Abstract: The purpose of the present invention is to provide an antithrombotic material which exhibits high antithrombotic activity that is sustained over a long period while reducing the thickness of the coating material. The present invention is an antithrombotic material comprising a coating material containing a compound having anionic anti clotting activity and including sulfur atoms together with a cationic polymer containing as a constituent monomer a compound selected from the group consisting of alkylene imine vinyl amine allyl amine lysine protamine and diallyl dimethyl ammonium chloride and a substrate having the surface thereof coated by said coating material wherein the cationic polymer is covalently bonded to the substrate and the compound having anionic anticoagulant activity and including sulfur atoms is immobilized on the substrate surface by ionic bonding with the cationic polymer and the average thickness of the coating material is 15 400nm.
CLAIMS
1. An antithrombogenic material comprising:
a coating material containing: a cationic polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and
a base material whose surface is coated with said coating material; wherein
said cationic polymer is covalently bound to said base material;
said anionic compound containing a sulfur atom and having anticoagulant activity is ionically bound to said cationic polymer; and
the average thickness of said coating material is 15 to 400 nm.
2. The antithrombogenic material according to claim 1, wherein the total amount of said anionic compound having anticoagulant activity contained in said coating material as calculated from anti-factor Xa activity is 50 to 1000 mlU/cm .
3. The antithrombogenic material according to claim 1 or 2, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 6.5 to 9.5 atomic percent.
4. The antithrombogenic material according to any one of claims 1 to 3, wherein the weight average molecular weight of said cationic polymer is 10,000 to 1,000,000.
5. The antithrombogenic material according to any one of claims 1 to 4, wherein said base material is a polyester-based polymer, and the maximum stress of said antithrombogenic material is not less than 350 MPa.
6. The antithrombogenic material according to any one of claims 1 to 5, wherein
said cationic polymer has a positively charged functional group, and said base material has a negatively charged functional group; and
the abundance ratio of said positively charged functional group to said negatively charged functional group is 8.0 to 30.
7. The antithrombogenic material according to any one of claims 1 to 6, wherein the ratio of the abundance of said negatively charged functional group in said base material after the covalent bonding of said cationic polymer to the abundance of said negatively charged functional group in said base material before the covalent bonding of said cationic polymer is not more than 25%.
8. The antithrombogenic material according to any one of claims 1 to 7, having cellular adhesiveness.
9. A medical tool comprising the antithrombogenic material according to any one of claims 1 to 8.
| Section | Controller | Decision Date |
|---|---|---|
| # | Name | Date |
|---|---|---|
| 1 | 201747041592-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [21-11-2017(online)].pdf | 2017-11-21 |
| 1 | 201747041592-US(14)-HearingNotice-(HearingDate-05-05-2021).pdf | 2021-10-17 |
| 2 | 201747041592-Correspondence to notify the Controller [26-04-2021(online)].pdf | 2021-04-26 |
| 2 | 201747041592-STATEMENT OF UNDERTAKING (FORM 3) [21-11-2017(online)].pdf | 2017-11-21 |
| 3 | 201747041592-REQUEST FOR EXAMINATION (FORM-18) [21-11-2017(online)].pdf | 2017-11-21 |
| 3 | 201747041592-FORM 3 [09-12-2020(online)].pdf | 2020-12-09 |
| 4 | 201747041592-PROOF OF RIGHT [21-11-2017(online)].pdf | 2017-11-21 |
| 4 | 201747041592-ABSTRACT [15-10-2019(online)].pdf | 2019-10-15 |
| 5 | 201747041592-PRIORITY DOCUMENTS [21-11-2017(online)].pdf | 2017-11-21 |
| 5 | 201747041592-certified copy of translation (MANDATORY) [15-10-2019(online)].pdf | 2019-10-15 |
| 6 | 201747041592-POWER OF AUTHORITY [21-11-2017(online)].pdf | 2017-11-21 |
| 6 | 201747041592-CLAIMS [15-10-2019(online)].pdf | 2019-10-15 |
| 7 | 201747041592-FORM 18 [21-11-2017(online)].pdf | 2017-11-21 |
| 7 | 201747041592-FER_SER_REPLY [15-10-2019(online)].pdf | 2019-10-15 |
| 8 | 201747041592-FORM 3 [15-10-2019(online)].pdf | 2019-10-15 |
| 8 | 201747041592-FORM 1 [21-11-2017(online)].pdf | 2017-11-21 |
| 9 | 201747041592-DECLARATION OF INVENTORSHIP (FORM 5) [21-11-2017(online)].pdf | 2017-11-21 |
| 9 | 201747041592-OTHERS [15-10-2019(online)].pdf | 2019-10-15 |
| 10 | 201747041592-COMPLETE SPECIFICATION [21-11-2017(online)].pdf | 2017-11-21 |
| 10 | 201747041592-FER.pdf | 2019-04-29 |
| 11 | 201747041592-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [21-11-2017(online)].pdf | 2017-11-21 |
| 11 | 201747041592-FORM 3 [03-04-2018(online)].pdf | 2018-04-03 |
| 12 | 201747041592.pdf | 2017-11-24 |
| 12 | Correspondence by Agent_Executed Form 1_23-11-2017.pdf | 2017-11-23 |
| 13 | 201747041592.pdf | 2017-11-24 |
| 13 | Correspondence by Agent_Executed Form 1_23-11-2017.pdf | 2017-11-23 |
| 14 | 201747041592-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [21-11-2017(online)].pdf | 2017-11-21 |
| 14 | 201747041592-FORM 3 [03-04-2018(online)].pdf | 2018-04-03 |
| 15 | 201747041592-COMPLETE SPECIFICATION [21-11-2017(online)].pdf | 2017-11-21 |
| 15 | 201747041592-FER.pdf | 2019-04-29 |
| 16 | 201747041592-DECLARATION OF INVENTORSHIP (FORM 5) [21-11-2017(online)].pdf | 2017-11-21 |
| 16 | 201747041592-OTHERS [15-10-2019(online)].pdf | 2019-10-15 |
| 17 | 201747041592-FORM 3 [15-10-2019(online)].pdf | 2019-10-15 |
| 17 | 201747041592-FORM 1 [21-11-2017(online)].pdf | 2017-11-21 |
| 18 | 201747041592-FORM 18 [21-11-2017(online)].pdf | 2017-11-21 |
| 18 | 201747041592-FER_SER_REPLY [15-10-2019(online)].pdf | 2019-10-15 |
| 19 | 201747041592-POWER OF AUTHORITY [21-11-2017(online)].pdf | 2017-11-21 |
| 19 | 201747041592-CLAIMS [15-10-2019(online)].pdf | 2019-10-15 |
| 20 | 201747041592-PRIORITY DOCUMENTS [21-11-2017(online)].pdf | 2017-11-21 |
| 20 | 201747041592-certified copy of translation (MANDATORY) [15-10-2019(online)].pdf | 2019-10-15 |
| 21 | 201747041592-PROOF OF RIGHT [21-11-2017(online)].pdf | 2017-11-21 |
| 21 | 201747041592-ABSTRACT [15-10-2019(online)].pdf | 2019-10-15 |
| 22 | 201747041592-REQUEST FOR EXAMINATION (FORM-18) [21-11-2017(online)].pdf | 2017-11-21 |
| 22 | 201747041592-FORM 3 [09-12-2020(online)].pdf | 2020-12-09 |
| 23 | 201747041592-STATEMENT OF UNDERTAKING (FORM 3) [21-11-2017(online)].pdf | 2017-11-21 |
| 23 | 201747041592-Correspondence to notify the Controller [26-04-2021(online)].pdf | 2021-04-26 |
| 24 | 201747041592-US(14)-HearingNotice-(HearingDate-05-05-2021).pdf | 2021-10-17 |
| 24 | 201747041592-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [21-11-2017(online)].pdf | 2017-11-21 |
| 1 | SS201747041592_29-04-2019.pdf |