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"An Improved And Commercially Viable Process For Preparation Of Pyrrole Derivatives With Imporved ..

Abstract: ABSTRACT: The present invention relates to improved process for the preparation of a pyrrole derivative as a racemic mixture, an enantiomer, a diastereoisomer, a mixture thereof, a tautomer thereof or a pharmaceutically acceptable salt and hydrates thereof and also intermediates involved therein. Particularly invention is directed to improved processes for the preparation of pyrrole derivatives such as (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(l-methyl-ethyl)-pyrrole-l-yl]-2,2-dimethyl-[l,3]dioxane-4-yl-acetic acid-tertiary butyl ester of formula IV followed by its conversion into [R-(R*, R*]-2-(4-fluorophenyl)- p,8-dihydroxy-5-(l-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l- heptanoic acid particularly calcium salt and its hydrate represented by Formulae I/IA respectively wherein formation of the impurities is either eliminated or minimized in the corresponding intermediaries.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
18 July 2018
Publication Number
43/2018
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
tarun@khuranaandkhurana.com
Parent Application
Patent Number
Legal Status
Grant Date
2024-02-29
Renewal Date

Applicants

ARCH PHARMALABS LIMITED
"H" WING, 4TH FLOOR, TEX CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI, ANDHERI (E), MUMBAI-400 072, MAHARASHTRA, INDIA.

Inventors

1. AJIT ANNU KAMATH
ARCH PHARMALABS LIMITED "H" WING, 4TH FLOOR, TEX CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI, ANDHERI (E), MUMBAI-400 072, MAHARASHTRA, INDIA.
2. ASHISH MOHAN UJAGARE
ARCH PHARMALABS LIMITED "H" WING, 4TH FLOOR, TEX CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI, ANDHERI (E), MUMBAI-400 072, MAHARASHTRA, INDIA.
3. BHAUSAHEB NANA GHOGARE
ARCH PHARMALABS LIMITED "H" WING, 4TH FLOOR, TEX CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI, ANDHERI (E), MUMBAI-400 072, MAHARASHTRA, INDIA.
4. SANJAY GULAB SHILEWANT
ARCH PHARMALABS LIMITED "H" WING, 4TH FLOOR, TEX CENTRE, OFF SAKI VIHAR ROAD, CHANDIVALI, ANDHERI (E), MUMBAI-400 072, MAHARASHTRA, INDIA.

Specification

Documents

Application Documents

# Name Date
1 201821026818-Other Patent Document-180718.pdf 2018-08-12
2 201821026818-Form 5-180718.pdf 2018-08-12
3 201821026818-Form 3-180718.pdf 2018-08-12
4 201821026818-Form 2(Title Page)-180718.pdf 2018-08-12
5 201821026818-Form 1-180718.pdf 2018-08-12
6 201821026818-Form 9-100818.pdf 2018-08-13
7 201821026818-Form 18-100818.pdf 2018-08-13
8 201821026818-Correspondence-100818.pdf 2018-08-13
9 201821026818-Correspondence-260619.pdf 2019-06-28
10 201821026818-Request Letter-Correspondence [17-07-2019(online)].pdf 2019-07-17
11 201821026818-CERTIFIED COPIES TRANSMISSION TO IB [17-07-2019(online)].pdf 2019-07-17
12 201821026818-Form 13-260619.pdf 2019-09-16
13 201821026818-FER.pdf 2020-03-20
14 201821026818-PRE GRANT OPPOSITION FORM [26-02-2021(online)].pdf 2021-02-26
15 201821026818-PRE GRANT OPPOSITION DOCUMENT [26-02-2021(online)].pdf 2021-02-26
16 201821026818-OTHERS [26-02-2021(online)].pdf 2021-02-26
17 201821026818-Statement and Evidence [15-04-2021(online)].pdf 2021-04-15
18 201821026818-ORIGINAL UR 6(1A) FORM 26-110321.pdf 2021-10-18
19 201821026818-FORM7A(PREGRANT)-210920.pdf 2021-10-18
20 201821026818-FORM 7A (PREGRANT)-291220.pdf 2021-10-18
21 201821026818-Examination Report Reply Recieved-291220.pdf 2021-10-18
22 201821026818-Claims-291220.pdf 2021-10-18
23 201821026818-RELEVANT DOCUMENTS [22-10-2021(online)].pdf 2021-10-22
24 201821026818-POA [22-10-2021(online)].pdf 2021-10-22
25 201821026818-FORM 13 [22-10-2021(online)].pdf 2021-10-22
26 201821026818-PETITION u-r 6(6) [23-10-2021(online)].pdf 2021-10-23
27 201821026818-Covering Letter [23-10-2021(online)].pdf 2021-10-23
28 201821026818-PETITION UNDER RULE 138 [13-05-2022(online)].pdf 2022-05-13
29 201821026818-RELEVANT DOCUMENTS [23-08-2022(online)].pdf 2022-08-23
30 201821026818-MARKED COPIES OF AMENDEMENTS [23-08-2022(online)].pdf 2022-08-23
31 201821026818-FORM 13 [23-08-2022(online)].pdf 2022-08-23
32 201821026818-AMMENDED DOCUMENTS [23-08-2022(online)].pdf 2022-08-23
33 201821026818-RELEVANT DOCUMENTS [07-09-2022(online)].pdf 2022-09-07
34 201821026818-FORM 13 [07-09-2022(online)].pdf 2022-09-07
35 201821026818-Response to office action [04-10-2022(online)].pdf 2022-10-04
36 201821026818-Annexure [04-10-2022(online)].pdf 2022-10-04
37 201821026818-PreGrant-HearingNotice-(HearingDate-21-11-2023).pdf 2023-09-19
38 201821026818-PreGrant-ExtendedHearingNotice-(HearingDate-22-11-2023).pdf 2023-09-19
39 201821026818-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [17-11-2023(online)].pdf 2023-11-17
40 201821026818-Correspondence to notify the Controller [17-11-2023(online)].pdf 2023-11-17
41 201821026818-PreGrant-ExtendedHearingNotice-(HearingDate-18-12-2023).pdf 2023-11-22
42 201821026818-Response to office action [06-12-2023(online)].pdf 2023-12-06
43 201821026818-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [12-12-2023(online)].pdf 2023-12-12
44 201821026818-PreGrant-ExtendedHearingNotice-(HearingDate-18-01-2024).pdf 2023-12-15
45 201821026818-Correspondence to notify the Controller [16-01-2024(online)].pdf 2024-01-16
46 201821026818-Correspondence to notify the Controller [17-01-2024(online)].pdf 2024-01-17
47 201821026818-Written submissions and relevant documents [02-02-2024(online)].pdf 2024-02-02
48 201821026818-Written submissions and relevant documents [02-02-2024(online)]-1.pdf 2024-02-02
49 201821026818-PETITION UNDER RULE 137 [02-02-2024(online)].pdf 2024-02-02
50 201821026818-MARKED COPIES OF AMENDEMENTS [02-02-2024(online)].pdf 2024-02-02
51 201821026818-FORM 13 [02-02-2024(online)].pdf 2024-02-02
52 201821026818-Annexure [02-02-2024(online)].pdf 2024-02-02
53 201821026818-AMMENDED DOCUMENTS [02-02-2024(online)].pdf 2024-02-02
54 201821026818-PatentCertificate29-02-2024.pdf 2024-02-29
55 201821026818-IntimationOfGrant29-02-2024.pdf 2024-02-29

Search Strategy

1 201821026818SearchstrategyE_19-03-2020.pdf

ERegister / Renewals

3rd: 09 Apr 2024

From 18/07/2020 - To 18/07/2021

4th: 09 Apr 2024

From 18/07/2021 - To 18/07/2022

5th: 09 Apr 2024

From 18/07/2022 - To 18/07/2023

6th: 09 Apr 2024

From 18/07/2023 - To 18/07/2024

7th: 09 Apr 2024

From 18/07/2024 - To 18/07/2025

8th: 29 May 2025

From 18/07/2025 - To 18/07/2026