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Animal Model Expressing Luciferase Under Control Of The Myelin Basic Protein Promoter (Mbp Luci) And Use Of The Model For Bioluminescence In Vivo Imaging
Abstract: A Myelin Basic Protein-luciferase bioimaging noninvasive model to visualize and quantify demyelination and remyelination events in the CNS at transcriptional level in vivo is provided. Luciferase-expressing transgenic animals were generated with myelin basic protein (MBP) promoter coupled to firefly luciferase reporter. The MBP-luci bioimaging model provides a means to monitor myelination status and the efficacy of a remyelination modulating test compound. An advantage of bioimaging is that a subject in a longitudinal study can serve as its own control. The same subject can be tracked over a demyelination and remyelination process continuously over a period of at least 10 weeks. This model enables normalization of individual animal imaging response and provides quality data with considerably reduced variance In addition because cohorts of animals need not be sacrificed at different time points reduction in the number necessary for a compound efficacy study is possible.
Notices, Deadlines & Correspondence
Patent Information
Applicants
SANOFI
Inventors
1. CAO James
2. CHANDROSS Karen
3. ECONOMIDES Kyriakos D.
4. POLITES Harry Gregory
5. WEINSTOCK Daniel
6. YING Xiaoyou
Specification
please see the attachment
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 5224-CHENP-2012-AbandonedLetter.pdf | 2018-07-04 |
| 1 | Form-5.pdf | 2012-06-26 |
| 2 | 5224-CHENP-2012-FER.pdf | 2017-12-20 |
| 2 | Form-3.pdf | 2012-06-26 |
| 3 | Form-18(Online).pdf | 2013-12-09 |
| 3 | Form-1.pdf | 2012-06-26 |
| 4 | 5224-CHENP-2012 CORRESPONDENCE OTHERS. 20-07-2012.pdf | 2012-07-20 |
| 4 | 5224-CHENP-2012 CORRESPONDENCE OTHERS 01-11-2013.pdf | 2013-11-01 |
| 5 | 5224-CHENP-2012 POWER OF ATTORNEY 20-07-2012.pdf | 2012-07-20 |
| 5 | 5224-CHENP-2012 FORM-3 14-12-2012.pdf | 2012-12-14 |
| 6 | 5224-CHENP-2012 CORRESPONDENCE OTHERS 14-12-2012.pdf | 2012-12-14 |
| 7 | 5224-CHENP-2012 POWER OF ATTORNEY 20-07-2012.pdf | 2012-07-20 |
| 7 | 5224-CHENP-2012 FORM-3 14-12-2012.pdf | 2012-12-14 |
| 8 | 5224-CHENP-2012 CORRESPONDENCE OTHERS 01-11-2013.pdf | 2013-11-01 |
| 8 | 5224-CHENP-2012 CORRESPONDENCE OTHERS. 20-07-2012.pdf | 2012-07-20 |
| 9 | Form-1.pdf | 2012-06-26 |
| 9 | Form-18(Online).pdf | 2013-12-09 |
| 10 | Form-3.pdf | 2012-06-26 |
| 10 | 5224-CHENP-2012-FER.pdf | 2017-12-20 |
| 11 | Form-5.pdf | 2012-06-26 |
| 11 | 5224-CHENP-2012-AbandonedLetter.pdf | 2018-07-04 |
Search Strategy
| 1 | 5224chenp2012ss_19-12-2017.pdf |