COMPLETE DESCRIPTION
FIELD OF THE INVENTION
The present invention is related to a ayurvedic formulation used for the treatment of gout. The various herbs used in the formulation shows the synergistic effect in the treatment of gout.
BACKGROUND OF THE INVENTION
Application No.: 152/DEL/2007 in Indian Patent Office provides for a novel, Unani composition comprising Majeeth, Saleekha, Kaifal, Charela, Sad Kufi, Waj-e-Turki, Qaranful, Narkachoor, Raughan-e-Kunjad, Raughan-e-Sarashf and Aab-e-Aahak. The peesent invention also provides for a process of preparation of the same. The synergistic composition is used for the treatment of rheumatoid arthritis, sciatica, gout and related ailments.
Application No.: 2464/MUM/2007 in Indian Patent Office discloses novel synergistic pharmaceutical composition comprising Colchicine in combination with NSAIDs selected from the group comprising Etodolac, aceclofenac, Indomethacin, Nabumetone, Etoricoxib, Celecoxib, Diclofenac, Piroxicam along with pharmaceutical excipients/ carriers useful in treating acute and chronic painful conditions, including gout and osteoarthritis.
Application No.: 2919/KOLNP/2009 in Indian Patent Office relates to methods of preventing gout flares in a subject in need thereof by administering to the subject a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting
compound or salt thereof and at least one non-steroidal antiinflammatory drug for a period of six months on a regular basis.
US 6352728 patent relates to biologically active extracts of celery seed are produced by controlled ethanolic extraction, distillation and drying, and further processing by supercritical fluid extractions (SFE), and may be further fractionated by column fractionation, distillation, LiAIH reduction and the like. These extracts possess activity for the treatment and prevention of acute and chronic pain, inflammation and gastrointestinal irritation.
OBJECTIVES OF THE PRESENT INVENTION
The object of the present invention is to provide the formulation which is used for the effective management of gout and related symptoms.
Yet another object of the present invention is to manage the gout without side effects.
SUMMARY OF THE INVENTION
The present invention directs towards the ayurvedic composition comprising Boswellia serrata extract, Curcuma longa, Zingiber officinale, Celery seed extract, Piperine (Piper sp. Extract ) and Colchicum luteum. The composition is used for the management of gout and related symptoms.
DETAILED DESCRIPTION OF THE INVENTION
Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard
lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).
Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of painful arthritis (gout attack), kidney stones, and blockage of the kidney-filtering tubules with uric acid crystals, leading to kidney failure. On the other hand, some people may only develop elevated blood uric acid levels (hyperuricemia) without having manifestations of gout, such as arthritis or kidney problems. The state of elevated levels of uric acid in the blood without symptoms is referred to as asymptomatic hyperuricemia. Asymptomatic hyperuricemia is considered a precursor state to the development of gout. The term gout refers the disease that is caused by an overload of uric acid in the body, resulting in painful arthritic attacks and deposits of lumps of uric acid crystals in body tissues.
Gouty arthritis is typically an extremely painful attack with a rapid onset of joint inflammation. The joint inflammation is precipitated by deposits of uric acid crystals in the joint fluid (synovial fluid) and joint lining (synovial lining). Intense joint inflammation occurs as the immune system reacts, causing white blood cells to engulf the uric acid crystals and chemical messengers of inflammation to be released, leading to pain, heat, and redness of the joint tissues. As gout progresses, the attacks of gouty arthritis typically occur more frequently and often in additional joints.
Boswellia resin has anti-inflammatory and analgesic properties. The active constituents, boswellic acids, reduce the formation of
inflammatory leukotrienes, which is a principle characteristic of gout. Improvement in the symptoms of rheumatoid arthritis (RA) was observed in open trials for both boswellic acid and Boswellia. For gout, boswellia works well in combination with celery seed and ginger;
Curcuminoids inhibit enzymes which participate in the synthesis of inflammatory substances in the body. The natural antiinflammatory activity of curcuminoids is comparable in strength to steroidal drugs, and such nonsteroidal drugs as indomethacin and phenylbutazone, which have dangerous side effects.
Arthritis is caused by continuous inflammation, which is a result from a complex series of actions and/or reactions triggered by the body's immunological response to tissue damage. Moderate inflammation is necessary for the healing process; however, continuous inflammation leads to chronic conditions like arthritis and its associated pain. In a double-blind, controlled study, three groups of patients received either curcumin (400 mg), the antiinflammatory prescription drug phenylbutazone (100 mg), or a placebo (250 mg of lactose powder) three times daily for five consecutive days after surgery. They had been admitted for either a hernia condition or an accumulation of fluid in the scrotum. The results: curcumin was just as effective as phenylbutazone in reducing post-operative inflammation.
Curcuminoids prevent the synthesis of several inflammatory prostaglandins and leukotrienes. When the anti-inflammatory properties of curcumin were tested in a double-blind clinical trial in patients with rheumatoid arthritis, curcumin produced significant improvement in all patients, and again the therapeutic effects were comparable to those obtained with phenylbutazone.
Ginger is described in Ayurvedic and Tibetan systems of medicine to be useful in inflammation and rheumatism. It is suggested that
at least one of the mechanisms by which ginger shows its ameliorative effects could be related to inhibition of prostaglandin and leukotriene biosynthesis, i.e. it works as a dual inhibitor of eicosanoid biosynthesis.
Celery seed h as been used traditionally for the clearance of acidic metabolites via the kidneys, and traditional sources recommend its use for rheumatism, arthritis and gout. This herb has also demonstrateed anti-inflammatory activity against chronic inflammation during an Australian open, pre-clinical trial of 12-weeks duration. People prone to gout may reduce the frequency and severity of their episodes by using celery Seed as a preventative measure. Celery seed should be used under the guidance of a physician if there is underlying kidney disease.
Piperine is known to be of value in diseases where inflammation is involved like rheumatoid arthritis and osteoarthritis. This also makes it a good pain reliever.
Colchicum luteum is effective in sciatica, rheumatoid arthritis and rheumatic pains. It also relieves coxalgia and articular pains by excretion of uric acid.
The present composition comprises Bosweiiia serrata extract in the range lOOmg to 200 mg, more preferably 150 mg, Zingiber officinale extract in the range 50mg to 100 mg, more preferably 75 mg, Curcuma longa extract in the range lOOmg to 180 mg, more preferably 120 mg, Celery seed extract in the range 25 mg to 75 mg, more preferably 50 mg, Piperine (Piper sp. extract) in the range 5 mg to 20 mg, more preferably 10 mg, and Colchicum luteum extract in the range 50mg to 100 mg, more preferably 65 mg.
The ingredients of the present invention are taken in the required quantity and mixed well. The mixture so obtained is administered through a solid oral dosage formulation preferably a capsule.

1) The ayurvedic formulation comprising Boswellia serrata extract, Curcuma longa, Zingiber officinale, Celery seed extract, Piperine extract and Colchicum luteum for the management of gout and related symptoms.
2) Boswellia serrata extract as claimed in 1 is in the range lOOmg to 200 mg, more preferably 150 mg.
3) Zingiber officinale extract as claimed in 1 is in the range 50mg to 100 mg, more preferably 75 mg.
4) Curcuma longa extract as claimed in 1 is in the range lOOmg to 180 mg, more preferably 120 mg.
5) Celery seed extract as claimed in 1 is in the range 25 mg to 75 mg, more preferably 50 mg.
6) Piper species extract as claimed in 1 is in the range 5 mg to 20 mg, more preferably 10 mg.
7) Colchicum luteum extract as claimed in 1 is in the range 50mg to 100 mg, more preferably 65 mg.
8) The composition as claimed in claim 1 is administered as oral formulation, more preferably capsule.