DESC:FIELD OF THE INVENTION:

The present invention relates to synergistic insecticidal compositions comprising bioactive amounts of (A) Emamectin benzoate; (B) at least one insecticide from nereistoxin group; (C) at least one insecticidal compound selected from phenylpyrazole; pyrethroids; nicotinic insecticides; spinosyns or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.

BACKGROUND OF THE INVENTION:

Combination of insecticides are used to broaden the spectrum of control of insect, to improve the pest control with synergistc effect, reduce dosage, thereby reducing environmental impact, to broaden the spectrum of control, i.e. chewing and sucking insects at a time, decrease chances of development and management of resistance and to enhance residual control so lesser the number of sprays for crop protections and minimizing the pesticidal load in ecosystem. The combination of insecticides at times demonstrate an additive or synergistic effect that results in an improved control on the pests.

Insecticide or pesticides are used widely and very frequently in commercial agriculture and have enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in term of economic advantage as well as ease of farming activities.

There are many combinations of insecticide known in the art for the control of soil borne pests. For example, JP2020019789A patent relates to the use of carboxamide derivatives for controlling arthropods, in particular insects and arachnids, mites and / or nematodes. Further it relates to an emamectin benzoate insecticide along with insecticide nereistoxin.

CN101626678B patent relates to a method to overcome negative effects of the treatment of seeds with insecticides, acaricides or nematicides on the germination of seeds and vitality of seedlings. Further it relates to an emamectin benzoate insecticide along with insecticide nereistoxin.

US10219516B2 patent relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. This patent discloses the composition comprising insecticide like emamectin benzoate, bensultap and cartap.

CN103228646B patent relates to the field of pyrimidine compound and the purposes aspect pest control thereof. Further it relates to an emamectin benzoate insecticide along with insecticide nereistoxin.

CN102686585B patent relates to the heterogeneous ring compound of particular types and for preventing and treating the purposes of pests.

JP6644679B2 patent relates to a mixture of active ingredients having a synergistic enhancing action, and to a method comprising applying said mixture. Further it relates to an emamectin benzoate insecticide along with insecticide nereistoxin to treat the lepidopterans, coleopterans etc.

There is however a need for improvement of these combinations. Single and multiple active combinations used over a long period of time has resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of disease and pest control. Objects of the invention.

However still there is a need for a composition comprises emamectin benzoate; insecticide from nereistoxin group of compounds; and at least one insecticide selected from compound having various mode of action which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
Nereistoxin insecticide is strictly, a substance intended to kill members of the class insecta. It is a natural product identified in 1962 as the toxic organic compound N, N-dimethyl-1, 2-dithiolan-4-amine. It had first been isolated in 1934 from the marine annelid Lumbriconereis heteropoda and acts by blocking the nicotinic acetylcholine receptor.
In general use, the pesticide actives are used in the form of a dilute aqueous composition nereistoxin on because it can attain a good interaction with the target organism, such as plants, fungi and insects. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved combinations of insecticides for the control of foliar feeder and soil born pests. Another object of the present invention is to provide a method and a composition for controlling insect pests.
Yet another object of the present invention is to provide improved combinations of insecticides that promote plant health.
Inventors of the present invention have surprisingly found that the novel synergistic
composition of Emamectin benzoate insecticide; Nereistoxin insecticide from group of compounds; and at least one insecticide selected from compound having various mode of action as described herein which can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION:
Therefore an aspect of the present invention provides an insecticidal composition comprising (A) Emamectin benzoate; (B) at least one insecticide from nereistoxin group; (C) at least one insecticidal compound selected from phenylpyrazole; pyrethroids; nicotinic insecticides; spinosyns or mixture thereof.
Accordingly, in a further aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage by applying to the plant propagation material a composition comprising an insecticidal composition defined in the first aspect.
As per one embodiment formulation for an insecticidal composition is selected from Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR), Capsule suspension (CS), Dispersible concentrate (DC), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion for seed treatment (ES), Emulsion, oil in water (EW), Flowable suspension/concentrate for seed treatment (FS), Jambo balls or bags (bags in water soluble pouch), Solution for seed treatment (LS), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (= flowable concentrate) (SC), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP), Water dispersible granule (WG or WDG), Wettable powder (WP), Water dispersible powder for slurry treatment (WS), A mixed formulation of CS en SC (ZC), A mixed formulation of CS en SE (ZE), A mixed formulation of CS en EW (ZW).
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR).

DETAILED DESCRIPTION OF THE INVENTION:
The term "synergistic", as used herein, refers the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.
"Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
Therefore an aspect of the present invention provides an insecticidal composition comprising (A) Emamectin benzoate; (B) at least one insecticide from nereistoxin group; (C) at least one insecticidal compound selected from phenylpyrazole; pyrethroids; nicotinic insecticides; spinosyns or mixture thereof.
In an embodiment of the present invention the insecticide from group of nereistoxin selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium.
In an embodiment of the present invention the insecticide from group of Phenylpyrazole selected from ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole.
In an embodiment of the present invention the insecticide from group of pyrethroids selected from bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (py rethrum).
In an embodiment of the present invention the insectide from group of nicotinic insecticides selected from neonicotinoids: acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin;
In a further embodiment of the present invention the insecticide from sulfoximines class of compound is sulfoxaflor.
In a further embodiment of the present invention the insecticide from butenolides class of compound is flupyradifurone.
In a further embodiment of the present invention the insecticide from mesoionics class of compounds are triflumezopyrim, dichloromezotiaz, fenmezoditiaz.
In an embodiment of the present invention the insectide from group of spinosyns may be selected from spinosad, spinetoram.
More particularly an aspect of the present invention provides an insecticidal composition comprising (A) Emamectin benzoate; (B) at least one insecticide from nereistoxin group; (C) at least one insecticidal compound selected from phenylpyrazole; pyrethroids; nicotinic insecticides; spinosyns or mixture thereof.
The present invention provides formulation for the aforesaid composition and method of preparation thereof.
Emamectin benzoate is an insecticide, with a mechanism of action and a strong activity against Lepidoptera as well as with and a high selectivity on useful organisms. This molecule acts if swallowed and has some contact action. It penetrates leaf tissues (translaminar activity) and forms a reservoir within the leaf. The mechanism of action is unique in the panorama of insecticides. In facts, it inhibits muscle contraction, causing a continuous flow of chlorine ions in the GABA and H-Glutamate receptor sites.
Nereistoxin group of insecticides:
Nereistoxin has chemical similarity to acetylcholine and its mode of action was suggested originally as being possibly by interference with acetylcholinesterase. Later electrophysiological studies using synapses from the cockroach Periplaneta Americana showed that it acts by blocking the nicotinic acetylcholine receptor / ion channel complex in the insect central nervous system. This is also the mode of action of the related insecticides, all of which can produce the dithiol corresponding to cleavage of the 1, 2-thiolane ring in the parent compound.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combinations of the present invention allow for a broad spectrum of pest control and has surprisingly improved plant vigour and yield. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic composition has very advantageous curative, preventive and systemic fungicidal properties for protecting cultivated plants. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens. Active ingredient composition has the special advantage of being highly active against diseases in the soil that mostly occur in the early stages of plant development.
The synergistic composition of pesticide are used to protect the crops and plants from insect and fungus pests. The lists of crops on which the present innovative compositions may be used include but are not limited to GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sugarcane (Saccharum officinarum), Soybean (Glycin max), Peanut (Arachis hypogaea), Mustard (Brassica juncea), Green gram (Vigna radiata), Chickpea (Cicer aritinum), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Chilly (Capsicum annum), Garlic (Allium sativum), Bottle gourd (Lagenaria siceraria), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Pomegranate (Punica granatum), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum).
The composition according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of the inventive mixtures or of compositions comprising the mixtures.
The synergistic combination of the present invention used to control the insects-pests belongs to the order of the Hemiptera, for example, rice leafhopper Nephotettix nigropictus, rice brown plant hopper Nilaparvata lugen, rice white backed plant hopper, Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, cotton aphid Aphis gossypii, cotton jassid Amrasca biguttula biguttla, cotton mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, cotton whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp.
From order Lepidoptera for example army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, tobacco budworm Heliothis virescens, tomato fruitworm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza novella, Tuta absoluta.
From the order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc.
From the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.
From the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci and Scirtothrips dorsalis.
From the order termites (Isoptera), for example Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis.
From the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp.
From the order Hymenoptera, for example, Solenopsis spp.
From the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp.
From the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, Tetranychus cinnabarinus.
Plant parasitic nematodes such as root-knot nematodes, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; seed gall nematodes, Anguina funesta, Anguina tritici and other Anguina species; stem and foliar nematodes, Aphelenchoides besseyi, Aphelen-choides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species; sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; ring ne-matodes, Criconema species, Criconemella species, Criconemoides species, and Me-socriconema species; stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species; awl nematodes, Dolichodorus species; spiral nematodes, Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicotylenchus species, Rotylenchus robustus and other Roty-lenchus species; sheath nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; lance nematodes, Hoplolaimus columbus, Hoplolai-mus galeatus and other Hoplolaimus species; false root-knot nematodes, Nacobbus aberrans and other Nacobbus species; needle nematodes, Longidorus elongates and other Longidorus species; pin nematodes, Paratylenchus species; lesion nematodes, Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylencus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species; Radinaphelenchus cocophilus and other Radinaphelenchus species; burrowing nematodes, Radopholus similis and other Radopholus species; reniform nematodes, Rotylenchulus reniformis and other Rotylenchulus species; Scutellonema species; stubby root nematodes, Tri-chodorus primitivus and other Trichodorus species; Paratrichodorus minor and other Paratrichodorus species; stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhyn-chus dubius and other Tylenchorhynchus species and Merlinius species; citrus nematodes, Tylenchulus semipenetrans and other Tylenchulus species; dagger nematodes, Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xi-phinema species; and other plant parasitic nematode species.
Formulation of the present invention can be in any of the formulations selected from Granule/ soil applied (GR), Controlled (Slow or Fast) release granules (CR), Capsule suspension (CS), Dispersible concentrate (DC), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion for seed treatment (ES), Emulsion, oil in water (EW), Flowable suspension/concentrate for seed treatment (FS), Jambo balls or bags (bags in water soluble pouch), Solution for seed treatment (LS), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (= flowable concentrate) (SC), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP), Water dispersible granule (WG or WDG), Wettable powder (WP), Water dispersible powder for slurry treatment (WS), A mixed formulation of CS en SC (ZC), A mixed formulation of CS en SE (ZE), A mixed formulation of CS en EW (ZW).
The preferred formulation for the present insecticidal composition is selected from Granule formulation, soil applied Granule formulation (GR), Controlled (Slow or Fast) release granules (CR).
Further composition comprising of (A) Emamectin benzoate; (B) an insecticide from nereistoxin group; and (C) at least one insecticidal compound selected from phenylpyrazole, pyrethroids, nicotinic insecticides, spinosyns or mixture thereof; which are bio active ingredient for the present composition are present in specific fixed ratio.
One or more of the active ingredients can be encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.
Further (A) Emamectin benzoate present in an amount of 0.01 - 5 % by weight; ; (B) an insecticide from nereistoxin group present in an amount of 0.1 % - 20 % by weight; and (C) an insecticide selected from phenylpyrazole, pyrethroids, nicotinic insecticides, spinosyns, mixture or thereof present in an amount of 1% -20% by weight; along with inactive excipients are present in fixed specific percentage by weight.
Compounds Compound A Compound B Compound C
Composition Emamectin benzoate an insecticide from nereistoxin A group of insecticides
Ratio 0.01% to 5% w/w 0.1% to 20% w/w 1% to 20% w/w

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased.
Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.
In an especially preferred embodiment of the invention, the yield of the treated plant is increased.
In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.
Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.
According to the present invention, the yield is increased by at least 4 %, preferable by 5 to 10 %, more preferable by 10 to 20 %, or even 20 to 30 % compared to the untreated control plants or plants treated with pesticides in a way different from the method according to the present invention. In general, the yield increase may even be higher.
A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased CO2 assimilation rate), increased stomatal conductance, increased CO2 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defence mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.
The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).
Another indicator for the condition of the plant is the "quality" of a plant and/or its products.
In an especially preferred embodiment of the invention, the quality of the treated plant is increased.
In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.
The advantages of innovative combination includes the one shot control of soil hibernating (termites, whitegrub, root weevil, root feeder) and foliage feeding insects (stem borers, internode borers, sap suckers etc.). It also delays or prevent the resistance development in insect-pests. It helps to increase the yield of treated plants (cereals, pulses, oilseeds, fiber crop, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamentals etc.) which helps to increase in yield due to more number of tillers, more branches and sub branches, more number of flowers, and more number of fruits. It also Increases the plant vigor and improves the quality (means visual appearance, color, size, shape etc.) in grains, fruits, fiber, flowers, tuber, bulb, rhizomes, straw, leaves and other plant parts and plant products.
The process for preparing the present Granular agrochemical composition comprising can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.
Preferred granular compositions containing emamectin benzoate (compound A+ nereistoxin (compound B) +one more insecticide (compound C) :
Compound A Compound B Compound C Active ingredients (%) Formulation Strength (%)
A B C
Emamectin benzoate Cartap hydrochloride Clothianidin 0.15 4.5 0.6 5.25
Emamectin benzoate Cartap hydrochloride Thiamethoxam 0.15 4.5 0.6 5.25
Emamectin benzoate Cartap hydrochloride Imidacloprid 0.15 4.5 0.6 5.25
Emamectin benzoate Cartap hydrochloride Flupyrimin 0.15 4.5 0.9 5.55
Emamectin benzoate Cartap hydrochloride Triflumezopyrim 0.15 4.5 0.15 4.80
Emamectin benzoate Cartap hydrochloride Dichloromezotiaz 0.1 4 0.5 4.60
Emamectin benzoate Cartap hydrochloride Fenmezoditiaz 0.1 4 0.5 4.60
Emamectin benzoate Cartap hydrochloride Fipronil 0.12 5 0.4 5.52
Emamectin benzoate Cartap hydrochloride Bifenthrin 0.12 5 0.4 5.52
Emamectin benzoate Cartap hydrochloride Spinosad 0.12 5 0.4 5.52
Emamectin benzoate Cartap hydrochloride Spinetoram 0.12 5 0.4 5.52
Emamectin benzoate Thiocyclam hydrogen oxalate Clothianidin 0.2 6 0.8 7.00
Emamectin benzoate Thiocyclam hydrogen oxalate Thiamethoxam 0.2 6 0.8 7.00
Emamectin benzoate Thiocyclam hydrogen oxalate Imidacloprid 0.2 6 0.4 6.60
Emamectin benzoate Thiocyclam hydrogen oxalate Flupyrimin 0.2 6 1.2 7.40
Emamectin benzoate Thiocyclam hydrogen oxalate Triflumezopyrim 0.2 6 0.2 6.40
Emamectin benzoate Thiocyclam hydrogen oxalate Dichloromezotiaz 0.1 4 0.5 4.60
Emamectin benzoate Thiocyclam hydrogen oxalate Fenmezoditiaz 0.1 4 0.5 4.60
Emamectin benzoate Thiocyclam hydrogen oxalate Fipronil 0.096 3.6 0.32 4.02
Emamectin benzoate Thiocyclam hydrogen oxalate Bifenthrin 0.096 3.6 0.32 4.02
Emamectin benzoate Thiocyclam hydrogen oxalate Spinosad 0.096 3.6 0.32 4.02
Emamectin benzoate Thiocyclam hydrogen oxalate Spinetoram 0.096 3.6 0.32 4.02
The granular agrochemical composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to dispersing agent, emulsifier, buffering agent, controlled release agent, inert material, solvent, carrier or filler and colouring agent.
Example of dispersing agent used herein for present Granule formulation is selected from Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly (oxypropylene) block polymer with poly(oxyethylene), ethoxylated tristyrene phenol is alpha-[2,4,6-tris[1-(phenyl)ethyl] phenyl]-omega-hydroxy poly(oxyethylene, poly(oxy-1,2-ethanediyl)-alpha-C10-15alkyl-omega-hydroxy phosphate or sulphate and/or a C10-13alkylbenzenesulfonic acid, tristyrylphenols, nonylphenols, dinonylphenol and octylphenols, styrylphenol polyethoxyester phosphate, alkoxylated C14-20 fatty amines, alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, phenol sulfonic acid urea formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, polyacrylates and phosphate esters, calcium lignosulfonate, sodium lignosulfonate, sodium lignosulfonate-sulfomethylated.
More preferred dispersing agent for Granule formulation is selected from Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly (oxypropylene) block polymer with poly(oxyethylene), naphthalene condensates, polyacrylates and phosphate esters, calcium lignosulfonate, sodium lignosulfonate, sodium lignosulfonate-sulfomethylated present in more preferred range in an amount of 0.1-8.0%w/w.
Most preferred dispersing agent for Granule formulation is selected from Copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), calcium lignosulfonate, present in most preferred range in an amount of 0.5-4.0%w/w.
Example of emulsifier or emulsifying agent used herein for present Granule formulation is selected from mono C2-6 alkyl ether of a poly C2-4alkylene oxide block copolymer, condensation product of castor oil and poly C2-4alkylene oxide, alkoxylated castor oil is available under the trade name Agnique CSO-36, a mono- or di-ester of a C12-24fatty acid and polyC2-4alkylene oxide, carboxylates, sulphates, sulphonates, alcohol ethoxylates, Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate, alkyl phenol ethoxylates, fatty acid ethoxylates, sorbitan esters, ethoxylated fats or oils, amine ethoxylates, phosphate esters, ethylene oxide - propylene oxide copolymers, fluorocarbons,alkyd-polyethylene glycol resin, polyalkylene glycol ether, apolyalkoxylated nonyl phenyl, alkoxylated primary alcohol, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts,alkyd-polyethylene glycol resin, polyalkylene glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt.
More preferred emulsifier or emulsifying agent for Granule formulation is selected from ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts,alkyd-polyethylene glycol resin, polyalkylene glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt, Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate present in more preferred range in an amount of 0.05-8.0%w/w.
Most preferred emulsifier or emulsifying agent for Granule formulation is selected from ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate present in most preferred range in an amount of 0.1-4.0%w/w.
Example of solvents used herein for present Granule formulation is selected from liquid paraffin oil fatty acid methyl ester, cyclohexane, xylene, mineral oil or kerosene, mixtures or substituted naphthalene, mixtures of mono- and poly alkylated aromatics, dibutyl phthalate or dioctyl phthalate, ethylene glycol monomethyl or mono ethyl ether, butyrolactone, octanol, castor oil, soybean oil, cottonseed oil, epoxidised coconut oil or soybean oil, aromatic hydrocarbons, dipropylene glycol mono methylether, polypropylene glycol [M.W. 2000-4000], polyoxyethylene polyoxypropylene glycols, polyoxypropylene polyoxyethylene glycols, diethyleneglycol, polyethylene glycol [M.W. 200-4000 amu], methoxy polyethylene glycols 350, 550, 750, 2000, 5000; glycerol, methyl oleate, n-octanol, alkyl phosphates such as tri-n-butyl phosphate, propylene carbonate and isoparaffinic, tetrahydrofurfuryl alcohol, gamma-butyrolactone, N-methyl-2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide, diacetone alcohol, polybutene, propylene carbonate, dipropylene glycol isomer mixture, water.
More preferred solvent used herein for present Granule formulation is selected from Liquid paraffin oil, N-methyl-2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide, diacetone alcohol, polybutene, propylene carbonate, dipropylene glycol isomer mixture, water present in more preferred range in an amount of 0.05-8.0%w/w.
Most preferred solvent used herein for present Granule formulation is selected from Liquid paraffin oil, N-methyl-2-pyrrolidone, N,N-dimethylacetamide, water present in most preferred range in an amount of 0.1-4.0%w/w.
Example of Carrier or filler agent used herein for present Granule formulation is selected from diatomaceous earth, attapulgite or zeolites, dolomite, limestone, silica, river sand (Silica), sand, fly ash, hydrated lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, attapulgite, diatomaceous earth, calcium carbonate, calcium silicate, magnesium stearate, talc, muscovite mica, fused sodium potassium, aluminum silicate, perlite, talc, muscovite mica, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple super phosphate, phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide.
More preferred Carrier or filler agent used herein for present Granule formulation is selected from silica, river sand (Silica), sand, phosphoric acid, talc powder present in more preferred range in an amount of 60-92%w/w.
Most preferred Carrier or filler agent used herein for present Granule formulation is selected from silica, river sand (Silica) present in most preferred range in an amount of 80-90%w/w.
Example of colouring agent used herein for present Granule formulation is selected from crystal violet, thalocyano dye chlorinated, aerosol green FFB dye, rhodamine, azo compound, dye blue present in an amount of 0.01-1.0%w/w.
Most preferred colouring agent used herein for present Granule formulation is selected from aerosol green FFB dye, rhodamine, dye blue present in most preferred range in an amount of 0.01-1.0%w/w.
Example of slow release or controlled release agent used herein for present Granule formulation is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, Polyacrylic acid, sodium polyacrylate, modified starch, paraffin wax, polyvinyl acetate, montan wax and vinyl acetate, polyethylene glycol 6000, cationic hydrosoluble polymer, C4 alkylated polyvinyl pyrrolidone.
More preferred slow release or controlled release agent used herein for present Granule formulation is selected from carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, Polyacrylic acid, sodium polyacrylate, modified starch, paraffin wax, polyvinyl acetate present in more preferred range in an amount of 0.05-8.0%w/w.
Most preferred slow release or controlled release agent used herein for present controlled Release Granule formulation is selected from polyvinyl alcohols, Polyacrylic acid, paraffin wax present in most preferred range in an amount of 0.1-6.0%w/w.
Example of Inert agent used herein for present Granule formulation is selected from Precipitated silica, Nano polysaccharide, china clay, silica, lactose anhydrous, lactose monohydrate, ammonium sulphate, sodium sulphate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc powder, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels.
Most preferred inert agent or material used herein for present Granule formulation is selected from precipitated silica, Nano polysaccharide, china clay, silica, talc powder present in most preferred range in an amount of present in an amount of 0.5-3.0%w/w.
Example of buffering agent used herein for present Granule formulation is selected from calcium hydroxyapatite, phosphoric acid, sodium citrate, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.
Most preferred buffering agent used herein for present Granule formulation is selected from phosphoric acid, sodium citrate present in most preferred range in an amount of present in an amount of 0.1-1.0%w/w.

Example 1:
Granular composition of Emamectin benzoate 0.15% + Cartap hydrochloride 4.5% + Clothianidin 0.6%
Ingredients Content % (w/w) Function
Emamectin Benzoate a.i. 0.15 active ingredient 1
Cartap Hydrochloride a.i. 4.50 active ingredient 2
Clothianidin a.i. 0.60 active ingredient 3
Tri-styryl Phenol Ethoxylate 3.00 emulsifier
Phosphoric acid 0.50 Buffering agent
N-methyl-2-pyrrolidone 3.00 solvent
Copolymer of propylene oxide (PO) and ethylene oxide (EO) 2.50 dispersing agent
Rhodamine 0.50 colourant
Precipitated silica 2.00 inert
River sand (silica) 83.25 carrier/filler
Total 100.00
a.i.-active ingredient on 100% purity basis.

Method of Preparation:
Manufacturing process for preparing 100 kg granular composition of Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Clothianidin 0.6%
Step 1-Add 0.15 kg of Emamectin Benzoate technical into 3.0 kg of N-methyl-2-pyrrolidone, 2.5 kg of Copolymer of propylene oxide (PO) and ethylene oxide (EO), 0.5 kg of Rhodamine dye, add 3.0 kg of Tri-styryl Phenol Ethoxylate and 0.50 kg of Phosphoric acid and homogenize the mixture.
Step 2-Now spray this mixture on 83.25 kg of River sand and blend it till homogeneity
Step 3- Now blend 4.5 kg of Cartap Hydrochloride technical and 0.6 kg of Clothianidin technical on this treated sand and homogenize it till homogeneity
Step 4- Finally add silica to make granules free flowing and free of moisture
Step 5- Final product is sent for QC approval.
Stability Study:
Storage stability-Emamectin benzoate 0.15%+Cartap hydrochloride 4.5% + Clothianidin 0.6% Granule.
Laboratory storage stability
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Emamectin Benzoate a.i. 0.1425 to 0.165 0.158 0.151 0.156
Cartap Hydrochloride a.i. 4.275 to 4.95 4.90 4.54 4.86
Clothianidin a.i. 0.57 to 0.66 0.64 0.62 0.63
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.5 99.2 99.3
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.50
Room temperature storage stability
Parameters specification (in house) 1 month 6 months 12 months
Emamectin Benzoate a.i. 0.1425 to 0.165 0.158 0.155 0.151
Cartap Hydrochloride a.i. 4.275 to 4.95 4.90 4.82 4.55
Clothianidin a.i. 0.57 to 0.66 0.64 0.63 0.62
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.50 96.35 96.25
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.40

The storage stability study of composition of Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Clothianidin 0.6% Granule meets the all in-house parameters likes; active ingredients content, pH range, dustiness, dry sieve, attrition resistance, bulk density and moisture content, in laboratory condition (for 14 days) and room temperature (up to 12 months).
Example 2
Composition of Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Fipronil 0.32% Granule
Ingredients Content % (w/w) Function
Emamectin Benzoate a.i. 0.096 active ingredient 1
Thiocyclam hydrogen oxalate a.i. 3.60 active ingredient 2
Fipronil a.i. 0.32 active ingredient 3
Tri-styryl Phenol Ethoxylate 3.00 emulsifier
Liquid Paraffin Oil 3.00 solvent
Copolymer of propylene oxide (PO) and ethylene oxide (EO) 1.00 dispersing agent
Rhodamine 0.50 colourant
Precipitated silica 2.00 inert
Riversand (Silica) 86.48 carrier/filler
Total 100.00
a.i.-active ingredient on 100% purity basis.

Method of Preparation: Process of preparation is as per Example 1.
Stability Study:
Storage stability-Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Fipronil 0.32% Granule
Laboratory storage stability
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Emamectin Benzoate a.i. 0.0912 to 0.1056 0.105 0.100 0.103
Thiocyclam hydrogen oxalate a.i. 3.42 to 3.96 3.90 3.64 3.85
Fipronil a.i. 0.304 to 0.352 0.35 0.33 0.35
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.5 99.2 99.3
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.50
Room temperature storage stability
Parameters specification (in house) 1 month 6 months 12 months
Emamectin Benzoate a.i. 0.0912 to 0.1056 0.105 0.103 0.100
Thiocyclam hydrogen oxalate a.i. 3.42 to 3.96 3.90 3.85 3.64
Fipronil a.i. 0.304 to 0.352 0.35 0.35 0.33
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.50 96.35 96.25
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.40

The storage stability study of composition of Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6% + Fipronil 0.32% Granule meets the all in-house parameters likes; active ingredients content, pH range, dustiness, dry sieve, attrition resistance, bulk density and moisture content, in laboratory condition (for 14 days) and room temperature (up to 12 months).
Example 3:
Granular composition of Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2% Granule

Ingredients Content % (w/w) Function
Emamectin Benzoate a.i. 0.20 active ingredient 1
Thiocyclam hydrogen oxalate a.i. 6.00 active ingredient 2
Triflumezopyrim a.i. 0.20 active ingredient 3
Tri-styryl Phenol Ethoxylate 3.00 emulsifier
Polyvinyl alcohols 1.00 slow release agent
Nano polysaccharide 2.50 inert 1
Liquid Paraffin oil 3.00 solvent
Copolymer of propylene oxide (PO) and ethylene oxide (EO) 1.00 dispersing agent
Rhodamine 0.50 colourant
Precipitated silica 1.00 inert 2
River sand (silica) 81.60 carrier/filler
Total 100.00

a.i.-active ingredient on 100% purity basis

Method of Preparation:
Manufacturing process for preparing 100 kg granular composition of Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2%
Step 1-Add 0.2 kg of Emamectin Benzoate and 0.2 kg of Triflumezopyrim technical into 3.0 kg of Liquid Paraffin oil, 0.5 kg of Rhodamine dye, 3.0 kg of Tri-styryl Phenol Ethoxylate, 1.0 kg of Copolymer of propylene oxide (PO) and ethylene oxide (EO) then add 1.0 kg of polyvinyl alcohols and homogenize the mixture.
Step 2-Now spray this mixture on 81.60 kg of River sand granules and blend it till homogeneity
Step 3- Now add 6.0 kg of Thiocyclam hydrogen oxalate technical on these treated granules and blend till homogeneity.
Step 4- Finally add 1.0 kg of silica to make granules free flowing and free of moisture
Step 5- Final product is sent for QC approval.
Step 6- After approval, material is packed in required pack sizes.
Stability Study:
Storage stability-Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2% Granule
Laboratory storage stability
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Emamectin Benzoate a.i. 0.19 to 0.22 0.250 0.235 0.24
Thiocyclam hydrogen oxalate a.i. 5.70 to 6.60 6.25 6.15 6.23
Triflumezopyrim a.i. 0.19 to 0.22 0.250 0.235 0.25
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.5 99.2 99.3
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.50
Room temperature storage stability
Parameters specification (in house) 1 month 6 months 12 months
Emamectin Benzoate a.i. 0.19 to 0.22 0.250 0.250 0.24
Thiocyclam hydrogen oxalate a.i. 5.70 to 6.60 6.25 6.25 6.23
Triflumezopyrim a.i. 0.19 to 0.22 0.250 0.250 0.24
pH range (1% aq. Suspension) 4.0 to 7.0 5.50 5.50 5.50
Dustiness < 20 mg 10 10 10
Dry sieve (300 micron) percent by mass min. > 90% 99.50 96.35 96.25
Attrition Resistance (<100 micron) < 5% 2.10 2.10 2.10
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 1.50 1.50 1.40

The storage stability study of composition of Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2% Granule meets the all in-house parameters likes; active ingredients content, pH range, dustiness, dry sieve, attrition resistance, bulk density and moisture content, in laboratory condition (for 14 days) and room temperature (up to 12 months).
Example 4
Composition of Emamectin benzoate 0.15%+Cartap hydrochloride 4.5% + Flupyrimin 0.9% Granule
Ingredients Content % (w/w) Function
Emamectin Benzoate a.i. 0.15 active ingredient 1
Cartap hydrochloride a.i. 4.50 active ingredient 2
Flupyrimin a.i. 0.90 active ingredient 3
Polyacrylic acid 0.40 controlled release agent
Water 0.40 solvent
Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate 0.40 emulsifier
Calcium lignosulfonate 1.00 dispersing agent
Dye blue 0.05 colourant
Talc powder 8.00 inert
Sand 84.20 carrier/filler
Total 100.00
a.i. - active ingredient on 100% purity basis
Method of Preparation: Process of preparation is as per Example 4.
Stability Study:
The storage stability study of composition of Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Flupyrimin 0.9% Granule meets the all in-house parameters likes; active ingredients content, pH range, dustiness, dry sieve, attrition resistance, bulk density and moisture content, in laboratory condition (for 14 days) and room temperature (up to 12 months).

Biological Examples:
The granular compositions of emamectin benzoate+nereistoxin insecticide+insecticide has been developed in the laboratory and evaluated under field condition in terms of bio-efficacy, residual control and compared with conventional combinations and tank mixes.
A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:

Experiment 1: Bioefficacy of granular composition of Emamectin benzoate+Cartap hydrochloride+Insecticide on insect-pests control and yield attributing characters in rice crop
Crop : Rice
Location : Dhamtari, Chattishgarh
Number of Treatments: Twenty four
Replication : Two
Method of Application: Soil application-manual broadcasting at 27 DATP (Days after transplanting)
Observation Methods:
Stem borer control (%): Stem borer (Scirpophaga incertulas) causes damage as dead heart (damaged tiller) symptoms in vegetative growth stage and white ear (tillers with damaged ear head/panicles) symptoms in reproductive stage.
Dead heart symptoms: Count the number of healthy and damaged tillers (dead heart) per hill. Record the observations from 10 hills per plot at 50 DATP (days after transplanting). Calculate Dead Heart (%) incidence and recalculate stem borer (%) control.
White ear symptoms: Count the number of tillers with healthy earhead and white ear per hill. Record the observations from 10 hills per plot at 100 DATP. Calculate white ear incidence (%) and recalculate stem borer control (%).




Leaf folder (Cnaphalocrocis medinalis) control (%): Count the number of damaged leaflet and healthy leaflet per hill. Record the observations from 10 hills per plot at 40 DATP. Calculate Leaf folder damage (%).


Brown Plant Hopper (BPH, Nilaparvata lugens) Control (%): Count the number of live BPH (nymph+adult stage) per hill. Record the observations from 10 hills per plot at 75 DATP. Calculate BPH control (%).

Productive Tillers Count: Count the number of productive tillers per hill. Record the observations from 20 hills per plot.
Table 1: Treatment details
Treatment number Treatment details Formulation (g or ml) per hectare gram active ingredients per hectare
T1 Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Clothianidin 0.6% Granule 10000 15+450+60
T2 Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Thiamethoxam 0.6% Granule 10000 15+450+60
T3 Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Imidacloprid 0.3% Granule 10000 15+450+30
T4 Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Flupyrimin 0.9% Granule 10000 15+450+90
T5 Emamectin benzoate 0.15%+Cartap hydrochloride 4.5%+Triflumezopyrim 0.15% Granule 10000 15+450+15
T6 Cartap hydrochloride 4.5%+Clothianidin 0.6% Granule 10000 450+60
T7 Cartap hydrochloride 4.5%+Thiamethoxam 0.6% Granule 10000 450+60
T8 Cartap hydrochloride 4.5%+Imidacloprid 0.3% Granule 10000 450+30
T9 Cartap hydrochloride 4.5%+Flupyrimin 0.9% Granule 10000 450+90
T10 Cartap hydrochloride 4.5%+Triflumezopyrim 0.15% Granule 10000 450+15
T11 Emamectin benzoate 0.2%+Clothianidin 0.8% Granule 7500 15+60
T12 Emamectin benzoate 0.2%+Thiamethoxam 0.8% Granule 7500 15+60
T13 Emamectin benzoate 0.2%+Imidacloprid 0.4% Granule 7500 15+30
T14 Emamectin benzoate 0.2%+Flupyrimin 1.2% Granule 7500 15+90
T15 Emamectin benzoate 0.2%+Triflumezopyrim 0.2% Granule 7500 15+15
T16 Emamectin benzoate 0.2%+Cartap Hydrochloride 6% GR 7500 15+450
T17 Emamectin benzoate 5% SG 300 15
T18 Cartap hydrochloride 4% GR 11250 450
T19 Clothianidin 0.5% GR 12000 60
T20 Thiamethoxam 25% WG 240 60
T21 Imidacloprid 0.3% GR 10000 30
T22 Flupyrimin 2% GR 4500 90
T23 Triflumezopyrim 10.6% SC 141.5 15
T24 UTC (Untreated Control) - -

T1 to T5-ready mix granular compositions, T6 to T23-conventional treatments. SG-soluble granule, WG-Wettable Granule, SC-Suspension concentrate, T17, T20, T23- mixed with sand and broadcasted manually

Table 2: Control of stem borer in rice crop
Treatment number Stem borer control (%) Leaf folder control (%)
Observed Expected Colby's ratio Synergism (Y/N)
T1 100.0 92.08 1.09 Y 94.7
T2 100.0 95.27 1.05 Y 92.5
T3 96.2 91.08 1.06 Y 90.3
T4 100.0 95.55 1.05 Y 98.3
T5 98.3 92.29 1.07 Y 94.7
T6 82.8 72.8
T7 81.2 71.6
T8 80.7 71.3
T9 90.3 85.4
T10 83.5 77.4
T11 75.5 69.3
T12 74.1 68.2
T13 72.3 68.5
T14 86.5 83.5
T15 76.3 74.1
T16 87.2 86.8
T17 57.2 59.3
T18 68.8 63.8
T19 40.7 23.7
T20 38.3 20.6
T21 33.2 19.3
T22 66.7 57.2
T23 42.3 35.3
T24 0.0 0.0

The granular composition of emamectin benzoate+cartap hydrochloride+insecticide (T1 to T5) provides synergistic residual control of stem borer rice leaf folder as compared to all conventional treatments.

Table 3: Control of Leaf folder, Brown Plant Hopper in rice
Treatment number BPH control (%) Productive tillers per sq.m. Increase over T24

T1 98.2 286.5 57.0
T2 97.5 284.1 55.7
T3 92.7 280.2 53.5
T4 98.5 288.7 58.2
T5 99.2 285.3 56.3
T6 85.3 261.5 43.3
T7 82.3 257.3 41.0
T8 78.4 254.7 39.6
T9 88.6 262.8 44.0
T10 91.4 260.5 42.7
T11 84.2 253.1 38.7
T12 81.7 248.2 36.0
T13 75.4 244.3 33.9
T14 84.6 256.3 40.4
T15 87.3 251.6 37.9
T16 60.3 240.5 31.8
T17 27.5 225.4 23.5
T18 31.8 227.6 24.7
T19 68.5 219.7 20.4
T20 66.2 215.6 18.1
T21 60.3 210.3 15.2
T22 70.7 234.6 28.5
T23 73.8 230.2 26.1
T24 0.0 182.5 0.0

The granular composition of emamectin benzoate+cartap hydrochloride+insecticide (T1 to T5) provides excellent control of brown plant hopper and also bears higher number of productive tillers compared to all conventional treatments (T6 to T23).

Experiment 2: Bioefficacy of granular composition of Emamectin benzoate+Cartap hydrochloride+Insecticide against rice stem borer and leaffolder
Crop : Rice
Location : Rudrapur, Uttarakhand
Number of Treatments: Twenty
Replication : Two
Method of Application: Soil application-manual broadcasting at 22 DATP (Days after transplanting)
Observation Methods:
Stem borer control (%): as given in experiment 1.

Table 4: Treatment details
Treatment number Treatment details Formulation (g or ml) per hectare gram active ingredients per hectare
T1 Emamectin benzoate 0.12%+Cartap hydrochloride 5%+Fipronil 0.4% Granule 10000 12+500+40
T2 Emamectin benzoate 0.12%+Cartap hydrochloride 5%+Bifenthrin 0.4% Granule 10000 12+500+40
T3 Emamectin benzoate 0.12%+Cartap hydrochloride 5%+Spinosad 0.4% Granule 10000 12+500+40
T4 Emamectin benzoate 0.12%+Cartap hydrochloride 6%+Spinetoram 0.4% Granule 10000 12+500+40
T5 Cartap hydrochloride 5%+Fipronil 0.4% Granule 10000 500+40
T6 Cartap hydrochloride 5%+Bifenthrin 0.4% Granule 10000 500+40
T7 Cartap hydrochloride 5%+Spinosad 0.4% Granule 10000 500+40
T8 Cartap hydrochloride 5%+Spinetoram 0.4% Granule 10000 500+40
T9 Emamectin benzoate 0.12%+Fipronil 0.4% Granule 10000 12+40
T10 Emamectin benzoate 0.12%+Bifenthrin 0.4% Granule 10000 12+40
T11 Emamectin benzoate 0.12%+Spinosad 0.4% Granule 10000 12+40
T12 Emamectin benzoate 0.12%+Spinetoram 0.4% Granule 10000 12+40
T13 Emamectin benzoate 0.12%+Cartap Hydrochloride 5% GR 10000 12+500
T14 Emamectin benzoate 5% SG 240 12
T15 Cartap hydrochloride 4% GR 12500 500
T16 Fipronil 0.6% GR 6666.7 40
T17 Bifenthrin 10% EC 400 40
T18 Spinosad 0.8% GR 5000 40
T19 Spinetoram 0.8% GR 5000 40
T20 UTC (Untreated Control) - -
T1 to T4- ready mix granular composition; T5 to T19-conventional treatments; T14, T17-mixed with sand and broadcasted manually.

Table 5: Stem borer and leaffolder control
Treatment number Stem borer control (%) Leaf folder control (%)
Observed Expected Colby's ratio Synergism (Y/N)
T1 100.0 93.69 1.07 Y 100.0
T2 96.8 88.23 1.10 Y 95.7
T3 100.0 93.71 1.07 Y 100.0
T4 100.0 93.95 1.06 Y 100.0
T5 87.6 80.5
T6 86.2 77.4
T7 88.2 79.7
T8 88.4 80.2
T9 78.4 77.3
T10 75.3 70.1
T11 78.3 72.3
T12 79.6 73.5
T13 85.7 77.6
T14 49.6 47.6
T15 71.2 67.2
T16 56.5 52.5
T17 50.3 43.7
T18 56.7 43.7
T19 58.3 45.2
T20 0.0 0.0

The ready mix granular composition of emamectin benzoate+cartap hydrochloride+insecticide (T1 to T4) provides synergistic residual control of rice stem borer and leaffolder compared to all conventional treatments (T5 to T19).

Experiment 3: Bioefficacy of granular composition of Emamectin benzoate+Thiocyclam hydrogen oxalate+ Insecticide against rice stem borer.
Crop : Rice
Location : Kurud, Chhattishgarh
Number of Treatments: Twenty four
Replication : Two
Method of Application: Soil application-manual broadcasting at 29 DATP (Days after transplanting)
Observation Methods: as per the experiment 1.

Table 6: Treatment details
Treatment number Treatment details Formulation (g or ml) per hectare gram active ingredients per hectare
T1 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Clothianidin 0.8% Granule 7500 15+450+60
T2 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Thiamethoxam 0.8% Granule 7500 15+450+60
T3 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Imidacloprid 0.4% Granule 7500 15+450+30
T4 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Flupyrimin 1.2% Granule 7500 15+450+90
T5 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2% Granule 7500 15+450+15
T6 Thiocyclam hydrogen oxalate 6%+Clothianidin 0.8% Granule 7500 450+60
T7 Thiocyclam hydrogen oxalate 6%+Thiamethoxam 0.8% Granule 7500 450+60
T8 Thiocyclam hydrogen oxalate 6%+Imidacloprid 0.4% Granule 7500 450+30
T9 Thiocyclam hydrogen oxalate 6%+Flupyrimin 1.2% Granule 7500 450+90
T10 Thiocyclam hydrogen oxalate 6%+Triflumezopyrim 0.2% Granule 7500 450+15
T11 Emamectin benzoate 0.2%+Clothianidin 0.8% Granule 7500 15+60
T12 Emamectin benzoate 0.2%+Thiamethoxam 0.8% Granule 7500 15+60
T13 Emamectin benzoate 0.2%+Imidacloprid 0.4% Granule 7500 15+30
T14 Emamectin benzoate 0.2%+Flupyrimin 1.2% Granule 7500 15+90
T15 Emamectin benzoate 0.2%+Triflumezopyrim 0.2% Granule 7500 15+15
T16 Emamectin benzoate 0.2%+Thiocyclam hydrogen oxalate 6% GR 7500 15+450
T17 Emamectin benzoate 5% SG 300 15
T18 Thiocyclam hydrogen oxalate 4% GR 11250 450
T19 Clothianidin 0.5% GR 12000 60
T20 Thiamethoxam 25% WG 240 60
T21 Imidacloprid 0.3% GR 10000 30
T22 Flupyrimin 2% GR 4500 90
T23 Triflumezopyrim 10.6% SC 141.5 15
T24 UTC (Untreated Control) - -
T1 to T5- ready mix granular composition, T6 to T23-conventional treatments.

Table 7: Control of rice stem borer and leaffolder
Treatment number Stem borer control (%) Leaf folder control (%)
Observed Expected Colby's ratio Synergism (Y/N)
T1 100.0 92.80 1.08 Y 100.0
T2 100.0 94.76 1.06 Y 100.0
T3 97.3 91.95 1.06 Y 94.6
T4 100.0 95.81 1.04 Y 100.0
T5 99.6 92.88 1.07 Y 97.2
T6 83.7 72.3
T7 82.5 69.6
T8 81.7 64.5
T9 90.3 81.7
T10 83.2 74.3
T11 76.5 68.3
T12 75.3 65.4
T13 73.1 60.8
T14 86.3 72.8
T15 76.8 67.5
T16 88.4 81.5
T17 58.3 58.7
T18 70.6 62.5
T19 41.3 22.9
T20 37.7 21.7
T21 34.3 20.4
T22 65.8 56.7
T23 41.9 34.6
T24 0.0 0.0

The granular composition of emamectin benzoate+thiocyclam hydrogen oxalate+insecticide (T1 to T5) provides synergistic control of rice stem borer and leaf folder compared to all conventional treatments (T6 to T23).

Table 8: Control rice BPH and productive tillers
Treatment number BPH control (%) Productive tillers per sq.m. Increase over T24

T1 93.7 291.7 76.5
T2 91.2 289.5 75.1
T3 88.7 281.6 70.4
T4 90.5 292.5 77.0
T5 95.4 286.3 73.2
T6 86.3 272.3 64.7
T7 83.5 271.8 64.4
T8 78.6 266.5 61.2
T9 81.5 274.7 66.2
T10 88.3 271.5 64.2
T11 78.7 261.2 58.0
T12 73.4 260.7 57.7
T13 66.7 254.3 53.8
T14 78.4 263.5 59.4
T15 83.5 259.6 57.0
T16 74.6 254.3 53.8
T17 37.6 219.7 32.9
T18 46.4 230.5 39.4
T19 70.7 224.8 36.0
T20 67.3 221.3 33.9
T21 62.5 214.7 29.9
T22 68.4 233.7 41.4
T23 75.7 226.7 37.1
T24 0.0 165.3 0.0

The granular composition of emamectin benzoate+thiocyclam hydrogen oxalate+insecticide (T1 to T5) provides excellent control of Rice BPH and also produces higher number of productive tillers compared to all conventional treatments (T6 to T23).

Experiment 4: Bioefficacy of granular composition of Emamectin benzoate + tetraniliprole + insecticide against lepidopteran pest of rice
Crop : Rice
Location : Yamunanagar, Haryana
Plot size : 36 sq.m.
Number of Treatments: Twenty
Replication : Two

Table 9: Treatment details
Treatment number Treatment details Formulation (g or ml) per hectare gram active ingredients per hectare
T1 Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Fipronil 0.32% Granule 12500 12+450+40
T2 Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Bifenthrin 0.32% Granule 12500 12+450+40
T3 Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Spinosad 0.32% Granule 12500 12+450+40
T4 Emamectin benzoate 0.096%+Thiocyclam hydrogen oxalate 3.6%+Spinetoram 0.32% Granule 12500 12+450+40
T5 Thiocyclam hydrogen oxalate 4.5%+Fipronil 0.4% Granule 10000 450+40
T6 Thiocyclam hydrogen oxalate 4.5%+Bifenthrin 0.4% Granule 10000 450+40
T7 Thiocyclam hydrogen oxalate 4.5%+Spinosad 0.4% Granule 10000 450+40
T8 Thiocyclam hydrogen oxalate 4.5%+Spinetoram 0.4% Granule 10000 450+40
T9 Emamectin benzoate 0.12%+Fipronil 0.4% Granule 10000 12+40
T10 Emamectin benzoate 0.12%+Bifenthrin 0.4% Granule 10000 12+40
T11 Emamectin benzoate 0.12%+Spinosad 0.4% Granule 10000 12+40
T12 Emamectin benzoate 0.12%+Spinetoram 0.4% Granule 10000 12+40
T13 Emamectin benzoate 0.12%+Thiocyclam hydrogen oxalate 4.5% GR 10000 12+450
T14 Emamectin benzoate 5% SG 240 12
T15 Thiocyclam hydrogen oxalate 4% GR 11250 450
T16 Fipronil 0.6% GR 6666.7 40
T17 Bifenthrin 10% EC 400 40
T18 Spinosad 0.8% GR 5000 40
T19 Spinetoram 0.8% GR 5000 40
T20 UTC (Untreated Control) - -
T1 to T4- ready mix granular composition, T5 to T19-conventional treatments
Table 10: Lepidopteran insect control in rice
Treatment number Stem borer control (%) Leaf folder control (%)
Observed Expected Colby's ratio Synergism (Y/N)
T1 99.5 93.38 1.07 Y 100.0
T2 93.4 88.42 1.06 Y 95.7
T3 98.7 93.51 1.06 Y 100.0
T4 99.2 93.75 1.06 Y 100.0
T5 86.5 81.3
T6 85.7 78.5
T7 87.2 78.2
T8 87.4 79.5
T9 79.7 78.3
T10 76.3 71.3
T11 79.7 73.5
T12 80.1 72.9
T13 86.3 76.8
T14 50.7 46.7
T15 70.3 66.9
T16 54.8 51.4
T17 49.7 42.8
T18 55.7 42.3
T19 57.3 44.9
T20 0.0 0.0

The granular composition of emamectin benzoate+thiocyclam hydrogen oxalate+insecticide (T1 to T4) provides synergistic control of rice stem borer and leaf folder compared to all conventional treatments (T5 to T19).

,CLAIMS:CLAIMS
We claim;
[CLAIM 1]. A synergistic granular agrochemical composition comprising:
i. emamectin benzoate present in an amount of 0.01% to 5% by weight;
ii. an insecticide from nereistoxin present in an amount of 0.1 % - 20 % by weight;
iii. an insecticide selected from group of phenylpyrazole, pyrethroids, nicotinic insecticides, spinosyns or mixture thereof present in an amount of 1-20% by weight.
iv. emulsifier present in an amount of 0.1-4.0%w/w;
v. solvent present in an amount of 0.1-4.0%w/w;
vi. dispersing agent present in an amount of 0.5-4.0%w/w.

[CLAIM 2]. The synergistic granular agrochemical composition as claimed in claim 1, wherein an insecticides from nereistoxin is selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium.

[CLAIM 3]. The synergistic granular agrochemical composition as claimed in claim 1, wherein an insecticide from phenylpyrazole is selected from ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole.

[CLAIM 4]. The synergistic granular agrochemical composition as claimed in claim 1, wherein an insecticide from pyrethroid is selected from bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin.

[CLAIM 5]. The synergistic granular agrochemical composition as claimed in claim 1, wherein nicotinic insecticides from class of neonicotinoids is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin; from class of sulfoximines is sulfoxaflor; from class of butenolides is flupyradifurone from class of mesoionics is selected from triflumezopyrim, dichloromezotiaz, fenmezoditiaz.

[CLAIM 6]. The synergistic granular agrochemical composition as claimed in claim 1, wherein an insecticide from spinosyns is selected from spinosad, spinetoram.

[CLAIM 7]. The synergistic granular agrochemical composition as claimed in claim 1, wherein formulation for the said agrochemical composition is selected from Granule (GR), Soil Applied Granules (SAG), Controlled release granules (CR) either slow release granule or fast release granules.

[CLAIM 8]. The synergistic granular agrochemical composition as claimed in claim 1, wherein the preferred combinations of active ingredients for granule formulation in said composition comprises:
a. emamectin benzoate 0.15%w/w + cartap hydrochloride 4.5 %w/w + clothianidin 0.6 %w/w;
b. emamectin benzoate 0.15%w/w + cartap hydrochloride4.5% w/w+thiamethoxam0.6%w/w;
c. emamectin benzoate0.15%w/w +cartap hydrochloride4.5% w/w+imidacloprid0.6%w/w;
d. emamectin benzoate0.15%w/w +cartap hydrochloride4.5% w/w+flupyrimin0.9%w/w;
e. emamectin benzoate0.15%w/w +cartap hydrochloride4.5% w/w+triflumezopyrim0.15%w/w;
f. emamectin benzoate0.1%w/w +cartap hydrochloride4% w/w +dichloromezotiaz0.5%w/w;
g. emamectin benzoate 0.1%w/w +cartap hydrochloride4% w/w +fenmezoditiaz0.5%w/w;
h. emamectin benzoate0.12%w/w +cartap hydrochloride5% w/w +fipronil0.4%w/w;
i. emamectin benzoate0.12%w/w +cartap hydrochloride5% w/w +bifenthrin0.4%w/w;
j. emamectin benzoate0.12%w/w +cartap hydrochloride5% w/w +spinosad0.4%w/w;
k. emamectin benzoate0.12%w/w +cartap hydrochloride5%w/w +spinetoram0.4%w/w;
l. emamectin benzoate0.2%w/w +thiocyclam hydrogen oxalate 6%w/w+clothianidin0.8%w/w;
m. emamectin benzoate0.2%w/w +thiocyclam hydrogen oxalate 6%w/w+thiamethoxam0.8%w/w;
n. emamectin benzoate0.2%w/w +thiocyclam hydrogen oxalate 6%w/w+imidacloprid0.4%w/w;
o. emamectin benzoate0.2%w/w +thiocyclam hydrogen oxalate 6%w/w+flupyrimin1.2%w/w;
p. emamectin benzoate0.2%w/w +thiocyclam hydrogen oxalate 6%w/w+triflumezopyrim0.2%w/w;
q. emamectin benzoate 0.1%w/w +thiocyclam hydrogen oxalate 4%w/w+dichloromezotiaz0.5%w/w;
r. emamectin benzoate0.1%w/w +thiocyclam hydrogen oxalate 4%w/w+fenmezoditiaz0.5%w/w;
s. emamectin benzoate0.096%w/w +thiocyclam hydrogen oxalate 3.6%w/w+fipronil0.32%w/w;
t. emamectin benzoate0.096%w/w +thiocyclam hydrogen oxalate3.6%w/w+bifenthrin0.32%w/w;
u. emamectin benzoate0.096%w/w +thiocyclam hydrogen oxalate 3.6%w/w+spinosad0.32%w/w;
v. emamectin benzoate0.096%w/w +thiocyclam hydrogen oxalate 3.6%w/w+spinetoram0.32%w/w.

[CLAIM 9]. The synergistic granular agrochemical composition as claimed in claim 1, wherein the composition for granule formulation comprises:
a. emamectin benzoate in an amount of 0.01% to 5% w/w;
b. an insecticide selected from chlorantraniliprole, cyantraniliprole, tetraniliprole present in an amount of 0.1 % - 20 % w/w;
c. an insecticide selected from cartap hydrochloride, fipronil, clothianidin, flupyrimin, dichloromezotiaz, thiamethoxam, imidacloprid, triflumezopyrim present in an amount of 1-20% w/w
d. emulsifier present in an amount of 0.1-4.0%w/w;
e. buffering agent present in an amount of 0.1-1.0%w/w;
f. solvent present in an amount of 0.1-4.0%w/w;
g. dispersing agent present in an amount of 0.5-4.0%w/w.

[CLAIM 10]. The synergistic granular agrochemical composition as claimed in claim 1, wherein composition for Granule formulation comprises:
a. emamectin benzoate in an amount of 0.01% to 5% w/w;
b. an insecticide selected from cartap hydrochloride, thiocyclam hydrogen oxalate present in an amount of 0.1 % - 20 % w/w;
c. an insecticide selected from clothianidin, thiamethoxam, imidacloprid, flupyrimin, triflumezopyrim, dichloromezotiaz, fenmezoditiaz, fipronil, bifenthrin, spinosad, spinetoram present in an amount of 1-20% w/w;
d. controlled release agent present in an amount of 0.1-6.0%w/w;
e. emulsifier present in an amount of 0.1-4.0%w/w;
f. solvent present in an amount of 0.1-4.0%w/w;
g. dispersing agent present in an amount of 0.5-4.0%w/w.

[CLAIM 11]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein emulsifier is selected from ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, hydroxylated stearic acid polyalkylene glycol polymer, and their corresponding salts,alkyd-polyethylene glycol resin, polyalkylene glycol ether, ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, tristyrylphenol phosphate ester, tristyrylphenol phosphate potassium salt, dodecysulfate sodium salt, Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate.

[CLAIM 12]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein most preferred emulsifier is selected from ethoxylated distyrylphenol, ethoxylated distyrylphenol sulphate, ethoxylated tristyrylphenol phosphate, Dodecyl hydroxypoly (oxy-1,2 ethanediyl) phosphate.

[CLAIM 13]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein dispersing agent is selected from copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly (oxypropylene) block polymer with poly(oxyethylene), naphthalene condensates, polyacrylates and phosphate esters, calcium lignosulfonate, sodium lignosulfonate, sodium lignosulfonate-sulfomethylated.

[CLAIM 14]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein most preferred dispersing agent is selected from copolymer of propylene oxide (PO) and ethylene oxide (EO) and/or an ethoxylated tristyrene phenol, copolymer of PO and EO is alpha-butyl-omega-hydroxypoly(oxypropylene) block polymer with poly(oxyethylene), calcium lignosulfonate.

[CLAIM 15]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein solvent is selected from liquid paraffin oil, N-methyl-2-pyrrolidone, tetramethylurea, dimethylsulfoxide, N,N-dimethylacetamide, diacetone alcohol, polybutene, propylene carbonate, dipropylene glycol isomer mixture, water.

[CLAIM 16]. The synergistic granular agrochemical composition as claimed in claim 9-10, wherein most preferred solvent is selected from liquid paraffin oil, N-methyl-2-pyrrolidone, N,N-dimethylacetamide, water.

[CLAIM 17]. The synergistic granular agrochemical composition as claimed in claim 9, wherein buffering agent is selected from phosphoric acid, sodium citrate.

[CLAIM 18]. The synergistic granular agrochemical composition as claimed in claim 10, wherein controlled release agent is selected from polyvinyl alcohols, Polyacrylic acid, paraffin wax, polyvinyl acetate, sodium polyacrylate.

[CLAIM 19]. The synergistic granular agrochemical composition as claimed in claim 10, wherein most preferred controlled release agent is selected from polyvinyl alcohols, Polyacrylic acid, paraffin wax.

Dated this 05th day of November 2022