Anti Tspan8 Anti Cd3 Bispecific Antibody And Anti Tspan8 Antibody

Abstract: The present invention addresses the problem of providing an anti-TSPAN8-anti-CD3 bispecific antibody and an anti-TSPAN8 antibody each of which can be used for treatment or prevention in human bodies. A human-monoclonal-antibody-producing mouse is immunized with a cancer peritoneal dissemination cell isolated from a patient to produce a 16B11 antibody and a 16B12 antibody each of which has been bound selectively to the cancer peritoneal dissemination cell. These antibodies are anti-TSPAN8 antibodies capable of binding to a region lying between amino acid residue Nos. 126 to 155 in TSPAN8, and exhibit a potent binding activity to TSPAN8 expressed in a cancer peritoneal dissemination cell. Furthermore, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody which is produced on the basis of the sequence for 16B11 shows cytotoxicity to a TSPAN8-expressing cancer cell in vitro, and shows an anti-tumor activity to a cancer-affected mouse carrying a TSPAN8-expressing cancer cell and extends the survival period of a peritoneal dissemination model mouse in vivo.

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