FORM-2
THE PATENTS ACT, 1970
(39 of 1970)
& THE PATENTS RULES 2003
Complete Specification
(See section 10 and rule 13) ANTIMICROBIAL FORMULATION
NANO CUTTING EDGE TECHNOLOGY PVT. LTD.
an Indian Company
of 79/87, D. Lad Path, Kalachowki, Mumbai 400 033,
Maharashtra, India
THE FOLLOWING SPECIFICATION PARTICULARLY DESCRIBES THE INVENTION AND THE MANNER IN WHICH IT IS TO BE PERFORMED.
FIELD OF INVETION
This invention relates to an antimicrobial formulation.
BACKGROUND OF INVENTION
The usefulness of silver (symbol- Ag, atomic number-47) as an antimicrobial agent has been known for a long time. For thousands of years silver has been used as a healing and anti-bacterial agent by civilizations throughout the world. Its medical, preservative and restorative powers can be traced as far back as the ancient Greek and Roman Empires. Long before the development of modern pharmaceuticals, silver was employed as a germicide and antibiotic:
• The Greeks used silver vessels to keep water and other liquids fresh. Herodotus, the Greek philosopher and historian, dates the use of silver to before the birth of Christ.
• The Roman Empire stored wine in silver urns to prevent spoilage.
• The use of silver is mentioned in ancient Indian and Egyptian writings.
• In the Middle Ages, silverware protected the wealthy from the full brunt of the plague.
• Before the advent of modern germicides and antibiotics, it was known that disease-causing pathogens could not survive in the presence of silver. Consequently, silver was used in dishware, drinking vessels and eating utensils.
• In particular, the wealthy stored and ate their food from silver vessels to keep bacteria from growing.
• The Chinese emperors and their courts ate with silver chopsticks.
• The Druids have left evidence of their use of silver.
• Settlers in the Australian outback suspend silverware in their water tanks to retard spoilage.
• Pioneers trekking across the American West found that if they placed silver or copper coins in their casks of drinking water, it kept the water safe from bacteria, algae, etc.
• All along the frontier, silver dollars were put in milk to keep it fresh.
• Silver leaf was used to combat infection in wounds sustained by troops during World War I.
• Prior to the introduction of antibiotics. Colloidal silver was used widely in hospitals and has been known as a bactericide for at least 1200 years.
• In the early 1800s. doctors used silver sutures in surgical wounds with very successful results.
Not until the late 1800's did eastern scientists re-discover what had been known for thousands of years-that silver is a powerful germ fighter. Medicinal silver compounds were then developed and silver became commonly used as a medicine. By the early part of the 1900s. the use of silver as an antibacterial substance was becoming widespread. By 1940 there were approximately four dozen different silver compounds in the market being used to treat every known infectious disease. These were available in oral, injectable, and topical forms. However, these medicinal silver preparations caused a discoloration of the skin called argyria specially certain types of protein-bound silver compounds and improperly prepared and unstable compositions.
New knowledge of body chemistry gave rise to the enormous array of applications for colloidal disinfectants and medicines and for on-going research into the capabilities and possibilities for silver colloids. However, Silver's "new-found" fame as a superior infection-fighting agent was short lived.
During the 1930s, synthetically manufactured drugs began to make their appearance and the profits, together with the simplicities of manufacturing this new source of treatment, became a powerful force in the marketplace. There was much excitement over the new 'wonder drugs' and at that time, no antibiotic-resistant strains of disease organisms had surfaced. Silver quickly lost its status to modern antibiotics.
The use of some silver preparations in mainstream medicine survived. Among them are the use of dilute silver nitrate in newborn babies' eyes to protect from infection and the use of "Silvadine", a silver based salve, in burn wards to kill infection. Silver based bandages have also been approved by the FDA and licensed for sale. Other uses that did not lose favor include:
• Silver water purification filters and tablets are used to prevent growth of algae
and bacteria.
• Electrical ionization units that impregnate the water with silver and copper ions are used to sanitize pool water without the harsh effects of chlorine.
• Silver has been used to sterilize recycled water on space vehicles.
• The Swiss use silver filters in homes and offices-
• Municipalities use silver in treatment of sewage-
• Silver is a popular agent in the fight against airborne toxins as well other
industrial poisons.
But for the most part, with the discovery of pharmaceutical antibiotics, interest in Silver as an anti-microbial agent declined almost to the point of extinction. Silver re-emerged as an adjunct to antibiotic treatment £S a result of the notable work of Dr. Margraf who found that the use of diluted silver nitrate to a 5 percent solution was found to kill invasive burn bacteria and permitted wounds to heal. Importantly, resistant strains did not appear. Silver nitrate was widely used in 1960s for the treatment of burn victims by Moyer. But, silver nitrate was far from ideal. Eventually, it was not co^i^eced as a