Claims:1. An anti-glycation composition comprising:
a. a mixture of sodium lactate and sodium gluconate; and
b. (R)-(-)-2-oxothiazolidine-4-carboxylic acid,
wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%, and said mixture to (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration ratio in said composition is in the range of 10:1-100:1.
2. The anti-glycation composition as claimed in claim 1, wherein said mixture weight concentration is in the range of 0.009-0.011%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
3. The anti-glycation composition as claimed in claim 1, wherein said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.009-0.011%.
4. The anti-glycation composition as claimed in claim 1, wherein said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
5. An anti-glycation formulation comprising:
a. a mixture of sodium lactate and sodium gluconate; and
b. (R)-(-)-2-oxothiazolidine-4-carboxylic acid,
wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%, and said mixture to (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration ratio in said composition is in the range of 10:1-100:1.
6. The anti-glycation formulation as claimed in claim 5 further comprising at least one cosmetically acceptable ingredient.
7. The anti-glycation formulation as claimed in claim 6, wherein said at least one cosmetically acceptable ingredient is selected from the group consisting of suitable carriers, diluents, skin benefitting agents, pH adjusting agents, emollients, moisturizing agent, antimicrobial agents, and excipients.
8. The anti-glycation formulation as claimed in claim 5, wherein said mixture weight concentration is in the range of 0.009-0.011%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
9. The anti-glycation formulation as claimed in claim 5, wherein said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.009-0.011%.
10. The anti-glycation formulation as claimed in claim 5, wherein said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
11. A method of preparing an anti-glycation composition comprising a mixture of sodium lactate and sodium gluconate; and (R)-(-)-2-oxothiazolidine-4-carboxylic acid, wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%, and said mixture to (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration ratio in said composition is in the range of 10:1-100:1, said mixture weight concentration is in the range of 0.009-0.011%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011% or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.009-0.011% or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
12. A method of preparing an anti-glycation formulation comprising a mixture of sodium lactate and sodium gluconate; (R)-(-)-2-oxothiazolidine-4-carboxylic acid; and suitable carriers, diluents, and excipients, wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%, and said mixture to (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration ratio in said composition is in the range of 10:1-100:1, said mixture weight concentration is in the range of 0.009-0.011%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011% or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.009-0.011% or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%.
13. An anti-glycation formulation for topical application comprising:
a. a mixture comprising sodium lactate and sodium gluconate having volume percentage in the range of 0.01-0.1%, wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%;
b. (R)-(-)-2-oxothiazolidine-4-carboxylic acid having volume percentage in the range of 0.001-0.01%;
c. acrylates/C10-30 alkyl acrylate cross-polymer having volume percentage of 0.07%;
d. glycerin having volume percentage of 5%;
e. butylene glycol having volume percentage of 2%;
f. D-panthenol having volume percentage of 0.5%;
g. triethanolamine having volume percentage of 0.06%;
h. mineral oil having volume percentage of 4%;
i. cetyl alcohol having volume percentage of 3%;
j. glycol distearate having volume percentage of 3%;
k. dimethicone having volume percentage of 0.5%;
l. allantoin having volume percentage of 0.1%;
m. phenoxyethanol having volume percentage of 0.3%;
n. fragrance having volume percentage of 0.2%; and
o. water having volume percentage of 81.16-81.259%.
14. A method of preparing a formulation comprising: a) a mixture comprising sodium lactate and sodium gluconate having volume percentage in the range of 0.01-0.1%, wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%; b) (R)-(-)-2-oxothiazolidine-4-carboxylic acid having volume percentage of 0.001-0.01%; c) acrylates/C10-30 alkyl acrylate cross-polymer having volume percentage of 0.07%; d) glycerin having volume percentage of 5%; e) butylene glycol having volume percentage of 2%; f) D-panthenol having volume percentage of 0.5%; g) triethanolamine having volume percentage of 0.06%; h) mineral oil having volume percentage of 4%; i) cetyl alcohol having volume percentage of 3%; j) glycol distearate having volume percentage of 3%; k) dimethicone having volume percentage of 0.5%; l) allantoin having volume percentage of 0.1%; m) phenoxyethanol having volume percentage of 0.3%; n) fragrance having volume percentage of 0.2%; and o) water having volume percentage of 81.16-81.259%.
15. A method for inhibiting glycation, said method comprising the steps:
a. obtaining a composition or a formulation comprising a mixture of sodium lactate and sodium gluconate; (R)-(-)-2-oxothiazolidine-4-carboxylic acid, wherein sodium lactate weight concentration in said mixture is 20-25%, sodium gluconate weight concentration in said mixture is 20-25%, and said mixture to (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration ratio in said composition or formulation is in the range of 10:1-100:1, said mixture weight concentration is in the range of 0.009-0.011%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%; or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.009-0.011%; or said mixture weight concentration is in the range of 0.09-0.11%, and said (R)-(-)-2-oxothiazolidine-4-carboxylic acid weight concentration is in the range of 0.0009-0.0011%; and
b. contacting said composition or formulation with a site susceptible to glycation,
wherein said method inhibits glycation.
, Description:As Attached