NA

WE CLAIM:
1. A compound or salt thereof, wherein:
the compound corresponds in structure to formula (I):
(Formula Removed)
R' is selected from the group consisting of:
(Formula Removed)
heteroarylcarbonyl;
is selected from the group consisting of single carbon-carbon bond and double carbon-carbon bond;
R5, R6, R8, R11, R12, R13, and R14 are independently selected from the group consisting of hydrogen, methyl, and nitrogen-protecting group;
R7 is selected from the group consisting of hydrogen and methyl;
R9 is halo;
R10 is halo;
n is selected from the group consisting of 1,2, and 3;
R15 is selected from the group consisting of hydrogen, amino, and nitrogen-protecting group substituted amino;
m is selected from the group consisting of 0, 1, 2, and 3;
R16 is selected from the group consisting of hydrogen, aryl, alkyl, and alkyloxycarbonyl;
R2 is selected from the group consisting of halo, alkyl, alkenyl, alkynyl, nitro, cyano, azido, alkyloxy, alkenyloxy, alkynyloxy, amino, aminocarbonyl, aminosulfonyl, alkylsulfonyl, carbocyclyl, and heterocyclyl, wherein:
(a) the amino, aminocarbonyl, and aminosulfonyl optionally are substituted with:
(1) one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, and alkylsulfonyl, or
(2) two substituents that, together with the amino nitrogen, form a single-ring heterocyclyl, and
(b) the alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, alkynyloxy, and alkylsulfonyl,
optionally are substituted with one or more substituents independently selected from the
group consisting of halo, oxo, nitro, cyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl,
carbocyclyl, and heterocyclyl, wherein:
the amino optionally is substituted with:
(1) one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylcarbonyl, alkylsulfonyl, alkyloxycarbonyl, carbocyclyl, heterocyclyl, carbocyclylalkyl, and heterocyclylalkyl, or
(2) two substituents that, together with the amino nitrogen, form a single-ring heterocyclyl, and
(c) the carbocyclyl and heterocyclyl optionally are substituted with up to three
substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halo,
oxo, nitro, cyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl, carbocyclyl, and
heterocyclyl, wherein:
the amino optionally is substituted with:
(1) one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylcarbonyl, alkylsulfonyl, alkyloxycarbonyl, carbocyclyl, heterocyclyl, carbocyclylalkyl, and
heterocyclylalkyl, or
(2) two substituents that, together with the amino nitrogen, form a single-ring heterocyciyl; R3 is selected from the group consisting of hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, alkynyloxy, alkylsulfonyloxy, amino, carbocyclylsulfonyloxy, haloalkylsulfonyloxy, and halo; as to L and R4:
L is a bond, and R4 is selected from the group consisting of C5-C6-carbocyclyl, fused 2-ring carbocyclyl and fused 2-ring heterocyciyl, wherein each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of RE, RF, RG, RH, RI, RJ, and RK, or
L is selected from the group consisting of C(RA)=C(RB), C≡C, C(O)N(RC), N(RD)C(O), C1-C1-alkylene, CH2O, OCH2, cyclopropyl-l,2-ene, CH2N(RL), N(RM)CH2, C(O)CH2, and CH2C(O), and R4 is selected from the group consisting of C5-C6-carbocyclyl and 5-6-membered heterocyciyl, wherein each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of RE, RF, RG, RH, RI, RJ and RK;
RA, RB, RL, and RM are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkyloxy, C3-C8-cycloalkyl, and halo, wherein:
the C1-C6-alkyl optionally is substituted with one or more substituents independently selected from the group consisting of carboxy, halo, hydroxy, nitro, 0x0, amino, cyano, alkyloxycarbonyl, alkylcarbonyloxy, alkyloxy, carbocyclyl, and heterocyciyl; RC is selected from the group consisting of hydrogen and alkyl; RD is selected from the group consisting of hydrogen and alkyl;
each RE is independently selected from the group consisting of halo, nitro, hydroxy, 0x0, carboxy, cyano, amino, imino, azido, and aldehydo, wherein:
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl;
each RF is independently selected from the group consisting of alkyl, alkenyl, and alkynyl, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of carboxy, hydroxy, halo, amino, imino, nitro, azido, oxo, aminosulfonyl, alkylsulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyciyl, cyano, and aminocarbonyl, wherein: the amino, imino, aminosulfonyl, aminocarbonyl, carbocyclyl, and heterocyciyl optionally are substituted with one or two substituents independently
selected from the group consisting of alky 1, alkenyl, alkynyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, alkylsulfonylamino, hydroxy, and alkyloxy, wherein:
amino portion of the alkylsulfonylamino optionally is substituted with a substituent selected from the group consisting of alkyl, alkenyl, and alkynyl; each RG is independently selected from the group consisting of carbocyclyl and heterocyclyl, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, carboxy, hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyclyl, cyano, and aminocarbonyl, wherein:
the amino, aminosulfonyl, and aminocarbonyl optionally are substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylsulfonyl, alkenylsulfonyl, and alkynylsulfonyl; each RH is independently selected from the group consisting of alkyloxy, alkenyloxy, alkynyloxy, alkylsulfonyloxy, alkenylsulfonyloxy, and alkynylsulfonyloxy, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of carboxy, hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyclyl, cyano, and aminocarbonyl, wherein:
the amino, aminosulfonyl, and aminocarbonyl optionally are substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylsulfonyl, alkenylsulfonyl, and alkynylsulfonyl; each R' is independently selected from the group consisting of alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, aminocarbonyl, alkyloxycarbonyl, carbocyclylcarbonyl, and heterocyclylcarbonyl, wherein;
(a) the alkylcarbonyl, alkenylcarbonyl, and alkynylcarbonyl optionally are substituted
with one or more substituents independently selected from the group consisting of carboxy,
hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl,
alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy,
alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyclyl, cyano, and
aminocarbonyl, and
(b) the aminocarbonyl optionally is substituted with one or two substituents
independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkyloxyalkyl, carbocyclyl, heterocyclyl, alkylsulfonyl, and alkylsulfonylamino, wherein:
the carbocyclyl and heterocyclyl optionally are substituted with one or two substituents independently selected from the group consisting of halo, alkyl, and oxo; each RJ is independently selected from the group consisting of carbocyclylsulfonylamino, heterocyclylsulfonylamino, alkylcarbonylamino, alkenylcarbonylamino, alkynylcarbonylamino, alkyloxycarbonylamino, alkenyloxycarbonylamino, alkynyloxycarbonylamino, alkylsulfonylamino, alkenylsulfonylamino, alkynylsulfonylamino, aminocarbonylamino, alkyloxycarbonylaminoimino, alkylsulfonylaminoimino, alkenylsulfonylaminoimino, and alkynylsulfonylaminoimino, wherein:
(a) the amino portion of such substituents optionally is substituted with a substituent
independently selected from the group consisting of carbocyclylalkyl, heterocyclylalkyl,
alkylcarbonyloxy, aminocarbonylalkyl, alkyl, alkenyl, alkynyl, alkylcarbonyl,
alkenylcarbonyl, alkynylcarbonyl, alkyloxycarbonyl, alkyloxyalkyloxycarbonyl,
alkylcarbonyloxyalkyl, and alkylsulfonyl, wherein:
(1) the carbocyclyl portion of the carbocyclylalkyl and the heterocyclyl portion of the heterocyclylalkyl optionally are substituted with one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, carboxy, hydroxy, alkyloxy, alkenyloxy, alkynyloxy, halo, nitro, cyano, azido, oxo, and amino, and
(2) the amino portion of the aminocarbonylalkyl optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl,
(b) the alkyl, alkenyl, and alkynyl portion of such substituents optionally is
substituted with one or more substituents independently selected from the group consisting of
carboxy, halo, oxo, amino, alkyloxycarbonyl, alkylcarbonyloxy, hydroxy, alkyloxy,
carbocyclyl, heterocyclyl, and cyano, wherein:
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, and alkynyloxy, wherein:
the alkyl optionally is substituted with one or more hydroxy;
(c) the carbocyclyl and heterocyclyl portions of such substituents optionally are
substituted with one or more substituents independently selected from the group consisting of
alkyl, alkenyl, alkynyl, carboxy, hydroxy, alkyloxy, alkenyloxy, alkynyloxy, halo, nitro,
cyano, azido, and amino, wherein:
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl; and each RK is independently selected from the group consisting of aminosulfonyl, alkylsulfonyl,
alkenylsulfonyl, and alkynylsulfonyl, wherein:
(a) the alkylsulfonyl, alkenylsulfonyl, and alkynylsulfonyl optionally are substituted
with one or more substituents independently selected from the group consisting of carboxy,
hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl,
alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy,
alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyclyl, cyano, and
aminocarbonyl, wherein:
the amino, aminosulfonyl, and aminocarbonyl optionally are substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl; and
(b) the aminosulfonyl optionally is substituted with one or two substituents
independently selected from the group consisting of alkyl, alkenyl, and alkynyl.
2. The compound or salt of claim 1, wherein the compound corresponds in structure to
formula I-1:
(Formula Removed)
3. The compound or salt of any one of claims 1 and 2, wherein R5 is selected from the group consisting of hydrogen and methyl.
4. The compound or salt of any one of claims 1-3, wherein R6 is selected from the group consisting of hydrogen and methyl.
5. The compound or salt of any one of claims 1-4, wherein R7 is hydrogen.
6. The compound or salt of claim 1, wherem R1 is (Formula Removed)
7. The compound or salt of any one of claims 1 and 6, wherein in is 0.
8. The compound or salt of any one of claims 1 and 6, wherein m is 1.
9. The compound or salt of any one of claims 1 and 6, wherein m is 2.
10. The compound or salt of any one of claims 1 and 6, wherein m is 3.
11. The compound or salt of any one of claims 1 and 6-10, wherein R16 is hydrogen.
12. The compound or salt of any one of claims 1 and 6-10, wherein R16 is phenyl.
13. The compound or salt of any one of claims 1 and 6-10, wherein R16 is C1-C3-alkyl.
14. The compound or salt of any one of claims 1 and 6-10, wherein R16 is C1-C3-alkyloxy-carbonyl.
15. The compound or salt of any one of claims 1-14, wherein R2 is selected from the group consisting of C1-C4-alkyl, C3-C6-carbocyclyl, and 5-6-membered heterocyclyl, wherein:

(a) the C1-C4-alkyl optionally is substituted with up to three substituents independently selected from the group consisting of halo, oxo, hydroxy, alkyloxy, and trimethylsilyl, and
(b) the C3-C6-carbocyclyl and 5-6-membered heterocyclyl optionally are substituted with one or two substituents independently selected from the group consisting of alkyl, halo, and alkylsulfonylamino.

16. The compound or salt of any one of claims 1-14, wherein R2 is selected from the group consisting of halo, alkyl, and alkyloxy.
17. The compound or salt of any one of claims 1-14, wherein R2 is selected from the group consisting of tert-butyl, perfluoroethyl, trifluoromethyl, and 5-6-membered heterocyclyl optionally substituted with methyl.
18. The compound or salt of any one of claims 1-14, wherein R2 is selected from the group consisting of furanyl, pyrazolyl, and thiophenyl, wherein each such substituent optionally is substituted with methyl.
19. The compound or salt of any one of claims 1-18, wherein R3 is selected from the group consisting of hydrogen, hydroxy, C1-C3-alkenyl, C1-C3-alkyl, alkyloxy, amino, and halo.
20. The compound or salt of any one of claims 1-18, wherein R3 is selected from the group consisting of hydrogen, hydroxy, and methoxy.
21. The compound or salt of any one of claims 1-20, wherein L is a bond.
22. The compound or salt of any one of claims 1-20, wherein:
L is a bond; and
R4 is selected from the group consisting of fused 2-ring heterocyclyl and fused 2-ring
carbocyclyl, wherein each such substituent is substituted with one, two, or three substituents independently selected from the group consisting of RE, RF, and RJ.
23. The compound or salt of any one of claims 1-20, wherein:
L is a bond;
R4 is a fused 2-ring carbocyclyl selected from the group consisting of naphthalenyl, dihydronaphthalenyl, tetrahydronaphthalenyl, hexahydronaphthalenyl, octahydronaphthalenyl, decahydronaphthalenyl, indenyl, dihydroindenyl, hexahydroindenyl, octahydroindenyl, pentalenyl, octahydropentalenyl, and hexahydropentalenyl, wherein each such substituent is substituted with a substituent selected from the group consisting of RF and RJ;
RF is alkylsulfonylaminoalkyl; and
RJ is alkylsulfonylamino.
24. The compound or salt of any one of claims 1-20, wherein:
L is a bond;
R4 is a fused 2-ring carbocyclyl selected from the group consisting of naphthalenyl, indenyl, and dihydroindenyl, wherein each such substituent is substituted with a substituent selected from the group consisting of RF and RJ;
RF is alkylsulfonylaminoalkyl; and
RJ is alkylsulfonylamino.
25. A compound or salt thereof, wherein the compound is selected from the group of compounds shown in Examples 1 through 52.