Abstract: The present invention relates to an improved, robust and industrially feasible process for preparing 5-Aminolevulinic acid hydrochloride and its novel intermediates.
Claims:
1. An improved process for preparing 5-Aminolevulinic acid hydrochloride of Formula-la
(a) Esterifying succinic anhydride in presence of lewis acid and solvent
(b) Chlorinating 4-isopropoxy-4-oxobutanoic acid with thionyl chloride
(c) Acylating isopropyl 4-chloro-4-oxobutanoate with 2-benzamidoacetic acid in
presence of base
(d) Hydrolyzing isopropyl 4-oxo-4-(5-oxo-2-phenyl-4,5-dihydrooxazol-4-yl)butanoate in presence of hydrochloric acid
(e) Isolating 5-Aminolevulinic acid hydrochloride
2. The process according to claim 1, wherein solvent selected from the group consisting of methanol, isopropanol, Isobutanol, toluene, dichloromethane, acetone or mixtures of.
3. The process according to claim 1, wherein base selected from the group consisting of 4-picoline, pyridine, triethylamine or mixtures of.
4. The process according to claim 1, wherein aluminium chloride.
| # | Name | Date |
|---|---|---|
| 1 | 201941033090-Correspondence_05-10-2020.pdf | 2020-10-05 |
| 1 | Form26_Power of Attorney_16-08-2019.pdf | 2019-08-16 |
| 2 | Form2 Title Page_Provisional_16-08-2019.pdf | 2019-08-16 |
| 2 | 201941033090-Form 1_After Filing _05-10-2020.pdf | 2020-10-05 |
| 3 | Form 5_As Filed_16-08-2019.pdf | 2019-08-16 |
| 3 | 201941033090-Abstract_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 4 | Form 3_As Filed_16-08-2019.pdf | 2019-08-16 |
| 4 | 201941033090-Claims_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 5 | Form 1_As Filed_16-08-2019.pdf | 2019-08-16 |
| 5 | 201941033090-Correspondence_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 6 | Description Provisional_As Filed_16-08-2019.pdf | 2019-08-16 |
| 6 | 201941033090-Description Complete_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 7 | Correspondence by Applicant _As Filed_16-08-2019.pdf | 2019-08-16 |
| 7 | 201941033090-Form2 Title Page_Complete_14-08-2020.pdf | 2020-08-14 |
| 8 | 201941033090-Form5_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 8 | 201941033090-Form3_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 9 | 201941033090-Form5_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 9 | 201941033090-Form3_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 10 | 201941033090-Form2 Title Page_Complete_14-08-2020.pdf | 2020-08-14 |
| 10 | Correspondence by Applicant _As Filed_16-08-2019.pdf | 2019-08-16 |
| 11 | Description Provisional_As Filed_16-08-2019.pdf | 2019-08-16 |
| 11 | 201941033090-Description Complete_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 12 | Form 1_As Filed_16-08-2019.pdf | 2019-08-16 |
| 12 | 201941033090-Correspondence_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 13 | Form 3_As Filed_16-08-2019.pdf | 2019-08-16 |
| 13 | 201941033090-Claims_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 14 | Form 5_As Filed_16-08-2019.pdf | 2019-08-16 |
| 14 | 201941033090-Abstract_Complete After Provisional_14-08-2020.pdf | 2020-08-14 |
| 15 | Form2 Title Page_Provisional_16-08-2019.pdf | 2019-08-16 |
| 15 | 201941033090-Form 1_After Filing _05-10-2020.pdf | 2020-10-05 |
| 16 | Form26_Power of Attorney_16-08-2019.pdf | 2019-08-16 |
| 16 | 201941033090-Correspondence_05-10-2020.pdf | 2020-10-05 |