CLAIMS
1. An antithrombogenic material comprising:
a coating material containing:
a polymer containing, as a constituent monomer, a compound selected
from the group consisting of alkyleneimines, vinylammes, allylamines, lysine,
protamine, and diallyldimethylammonium chloride; and
an anionic compound containing a sulfur atom and having
anticoagulant activity; and
a base material whose surface is coated with said coating material;
wherein
said polymer is covalently bound to said base material; and
the abundance ratio of nitrogen atoms to the abundance of total atoms as
measured by X-ray photoelectron spectroscopy (XPS) on the surface is 6.0 to 12.0
atomic percent.
2. The antithrombogenic material according to claim 1, wherein the abundance ratio of sulfur atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 3.0 to 6.0 atomic percent.
3. The antithrombogenic material according to claim 1 or 2, wherein said polymer has a quaternary ammonium group.
4. The antithrombogenic material according to claim 3, wherein each carbon chain bound to the nitrogen atom in said quaternary ammonium group is constituted by an alkyl group, and the carbon number per alkyl group is 1 to 12.
5. The antithrombogenic material according to any one of claims 1 to 4, wherein said coating material comprises:
an anionic polymer containing, as a constituent monomer, a compound selected from the group consisting of acrylic acid, methacrylic acid, a-glutamic acid, y-glutamic acid, and aspartic acid; or

an anionic compound selected from the group consisting of oxalic acid, malonic acid, succinic acid, fumaric acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, malic acid, tartaric acid, and citric acid.
6. The antithrombogenic material according to any one of claims 1 to 4, wherein said anionic compound containing a sulfur atom and having anticoagulant activity is heparin or a heparin derivative.
7. The antithrombogenic material according to any one of claims 1 to 6, wherein the weight average molecular weight of said polymer is 600 to 2,000,000.
8. The antithrombogenic material according to claim 5, wherein the weight average molecular weight of said anionic polymer is 600 to 2,000,000.
9. The antithrombogenic material according to any one of claims 1 to 8, wherein the abundance ratio of the n2 component as a split peak of nitrogen atoms to the total component of the Nls peak as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 20 to 70 atomic percent.
10. The antithrombogenic material according to any one of claims 1 to 9, wherein the abundance ratio of the c3 component as a split peak of carbon atoms to the total component of the CI s peak as measured by X-ray photoelectron spectroscopy (XPS) on the surface is not less than 2.0 atomic percent.
11. The antithrombogenic material according to any one of claims 1 to 10, wherein said coating material has a mean thickness of 1 to 600 nm.
12. The antithrombogenic material according to any one of claims 1 to 11, wherein said coating material is placed to a depth of 20 to 100 nm from an interface of said base material.
13. The antithrombogenic material according to any one of claims 1 to 12, having cellular adhesiveness.