FIELD OF THE INVENTION
[0001] The present disclosure generally relates to ophthalmic compositions. Specifically, the present disclosure relates to a herbal ophthalmic formulation including therapeutically effective amounts of an extract of badam (Prunus Dulcis), an extract of sheesham (Dalbergia Sissoo), and an extract of giri harar (Terminalia Chebula).
BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Eye is the most important sensory organ of the human body. It gives us a sense of sight. Sight and vision are important as they allow us to connect with our surroundings, keep us safe, and help in maintaining sharpness of our minds. Impairment with eye function or eye-sight occurring from any reason is tragic, wherever it strikes. The global burden of eye disease is shouldered by developing countries, where treatable diseases often go undiagnosed. Lack of knowledge for the treatment of eye is one reason for such conditions, however, side-effects associated with the existing drugs plays a major role. The existing drugs or medications may be life-saving, but can have more negative effect on one's vision over a period of time. Several steroidal based eye-drops were reported to date. However, they cause allergic reactions such as redness, itching or swelling in and around the eyes. Few eye drops were reported to results in wheezing, dizziness, and some-time vomiting due to anaphylactic allergic reactions. Hence, these conventional therapeutic agents have their own certain limitations, side effects and toxicity precluding utility thereof in long term treatment of eye disorders or diseases.
[0004] There is therefore a need in the art to develop a herbal ophthalmic composition, which is safe and effective against ocular conditions such as blepharitis, ocular rosacea, sore/burning eyes, pain/inflammation in the eye, eye allergies, blurred vision, watery eyes, itching in the eye, and the like, yet devoid of any substantial side-effects and/or toxicity. The present invention satisfies the existing needs, as well as others, and generally overcomes the deficiencies found in the prior art.
2
OBJECTS OF THE INVENTION
[0005] Primary object of the present disclosure is to provide a herbal ophthalmic formulation.
[0006] Another object of the present disclosure is to provide a herbal ophthalmic formulation that is safe to use.
[0007] Another object of the present disclosure is to provide a herbal ophthalmic formulation that is ease to prepare.
[0008] Another object of the present disclosure is to provide a herbal ophthalmic formulation that is substantially devoid of any side-effects.
[0009] Another object of the present disclosure is to provide a herbal ophthalmic formulation that is devoid of any preservatives.
[00010] Another object of the present disclosure is to provide a herbal ophthalmic formulation that has an improved shelf life.
[00011] Other objects of the present disclosure will be apparent from the description of the invention herein below.
SUMMARY OF THE INVENTION
[00012] The present disclosure generally relates to ophthalmic compositions. Specifically, the present disclosure relates to a herbal ophthalmic formulation including therapeutically effective amounts of an extract of badam (Prunus Dulcis), an extract of sheesham (Dalbergia Sissoo), and an extract of giri harar (Terminalia Chebula).
[00013] An aspect of the present disclosure provides an ophthalmic formulation comprising: a therapeutically effective amount of an extract of badam (Prunus Dulcis); a therapeutically effective amount of an extract of sheesham (Dalbergia Sissoo); a therapeutically effective amount of an extract of giri harar (Terminalia Chebula); and water. In an embodiment, the formulation comprises the extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation. In an embodiment, the formulation comprises the extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation. In an embodiment, the formulation comprises the extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation further comprises an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation. In an embodiment, the formulation further comprises an extract of kala 3
bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation further comprises ganga jal in an amount ranging from about 10% to about 30% by volume of the formulation. In an embodiment, the formulation further comprises an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation comprises: the extract of badam (Prunus Dulcis) in an amount of about 10% by volume of the formulation; the extract of sheesham (Dalbergia Sissoo) in an amount of about 2% by volume of the formulation; the extract of giri harar (Terminalia Chebula) in an amount of about 7% by volume of the formulation; the extract of sambhalu (Vitex Negundo) in an amount of about 10% by volume of the formulation; the extract of kala bhangra (Anisomeles Indica) in an amount of about 10% by volume of the formulation; the extract of haldi (Curcuma Longa) in an amount of about 10% by volume of the formulation; ganga jal in an amount of about 20%; and the rest being water.
[00014] Another aspect of the present disclosure provides an eye-drop formulation comprising: an extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation; an extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation; an extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation; an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation; an extract of kala bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation; an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation; ganga jal in an amount ranging from about 10% to about 30%; and the rest being water. In an embodiment, the formulation is substantially devoid of any preservatives.
DETAILED DESCRIPTION OF THE INVENTION
[00015] The embodiments herein and the various features and advantageous details thereof are explained more comprehensively with reference to the non-limiting embodiments that are detailed in the following description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of the ways in which the embodiments herein may be practiced and to further enable those of skill in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein. 4
[00016] Unless otherwise specified, all terms used in disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. By means of further guidance, term definitions may be included to better appreciate the teaching of the present invention.
[00017] As used in the description herein, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[00018] As used herein, the terms “comprise”, “comprises”, “comprising”, “include”, “includes”, and “including” are meant to be non- limiting, i.e., other steps and other ingredients which do not affect the end of result can be added. The above terms encompass the terms “consisting of” and “consisting essentially of”.
[00019] As used herein, the terms “composition” “blend,” or “mixture” are all intended to be used interchangeably.
[00020] The terms “volume percent,” “vol-%,” “percent by volume,” “% by volume,” and variations thereof, as used herein, refer to the concentration of a substance as the volume of that substance divided by the total volume of the composition and multiplied by 100. It is understood that, as used here, “percent,” “%,” and the like are intended to be synonymous with “volume percent,” “vol-%,” etc.
[00021] The present disclosure generally relates to ophthalmic compositions. Specifically, the present disclosure relates to a herbal ophthalmic formulation including therapeutically effective amounts of an extract of badam (Prunus Dulcis), an extract of sheesham (Dalbergia Sissoo), and an extract of giri harar (Terminalia Chebula).
[00022] An aspect of the present disclosure provides an ophthalmic formulation comprising: a therapeutically effective amount of an extract of badam (Prunus Dulcis); a therapeutically effective amount of an extract of sheesham (Dalbergia Sissoo); a therapeutically effective amount of an extract of giri harar (Terminalia Chebula); and water. In an embodiment, the formulation comprises the extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation. In an embodiment, the formulation comprises the extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation. In an embodiment, the formulation comprises the extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation further 5
comprises an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation. In an embodiment, the formulation further comprises an extract of kala bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation further comprises ganga jal in an amount ranging from about 10% to about 30% by volume of the formulation. In an embodiment, the formulation further comprises an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation. In an embodiment, the formulation comprises: the extract of badam (Prunus Dulcis) in an amount of about 10% by volume of the formulation; the extract of sheesham (Dalbergia Sissoo) in an amount of about 2% by volume of the formulation; the extract of giri harar (Terminalia Chebula) in an amount of about 7% by volume of the formulation; the extract of sambhalu (Vitex Negundo) in an amount of about 10% by volume of the formulation; the extract of kala bhangra (Anisomeles Indica) in an amount of about 10% by volume of the formulation; the extract of haldi (Curcuma Longa) in an amount of about 10% by volume of the formulation; ganga jal in an amount of about 20%; and the rest being water.
[00023] In an embodiment, said ophthalmic formulation can be safe and effective against ocular conditions such as blepharitis, ocular rosacea, sore/burning eyes, pain/inflammation in the eye, eye allergies, blurred vision, watery eyes, itching in the eye, and the like, yet devoid of any substantial side-effects and/or toxicity.
[00024] Badam (Prunus Dulcis) or almond is a small, naturally found or cultivated tree, particularly in Middle East, Indian subcontinent (Kashmir, Himachal etc.) and North Africa. It belongs Rosaceae family and Prunus genus. Badam is reported to be useful for the treatment of nerve disorder, general debility, memory power and sexual vigor.
[00025] Sheesham (Dalbergia Sissoo) also known as Indian rosewood is a medium to large deciduous tree, native to India. It belongs to the genus Dalbergia. Conventionally, it is used for treatment of variety of diseases. The wood and bark of Sissoo have abortifacient, anthelmintic, antipyretic, aphrodisiac, expectorant and refrigerant properties. Even in Africa, this tree is used for treatment of wounds and gonorrhoea.
[00026] Harar (Terminalia Chebula) also known as Halela or Haser or Haritaki is a wonder fruit grown on Haritaki Tree. It belongs to Combretaceae family and Terminalia genus. It is found abundantly in North India, though it is distributed throughout India upto 5000 feet height. Harar is 6
reported to be effective against chronic acidity problems, digestive disorders, vomiting, wound healing, detoxification and related disorders.
[00027] Ganga not only holds great spiritual and cultural significance, but her unique, natural characteristics have made her a fascinating subject of study for many scientific inquiries. It is rich of purest oxygen, nutrients, and salts, which make it beneficial to health. Ganga jal is also reported to cure numerous chronic diseases, stomach related problems, diabetes, kidney disorder, asthma, arthritis and many more.
[00028] Sambhalu (Vitex Negundo) also known as Nirgundi is a plant belongs to Verbinaceae family and Vitex genus. Vitex negundo is known as a very good muscle relaxant, pain relieving, anti mosquito, anti anxiety, anti asthmatic agent. It is used in the treatment of headache, orchitis (swelling in testicles), rheumatoid and osteo arthritis.
[00029] Kala bhangra (Anisomeles Indica) also known as Indian Catmint belongs to family Lamiaceae and genus Anisomeles. It is a perennial shrub that grows in tropical climate. Anisomeles indica have anti-inflammatory and anti-bacterial effect, and is known to be useful in the treatment of rheumatism, stomachic, toothache, skin problem, gastrointestinal disorders etc.
[00030] Haldi (Curcuma Longa) also known commonly as turmeric belongs to the family Zingiberaceae and commonly found throughout the territories of India. It is conventionally used for the treatment of internal disorders, such as indigestion, throat infections, common colds, or liver ailments, as well as topically, to cleanse wounds or treat skin sores.
[00031] The extracts used for the present disclosure preferentially utilize the plant parts as described hereinbelow. The extract of badam (Prunus Dulcis) is prepared from the badam seeds. The extract of sheesham (Dalbergia Sissoo) is prepared from the leaves of the sheesham. The extract of Sambhalu (Vitex Negundo) is prepared from the leaves thereof. The extract of Kala bhangra (Anisomeles Indica) is prepared from the leaves. However, any other plant part of the Kala bhangra (Anisomeles Indica) can be used for preparation of the extract. The extract of giri Harar (Terminalia Chebula) is prepared from the fruits thereof. The extract of haldi (Curcuma Longa) is prepared from the rhizomes thereof. Any extraction techniques as known to or appreciated by a person skilled in the art, for example utilization of soxhlate apparatus or by simple maceration, can be utilized to serve its intended purpose as laid down in the present disclosure without departing from the scope and spirit of the present disclosure. 7
[00032] Another aspect of the present disclosure provides an eye-drop formulation comprising: an extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation; an extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation; an extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation; an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation; an extract of kala bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation; an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation; ganga jal in an amount ranging from about 10% to about 30%; and the rest being water. In an embodiment, the formulation is substantially devoid of any preservatives.
[00033] The present disclosure may be more fully understood by reference to the following examples:
EXAMPLE
[00034] An eye drop formulation (100 ml)
Ingredients
Amount (ml)
extract of badam (Prunus Dulcis)
10
extract of sheesham (Dalbergia Sissoo)
2
extract of giri harar (Terminalia Chebula)
7
extract of sambhalu (Vitex Negundo)
10
extract of kala bhangra (Anisomeles Indica)
10
ganga jal
20
extract of Haldi
10
water
qs
[00035] Extracts of each of the herbs and ganga jal were taken in the amount as defined in the table 1 above and uniformly mixed. Then required amount of water was added to prepare 100 ml of eye-drops.
[00036] Activity data
Patient.
Patient
Patient Symptoms
Treatment Time 8
No.
Age (in years)
with ophthalmic formulation of the present disclosure (in Days)
1
60
Pain in the eyes
10
2
21
Burning eyes, Blurred vision
12
3
20
Headache
10
4
22
Pain in the eyes
10
5
50
Blurred vision
25
6
70
Watery eyes, Itching
25
7
55
Blurred vision, dry eyes
25
8
71
Blurred vision
75
9
19
Cloudy spots on the eye
15
10
52
Compromised vision
30
11
37
Sore/swollen eyes
20
12
21
Watery eyes
12
13
21
Eye infection
25
14
46
Blurred vision
40
15
24
Headache, watery eyes
15
16
24.5
Eye infection
20
17
45
Watery eyes
15
18
20
Pain in the eyes
20
19
45
Inflammation in the eye
3
20
48
Inflammation in the eye
30
[00037] An ophthalmic formulation was prepared comprising extracts of each of the herbs and ganga jal in the amount as defined in the table 1 above and uniformly mixed. The formulation was tested in a set of twenty patients bearing symptoms as mentioned in the table 2 above and the treatment time was recorded. The patients were treated with the ophthalmic formulation of the instant
9
disclosure in a time period ranging from 3 to 75 days, depending upon the severity of the eye condition.
[00038] The foregoing description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein.
ADVANTAGES OF THE INVENTION
[00039] The present disclosure provides a herbal ophthalmic formulation.
[00040] The present disclosure provides a herbal ophthalmic formulation that is ease to prepare.
[00041] The present disclosure provides a herbal ophthalmic formulation that is safe to use.
[00042] The present disclosure provides a herbal ophthalmic formulation that is substantially devoid of any side-effects.
[00043] The present disclosure provides a herbal ophthalmic formulation that is devoid of any preservatives.
[00044] The present disclosure provides a herbal ophthalmic formulation that has an improved shelf life.

I Claim:
1. An ophthalmic formulation comprising:
a therapeutically effective amount of an extract of badam (Prunus Dulcis); a therapeutically effective amount of an extract of sheesham (Dalbergia Sissoo); a therapeutically effective amount of an extract of giri harar (Terminalia Chebula).
2. The formulation as claimed in claim 1, wherein the formulation comprises the extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation.
3. The formulation as claimed in claim 1, wherein the formulation comprises the extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation.
4. The formulation as claimed in claim 1, wherein the formulation comprises the extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation.
5. The formulation as claimed in claim 1, wherein the formulation further comprises an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation.
6. The formulation as claimed in claim 1, wherein the formulation further comprises an extract of kala bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation.
7. The formulation as claimed in claim 1, wherein the formulation further comprises an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation.
8. The formulation as claimed in claim 1, wherein the formulation further comprises ganga jal in an amount ranging from about 10% to about 30% by volume of the formulation.
9. The formulation as claimed in any of the claim 1 to claim 8, wherein the formulation comprises:
the extract of badam (Prunus Dulcis) in an amount of about 10% by volume of the formulation; 11
the extract of sheesham (Dalbergia Sissoo) in an amount of about 2% by volume of the formulation;
the extract of giri harar (Terminalia Chebula) in an amount of about 7% by volume of the formulation;
the extract of sambhalu (Vitex Negundo) in an amount of about 10% by volume of the formulation;
the extract of kala bhangra (Anisomeles Indica) in an amount of about 10% by volume of the formulation;
the extract of haldi (Curcuma Longa) in an amount of about 10% by volume of the formulation;
ganga jal in an amount of about 20%; and
the rest being water.
10. An eye-drop formulation comprising:
an extract of badam (Prunus Dulcis) in an amount ranging from about 5% to about 20% by volume of the formulation;
an extract of sheesham (Dalbergia Sissoo) in an amount ranging from about 1% to about 10% by volume of the formulation;
an extract of giri harar (Terminalia Chebula) in an amount ranging from about 5% to about 15% by volume of the formulation;
an extract of sambhalu (Vitex Negundo) in an amount ranging from about 5% to about 20% by volume of the formulation;
an extract of kala bhangra (Anisomeles Indica) in an amount ranging from about 5% to about 15% by volume of the formulation;
an extract of haldi (Curcuma Longa) in an amount ranging from about 5% to about 15% by volume of the formulation;
ganga jal in an amount ranging from about 10% to about 30%; and
the rest being water.