We claim:
1. A compound selected from the group consisting of:
(i) a compound of Formula (I):
FORMULA I
wherein:
X is C, N, or CRg; Ri is a C1-C3 alkyl or cyclopropyl, or R! forms a link to X or
R2;
R2 is H, SH or alkyl; R3 is H or halo;
R8 is H, Ci-Cealkyl, Ci-Cealkoxy or halo; A is absent or a linker; B is absent or a linker; and
R4 is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R4 is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R4 is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R4 is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents, or
II ' 'p
R4is Y K , where p is 0-10; M is CH, NH, orS;YisNH, CH,
O or S; L is a linker or Z; and Z is NH2, OH, SH, alkyl, -COOH, or CONH2, (ii) a compound of Formula (II):

wherein: XisO, S, orN;
Ri is H, Ci-C6alkyl, -COCHY2, -COCH2Y, haloalkyl, CH2CN, amino, OCH3, COOCH3, SO2CH3, COCHjOH, or -[NHC(R7)]n-M; R2 and R3 are independently H or halo;
R4 is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R4 is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R4 is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R4 is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or
R4 is Y P Where p is 0-10; M is CH, NH, or S; Y is NH, CH,
O or S; L is a linker or Z; and Z is NH2, OH, SH, alkyl, -COOH, or CONH2; or R4 is a a carbohydrate, (iii) a compound of Formula (III):
FORMULA III
wherein: (a) n is 1;
X and Y are oxygen atom;
W is carbon atom;
Z is absent;
R! is hydrogen atom, hydroxyl, methoxy, amino, -NH-(CH2)P-R, where p is 0,
1, 2, 3, 4 or 5; R is hydrogen atom, amine, guanidine, piperazine, morpholine,
NHCOCH3, NHS02CH3, NHS02-C6H5 or -L!-B-R7;
L! is -(CH2)q-, -(CH2)q-CH=CH-(CH2)q-, _(CH2)q-0-(CH2)q-, -(CH2)q-
NH-(CH2)q-, where q is 0, 1, 2 or 3;
A and B are independently a cyclyl, heterocyclyl, aryl or heteroaryl, where the
cyclyl, heterocyclyl, aryl or heteroaryl can be optionally substituted with 1, 2
or 3 substituents;

R7 is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of carboxylic acid, OMe, nitrile, C(NH)-NH2, amino, -NHCOCH3, NHS02CH3NHS02-benzene, where the benzene can be optionally and independently substituted at ortho, meta or para position; R2 is -L1-A-R7; R3 is H;
R4 and R5 independently are hydrogen, halogen, hydroxyl, or -0-(CH2)t-R8, where Rg is Q-Cealkyl, amino, di(Ci-C6alkyl)amino, aminocyclopropane, aminocyclopentane, piperazino, or morpholine, and t is 0-10; or
(b) n is 1;
X and W are carbon atom, or X is carbon atom and W is nitrogen atom;
Y is -NH(CH2)q-R6 or (CH2)q-R6, where q = 0 to 10;
R6 is -COOH, amine, guanidine, piperazine, morpholine;
Z is hydrogen, methyl, NHR, COCH3, S02CH3, or -NH-(CH2)i-COOH,
where 1 is 0-10;
Ri and R3 independently hydrogen atom, hydroxyl, methoxy, amino, or -Li-
A-R6
R is CH3, -(CH2)p-CH3, where p= 0 to 10;
U is -(CH2)n-, -(CH2)t-CH=CH-(CH2)t-, _(CH2)t-0-(CH2)t-, -(CH2)t-NH-
(CH2)t-, where t is 0, 1, 2, or 3;
A is cyclyl, heterocycly, aryl or heteroaryl, where the cyclyl, heterocycly, aryl
or heteroaryl can be optionally substituted with 1, 2 or 3 substituents;
R6 is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of
carboxylic acid, OMe, nitrile, C(NH)-NH2, amino, -NHCOCH3,
NHS02CH3NHS02-benzene, where the benzene can be optionally and
independently substituted at ortho, meta or para position;
R2 is hydrogen atom;
R4 and R5 are independently hydrogen, halogen, hydroxyl, or -0(CH2)X-R8,
where R8 is CrC6alkyl, amino, di( N(CH3)2, N(C2H5)2, N(7-Pr)2j
aminocyclopropane, aminocyclopentane, piperazino or morpholine, and x is
0-10, or
(c) n is 2;
X and W are carbon atom;
Y is -NH(CH2)q-R6 or (CH2)q-R6, where q = 0 to 10;
R6 is -COOH, amine, guanidine, piperazine, morpholine;

Z is hydrogen, methyl, NHR, COCH3, S02CH3, or -NH-(CH2)i-COOH, where 1 is 0-10;
Ri and R3 independently hydrogen atom, hydroxyl, methoxy, amino, or -Li-A-R6
R is CH3, -(CH2)P-CH3, where p= 0 to 10;
U is -(CH2)n-, -(CH2)t-CH=CH-(CH2)t-, _(CH2)t-0-(CH2)t-, -(CH2)t-NH-(CH2),-, where t is 0, 1, 2, or 3;
A is cyclyl, heterocycly, aryl or heteroaryl, where the cyclyl, heterocycly, aryl or heteroaryl can be optionally substituted with 1, 2 or 3 substituents; R6 is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of carboxylic acid, OMe, nitrile, C(NH)-NH2, amino, -NHCOCH3, NHS02CH3 NHS02-benzene, where the benzene can be optionally and independently substituted at ortho, meta or para position; R2 is hydrogen atom;
R4 and R5 are independently hydrogen, halogen, hydroxyl, or -0(CH2)x-R8 where R8 is Ci-C6alkyl, amino, di( N(CH3)2, N(C2H5)2, N(7-Pr)2, aminocyclopropane, aminocyclopentane, piperazino or morpholine, and x is 0-10, and (iv) a compound of Formula (IV):
FORMULA IV
wherein:
B is absent or a linker; and
Ri is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R! is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R! is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents, /) a compound of Formula (V):

FORMULA V
wherein:
X and Z are independently C or N; Y is C, N or O; Ri is H or -LrA;
R2 and R3 are independently O or S;
R4 is hydrogen, oxygen, sulphur, hydroxyl, methoxy or -L2-B; R5, R6, R7 and R8 are independently, hydrogen, hydroxyl, fluoro, chloro, bromo, cycloalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, amino substituted hexose, or guanidine;
L! is absent, a bond or a linker; L2 is absent, a bond or a linker;
A and B are independently a cyclyl, heterocyclyl, aryl or heteroaryl, where cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or 3 substituents, (vi) a compound of Formula (VI):
FORMULA VI
wherein:
X and Z are independently C or N;
Y is CH2, NH or O;
Ri can be H, OH or -Li-A;
R3 is hydrogen, OH, oxygen, sulphur, hydroxyl, methoxy or -L2-B;
R4 is O or S;
R5, R6, R7 and Rg are independently hydrogen, hydroxyl, halo, cycloalkyl,
heterocyclyl, aryl, heteroaryl, hydroxyl, amino substituted hexose, or guanidine;

L! is absent, a bond or a linker; L2 is absent, a bond or a linker; and
A and B are independently cyclyl, heterocyclyl, aryl or heteroaryl, where cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or 3 substituents, and (vii) a compound of Formula (VII):
wherein:
X is CHR12, C=R13, NH, S or O;
YisOorS;
Ri can be H, alkylamino, -OH, -NH(CH2)2NH2or -LrA;
R2 and R3 are independently hydrogen, hydroxyl of or -L2-B;
R4 and R5 are independently H, halo, hydroxyl, or -(CH2)n-0-(CH2)n-D-R8, -
(CH2)n-NH-(CH2)n-D-R8;
R8 is H, hydroxyl, halo, trifluoromehtyl, alkyl, alkoxy, acyloxy, amino,
dialkylamino, -C02H, nitro, nitrile or-NHS02CH3;
Ri2 is H, amino, hydroxyl, or thiol;
R13 is O, S or NH;
Li is absent, a bond or a linker;
L2 is absent, a bond or a linker;
A, B and D are independently cyclyl, heterocyclyl, aryl or heteroaryl, where
cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or
3 substituents; and
n is 0, 1, 2 or 3. The compound of claim 1, wherein the compound is selected from the group consisting of:

3. A pharmaceutical composition comprising a compound of claim 1 or 2 and a pharmaceutical^ acceptable carrier or excipient.
4. A composition for topical application comprising a compound of claim 1 or 2.
5. A composition for oral administration comprising a compound of claim 1 or 2.
6. A composition for administration by injection comprising a compound of claim 1 or 2.
7. A composition comprising a polymer matrix and a compound of claim 1 or 2.
8. A method for treating an infection, the method comprising administering a therapeutically effective amount of a compound of claim 1 or 2 to a subject in need thereof.
9. The method of claim 8, wherein said infection is caused by a resitant pathogen.
10. The method of claim 8, wherein said infection is caused by a methicillin resistant or vancomycin-resistant pathogen.
11. The method of claim 8, wherein said infection is caused by a quinolone resistant pathogen.
12. A method for wound treatment, the method comprising applying a compound of claim 1 or 2 to a wound.
13. A method for preventing or reducing infection caused by an implant, the method comprising applying a compound of claim 1 or 2 to the implant.
14. A method for preventing or reducing infection caused by an implant, the method comprising administering a compound of claim 1 or 2 to a subject in need thereof.
15. A method for the treatment of pneumonia, the method comprising administering a compound of claim 1 or 2 to a subject in need thereof.
16. A method for the treatment of urinary tract infection, the method comprising administering a compound of claim 1 or 2 to a subject in need thereof.

17. A method for the treatment of impetigo, the method comprising administering a compound of claim 1 or 2 to a subject in need thereof.
18. A method for the treatment of acne, the method comprising administering a compound of claim 1 or 2 to a subject in need thereof.
19. A method of inhibiting or reducing biofilm formation, the method comprising applying a compound of claim 1 or 2 to a surface or biofilm.