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57) Abstract:-The present invention relates to a process for the preparation of antitumor drug 'Docetaxel'. The present invention more particularly relates to a short synthesis of docetaxel following a semi-synthetic approach comprising C-13 esterification of a suitably protected 10-deacetyIbaccatin III with a suitably protected side chain acid and subsequent deprotections to produce docetaxel. The process described in the present invention comprises (i) reacting 10-deactylbaccatin III with a heterocyclic compound to produce a novel 7,10-deacetylbaccatin III (ii) esterifying the C-13 hydroxy group in the 7,10-diprotected lO-deacetylabaccatin III compound obtained in step(i) with an oxazolidine side chain acid to obtain a novel C-13 coupled adduct (iii) deprotecting the protecting groups at C-7, C-10 & oxazolidine group an intermediate amino alcohol (iv) derivatising the free amine group in the amino alcohol obtained in the step (iii) with di-tert.buty) dicarbonate to get the desired 'Docetaxel' compound.PRICE: THIRTY RUPEES
Notices, Deadlines & Correspondence
Patent Information
Applicants
DR. REDDY'S LABORATORIES LTD
Inventors
1. DUVVURI SUBRAHMANYAM
2. RAMACHANDRA PURANIK
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 0538-mas-1999 form-6.pdf | 2011-09-03 |
| 2 | 0538-mas-1999 form-4.pdf | 2011-09-03 |
| 3 | 0538-mas-1999 form-3.pdf | 2011-09-03 |
| 4 | 0538-mas-1999 form-1.pdf | 2011-09-03 |
| 5 | 0538-mas-1999 description (complete).pdf | 2011-09-03 |
| 6 | 0538-mas-1999 correspondence-po.pdf | 2011-09-03 |
| 7 | 0538-mas-1999 correspondence-others.pdf | 2011-09-03 |
| 8 | 0538-mas-1999 claims.pdf | 2011-09-03 |
| 9 | 0538-mas-1999 assignment.pdf | 2011-09-03 |
| 10 | 0538-mas-1999 abstract.pdf | 2011-09-03 |
| 11 | Description_Granted 192991_28-11-05.pdf | 2018-01-24 |
| 12 | Claims_Granted 192991_28-11-05.pdf | 2018-01-24 |
| 13 | Abstract_Granted 192991_28-11-05.pdf | 2018-01-24 |