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An Improved Process For The Preparation Of Pemetrexed
Abstract: An improved process for the preparation of Pemetrexed of Formula I or its salt, the process comprisesReacting 4-(2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)-ethyl) benzoic acid with L-glutamic acid or its ester, or its acid salt, in the presence of acid activating reagent having carbodiimide group, to obtain Pemetrexed Diester; hydrolysis of the same to obtain Pemetrexed; and optionally converting Pemetrexed to Pemetrexed disodium.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
25 October 2010
Publication Number
17/2012
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2019-09-17
Renewal Date
Applicants
FRESENIUS KABI ONCOLOGY LTD.
B-310, SOM DATT CHAMBERS - I, BHIKAJI CAMA PLACE, NEW DELHI 110066, INDIA
Inventors
1. SINGH, GOVIND
FRESENIUS KABI ONCOLOGY LTD., ECHELON INSTITUTIONAL AREA, PLOT NO. 11, SECTOR-32, GURGAON - 122001, HARYANA, INDIA
2. GIRIGANI, SATHYANARAYANA
FRESENIUS KABI ONCOLOGY LTD., ECHELON INSTITUTIONAL AREA, PLOT NO. 11, SECTOR-32, GURGAON - 122001, HARYANA, INDIA
3. KUMAR, SRUZEN, SUNEEL
FRESENIUS KABI ONCOLOGY LTD., ECHELON INSTITUTIONAL AREA, PLOT NO. 11, SECTOR-32, GURGAON - 122001, HARYANA, INDIA
4. LAHIRI, SASWATA
FRESENIUS KABI ONCOLOGY LTD., ECHELON INSTITUTIONAL AREA, PLOT NO. 11, SECTOR-32, GURGAON - 122001, HARYANA, INDIA
5. DUBEY, SUSHIL, KUMAR
FRESENIUS KABI ONCOLOGY LTD., ECHELON INSTITUTIONAL AREA, PLOT NO. 11, SECTOR-32, GURGAON - 122001, HARYANA, INDIA
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 2542-DEL-2010-GPA-(24-01-2011).pdf | 2011-01-24 |
| 1 | 2542-DEL-2010-RELEVANT DOCUMENTS [20-03-2020(online)].pdf | 2020-03-20 |
| 2 | 2542-DEL-2010-2. Marked Copy under Rule 14(2) (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 2 | 2542-DEL-2010-Form-1-(24-01-2011).pdf | 2011-01-24 |
| 3 | 2542-DEL-2010-IntimationOfGrant17-09-2019.pdf | 2019-09-17 |
| 3 | 2542-DEL-2010-Correspondence-Others-(24-01-2011).pdf | 2011-01-24 |
| 4 | 2542-DEL-2010-PatentCertificate17-09-2019.pdf | 2019-09-17 |
| 4 | 2542-del-2010-form-3.pdf | 2011-08-21 |
| 5 | 2542-DEL-2010-PETITION UNDER RULE 137 [17-09-2019(online)].pdf | 2019-09-17 |
| 5 | 2542-del-2010-form-2.pdf | 2011-08-21 |
| 6 | 2542-DEL-2010-RELEVANT DOCUMENTS [17-09-2019(online)].pdf | 2019-09-17 |
| 6 | 2542-del-2010-form-1.pdf | 2011-08-21 |
| 7 | 2542-DEL-2010-Retyped Pages under Rule 14(1) (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 7 | 2542-del-2010-description (complete).pdf | 2011-08-21 |
| 8 | 2542-DEL-2010-Written submissions and relevant documents (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 8 | 2542-del-2010-correspondence-others.pdf | 2011-08-21 |
| 9 | 2542-del-2010-claims.pdf | 2011-08-21 |
| 9 | 2542-DEL-2010-ExtendedHearingNoticeLetter_13-09-2019.pdf | 2019-09-13 |
| 10 | 2542-del-2010-abstract.pdf | 2011-08-21 |
| 10 | 2542-DEL-2010-ENDORSEMENT BY INVENTORS [12-09-2019(online)].pdf | 2019-09-12 |
| 11 | 2542-del-2010-Correspondence Others-(28-10-2011).pdf | 2011-10-28 |
| 11 | 2542-DEL-2010-ExtendedHearingNoticeLetter_11-09-2019.pdf | 2019-09-11 |
| 12 | 2542-del-2010-Correspondence Others-(07-05-2012).pdf | 2012-05-07 |
| 12 | 2542-DEL-2010-HearingNoticeLetter08-08-2019.pdf | 2019-08-08 |
| 13 | 2542-del-2010-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [05-08-2019(online)].pdf | 2019-08-05 |
| 13 | Form 13_2542DEL2010.pdf | 2014-10-28 |
| 14 | 2542-del-2010-CLAIMS [31-05-2018(online)].pdf | 2018-05-31 |
| 14 | Form 3 [28-06-2016(online)].pdf | 2016-06-28 |
| 15 | 2542-DEL-2010-FER.pdf | 2017-12-12 |
| 15 | 2542-del-2010-FER_SER_REPLY [31-05-2018(online)].pdf | 2018-05-31 |
| 16 | 2542-del-2010-OTHERS [31-05-2018(online)].pdf | 2018-05-31 |
| 17 | 2542-del-2010-FER_SER_REPLY [31-05-2018(online)].pdf | 2018-05-31 |
| 17 | 2542-DEL-2010-FER.pdf | 2017-12-12 |
| 18 | Form 3 [28-06-2016(online)].pdf | 2016-06-28 |
| 18 | 2542-del-2010-CLAIMS [31-05-2018(online)].pdf | 2018-05-31 |
| 19 | 2542-del-2010-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [05-08-2019(online)].pdf | 2019-08-05 |
| 19 | Form 13_2542DEL2010.pdf | 2014-10-28 |
| 20 | 2542-del-2010-Correspondence Others-(07-05-2012).pdf | 2012-05-07 |
| 20 | 2542-DEL-2010-HearingNoticeLetter08-08-2019.pdf | 2019-08-08 |
| 21 | 2542-del-2010-Correspondence Others-(28-10-2011).pdf | 2011-10-28 |
| 21 | 2542-DEL-2010-ExtendedHearingNoticeLetter_11-09-2019.pdf | 2019-09-11 |
| 22 | 2542-del-2010-abstract.pdf | 2011-08-21 |
| 22 | 2542-DEL-2010-ENDORSEMENT BY INVENTORS [12-09-2019(online)].pdf | 2019-09-12 |
| 23 | 2542-del-2010-claims.pdf | 2011-08-21 |
| 23 | 2542-DEL-2010-ExtendedHearingNoticeLetter_13-09-2019.pdf | 2019-09-13 |
| 24 | 2542-DEL-2010-Written submissions and relevant documents (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 24 | 2542-del-2010-correspondence-others.pdf | 2011-08-21 |
| 25 | 2542-DEL-2010-Retyped Pages under Rule 14(1) (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 25 | 2542-del-2010-description (complete).pdf | 2011-08-21 |
| 26 | 2542-DEL-2010-RELEVANT DOCUMENTS [17-09-2019(online)].pdf | 2019-09-17 |
| 26 | 2542-del-2010-form-1.pdf | 2011-08-21 |
| 27 | 2542-DEL-2010-PETITION UNDER RULE 137 [17-09-2019(online)].pdf | 2019-09-17 |
| 27 | 2542-del-2010-form-2.pdf | 2011-08-21 |
| 28 | 2542-DEL-2010-PatentCertificate17-09-2019.pdf | 2019-09-17 |
| 28 | 2542-del-2010-form-3.pdf | 2011-08-21 |
| 29 | 2542-DEL-2010-IntimationOfGrant17-09-2019.pdf | 2019-09-17 |
| 29 | 2542-DEL-2010-Correspondence-Others-(24-01-2011).pdf | 2011-01-24 |
| 30 | 2542-DEL-2010-Form-1-(24-01-2011).pdf | 2011-01-24 |
| 30 | 2542-DEL-2010-2. Marked Copy under Rule 14(2) (MANDATORY) [17-09-2019(online)].pdf | 2019-09-17 |
| 31 | 2542-DEL-2010-GPA-(24-01-2011).pdf | 2011-01-24 |
| 31 | 2542-DEL-2010-RELEVANT DOCUMENTS [20-03-2020(online)].pdf | 2020-03-20 |
Search Strategy
| 1 | 2542del2010_12-12-2017.pdf |