ammonium phosphate, ammonium nitrate, urea, grain meals, flours, bark meals, wood meals, nutshell meals, cellulosic powders, ground or powdered plastics, resins, bentonites, zeolites, titanium dioxide, iron oxides, hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.

13) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 and claim 5, wherein the preferred composition for Suspension Concentrate (SC) formulation comprises:
i Suspension Concentrate (SC) formulation of Topramezone 2.5% + Tolpyralate 8% + Chlorantraniliprole 7.5%;
ii Suspension Concentrate (SC) formulation of Topramezone 2.5% + Mesotrione 8% + Chlorantraniliprole 7.5%;
iii Suspension Concentrate (SC) formulation of Topramezone 2.5% + Tembotrione 8% + Chlorantraniliprole 7.5%;
iv Suspension Concentrate (SC) formulation of Topramezone 0.7% + Atrazine 20% + Chlorantraniliprole 2.13%; and
v Suspension Concentrate (SC) formulation of Topramezone 0.7% + Metribuzin 20% + Chlorantraniliprole 2.13%.

14) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 18 wherein, Suspension Concentrate (SC) formulation comprises:
i topramezone in an amount of 0.1 to 50% by weight;
ii one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof in an amount of 0.001 to 50% by weight;
iii an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener thereof in an amount 0.001 to 20% by weight;
iv wetting spreading and penetrating agent in an amount of 3 to 8% by weight;
v dispersing agent in an amount of 1 to 12% by weight;
vi suspending agent in an amount of 0.2 to 1% by weight;
vii antifoaming agent in an amount of 0.1 to 0.5% by weight;
viii adjuvant in an amount of 12 to 17% by weight;
ix preservative in an amount of 0.11 to 0.3% by weight;
x anti-freezing agent in an amount of 3 to 8% by weight;
xi thickner in an amount of 0.1 to 3% by weight; and
xii diluent water in an amount of 40 to 75% by weight.

15) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, wetting-spreading-penetrating agent is selected from trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.

16) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, dispersing agent is selected from Naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide; acrylic graft copolymer, ethoxylated tridecyl and/ or isotridecyl alcohol; Block copolymer of polyhydroxystearic acid and polyalkylene glycols.

17) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, adjuvant is Methylated seed oil.

18) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, antifoaming agent is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.

19) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, preservative is selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

20) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, anti-freezing agent is selected from ethylene glycol, propane diols, glycerine, urea, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, propylene glycol, magnesium sulphate heptahydrate, sodium chloride.

21) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 14 wherein, thickner is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch; Silicon dioxide.

22) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 1 and claim 5, wherein the preferred composition for OD (Oil Dispersion) formulation comprises:
i OD (Oil Dispersion) formulation of Topramezone 2.5% + Tolpyralate 5% + Cyantraniliprole 5%;
ii OD (Oil Dispersion) formulation of Topramezone 2.5% + Mesotrione 8% + Cyantraniliprole 5%;
iii OD (Oil Dispersion) formulation of Topramezone 2.5% + Tembotrione 8% + Cyantraniliprole 5%;
iv OD (Oil Dispersion) formulation of Topramezone 2.5% + Sulcotrione 8% + Cyantraniliprole 5%;
v OD (Oil Dispersion) formulation of Topramezone 2.5% + Halosulfuron methyl 7.5% + Broflanilide 1%;
vi OD (Oil Dispersion) formulation of Topramezone 2.5% + Pyrazosulfuron ethyl 7.5% + Broflanilide 1%;
vii OD (Oil Dispersion) formulation of Topramezone 2.5% + Tolpyralate 5% + Broflanilide 5%;
viii OD (Oil Dispersion) formulation of Topramezone 2.5% + Mesotrione 8% + Broflanilide 5%;
ix OD (Oil Dispersion) formulation of Topramezone 2.5% + Tembotrione 8% + Broflanilide 5%; and
x OD (Oil Dispersion) formulation of Topramezone 2.5% + Sulcotrione 8% + Broflanilide 5%.

23) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 22 wherein, OD (Oil Dispersion) formulation comprises:
i topramezone in an amount of 0.1 to 50% by weight;
ii one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof in an amount of 0.001 to 50% by weight;
iii an insecticide selected from the class of diamide, metadiamide or isoxazoline as safener thereof in an amount 0.001 to 20% by weight; wetting agent in an amount of 0.5 to 0.8% by weight;
iv wetting-spreading-penetrating agent in an amount of 3 to 8% by weight; and
v emulsifying agent in an amount of 8 to 12% by weight;
vi dispersing agent in an amount of 8 to 12% by weight;
vii suspending agent in an amount of 0.5 to 2% by weight;
viii antifoaming agent in an amount of 0.1 to 0.5% by weight;
ix preservative in an amount of 0.2 to 0.4% by weight;
x anti-freezing agent in an amount of 3 to 8% by weight;
xi thickner in an amount of 1 to 4% by weight; and
xii diluent in an amount of 40 to 60% by weight.

24) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, wetting-spreading-penetrating agent is selected from trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.

25) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, emulsifying agent is selected from Tristrylphenol with 16 moles EO, castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, polyoxyethylene sorbitan monolaurate.

26) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, dispersing agent is selected from alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, n-butyl alcohol poly glycol ether, ethylene oxide-propylene oxide block copolymers, ethylene oxide-butylene oxide block copolymers, fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, block copolymer of polyhydroxystearic acid and polyglycol, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.

27) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, suspending agent is bentonite clay.

28) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, antifoaming agent is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.

29) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, preservative is selected from1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

30) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, anti-freezing agent is selected from ethylene glycol, propane diols, glycerine, propylene glycol, Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.

31) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, thickner is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, Silicon dioxide.

32) The herbicidal composition comprising topramezone with improved crop safety as claimed in claim 23 wherein, diluent is Methylated seed oil.