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Antithrombotic Material

Abstract: The purpose of the present invention is to provide an antithrombotic material which exhibits high antithrombotic activity that is sustained over a long period while reducing the thickness of the coating material. The present invention is an antithrombotic material comprising a coating material containing a compound having anionic anti clotting activity and including sulfur atoms together with a cationic polymer containing as a constituent monomer a compound selected from the group consisting of alkylene imine vinyl amine allyl amine lysine protamine and diallyl dimethyl ammonium chloride and a substrate having the surface thereof coated by said coating material wherein the cationic polymer is covalently bonded to the substrate and the compound having anionic anticoagulant activity and including sulfur atoms is immobilized on the substrate surface by ionic bonding with the cationic polymer and the average thickness of the coating material is 15 400nm.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
21 November 2017
Publication Number
47/2017
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 103-8666

Inventors

1. KADOWAKI, Koji
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
2. SAITO, Akihiro
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
3. NAKANISHI, Megumi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
4. FUJITA, Masaki
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
5. TANAHASHI, Kazuhiro
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558

Specification

CLAIMS
1. An antithrombogenic material comprising:
a coating material containing: a cationic polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and
a base material whose surface is coated with said coating material; wherein
said cationic polymer is covalently bound to said base material;
said anionic compound containing a sulfur atom and having anticoagulant activity is ionically bound to said cationic polymer; and
the average thickness of said coating material is 15 to 400 nm.
2. The antithrombogenic material according to claim 1, wherein the total amount of said anionic compound having anticoagulant activity contained in said coating material as calculated from anti-factor Xa activity is 50 to 1000 mlU/cm .
3. The antithrombogenic material according to claim 1 or 2, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 6.5 to 9.5 atomic percent.
4. The antithrombogenic material according to any one of claims 1 to 3, wherein the weight average molecular weight of said cationic polymer is 10,000 to 1,000,000.
5. The antithrombogenic material according to any one of claims 1 to 4, wherein said base material is a polyester-based polymer, and the maximum stress of said antithrombogenic material is not less than 350 MPa.
6. The antithrombogenic material according to any one of claims 1 to 5, wherein

said cationic polymer has a positively charged functional group, and said base material has a negatively charged functional group; and
the abundance ratio of said positively charged functional group to said negatively charged functional group is 8.0 to 30.
7. The antithrombogenic material according to any one of claims 1 to 6, wherein the ratio of the abundance of said negatively charged functional group in said base material after the covalent bonding of said cationic polymer to the abundance of said negatively charged functional group in said base material before the covalent bonding of said cationic polymer is not more than 25%.
8. The antithrombogenic material according to any one of claims 1 to 7, having cellular adhesiveness.
9. A medical tool comprising the antithrombogenic material according to any one of claims 1 to 8.

Documents

Orders

Section Controller Decision Date

Application Documents

# Name Date
1 201747041592-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [21-11-2017(online)].pdf 2017-11-21
1 201747041592-US(14)-HearingNotice-(HearingDate-05-05-2021).pdf 2021-10-17
2 201747041592-Correspondence to notify the Controller [26-04-2021(online)].pdf 2021-04-26
2 201747041592-STATEMENT OF UNDERTAKING (FORM 3) [21-11-2017(online)].pdf 2017-11-21
3 201747041592-REQUEST FOR EXAMINATION (FORM-18) [21-11-2017(online)].pdf 2017-11-21
3 201747041592-FORM 3 [09-12-2020(online)].pdf 2020-12-09
4 201747041592-PROOF OF RIGHT [21-11-2017(online)].pdf 2017-11-21
4 201747041592-ABSTRACT [15-10-2019(online)].pdf 2019-10-15
5 201747041592-PRIORITY DOCUMENTS [21-11-2017(online)].pdf 2017-11-21
5 201747041592-certified copy of translation (MANDATORY) [15-10-2019(online)].pdf 2019-10-15
6 201747041592-POWER OF AUTHORITY [21-11-2017(online)].pdf 2017-11-21
6 201747041592-CLAIMS [15-10-2019(online)].pdf 2019-10-15
7 201747041592-FORM 18 [21-11-2017(online)].pdf 2017-11-21
7 201747041592-FER_SER_REPLY [15-10-2019(online)].pdf 2019-10-15
8 201747041592-FORM 3 [15-10-2019(online)].pdf 2019-10-15
8 201747041592-FORM 1 [21-11-2017(online)].pdf 2017-11-21
9 201747041592-DECLARATION OF INVENTORSHIP (FORM 5) [21-11-2017(online)].pdf 2017-11-21
9 201747041592-OTHERS [15-10-2019(online)].pdf 2019-10-15
10 201747041592-COMPLETE SPECIFICATION [21-11-2017(online)].pdf 2017-11-21
10 201747041592-FER.pdf 2019-04-29
11 201747041592-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [21-11-2017(online)].pdf 2017-11-21
11 201747041592-FORM 3 [03-04-2018(online)].pdf 2018-04-03
12 201747041592.pdf 2017-11-24
12 Correspondence by Agent_Executed Form 1_23-11-2017.pdf 2017-11-23
13 201747041592.pdf 2017-11-24
13 Correspondence by Agent_Executed Form 1_23-11-2017.pdf 2017-11-23
14 201747041592-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [21-11-2017(online)].pdf 2017-11-21
14 201747041592-FORM 3 [03-04-2018(online)].pdf 2018-04-03
15 201747041592-COMPLETE SPECIFICATION [21-11-2017(online)].pdf 2017-11-21
15 201747041592-FER.pdf 2019-04-29
16 201747041592-DECLARATION OF INVENTORSHIP (FORM 5) [21-11-2017(online)].pdf 2017-11-21
16 201747041592-OTHERS [15-10-2019(online)].pdf 2019-10-15
17 201747041592-FORM 3 [15-10-2019(online)].pdf 2019-10-15
17 201747041592-FORM 1 [21-11-2017(online)].pdf 2017-11-21
18 201747041592-FORM 18 [21-11-2017(online)].pdf 2017-11-21
18 201747041592-FER_SER_REPLY [15-10-2019(online)].pdf 2019-10-15
19 201747041592-POWER OF AUTHORITY [21-11-2017(online)].pdf 2017-11-21
19 201747041592-CLAIMS [15-10-2019(online)].pdf 2019-10-15
20 201747041592-PRIORITY DOCUMENTS [21-11-2017(online)].pdf 2017-11-21
20 201747041592-certified copy of translation (MANDATORY) [15-10-2019(online)].pdf 2019-10-15
21 201747041592-PROOF OF RIGHT [21-11-2017(online)].pdf 2017-11-21
21 201747041592-ABSTRACT [15-10-2019(online)].pdf 2019-10-15
22 201747041592-REQUEST FOR EXAMINATION (FORM-18) [21-11-2017(online)].pdf 2017-11-21
22 201747041592-FORM 3 [09-12-2020(online)].pdf 2020-12-09
23 201747041592-STATEMENT OF UNDERTAKING (FORM 3) [21-11-2017(online)].pdf 2017-11-21
23 201747041592-Correspondence to notify the Controller [26-04-2021(online)].pdf 2021-04-26
24 201747041592-US(14)-HearingNotice-(HearingDate-05-05-2021).pdf 2021-10-17
24 201747041592-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [21-11-2017(online)].pdf 2017-11-21

Search Strategy

1 SS201747041592_29-04-2019.pdf