An Improved Process For The Preparation Of Carvedilol

Abstract: The present invention provides a more simplified, cost effective, commercially feasible process for the manufacture of Carvedilol (I) comprising a step of reacting 4-hydroxy carbazole (II) with epichlorohydrin and directly isolating the intermediate 4-(2,3-epoxypropoxy) carbazole (III) which on purification followed by reaction with 2-(2-methoxyphenoxy) ethylamine (IV) yields crude Carvedilol (I). The crude Carvedilol (I) is converted to pure product either through solvent crystallization (without salt formation) or through salt formation followed by salt cleavage and solvent crystallization resulting in highly pure (i.e. ICH grade) Carvedilol.

Patent Information

Application #

Filing Date

26 September 2006

Publication Number

14/2008

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

MOREPEN LABORATORIES LIMITED

VILLAGE-MASULKHANA, DISTT.-SOLAN, PARWANOO (HP), INDIA.

Inventors

1. SURI SANJAY

MOREPEN LABORATORIES LIMITED, VILLAGE-MASULKHANA, DISTT.-SOLAN, PARWANOO (HP), INDIA.

2. KASHYAP TAPAN

MOREPEN LABORATORIES LIMITED, VILLAGE-MASULKHANA, DISTT.-SOLAN, PARWANOO (HP), INDIA.

Specification

Documents

Application Documents

#	Name	Date
1	1711-del-2006-abstract.pdf	2011-08-21
1	1711-del-2006-gpa.pdf	2011-08-21
2	1711-del-2006-correspondence-others.pdf	2011-08-21
2	1711-del-2006-form-5.pdf	2011-08-21
3	1711-del-2006-description (provisional).pdf	2011-08-21
3	1711-del-2006-form-3.pdf	2011-08-21
4	1711-del-2006-form-1.pdf	2011-08-21
4	1711-del-2006-form-2.pdf	2011-08-21
5	1711-del-2006-form-1.pdf	2011-08-21
5	1711-del-2006-form-2.pdf	2011-08-21
6	1711-del-2006-description (provisional).pdf	2011-08-21
6	1711-del-2006-form-3.pdf	2011-08-21
7	1711-del-2006-correspondence-others.pdf	2011-08-21
7	1711-del-2006-form-5.pdf	2011-08-21
8	1711-del-2006-abstract.pdf	2011-08-21
8	1711-del-2006-gpa.pdf	2011-08-21