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An Improved Formulation For Enhancing Liver And Gall Bladder Function And A Process Of Preparing Thereof

Abstract: An improved Liver syrup formulation and composition process which helps the body to relax and compensate for nervous sleep disorders and strengthen and regenerate the liver. The invention contains Terminalia arjuna; Achillea millefolium; Cichorium intybus; Silybum marianum. The invention provides Improved Liver syrup formulation which reduce blood fat; and stimulate the bile secration; and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.

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Patent Information

Application #
Filing Date
26 October 2020
Publication Number
17/2022
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
info@knowledgentia.com
Parent Application

Applicants

SPV LABORATORIES PVT. LTD
20, Arihant Nagar, 2nd Floor, Punjabi Bagh (West), N.D.-110026, India

Inventors

1. Sanchit Garg
20, Arihant Nagar, 2nd Floor, Punjabi Bagh (West), N.D.-110026, India

Specification

The present invention relates to the field of improved Liver syrup.
More particularly, the present invention provide Improved Liver syrup formulation and composition processcontains Terminalia arjuna; Achillea millefolium; Cichoriumintybus; Silybummarianum; which reduce blood fat; and stimulate the bile secration; and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.
Background of the invention:
Few examples of related products are below, which are not fulfilling customer/people requirements.
Livclearsyrup:-Contains mainly Bhumi amla, Katuki, Kalmegh, Makoy, Punarnava, Kasni, Sharpunkha, Bhringraj and Neem claim that It stimulates appetite, restores liver function and speeds up the recovery of hepatic cells.
LivHealthy Syrup:- Contains Punarnava, Bhumi Amla, Bhringraj, Kalmegh, Guduchi, Makoy, Pittapapra, Sarpunkha, Amalaki, Haritaki, Baheda, Arjuna, Chiryata, Pippali, Kasni, Nimbu, Kalanamak, SendhaNamak, Sugar claim that Helps to Protects liver against hepatic dysfunction, cirrhosis of liver, drug induced hepatotoxicity.Acts as liver protective as it contains Guduchi, Bhumi Amla, Kalmegh, etc. Acts as digestive as it contain Punarnava, Pittapapra, Kansi, Nimbuetc.Acts as appetite booster as it contains Chiryata, Pippali, etc.
JivaLIvonSyrup ::-Contains kasni, sarponkha, punarnava, makoi and kutki.It is effective in detoxifying the liver and promoting bile secretion. The herbs in the tonic.
By thereference of United States Patent Number 10,675,322by Muniyal Ayurvedic Research Centre (Manipal, IN)dated June 9, 2020, titled”Herbal formulation for management of metabolic disorders and method of preparation thereof”discloses Herbal formulation for treatment/management of metabolic disorders and related complications are disclosed herein. The disclosed herbal formulation includes herb and mineral elements which facilitate in treating lipid metabolism disorders including Dyslipidemia, obesity, etc. The formulation disclosed herein may also be used in treating any condition associated with Dyslipidemia such as cardio vascular diseases, cerebro vascular diseases, stroke, pancreatitis, steatohepatitis, atherosclerosis, hyperglycemia, metabolic syndrome, etc. Further, the disclosed formulation may also be instrumental as anti-atherosclerotic and hypolipidemic agent.
In this invention, a herbal formulation for treatment and management of Metabolic disorders and associated complications, said formulation comprising a therapeutically effective amount of the following herb element and of the following mineral element: (i) a herb element comprising Premnaintegrifolia, Plumbago rosea and Commiphoramukul (Guggulu), or extracts thereof; and (ii) a mineral element comprising of shilajit and bhasma. The herb element further comprises at least one herb selected from the group consisting of Emblica officinalis, Terminalia bellerica, Terminalia chebula, Zingiber officinalis, Piper longum, Piper nigrum, Embeliaribes, Curcuma longa, Terminalia arjuna, Sidarhombifolia, Withaniasomnifera, Inularacemosa, Punicagranatum, Nardostachysjatamansi, Boerhaviadiffusa, Picrorhizakurroa, Ocimum sanctum, Azadirachtaindica, Aristolochiaindica, Aegle marmelos, Cyperus rotundas, Hemidesmus indicus, Trichosanthesdioica, Santalum album, Glycrrhiza glabra, Woodfordiafruticosa, Mucunapruriens, Myricanagi, Syzygiumcumini, Tinosporacordifolia and Bamboo manna, or extracts thereof.
The said mineral element comprises at least one bhasma selected from a group consisting of Abhrakabhasma, Swarna Makshikabhasma, Pravalabhasma, Mukta shuktibhasma, Lohabhasma, and Trivangabhasma.
The herbal formulation is further comprising a suitable excipient, preferably gum acacia.The herbal formulation is comprising one or more additives selected from the group consisting of a flavor, a colorant, a preservative, and a pH adjuster.
The formulation is administered in a form selected from a group consisting of powder, emulsion, tablets, capsules, troches and pills.
The formulation is used for the treatment for dyslipidemia and related disorders, comprising administering a therapeutically effective amount of the formulation.
By thereference of United States Patent Number 8,067,043 by Sahajanand Biotech Pvt. Ltd. (Surat, IN) dated November 29, 2011, titled”Herbal composition for treatment of hyperlipidemia and the inhibition of myocardial infarction”discloses This invention provides a pharmaceutical or medicinal herbal composition and method of making the composition comprised of a mixture of the following herbal ingredients: Glycine max, Plumbago zeylanica, Terminalia arjuna, Trigonella-foenum-graceum, Coleus forskohlii, Commiphoramukul, Camellia sinensis, and Azadirachtaindica.
The pharmaceutical composition is for treating hyperlipidemia. The composition is comprising: Glycine max seed extract in an amount of 10-15% by weight of the composition, wherein the Glycine max seed extract contains about 40% isoflavones; Plumagozeylanica root extract in an amount of 10-15% by weight of the composition, wherein the Plumagozeylanica root extract contains about 0.08-0.15% alkaloids; Terminalia arjuna bark extract in an amount of 10-15% by weight of the composition, wherein the Terminalia arjuna bark extract contains about 25% tannins and greater than 1% arjunic acid; Trigonella-foenumgraceum seed extract in an amount of 10-15% by weight of the composition, wherein the Trigonella-foenumgraceum seed extract contains about 10% saponins; Coleus forskohlii root extract in an amount of 10-15% by weight of the composition, wherein the Coleus forskohlii root extract contains greater than 2.5% forskolin; Commiphoramukul resin extract in an amount of 10-15% by weight of the composition, wherein the Commiphoramukul resin extract contains about 2.5-10% guggalsterones; Camellia sinensis leaf extract in an amount of 10-15% by weight of the composition, wherein the Camellia sinensis leaf extract contains greater than 45% polyphenols; and Azadiractaindica bark extract in an amount of 5-7.5% by weight of the composition, wherein the Azadiractaindica bark extract contains about 2.5% bitters.
The composition is administered in at least one form selected from the group consisting of: a gelatin capsule, a vegetarian capsule, a tablet, a liquid, a syrup, a diary beverage and a snack bar.
By thereference of United States Patent Number 7,416,743 by Department of Biotechnology (New Delhi, IN) dated August 26, 2008, titled”Polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia”discloses A polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia comprising a mixture of Commiphoramukul, Boswellia serrata, Semecarpus anacardium Strychnoxnux vomica, Terminalia arjuna and ShankhaBhasma.
The polyherbal preparation for treating and/or reducing the risk of atherosclerosis and hyperlipidemia comprising an effective amount of a mixture of Commiphoramukul, Boswellia serrata, Semecarpus anacardium, Strychnosnux vomica, Terminalia arjuna and ShankhaBhasma. The polyherbal preparation is further comprising Rubiacordifolia, Bacopa monnieri, Triphala and Trikatu.
By thereference of United States Patent Number 6,162,438by Chromak Research, Inc. (Bound Brook, NJ) dated December 19, 2000, titled”Herbal compositions and their use as agents for control of hypertension, hypercholesterolemia and hyperlipidemia”discloses Edible herbal compositions for use as agents for the control of hypertension, hypercholesterolemia and hyperlipidemia in mammals. The edible composition is a mixture of at least three, preferably at least six, herbs selected from the group consisting of Terminalia arjuna, Cynara scolymus, Zingibarofficinale, Allium sativum, Crataegusoxycantha, Curcuma longa, Boerhaaviadiffusa and Trigonella foenumgraecum. The composition preferably contains the herbs in approximately equal amounts.
The edible composition is for use as an agent for control of hypertension, hypercholesterolemia and hyperlipidemia in mammals comprising a mixture of at least six herbs selected from the group consisting of Terminalia arjuna, Cynara scolymus, Allium sativum, Crataegusoxycantha, Curcuma longa, Boerhaaviadiffusa and Trigonella foenumgraecum.
The six herbs comprise Terminalia arjuna, Cynara scolymus, Allium sativum, Crataegusoxycantha, Boerhaaviadiffusa and Trigonella foenumgraecum. Each of the herbs are present in the mixture in equal amounts.
By thereference of PCT/IN2018/050042 by MALHOTRA MOHIT [IN] dated 2018-01-27, titled” CARDIAC AND ANTILIPIDIMIC BEVERAGE AND METHOD THEREOF discloses The present invention discloses a cardiac and antilipidimic beverage. The same is prepared by boiling a mixture of water and milk with herbal mixture or by addition of extract of herbal mixture to the mixture of water and milk. The herbal mixture consists of a synergistic combination of 13 specific herbs- Five herbs viz. Terminalia arjuna, Inula racemose, Boerhaviadiffusa, Cinnamomumzeylanicum and Foeniculum vulgare are essential herbs with therapeutic benefits and remaining eight viz. Glycyrrhiza glabra, Cinnamomumtamala, Elettariacardamomum, Amomum subulatum, Alpinia galanga, Ocimum sanctum, Cyperusscariosus and Rosa centifolia impart color, taste and fragrance to the beverage so that it closely resembles 'Indian tea'. The beverage when consumed regularly for 3-6 months, in optimal quantity of 2-2.5 grams of herbal mixture or 200-250 mg of extract of herbal mixture, twice a day offers therapeutic benefits of controlling enhanced plasma lipid levels and clearing clogged arteries.
By thereference of Indian Patent application no. 1996/DEL/2009by PRAVEEN SHARMA, BAIJNATH PHARMACEUTICALS PVT. LTD. PAPROLA, DIST. KANGRA, HIMACHAL PRADESH, India and G.P. DUBEY, PRINCIPAL INVESTIGATOR, CENTRE OF PSYCHOSOMATIC AND BIOFEEDBACK MEDICINE FACULTY OF AYURVEDA, INSTITUTE OF MEDICAL SCIENCES, BANARAS HINDU UNIVERSITY Indiadated 24/09/2009, titled”A NOVEL HERBAL FORMULATION AND A PROCESS FOR PREPARATION THEREOF FOR THE PREVENTION AND MANAGEMENT OF METABOLIC SYNDROME-X”disclosesThis invention relates to a novel herbal formulation for the prevention and management of metabolic syndrome-x comprising of at least one plant selected from Dioscoreabulbifera, Hippophaerhamnoides, Terminalia chebula, Terminalia arjuna and Nardostachysjatamansi. This invention also relates to a process for the preparation of the novel formulation comprising of preparing hydro-methanolic extract of Dioscoreabulbifera, Hippophaerhamnoides, Terminalia chebula, Terminalia arjuna and Nardostachysjatamansi by using water and methanol in a ratio for example 30:70 at 70-80°c and maintaining pH of solution between 7-10.
By thereference of Indian Patent application no. 201621010191by SACHIN GIRDHARI KHEDIKAR, MAHATMA GANDHI AYURVED COLLEGE HOSPITAL AND RESEARCH CENTER, SALOD (HIRAPUR), WARDHA-442 001, MAHARASHTRA, INDIA and MANISH PURUSHOTTAM DESHMUCH, MAHATMA GANDHI AYURVED COLLEGE HOSPITAL AND RESEARCH CENTER, SALOD (HIRAPUR), WARDHA-442 001, MAHARASHTRA, INDIAdated 23/03/2016, titled”A NOVEL SYNERGISTIC HERBAL FORMULATION FOR THE TREATMENT OF OBESITY AND ASSOCIATED DISORDERS”discloses A Novel Synergistic Herbal Formulation For The Treatment Of Obesity And Associated Disorders Disclosed is a herbal formulation for use in obesity comprising the following mixtures a) dried powders obtained from the plant selected from the group consisting of Terminalia Chebula fruit; Embeliaribes seed, Ferula narthex latex, Cyperousrotundus root, Pterocarpus santalinus stem, Piper nigrum fruit, Piper longum fruit, Plumbago zelyanica bark, Commiphora Mukul latex, Asphaltumpunjabianum rock, mixture of Potassium Chloride 50.8%, Potassium Sulphate 20.2 %, and Potassium bicarbonate 6.8 %; b) aqueous extracts obtained from the plant selected from the group consisting of Curcuma longa rhizome, TinosporaCordifolia stem, Azadirachta Indica seed, Picrorhizakurroa rhizome, AdhatodaVasica leave, Trichosanthesdioica fruits, Andrographis Paniculata in whole; Garcinia Indica Chois fruits, GymnemaSylvestre leaves; triturating liquids obtained from the plant selected from the group consisting of Azadirachta Indica seed, CissusQuadrangularis stem, Momordica charantia fruit, Clerodendrumphlomidis bark, Alstoniascholaris stem bark, Terminalia Chebula fruit, Emblica officinalis fruit, Terminalia belerica fruit and Terminalia arjuna stem bark; cow’s urine; wherein said dried powders, said aqueous extracts and said triturating liquid are combined in 2.5:2.0:0.5 by weight.
By thereference of Indian Patent application no. 201711003595by Mohit Malhotra, Managing Partner, Ayurvedic Chikitsa Centre, Malhotra Clinic, Sabzi Chowk, Old Rajpura, Patiala-140401, Punjab, Indiadated 31/01/2017, titled”CARDIAC AND ANTILIPIDIMIC BEVERAGE AND METHOD THEREOF”discloses The present invention discloses a cardiac and antilipidimic beverage. The same is prepared by boiling a mixture of water and milk with herbal mixture or by addition of extract of herbal mixture to the mixture of water and milk. The herbal mixture consists of a synergistic combination of 13 specific herbs- Five herbs viz. Terminalia arjuna, Inula racemose, Boerhaviadiffusa, CinnamomumzeylanicumandFoeniculum vulgare are essential herbs with therapeutic benefits and remaining eight viz. Glycyrrhiza glabra, Cinnamomumtamala, Elettariacardamomum, Amomum subulatum, Alpinia galanga, Ocimum sanctum, Cyperusscariosus and Rosa centifolia impart color, taste and fragrance to the beverage so that it closely resembles ‘Indian tea’. The beverage when consumed regularly for 3-6 months, in optimal quantity of 2-2.5 grams of herbal mixture or 200-250 mg of extract of herbal mixture, twice a day offers therapeutic benefits of controlling enhanced plasma lipid levels and clearing clogged arteries.
By thereference of 823/DEL/1996by DABUR RESEARCH FOUNDATION 22, SITE IV, SAHIBABAD, GHAZIABAD 201 010, INDIA. dated 17/04/1996, titled”A POLY HERBAL PHARMACEUTICAL COMPOSITION AND A PROCESS OF PREPARING THE SAME”discloses The invention provides a novel polyherbal composition useful for treating acute Hepatitis E virus infection including acute liver failure due to HEV infection, healthy Hepatitis B virus carriers who develop superadded hepatitis E virus infection, acute hepatitis B virus infection, and animal hepadna virus, therapeutic effects on hepatitis B virus infection and also used as a hepatoprotective agent, said composition comprising essentially extracts of plants Rheum emodi Wall, Phyllanthus amarus Linn., Eclipta alba Hassk., Andrographis paniculate Nees., and PicrorhizakurroaRoyle ex Benth., and optionally Fumaria officinalis, TinosporacordifoliaMiers., Terminalia chebula Retz., Cichoriumintybus Linn., Tephroseapurpurea Linn, and Boerhaaviadiffusa Linn.
By thereference of Indian Patent application no. 623/DEL/1996by DABUR RESEARCH FOUNDATION 22SITE 1V SAHIBABAD,GHAZIABAD-201010,INDIAdated 25/05/1996, titled”A NOVEL POLYHERBAL COMPOSITION AND A PROCESS OF PREPARING THE SAME FOR TREATING ACUTE HEPATITIS E VIRUS”discloses The invention provides a novel polyherbal composition useful for treating acute Hepatitis E virus infection including acute liver failure due to HEV infection, healthy Hepatitis B virus carriers who develop superadded hepatitis E virus infection, acute hepatitis B virus infection, and animal hepadna virus, therapeutic effects on hepatitis B virus infection and also used as a hepatoprotective agent, said composition comprising essentially extracts of plants Rheum emodi Wall., Phyllanthus amarus Linn., Eclipta alba Hassk., Andrographis paniculate Nees., and PicrorhizakurroaRoyle ex Benth., and optionally Fumaria officinalis, TinosporacordifoliaMiers., Terminalia chebula Retz., Cichoriumintybus Linn., Tepliroseapurpurea Linn, and Boerhaaviadiffusa Linn.
By thereference of Indian Patent application no. 3/DEL/2010by HIMALAYA GLOBAL HOLDINGS LTD. ELIZABETHAN SQUARE, BLOCK B, P.O. BOX 1162, GRAND CAYMAN KY1-1102, CAYMAN ISLANDS, BRITISH WEST INDIESdated 01/01/2010, titled”A HERBAL COMPOSITION AS HEPATOPROTECTIVE AND TREATMENT FOR LIVER DISORDERS”discloses The invention relates to a herbal composition, more particularly, a composition comprising extracts of Ecliptaprostrata whole parts and/or Cichoriumintybus seeds and/or Andrographis paniculata whole parts and/or Fumaria indica whole parts and/or Oroxylumindicum leaves and/or Ailanthus excelsa leaves for hepatoprotective and methods of treating liver disorders such as jaundice, cirrhosis, non-alcoholic fatty liver disease etc. and other liver disorders due to infection and chemotherapy in humans using said natural herbal composition.
By thereference of Indian Patent application no. 201611006946by CENTRAL COUNCIL FOR RESEARCH IN UNANI MEDICINE (CCRUM) 61-65, INSTITUTIONAL AREA OPP. D-BLOCK, JANAKPURI, NEW DELHI-110058 INDIAdated 29/02/2016, titled”A NOVEL HERBAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF EFFECTIVE ILTEHAB-E-KABID (INFECTIVE HEPATITIS)”disclosesThis invention relates to a herbal Unani composition and a process for preparation of herbal composition for treating infective hepatitis in humans. The herbal composition effective against lltehab-e-Kabid (Infective Hepatitis) further comprises of Revandchini (Rheum emodi Wall); Sumbul-ut-tibb (Nardostachysjatamansi DC.); Naushadarthikri (Ammonium chloride), Shoraqalmi (Potassium nitrate), T11khm-e-kasni (Cichoriumintybus Linn) and Mako khusk (Solanum nigrum Linn.) and a combination thereof.
By thereference of Indian Patent application no. 201811011608by CENTRAL COUNCIL FOR RESEARCH IN UNANI MEDICINE (CCRUM) Dr Anil Khurana, Director General Incharge (DG)dated 28/03/2018, titled”A NOVEL HERBAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF EFFECTIVE AGAINST WARM-E-KABID (HEPATITIS)”discloses This invention relates to an herbal Unani composition and a process for preparation of herbal composition for treating hepatitis in humans. The herbal composition effective against Warm-e-Kabid (Hepatitis) further comprises of Bhui Amla (Phyllanthus fraternus Webster.), Tukm-e-kasni (Cichoriumintybus Linn.), Sumbul-ut-tib (Nardostachysjatamansi DC.), Mako (Solanum nigrum Linn.), Revandchini (Rheum emodi Wall.), Naushadar (Ammonium chloride), Shorakhalmi (Potassium nitrate), Samagh-e-Arabi (Acacia arabica) and Qand-e- Sufaid (Sugar) and a combination thereof.
An Improved Liver syrup formulation and composition processis without the following carcinogenic ingredients which having several disadvantages:-
EDTA:-It has been shown to enhance the dermal penetration of other ingredients contained in a product. Thus, cosmetic formulators must exercise caution when combining it with other ingredients potentially harmful if absorbed by the skin. Furthermore, some studies suggest that disodium EDTA is weakly mutagenic (probably due to the fact that it binds with metals required for healthy cell division.). The other point is that EDTA builds upcomplexes in the environment that are not biologically degradable.
Parabens (preservative):-The Cosmetics, Toiletries and Perfumery Association released a statement in response to the bad press parabens were receiving after a study by P.D. Darbre was published that suggested paraben usage could be connected to breast cancer. They declared: “Parabens are officially approved for use under the Cosmetics Directive (76/768/EEC), the European legislation that regulates all cosmetics and toiletries. We can reassure the public that all cosmetic and toiletry products containing parabens may continue to be used safely.” Despite this, many people still have doubts and the parabens get a very bad press. The claim “paraben free” becomes a real USP on the market. The EU Commission banned the use of five other parabens in cosmetic products - Isopropylparaben, Isobutylparaben, Phenylparaben, Benzylparaben and Pentylparaben (See Commission Regulation (EU) No 358/2014) due to the lack of data necessary for reassessment. Products placed on the market after 30 October 2014 will have to befree from these substances.
Steriod :Steroid use is associated with several adverse effects, such as an increased risk of heart disease and liver toxicity and there is an increased risk of contamination and infection. Steroid use may cause infertility and baldness in men. Deepening voice, facial changes and hair growth, enlarged clitoris, irregular menstrual cycles, decreased breast size and infertility in women.
No added flavour
Therefore, there is a need of technology or Improved Liver syrup formulation and composition processwhichreduce blood fat; and stimulate the bile secration;and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.
However, none of the above discussed inventions providesImproved Liver syrup formulation and composition process contains Terminalia arjuna; Achillea millefolium; Cichoriumintybus; Silybummarianum.All the above discussed inventions are not providing such Improved Liver syrup formulation which reduce blood fat; and stimulate the bile secration; and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.
Objects of the invention:
The main object of the present invention is to provide Improved Liver syrup formulation and composition process contains Terminalia arjuna; Achillea millefolium; Cichoriumintybus; Silybummarianum.
Another object of the present invention is to provide Improved Liver syrup formulation and composition processwherein, Terminalia arjuna provides a blood fat reducing effect.
Another object of the present invention is to provide Improved Liver syrup formulation and composition processwherein,Achillea millefolium stimulates the bile secration.
Another object of the present invention is to provide Improved Liver syrup formulation and composition processwherein,Cichoriumintybus Primarily provides strength to the digestive organs and for liver and gall bladder.
Another object of the present invention is to provide Improved Liver syrup formulation and composition processwherein,Silybummarianumprovides detoxifying effect on the body.
Yet another object of the present invention is to provide Improved Liver syrup formulation and composition process, whichhelps the body to relax and compensate for nervous sleep disorders.
Still another object of the present invention is to provide Improved Liver syrup formulation and composition process, whichhelps the body toStrengthen and regenerate the liver.

Summary of the invention:
An Improved Liver syrup formulation and composition process contains ingredient of Arjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*; Purified water; Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; Citric Acid. Improved Liver syrup formulation reduces blood fat and stimulate the bile secration and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.The Improved Liver syrup formulation and composition process comprises following steps:Step 1: Take purified water boil at 100oC and cool till 70oC add the components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin one after the other under stirring.Step 2: Then homogenize for 10 minutes. Step 3: Add the components of Arjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)* under stirring and homogenize. Step 4: Finally check the pH and adjust between 5.5-6.0 with the help of citric acid solution.
Statement of the invention:
An improved formulation for enhancing liver and gall bladder function and a process of preparing thereof, said formulation comprising of ingredients amounts as: Arjuna Extract isin the range 0.6 to 6.4 percent; Brinjasif Extract is in the range of 0.5 to 6.3 percent; Kasani Extract is in the range of0.1 to 5.4percent; Milk Thistle Extract is in the range of 0.2 to 5.6percent; Potassium Sorbate is in the range of 0.01 to 0.32 percent; Sodium Benzoateis in the range of 0.02 to0.35percent; Trehaloseis in the range of0.1to 3.5percent; Mannitolis in the range of0.2 to4.3percent; Sorbitol in the range of 2.1 to 9.8percent; Xanthan Gumin the range of 0.02 to 0.52percent; Sodium Saccharinin the range of0.01 to 1.0percent; Glycerinin the range of 0.7 to 12percent andCitricAcidin the range of0.003 to 0.1percent; Said process of preparing the formulation comprise the steps of: boiling purified water and cooling till 70oC; adding the components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin one after the other under stirring; homogenizing for 10 minutes under stirring and finally checking and adjusting the pH between 5.5-6.0 with the help of citric acid solution.
Detailed description of invention:
The present invention will now be described herein after with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. While the following description details the preferred embodiments of the present invention is not limited in its application to the details of construction and arrangement of the parts illustrated in the accompanying drawings.With reference to the figures, the enclosed description and drawings are merely illustrative of preferred embodiments and represent several different ways of configuring the present invention. Although specific components, materials, configurations and uses of the present invention are illustrated and set forth in this disclosure, it should be understood that a number of variations to the components and to the configuration of those components described herein and in the accompanying figures can be made without changing the scope and function of the invention set forth herein.
The present invention is proposed an Improved Liver syrup formulation and composition process contains ingredient ofArjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*; Purified water; Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; Citric Acid. Improved Liver syrup formulation reduces blood fatand stimulate the bile secration and also strength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.
The Improved Liver syrup formulation and composition process comprises following steps:
Step 1: Take purified water boil at 100oC and cool till 70oC add the components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerinone after the other under stirring.
Step 2:Then homogenize for 10minutes.
Step 3: Add the components of Arjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*under stirring and homogenize.
Step 4: Finally check the pH and adjust between 5.5-6.0 with the help of citric acid solution.
The present invention comprising means Arjuna Extract (WAS)* (Terminalia arjuna) fromQty. in % 0.6 to Qty. in %6.4 and exact amount of Qty. in %2.5.
The present invention comprising means Brinjasif Extract (WAS)*(Achillea millefolium) from Qty. in %0.5 to Qty. in %6.3and exact amount of Qty. in %2.5.
The present invention comprising means Kasani Extract (WAS)* (Cichoriumintybus) form Qty. in %0.1 to Qty. in %5.4 and exact amount of Qty. in %2.5.
The present invention comprising means Milk Thistle Extract (WAS)* (Silybummarianum) from Qty. in % 0.2 to Qty. in %5.6 and exact amount of Qty. in %2.5.
The present invention comprising means Purified water form Qty. in % QSto Qty. in %QS and exact amount of Qty. in %QS.
The present invention comprising means Potassium Sorbate from Qty. in %0.01 to Qty. in % 0.32 and exact amount of Qty. in %0.1.
The present invention comprising means Sodium Benzoate from Qty. in % 0.02 to Qty. in %0.35 and exact amount of Qty. in %0.15.
The present invention comprising means Trehalose from Qty. in %0.1 to Qty. in %3.5 and exact amount of Qty. in %1.0.
The present invention comprising means Mannitol from Qty. in %0.2 toQty. in %4.3 and exact amount of Qty. in %1.0.
The present invention comprising means Sorbitol 70% fromQty. in %2.1 to Qty. in %9.8 and exact amount of Qty. in %5.0.
The present invention comprising means Xanthan Gum from Qty. in % 0.02 to Qty. in %0.52and exact amount of Qty. in %0.2.
The present invention comprising means Sodium Saccharin from Qty. in %0.01 to Qty. in %1.0 and exact amount of Qty. in %0.1
The present invention comprising means Glycerin from Qty. in %0.7 to Qty. in %12 and exact amount of Qty. in %5.0.
The present invention comprising means Citric Acidfrom Qty. in %0.003 to Qty. in %0.1 and exact amount of Qty. in %0.05.
All these ingredients are mentioned in Table 1.
Table 1
S.No. Ingredients Botanical Name From to
Qty. in % Qty. in %
1 Arjuna Extract (WAS)* Terminalia arjuna 0.6 6.4
2 Brinjasif Extract (WAS)* Achillea millefolium 0.5 6.3
3 Kasani Extract (WAS)* Cichoriumintybus 0.1 5.4
4 Milk Thistle Extract (WAS)* Silybummarianum 0.2 5.6
5 Purified water QS QS
6 Potassium Sorbate 0.01 0.32
7 Sodium Benzoate 0.02 0.35
8 Trehalose 0.1 3.5
9 Mannitol 0.2 4.3
10 Sorbitol 70% 2,1 9.8
11 Xanthan Gum 0.02 0.52
12 Sodium Saccharin 0.01 1.0
13 Glycerin 0.7 12
14 Citric Acid 0.003 0.1

In embodiment of the present invention provides Improved Liver syrup formulation and composition process contains ingredient of Arjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*; Purified water; Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; Citric Acid.
In another embodiment of the present invention providesImproved Liver syrup formulation, whichreduces blood fat and stimulate the bile secration and alsostrength the digestive organs and for liver and gall bladder, and provide detoxifying effect on the body.
In another embodiment of the present invention providesArjuna Extract (WAS)* (Terminalia arjuna) fromQty. in % 0.6 to Qty. in %6.4 and exact amount of Qty. in %2.5.
In another embodiment of the present invention providesBrinjasif Extract (WAS)* (Achillea millefolium) from Qty. in %0.5 to Qty. in %6.3 and exact amount of Qty. in %2.5.
In another embodiment of the present invention providesKasani Extract (WAS)* (Cichoriumintybus) form Qty. in %0.1 to Qty. in %5.4 and exact amount of Qty. in %2.5.
In another embodiment of the present invention providesMilk Thistle Extract (WAS)* (Silybummarianum) from Qty. in % 0.2 to Qty. in %5.6 and exact amount of Qty. in %2.5.
In another embodiment of the present invention providesPurified water form Qty. in % QS to Qty. in %QS and exact amount of Qty. in %QS.
In another embodiment of the present invention providesPotassium Sorbate from Qty. in %0.01 to Qty. in %0.32 and exact amount of Qty. in %0.1.
In another embodiment of the present invention providesSodium Benzoate from Qty. in % 0.02 to Qty. in %0.35 and exact amount of Qty. in %0.15.
In another embodiment of the present invention providesTrehalose from Qty. in %0.1 to Qty. in %3.5 and exact amount of Qty. in %1.0.
In another embodiment of the present invention providesMannitol from Qty. in %0.2 toQty. in %4.3 and exact amount of Qty. in %1.0.
In another embodiment of the present invention providesSorbitol 70% from Qty. in % 2.1 to Qty. in %9.8 and exact amount of Qty. in % 5.0.
In another embodiment of the present invention providesXanthan Gum from Qty. in % 0.02 to Qty. in %0.52and exact amount of Qty. in %0.2.
In another embodiment of the present invention providesSodium Saccharin from Qty. in %0.01 to Qty. in %1.0 and exact amount of Qty. in %0.1
In another embodiment of the present invention providesGlycerin from Qty. in %0.7 to Qty. in %12 and exact amount of Qty. in %5.0.
In another embodiment of the present invention providesCitric Acidfrom Qty. in %0.003 to Qty. in %0.1 and exact amount of Qty. in %0.05.
In yet another embodiment, the present invention provides Improved Liver syrup formulation and composition process steps comprise: purified water boil at 100oC and cool till 70oC add the components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerinone after the other under stirring.
In yet another embodiment, the present invention provides Improved Liver syrup formulation and composition process steps comprise: homogenize for 10minutes.
Still another embodiment, the present invention provides Improved Liver syrup formulation and composition process steps comprise: Add the components of Arjuna Extract (WAS)*; Brinjasif Extract (WAS)*; Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*under stirring and homogenize.
Still another embodiment, the present invention providesImproved Liver syrup formulation and composition process steps comprise: finally check the pH and adjust between 5.5-6.0 with the help of citric acid solution.

So accordingly, the present invention provides an improved formulation for enhancing liver and gall bladder function and a process of preparing thereof, said formulation comprising of ingredients: Arjuna Extract (Terminalia arjuna); Brinjasif Extract (Achillea millefolium); Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*; Purified water; Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; Citric Acid such that all the ingredients are working together synergistically to achieve the desired function.
In an embodiment, said formulation is able to reduce blood fat and stimulate the bile secretion and also strengthen the digestive organs and provides detoxifying effect on the body.
In another embodiment, said ingredients are present in the amounts as: Arjuna Extract is in the range 0.6 to 6.4 percent; Brinjasif Extract is in the range of 0.5 to 6.3 percent; Kasani Extract is in the range of 0.1 to 5.4 percent; Milk Thistle Extract is in the range of 0.2 to 5.6 percent; Potassium Sorbate is in the range of 0.01 to 0.32 percent; Sodium Benzoateis in the range of 0.02 to0.35 percent; Trehaloseis in the range of 0.1to 3.5percent; Mannitolis in the range of 0.2 to4.3 percent; Sorbitol in the range of 2.1 to 9.8 percent; Xanthan Gumin the range of 0.02 to 0.52percent; Sodium Saccharin in the range of 0.01 to 1.0 percent; Glycerinin the range of 0.7 to 12 percent and Citric Acid in the range of 0.003 to 0.1 percent.
In another embodiment,process of preparing the formulation comprise the steps of: oiling purified water at 100oC and then cool it till 70oC; adding components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; one after the other under stirring; homogenizing for 10 minutes under stirring and Add Arjuna Extract(Terminalia arjuna), Brinjasif (Achillea millefolium) Extract and Kasani (Cichoriumintybus) Extract, Milk Thistle (Silybummarianum) Extract under continuous stirring and homogenization and checking and adjusting the pH between 5.5- 6.0 with the help of citric acid solution.
In another embodiment,said formulation is able to support the body in fighting the infection and helps the body to relax; and compensate for nervous sleep disorders; and regenerate the liver.
In another embodiment, said formulation is in the form of a syrup or tablet

Examples:
The following examples are for the purposes of illustration only and therefore should not be construed to limit the scope of the invention:

Table 2 represents the exact amount of the ingredients used in the formulation and composition.
Table 2:
S.No. Ingredients Botanical Name Qty. in %
1 Arjuna Extract (WAS) Terminalia arjuna 2.5
2 Brinjasif Extract (WAS) Achillea millefolium 2.5
3 Kasani Extract (WAS) Cichoriumintybus 2.5
4 Milk Thistle Extract (WAS) Silybummarianum 2.5
5 Purified water QS
6 Potassium Sorbate 0.1
7 Sodium Benzoate 0.15
8 Trehalose 1.0
9 Mannitol 1.0
10 Sorbitol 70% 5.0
11 Xanthan Gum 0.2
12 Sodium Saccharin 0.1
13 Glycerin 5.0
14 Citric Acid 0.05


Claims:We claim:
1. An improved formulation for enhancing liver and gall bladder function and a process of preparing thereof, said formulation comprising of ingredients: Arjuna Extract (Terminalia arjuna); Brinjasif Extract (Achillea millefolium); Kasani Extract (WAS)*; Milk Thistle Extract (WAS)*; Purified water; Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; Citric Acid such that all the ingredients are working together synergistically to achieve the desired function.
2. The improved formulation for enhancing liver and gall bladder function as claimed in claim 1, wherein said formulation is able to reduce blood fat and stimulate the bile secretion and also strengthen the digestive organs and provides detoxifying effect on the body.
3. The improved formulation for enhancing liver and gall bladder function as claimed in claim 1, wherein said ingredients are present in the amounts as: Arjuna Extract is in the range 0.6 to 6.4 percent; Brinjasif Extract is in the range of 0.5 to 6.3 percent; Kasani Extract is in the range of 0.1 to 5.4percent; Milk Thistle Extract is in the range of 0.2 to 5.6 percent; Potassium Sorbate is in the range of 0.01 to 0.32 percent; Sodium Benzoateis in the range of 0.02 to0.35percent; Trehaloseis in the range of0.1to 3.5percent; Mannitolis in the range of0.2 to4.3percent; Sorbitol in the range of 2.1 to 9.8percent; Xanthan Gumin the range of 0.02 to 0.52percent; Sodium Saccharin in the range of 0.01 to 1.0 percent; Glycerinin the range of 0.7 to 12 percent and Citric Acid in the range of 0.003 to 0.1percent.
4. The improved formulation for enhancing liver and gall bladder function as claimed in claim 1, wherein said process of preparing the formulation comprise the steps of: oiling purified water at 100oC and then cool it till 70oC; adding components of Potassium Sorbate; Sodium Benzoate; Trehalose; Mannitol; Sorbitol 70%; Xanthan Gum; Sodium Saccharin; Glycerin; one after the other under stirring; homogenizing for 10 minutes under stirring and Add Arjuna Extract(Terminalia arjuna), Brinjasif (Achillea millefolium) Extract and Kasani (Cichoriumintybus) Extract, Milk Thistle (Silybummarianum) Extract under continuous stirring and homogenization and checking and adjusting the pH between 5.5-6.0 with the help of citric acid solution.
5. The improved formulation for enhancing liver and gall bladder function as claimed in claim 1, wherein said formulation is able to support the body in fighting the infection and helps the body to relax; and compensate for nervous sleep disorders; and regenerate the liver.
6. The improved formulation for enhancing liver and gall bladder function as claimed in claim 1, wherein said formulation is in the form of a syrup or tablet.

Documents

Application Documents

# Name Date
1 202011046608-STATEMENT OF UNDERTAKING (FORM 3) [26-10-2020(online)].pdf 2020-10-26
2 202011046608-FORM 1 [26-10-2020(online)].pdf 2020-10-26
3 202011046608-DECLARATION OF INVENTORSHIP (FORM 5) [26-10-2020(online)].pdf 2020-10-26
4 202011046608-COMPLETE SPECIFICATION [26-10-2020(online)].pdf 2020-10-26
5 202011046608-Proof of Right [06-11-2020(online)].pdf 2020-11-06
6 202011046608-FORM-26 [06-11-2020(online)].pdf 2020-11-06
7 202011046608-Power of Attorney-091120.pdf 2021-10-19
8 202011046608-OTHERS-091120.pdf 2021-10-19
9 202011046608-Correspondence-091120.pdf 2021-10-19
10 202011046608-FORM 18 [20-09-2023(online)].pdf 2023-09-20
11 202011046608-Verified English translation [10-01-2025(online)].pdf 2025-01-10
12 202011046608-PRE GRANT OPPOSITION FORM [21-03-2025(online)].pdf 2025-03-21
13 202011046608-PRE GRANT OPPOSITION DOCUMENT [21-03-2025(online)].pdf 2025-03-21