NA

WE CLAIM:
1. A compound or salt thereof, wherein:
the compound correspoads in structure to formula (I):
(Formula Removed)
is selected from the group consisting of single carbon-carbon bond and double carbon-carbon bond;
R1 is selected from the group consisting of hydrogen, methyl, and nitrogen-protecting group;
R2 is selected from the group consisting of hydrogen, halo, hydroxy, methyl, cyclopropyl, and cyclobutyl;
R3 is selected from the group consisting of hydrogen, halo, oxo, and methyl;
R4 is selected from the group consisting of
(Formula Removed)

R5 is selected from the group consisting of halo, alkyl. alkenyl, alkynyl. nitro, cyano, azido, alkyloxy, alkcnyloxy, alkynyloxy, amino, aminocarbonyl, aminosulfonyl, alkylsulfonyl, carbocyclyl, and hctcrocyclyl, wherein:
(A) the amino, aminocarbonyl, and aminosulfonyl optionally are substituted with:
(1) one or two substitucnts independently selected from the group consisting of alkyl, alkcnyl, alkynyl, and alkylsulfonyl, or
(2) two substitucnts (bat, together with the amino nitrogen, form a single-ring heterocyclyl, and
(b) the alkyl, alkcnyl, alkynyl, alkyloxy, alkcnyloxy, alkynyloxy, and alkylsulfonnyl,
optionally arc substituted with one or more substitucnts independently selected from the
group consisting of halo, oxo, nitro, eyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl.
carbocyclyl, and heterocyclyl, wherein:
the amino optionally is substituted with:
(1) one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylcarbonyl, alkylsulfonyl, alkyloxycarbonyl, carbocyclyl, heterocyclyl, carbocyclylalkyl, and heterocyclylaikyl, or
(2) two substituents that, together with the amino nitrogen, form a single-ring heterocyclyl, and
(c) the carbocyclyl and heterocyclyl optionally are substituted with up to three
substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halo,
oxo, nitro, cyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl, carbocyclyl, and
heterocyclyl, wherein:
the amino optionally is substituted with:
(1) one or two substituents independently selected from the group
consisting of alkyl, alkenyl, alkynyl, alkylcarbonyl, alkylsulfonyl,
alkyloxycarbonyl, carbocyclyl, heterocyclyl, carbocyclylalkyl, and
heterocyclylaikyl, or
(2) two substituents that, together with the amino nitrogen, form a single-ring beterocyclyl;

R6 is selected from the group consisting of hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, alkynyloxy, alkylsulfonyloxy, ammo, carbocyclylsulfonyloxy, haloalkylsulfonyloxy, and halo;
R7 is selected from the group consisting of hydrogen, C5-C6-carbocyclyl, 5-6-membered heterocyclyl, fused 2-ring carbocyclyl, and fused 2-ring heterocyclyl, wherein:
the C5-C6-carbotyclyl, S-6-membered heterocyclyl, fused 2-ring carbocyclyl, and fused 2-ring heterocyciyi optionally are substituted with one or more substituents independently selected from the group consisting of KE, RF, RC, RU, RI, RJ, and RK; each RE is independently selected from the group consisting of halo, nitro, hydroxy, oxo, carboxy, cyano, amino, imino, azido, and aldeh3'do, wherein:
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl;
each RF is independently selected from the group consisting of alkyl, alkenyl, and alkynyl, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of carboxy, hydroxy, halo, amino, imino, nitro, azido, oxo, aminosulfonyl, alkylslfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyciyi, cyano, and aminocarbonyl, wherein: the amino, imino, aminosulfonyl, aminocarbonyl, carbocyclyl, and heterocyciyi optionally arc substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, alkylsulfonylamino, hydroxy, and alkyloxy, wherein:
amino portion of the alkylsulfonylamino optionally is substituted with a substituent selected from (he group consisting of alkyl, alkcnyl, and alkynyl; each RG is independently selected from the group consisting of carbocyclyl and heterocyclyl, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, carboxy, hydroxy, halo, amino, nitro. azido, oxo, aminosulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl. alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyciyi, cyano, and aminocarbonyl, wherein:
the amino, aminosulfonyl, and aminocarbonyl optionally arc substituted with one or two substituents independently selected from the group consisting of alkyl,
alkenyl, alkynyl, alkylsulfonyl, alkenylsulfonyi, and alkynylsulfonyl; each RH is independently selected from the group consisting of alkylcxy, alkenyloxy, alkynyloxy, alkylsulfonyloxy, alkenylsulfunyloxy, and alkynyisuifonyloxy, wherein:
each such substituent optionally is substituted with one or more substituents independently selected from the group consisting of carboxy, hydroxy, halo, amino, nitro. azido, oxo, aminosulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, hcterocyclyl, cyano, and aminocarbonyl, wherein:
the amino, aminosulibnyl, and aminocarbonyl optionally are substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkylsulfonyl, alkcnylsnlfonyl, and alkynylsulfonyl; each RI is independently selected from the group consisting of alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, aminocarbonyl, alkyloxycarbonyl, carbocyclylcarbonyl, and heterocyclylcarbonyl, wherein:
(a) the alkylcarbonyl. aikenylcaibonyl, and alkynylcarbonyl optionally are substituted with one or more substituents independently selected from the group consisting of carboxy, hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocyclyl, cyano, and aminocarbonyl, and
(b) the aminocarbonyl optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkyloxyalkyl, carbocyclyl, hetcrocyclyl, alkylsulfonyl, and alkylsulfonylamino, wherein:
the carbocyclyl and heterocyclyl optionally arc substituted with one or two substituents independently selected from the group consisting of halo, alkyl, and oxo; each RJ is independently selected from the group consisting of carbocyclylsulfonylamino, beterocyclylsulfonylamino, alkylcarbonytamino, alkenylcarbonylamino, alkynylcarbonyiamino, alkyloxycarbonylamino, alkenyloxycarbonylamino, alkynyloxycarbonylamino, alkylsulfonylamino, alkenylsulfonylamino, alkynylsulfonylamino, aminocarbonylamino, alkyloxycarbonylaminoimino, alkylsuifonylaminoimino, alkenylsulfonylaminoimino, and alkynylsulfonylaminoimino, wherein:
(a) the amino portion of such substituent; optionally is substituted with a substituent independently selected from the group consisting of carbocyclylalkyl, heterocyclylalkyl, alkylcarbonyloxy, aminocarbonylalkyl, alkyl, alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, alkyloxycarbonyl, alkyloxyalkyloxycarbonyl, alkylcarbonyloxyalkyl, and alkylsulfonyl, wherein:
(J) the carbocyclyl portion of the carbocyclylalkyl and the hctcrocyclyl portion of the heterocyclylalkyl optionally are substituted with one or more
substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, carboxy, hydroxy, alkyloxy, alkenyloxy, alkynyloxy, halo, nhro, cyano, azido, oxo, and amino, and
(2) the amino portion of the aminocarbonylalkyl optionally is substiluted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl,
(b) the alkyl, alkenyl, and alkynyl portion of such subsituents optionally is
substituted with one or more substituents independently selected from the group consisting of
carboxy, halo, oxo, amino, alkyloxycarbonyl, alkylcarbonyloxy, hydroxy, alkyloxy,
carbocyclyl, heterocyclyl, and cyano, wherein;
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, and alkynyloxy, wherein:
the alkyl optionally is substituted with one or more hydroxy;
(c) the carbocyclyl and heterocyclyl portions of such substituents optionally are
substituted with one or more substituents independently selected from the group consisting of
alkyl, alkenyl. alkynyl. carboxy, hydroxy, alkyloxy, alkenyloxy, alkynyloxy, halo, nitro,
cyano, azido, and amino, wherein:
the amino optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl; and each RK is independently selected from the group consisting of aminosulfonyl, alkylsulfonyl, alkenylsulfonyl, and alkynylsulfonyl, wherein:
(a) the alkylsulfonyl, alkenylsulfonyl, and alkynylsulfonyl optionally arc substituted
with one or more substituents independently selected from the group consisting of carboxy,
hydroxy, halo, amino, nitro, azido, oxo, aminosulfonyl, alkyloxycarbonyl,
alkenyloxycarbonyl, alkynyloxycarbonyl, alkylcarbonyloxy, alkenylcarbonyloxy,
alkynylcarbonyloxy, alkyloxy, alkenyloxy, alkynyloxy, carbocyclyl, heterocydyl, cyano, and
aminocarbonyl, wherein:
the amino, aminosulfonyl, and aminocarbonyl optionally arc substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl; and
(b) the aminosulfonyl optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, alkenyl, and alkynyl.
2. The compound or salt of claim 1, wherein the compound corresponds in structure to formula. 1-2:
(Formula Removed)
3. The compound or salt of claim 1, wherein the compound corresponds in structure to
formula 1-6:
(Formula Removed)
4. The compound or salt of claim 1, wherein the compound corresponds in structure to formula I-10:(Formula Removed)
5. The compound or salt of claim 1. wherein the compound corresponds in structure to formula 1-11:
(Formula Removed)
6. The compound or salt of any one of claims 1-5, wherein === is a single carbon-carbon bond.
7. The compound or salt of any one of claims 1-5, wherein === is a double carbon-carbon bond.
it. The compound or salt of any one of claims 1-7, wherein R1 is selected from the group consisting of hydrogen and methyl.
9. The compound or salt of any one of claims 1-8, wherein RZ is selected from the group
consisting of hydrogen, methyl, hydroxy, and halo.
10. The compound or salt of any one of claims 1-9, wherein R3 is selected from the group consisting of hydrogen, halo, and oxo.
11. The compound or salt of any one of claims 1-3, wherein R5 is selected from the group consisting of halo, alkyl, and alkyloxy.
12. The compound or salt of any one of claims 1-3, wherein R5 is tert-bulyl.
13. The compound or salt of any one of claims 1-3, wherein R5 is selected from the group consisting of C1-C4-alkyl and 5-6-membered heterocyclyl, wherein:
(a) the C1-C4-alkyl optionally is substitutcd with one or more independently selected
halo substituents; and
(b) the 5-6-membered heterocyclyl optionally is substituted with one or more
independently selected C1-C4-alkyl substituents.
14. The compound or salt of any one of claims 1-3, wherein R5 is selected from the group consisting of tert-butyl, trifluoromethyl, and 5-6-membered heterocyelyl optionally substituted with methyl.
15. The compound or salt of any one of claims 1 and 2, wherein R6 is selected from the group consisting of hydrogen, hydroxy, atkenyl, alkyl, alkyloxy, amino, and halo.
16. The compound or salt of any one of claims 1 and 2, wherein R6 is selected from the group consisdng of methyl, elhenyl, ethyl, hydroxy, methoxy, amino, and iodo.
17. The compound or salt of any one of claims 1-5, wherein B7 is hydrogen or C5-C6-carbocyclyl substituted with a substitucnt selected from the group consisting of RE, RF, RG, RH, RI, RJ, and RK.
18. The compound or salt of any one of claims 1-5, wherein R7 is 5-6-membered heterocyclyl substituted with a substituent selected from the group consisting of RF and RJ.
19. The compound or salt of any one of ckims 1-5, wherein RF is alkylsuifonylamino.
20. The compound or salt of claim I, wherein the compound is selected from the group consisting of
(Formula Removed)