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An Improved Process For Manufacture Of 4 Hydroxy Pyran 2 One Derivatives
Abstract: A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), and wherein R¹ and R² are methyl and R³ is hydrogen or methyl, comprising the steps of, heating a compound of formula (II), wherein R is as defined before, and R4 is hydrogen, NH4+ or an alkali metal, 29 in a solvent mixture consisting of an aromatic hydrocarbon and a ketone in an inert atmosphere at a temperature of between 60°C to 92°C in the absence or presence of orthophosphoric acid or its alkali dihydrogen salts or alkali hydrogen salts of a dibasic acid, followed by optional neutralization of the reaction mixture with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization. The process leads to formation of derivatives of formula I in high purity with dimmer impurity (III) less than 0.1% and anhydro impurity (IV) below 0.15%.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
25 September 2006
Publication Number
23/2007
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2010-06-08
Renewal Date
Applicants
LUPIN LTD.
159, CST Road, Kalina,
Santacruz (East),
Mumbai- 400 098,
Inventors
1. GHARPURE, Milind Moreshwar
Lupin Limited (Research Park)
46A/47A, Nande Village,
Taluka Mulshi,
Pune - 411 042,
2. SONAWANE, Swapnli, Panditrao
LupinLimited (Research Park) 46A/47A,
Nande Village Taluka Mulshi,
Pune- 411 042 Maharashtra,
India
3. MANE Srihari Shivaji
Lupin Limited (Research Park)
46A/47A Nanda Village Taluka Mulshi
Pune 411 042
Maharashra India
4. MAHALE Rajendra Dagesing
Lupin Limited (Research Park)
Village Taluka Mulshi
Pune 411 042
Maharashtra India
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1137-mumnp-2006-abstract(granted)-(8-6-2010).pdf | 2018-08-09 |
| 1 | 1137-mumnp-2006-correspondence(19-12-2005).pdf | 2005-12-19 |
| 2 | 1137-mumnp-2006-abstract.doc | 2018-08-09 |
| 2 | 1137-mumnp-2006-annexure to form 3(20-11-2006).pdf | 2006-11-20 |
| 3 | 1137-MUMNP-2006-SPECIFICATION(AMENDED)-(23-12-2009).pdf | 2009-12-23 |
| 3 | 1137-mumnp-2006-abstract.pdf | 2018-08-09 |
| 4 | 1137-MUMNP-2006-REPLY TO EXAMINATION REPORT(23-12-2009).pdf | 2009-12-23 |
| 4 | 1137-mumnp-2006-annexure to form 3(26-2-2007).pdf | 2018-08-09 |
| 5 | 1137-MUMNP-2006-OTHER DOCUMENT(23-12-2009).pdf | 2009-12-23 |
| 5 | 1137-mumnp-2006-annexure to form 3(3-9-2007).pdf | 2018-08-09 |
| 6 | 1137-MUMNP-2006-FORM 2(TITLE PAGE)-(23-12-2009).pdf | 2009-12-23 |
| 6 | 1137-mumnp-2006-claims(granted)-(8-6-2010).pdf | 2018-08-09 |
| 7 | 1137-MUMNP-2006-FORM 1(23-12-2009).pdf | 2009-12-23 |
| 8 | 1137-MUMNP-2006-CORRESPONDENCE(23-12-2009).pdf | 2009-12-23 |
| 8 | 1137-mumnp-2006-claims.pdf | 2018-08-09 |
| 9 | 1137-MUMNP-2006-CLAIMS(AMENDED)-(23-12-2009).pdf | 2009-12-23 |
| 9 | 1137-mumnp-2006-correspondance-received.pdf | 2018-08-09 |
| 10 | 1137-MUMNP-2006-CANCELLED PAGE(23-12-2009).pdf | 2009-12-23 |
| 10 | 1137-MUMNP-2006-CORRESPONDENCE(15-4-2009).pdf | 2018-08-09 |
| 11 | 1137-MUMNP-2006-ANNEXURE TO FORM 3(23-12-2009).pdf | 2009-12-23 |
| 11 | 1137-MUMNP-2006-CORRESPONDENCE(19-1-2009).pdf | 2018-08-09 |
| 12 | 1137-MUMNP-2006-ABSTRACT(23-12-2009).pdf | 2009-12-23 |
| 12 | 1137-MUMNP-2006-CORRESPONDENCE(2-3-2010).pdf | 2018-08-09 |
| 13 | 1137-MUMNP-2006-CORRESPONDENCE(29-9-2008).pdf | 2018-08-09 |
| 13 | 1137-MUMNP-2006-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(14-03-2011).pdf | 2011-03-14 |
| 14 | 1137-mumnp-2006-correspondence(ipo)-(1-7-2010).pdf | 2018-08-09 |
| 14 | abstract1.jpg | 2018-08-09 |
| 15 | 1137-MUMNP-2006-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(27-2-2012).pdf | 2018-08-09 |
| 15 | 1137-MUMNP-2006-OTHER DOCUMENT(15-4-2009).pdf | 2018-08-09 |
| 16 | 1137-mumnp-2006-form-5.pdf | 2018-08-09 |
| 16 | 1137-mumnp-2006-description (complete).pdf | 2018-08-09 |
| 17 | 1137-mumnp-2006-form-3.pdf | 2018-08-09 |
| 17 | 1137-mumnp-2006-form 18(14-1-2008).pdf | 2018-08-09 |
| 18 | 1137-mumnp-2006-form 2(granted)-(8-6-2010).pdf | 2018-08-09 |
| 18 | 1137-mumnp-2006-form-26.pdf | 2018-08-09 |
| 19 | 1137-mumnp-2006-form 2(title page)-(granted)-(8-6-2010).pdf | 2018-08-09 |
| 19 | 1137-mumnp-2006-form-2.pdf | 2018-08-09 |
| 20 | 1137-mumnp-2006-form-1.pdf | 2018-08-09 |
| 21 | 1137-mumnp-2006-form-1.pdf | 2018-08-09 |
| 22 | 1137-mumnp-2006-form 2(title page)-(granted)-(8-6-2010).pdf | 2018-08-09 |
| 22 | 1137-mumnp-2006-form-2.pdf | 2018-08-09 |
| 23 | 1137-mumnp-2006-form 2(granted)-(8-6-2010).pdf | 2018-08-09 |
| 23 | 1137-mumnp-2006-form-26.pdf | 2018-08-09 |
| 24 | 1137-mumnp-2006-form-3.pdf | 2018-08-09 |
| 24 | 1137-mumnp-2006-form 18(14-1-2008).pdf | 2018-08-09 |
| 25 | 1137-mumnp-2006-description (complete).pdf | 2018-08-09 |
| 25 | 1137-mumnp-2006-form-5.pdf | 2018-08-09 |
| 26 | 1137-MUMNP-2006-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(27-2-2012).pdf | 2018-08-09 |
| 26 | 1137-MUMNP-2006-OTHER DOCUMENT(15-4-2009).pdf | 2018-08-09 |
| 27 | 1137-mumnp-2006-correspondence(ipo)-(1-7-2010).pdf | 2018-08-09 |
| 27 | abstract1.jpg | 2018-08-09 |
| 28 | 1137-MUMNP-2006-CORRESPONDENCE(29-9-2008).pdf | 2018-08-09 |
| 28 | 1137-MUMNP-2006-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(14-03-2011).pdf | 2011-03-14 |
| 29 | 1137-MUMNP-2006-ABSTRACT(23-12-2009).pdf | 2009-12-23 |
| 29 | 1137-MUMNP-2006-CORRESPONDENCE(2-3-2010).pdf | 2018-08-09 |
| 30 | 1137-MUMNP-2006-ANNEXURE TO FORM 3(23-12-2009).pdf | 2009-12-23 |
| 30 | 1137-MUMNP-2006-CORRESPONDENCE(19-1-2009).pdf | 2018-08-09 |
| 31 | 1137-MUMNP-2006-CANCELLED PAGE(23-12-2009).pdf | 2009-12-23 |
| 31 | 1137-MUMNP-2006-CORRESPONDENCE(15-4-2009).pdf | 2018-08-09 |
| 32 | 1137-MUMNP-2006-CLAIMS(AMENDED)-(23-12-2009).pdf | 2009-12-23 |
| 32 | 1137-mumnp-2006-correspondance-received.pdf | 2018-08-09 |
| 33 | 1137-mumnp-2006-claims.pdf | 2018-08-09 |
| 33 | 1137-MUMNP-2006-CORRESPONDENCE(23-12-2009).pdf | 2009-12-23 |
| 34 | 1137-MUMNP-2006-FORM 1(23-12-2009).pdf | 2009-12-23 |
| 35 | 1137-MUMNP-2006-FORM 2(TITLE PAGE)-(23-12-2009).pdf | 2009-12-23 |
| 35 | 1137-mumnp-2006-claims(granted)-(8-6-2010).pdf | 2018-08-09 |
| 36 | 1137-MUMNP-2006-OTHER DOCUMENT(23-12-2009).pdf | 2009-12-23 |
| 36 | 1137-mumnp-2006-annexure to form 3(3-9-2007).pdf | 2018-08-09 |
| 37 | 1137-MUMNP-2006-REPLY TO EXAMINATION REPORT(23-12-2009).pdf | 2009-12-23 |
| 37 | 1137-mumnp-2006-annexure to form 3(26-2-2007).pdf | 2018-08-09 |
| 38 | 1137-MUMNP-2006-SPECIFICATION(AMENDED)-(23-12-2009).pdf | 2009-12-23 |
| 38 | 1137-mumnp-2006-abstract.pdf | 2018-08-09 |
| 39 | 1137-mumnp-2006-annexure to form 3(20-11-2006).pdf | 2006-11-20 |
| 40 | 1137-mumnp-2006-correspondence(19-12-2005).pdf | 2005-12-19 |
| 40 | 1137-mumnp-2006-abstract(granted)-(8-6-2010).pdf | 2018-08-09 |