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An Improved Process For The Preparation Of Thymidine Derivative
Abstract: The present invention provides an improved and economical method for the preparation of 3’-azido-3’ –deoxy-5’ –trityl thymidine of formula (I-A). The present invention further provides a simple and industrially useful method for the preparation of 3’ –azido-3’ –deoxy-5’ – trityl thymidine of formula (I-A), in a single-pot, which comprises the reaction of beta-thymidine (II) with trityl choride in presence of base utilizing an inert organic solvent to give a 5’ –O-tritylthymidine of formula (III), which on reaction with methanesulphonyl chloride in the same pot gives 5’ –O-trityl 3’ –O-mesylthymidine, which on subsequent cyclization with an inorganic base gives 5’-O-trityl-2,3’-anhydrothymidine (V). Thus, 3’ –azido-3’ –deoxy-5’ –O-tritylthymidine (VI), prepared from 5’ –O-trityl-2,3’ –anhydrothymidine (V), without isolation is allowed to react with sodium azide in presence of ammonium chloride to give 3’ –azido-3’ –deoxy-5’-trityl thymidine of formula (I-A).
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
28 January 2005
Publication Number
38/2007
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2009-06-24
Renewal Date
Applicants
EMCURE PHARMACEUTICALS LTD
12/2 F-II BLOCK,
M.I.D.C. PIMPRI PUNE 4110 018,
Inventors
1. MILIND MORESHWAR GHARPURE
R&D CENTRE II,
12/2 F-II BLOCK,
M.I.D.C. PIMPRI PUNE 4110018.
2. VISHNU HARI DESHPANDE
R&D CENTRE II,
12/2 F-II BLOCK,
M.I.D.C. PIMPRI PUNE 4110018.
3. SWAPNIL PANDITRAO SONAWANE
R&D CENTRE II,
12/2 F-II BLOCK,
M.I.D.C. PIMPRI PUNE 4110018.
4. SATISH RAMANLAL MEHTA
R&D CENTRE II,
12/2 F-II BLOCK,
M.I.D.C. PIMPRI PUNE 4110018.
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 91-MUM-2005-ABSTRACT(5-5-2009).pdf | 2018-08-09 |
| 1 | 91-MUM-2005-FORM 5(30-12-2005).pdf | 2005-12-30 |
| 2 | 91-MUM-2005-ABSTRACT(AMENDED)-(5-5-2009).pdf | 2018-08-09 |
| 2 | 91-MUM-2005-FORM 3(30-12-2005).pdf | 2005-12-30 |
| 3 | 91-MUM-2005-FORM 2(TITLE PAGE)-(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 3 | 91-mum-2005-abstract(granted)-(24-6-2009).pdf | 2018-08-09 |
| 4 | 91-MUM-2005-FORM 2(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 4 | 91-MUM-2005-CANCELLED PAGES(5-5-2009).pdf | 2018-08-09 |
| 5 | 91-MUM-2005-FORM 1(30-12-2005).pdf | 2005-12-30 |
| 5 | 91-MUM-2005-CLAIMS(5-5-2009).pdf | 2018-08-09 |
| 6 | 91-MUM-2005-DESCRIPTION(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 6 | 91-mum-2005-claims(granted)-(24-6-2009).pdf | 2018-08-09 |
| 7 | 91-MUM-2005-CORRESPONDENCE(5-5-2009).pdf | 2018-08-09 |
| 7 | 91-MUM-2005-CLAIMS(30-12-2005).pdf | 2005-12-30 |
| 8 | abstract1.jpg | 2018-08-09 |
| 8 | 91-MUM-2005-CORRESPONDENCE(7-7-2006).pdf | 2018-08-09 |
| 9 | 91-MUM-2005-CORRESPONDENCE(IPO)-(14-7-2009).pdf | 2018-08-09 |
| 9 | 91-MUM-2005_EXAMREPORT.pdf | 2018-08-09 |
| 10 | 91-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(23-9-2009).pdf | 2018-08-09 |
| 10 | 91-MUM-2005-SPECIFICATION(AMENDED)-(5-5-2009).pdf | 2018-08-09 |
| 11 | 91-MUM-2005-DESCRIPTION(COMPLETE)-(5-5-2009).pdf | 2018-08-09 |
| 11 | 91-MUM-2005-PETITION UNDER RULE 137(5-5-2009).pdf | 2018-08-09 |
| 12 | 91-mum-2005-description(granted)-(24-6-2009).pdf | 2018-08-09 |
| 12 | 91-MUM-2005-FORM 5(28-1-2005).pdf | 2018-08-09 |
| 13 | 91-MUM-2005-DESCRIPTION(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 13 | 91-MUM-2005-FORM 3(28-1-2005).pdf | 2018-08-09 |
| 14 | 91-MUM-2005-FORM 1(28-1-2005).pdf | 2018-08-09 |
| 14 | 91-MUM-2005-FORM 26(5-5-2009).pdf | 2018-08-09 |
| 15 | 91-MUM-2005-FORM 1(30-2-2005).pdf | 2018-08-09 |
| 15 | 91-MUM-2005-FORM 2(TITLE PAGE)-(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 16 | 91-MUM-2005-FORM 1(5-5-2009).pdf | 2018-08-09 |
| 16 | 91-mum-2005-form 2(title page)-(granted)-(24-6-2009).pdf | 2018-08-09 |
| 17 | 91-MUM-2005-FORM 2(TITLE PAGE)-(5-5-2009).pdf | 2018-08-09 |
| 17 | 91-MUM-2005-FORM 18(7-7-2006).pdf | 2018-08-09 |
| 18 | 91-mum-2005-form 2(5-5-2009).pdf | 2018-08-09 |
| 18 | 91-MUM-2005-FORM 2(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 19 | 91-mum-2005-form 2(granted)-(24-6-2009).pdf | 2018-08-09 |
| 20 | 91-mum-2005-form 2(5-5-2009).pdf | 2018-08-09 |
| 20 | 91-MUM-2005-FORM 2(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 21 | 91-MUM-2005-FORM 18(7-7-2006).pdf | 2018-08-09 |
| 21 | 91-MUM-2005-FORM 2(TITLE PAGE)-(5-5-2009).pdf | 2018-08-09 |
| 22 | 91-MUM-2005-FORM 1(5-5-2009).pdf | 2018-08-09 |
| 22 | 91-mum-2005-form 2(title page)-(granted)-(24-6-2009).pdf | 2018-08-09 |
| 23 | 91-MUM-2005-FORM 1(30-2-2005).pdf | 2018-08-09 |
| 23 | 91-MUM-2005-FORM 2(TITLE PAGE)-(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 24 | 91-MUM-2005-FORM 26(5-5-2009).pdf | 2018-08-09 |
| 24 | 91-MUM-2005-FORM 1(28-1-2005).pdf | 2018-08-09 |
| 25 | 91-MUM-2005-FORM 3(28-1-2005).pdf | 2018-08-09 |
| 25 | 91-MUM-2005-DESCRIPTION(PROVISIONAL)-(28-1-2005).pdf | 2018-08-09 |
| 26 | 91-mum-2005-description(granted)-(24-6-2009).pdf | 2018-08-09 |
| 26 | 91-MUM-2005-FORM 5(28-1-2005).pdf | 2018-08-09 |
| 27 | 91-MUM-2005-DESCRIPTION(COMPLETE)-(5-5-2009).pdf | 2018-08-09 |
| 27 | 91-MUM-2005-PETITION UNDER RULE 137(5-5-2009).pdf | 2018-08-09 |
| 28 | 91-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(23-9-2009).pdf | 2018-08-09 |
| 28 | 91-MUM-2005-SPECIFICATION(AMENDED)-(5-5-2009).pdf | 2018-08-09 |
| 29 | 91-MUM-2005-CORRESPONDENCE(IPO)-(14-7-2009).pdf | 2018-08-09 |
| 29 | 91-MUM-2005_EXAMREPORT.pdf | 2018-08-09 |
| 30 | 91-MUM-2005-CORRESPONDENCE(7-7-2006).pdf | 2018-08-09 |
| 30 | abstract1.jpg | 2018-08-09 |
| 31 | 91-MUM-2005-CORRESPONDENCE(5-5-2009).pdf | 2018-08-09 |
| 31 | 91-MUM-2005-CLAIMS(30-12-2005).pdf | 2005-12-30 |
| 32 | 91-MUM-2005-DESCRIPTION(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 32 | 91-mum-2005-claims(granted)-(24-6-2009).pdf | 2018-08-09 |
| 33 | 91-MUM-2005-FORM 1(30-12-2005).pdf | 2005-12-30 |
| 33 | 91-MUM-2005-CLAIMS(5-5-2009).pdf | 2018-08-09 |
| 34 | 91-MUM-2005-FORM 2(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 34 | 91-MUM-2005-CANCELLED PAGES(5-5-2009).pdf | 2018-08-09 |
| 35 | 91-MUM-2005-FORM 2(TITLE PAGE)-(COMPLETE)-(30-12-2005).pdf | 2005-12-30 |
| 35 | 91-mum-2005-abstract(granted)-(24-6-2009).pdf | 2018-08-09 |
| 36 | 91-MUM-2005-FORM 3(30-12-2005).pdf | 2005-12-30 |
| 36 | 91-MUM-2005-ABSTRACT(AMENDED)-(5-5-2009).pdf | 2018-08-09 |
| 37 | 91-MUM-2005-ABSTRACT(5-5-2009).pdf | 2018-08-09 |
| 37 | 91-MUM-2005-FORM 5(30-12-2005).pdf | 2005-12-30 |