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Antibiotic Compounds And Process Of Preparation Thereof
Abstract: ABSTRACT RECOMBINANT CONSTRUCT, IMMUNOGENIC COMPOSITION AGAINST DENGUE VIRUS AND IMPLEMENTATION THEREOF The present disclosure provides recombinant immunogenic compositions against Dengue serotypes. In particular, the present disclosure discloses the recombinant construct comprising a nucleic acid fragment encoding a dengue envelope protein(E) having an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 34, SEQ ID NO: 36, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 58 or SEQ ID NO: 60. The disclosure also provides a two-step purification method to obtain soluble, cleaved, well-ordered, native-like E dimers with high purity and more than 99% homogeneity. Also, efficacious and safe subunit vaccine immunogens (immunogenic composition) comprising the E dimers are disclosed, which can elicit high immunization titers against dengue virus and other flaviviruses in a subject.
Notices, Deadlines & Correspondence
Patent Information
Applicants
BUGWORKS RESEARCH INDIA PVT LTD
BUGWORKS RESEARCH INDIA PVT LTD
BUGWORKS RESEARCH INDIA PVT LTD
Inventors
1. PEER MOHAMED, Shahul Hameed
2. PEER MOHAMED, Shahul Hameed
3. PEER MOHAMED, Shahul Hameed
4. KAJIPALYA RANGANATHA RAO, Ranga Rao
5. KAJIPALYA RANGANATHA RAO, Ranga Rao
6. KAJIPALYA RANGANATHA RAO, Ranga Rao
7. BHARATHAM, Nagakumar
8. BHARATHAM, Nagakumar
9. BHARATHAM, Nagakumar
10. KATAGIHALLIMATH, Nainesh
11. KATAGIHALLIMATH, Nainesh
12. KATAGIHALLIMATH, Nainesh
13. SHARMA, Sreevalli
14. SHARMA, Sreevalli
15. SHARMA, Sreevalli
16. NANDISHAIAH, Radha
17. NANDISHAIAH, Radha
18. NANDISHAIAH, Radha
19. RAMACHANDRAN, Vasanthi
20. RAMACHANDRAN, Vasanthi
21. RAMACHANDRAN, Vasanthi
Specification
DESC:ANTIBIOTIC COMPOUNDS AND PROCESS OF PREPARATION THEREOF ,CLAIMS:AS ATTACHED
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202141036833-STATEMENT OF UNDERTAKING (FORM 3) [13-08-2021(online)].pdf | 2021-08-13 |
| 2 | 202141036833-PROVISIONAL SPECIFICATION [13-08-2021(online)].pdf | 2021-08-13 |
| 3 | 202141036833-FORM FOR STARTUP [13-08-2021(online)].pdf | 2021-08-13 |
| 4 | 202141036833-FORM FOR SMALL ENTITY(FORM-28) [13-08-2021(online)].pdf | 2021-08-13 |
| 5 | 202141036833-FORM 1 [13-08-2021(online)].pdf | 2021-08-13 |
| 6 | 202141036833-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [13-08-2021(online)].pdf | 2021-08-13 |
| 7 | 202141036833-Proof of Right [17-09-2021(online)].pdf | 2021-09-17 |
| 8 | 202141036833-FORM-26 [17-09-2021(online)].pdf | 2021-09-17 |
| 9 | 202141036833-DRAWING [12-08-2022(online)].pdf | 2022-08-12 |
| 10 | 202141036833-CORRESPONDENCE-OTHERS [12-08-2022(online)].pdf | 2022-08-12 |
| 11 | 202141036833-COMPLETE SPECIFICATION [12-08-2022(online)].pdf | 2022-08-12 |
| 12 | 202141036833-Request Letter-Correspondence [02-09-2022(online)].pdf | 2022-09-02 |
| 13 | 202141036833-Power of Attorney [02-09-2022(online)].pdf | 2022-09-02 |
| 14 | 202141036833-FORM28 [02-09-2022(online)].pdf | 2022-09-02 |
| 15 | 202141036833-Form 1 (Submitted on date of filing) [02-09-2022(online)].pdf | 2022-09-02 |
| 16 | 202141036833-Covering Letter [02-09-2022(online)].pdf | 2022-09-02 |
| 17 | 202141036833-CERTIFIED COPIES TRANSMISSION TO IB [02-09-2022(online)].pdf | 2022-09-02 |
| 18 | 202141036833-FORM 3 [08-02-2023(online)].pdf | 2023-02-08 |
| 19 | 202141036833-FORM 18 [24-07-2025(online)].pdf | 2025-07-24 |