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Bacterial Capsular Polysaccharide Yield Enhancement By Addition Of Defoaming Agents
Abstract: The instant invention provides significant improvement in bacterial capsular polysaccharide yield at fermentation harvest stage, particularly Neisseria meningitidis capsular polysaccharides by gradual addition of an antifoam agent alongwith an optimal feed solution from log phase onwards. Specifically, antifoam increases optical density of the culture thereby resulting in higher capsular polysaccharide yield of about 2 to 2.5 gm/L at fermentation harvest stage wherein polysaccharide obtained has optimal average molecular weight of about 800KDa to about 1200KDa and has minimum load of contaminants like proteins and nucleic acid. The antifoam agent of the present invention was found to be bifunctional such that it increased the polysaccharide productivity as well as resulted in effective defoaming thereby making said fermentation process suitable for further scale-up.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
02 June 2014
Publication Number
49/2015
Publication Type
INA
Invention Field
MICRO BIOLOGY
Status
Email
archana@anandandanand.com
Parent Application
Patent Number
Legal Status
Grant Date
2022-04-22
Renewal Date
Applicants
SERUM INSTITUTE OF INDIA LTD.
SERUM INSTITUTE OF INDIA LTD., 212/2, Off Soli Poonawalla Road, Hadapsar, Pune 411 028, Maharashtra, India
Inventors
1. PEDDIREDDY SRINIVAS REDDY
SERUM INSTITUTE OF INDIA LTD., 212/2, Off Soli Poonawalla Road, Hadapsar, Pune 411 028, Maharashtra, India
2. SINGH DIGAMBER CHAHAR
SERUM INSTITUTE OF INDIA LTD., 212/2, Off Soli Poonawalla Road, Hadapsar, Pune 411 028, Maharashtra, India
3. PISAL SAMBHAJI SHANKAR
SERUM INSTITUTE OF INDIA LTD., 212/2, Off Soli Poonawalla Road, Hadapsar, Pune 411 028, Maharashtra, India
4. DHERE RAJEEV MHALASAKANT
SERUM INSTITUTE OF INDIA LTD., 212/2, Off Soli Poonawalla Road, Hadapsar, Pune 411 028, Maharashtra, India
Specification
DESC:ATTACHED ,CLAIMS:ATTACHED
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1821-MUM-2014-FORM-27 [27-09-2024(online)].pdf | 2024-09-27 |
| 1 | REQUEST FOR CERTIFIED COPY [03-08-2015(online)].pdf | 2015-08-03 |
| 2 | 1821-MUM-2014-ORIGINAL UR 6(1A) AFFIDAVIT-300922.pdf | 2022-10-04 |
| 2 | Other Document [05-01-2016(online)].pdf | 2016-01-05 |
| 3 | Form 13 [05-01-2016(online)].pdf | 2016-01-05 |
| 3 | 1821-MUM-2014-IntimationOfGrant22-04-2022.pdf | 2022-04-22 |
| 4 | 1821-MUM-2014-PatentCertificate22-04-2022.pdf | 2022-04-22 |
| 4 | 1821-MUM-2014-OTHERS-(18-04-2016).pdf | 2016-04-18 |
| 5 | 1821-MUM-2014-GENERAL POWER OF ATTORNEY-(18-04-2016).pdf | 2016-04-18 |
| 5 | 1821-MUM-2014-CORRECTED PAGES [18-04-2022(online)].pdf | 2022-04-18 |
| 6 | 1821-MUM-2014-MARKED COPY [18-04-2022(online)].pdf | 2022-04-18 |
| 6 | 1821-MUM-2014-FORM 2(TITLE PAGE)-(18-04-2016).pdf | 2016-04-18 |
| 7 | 1821-MUM-2014-Written submissions and relevant documents [18-04-2022(online)].pdf | 2022-04-18 |
| 7 | 1821-MUM-2014-FORM 1-(18-04-2016).pdf | 2016-04-18 |
| 8 | 1821-MUM-2014-FORM 3 [31-03-2022(online)].pdf | 2022-03-31 |
| 8 | 1821-MUM-2014-CORRESPONDENCE-(18-04-2016).pdf | 2016-04-18 |
| 9 | 1821-MUM-2014-Correspondence to notify the Controller [30-03-2022(online)].pdf | 2022-03-30 |
| 9 | 1821-MUM-2014-FORM 18 [23-05-2018(online)].pdf | 2018-05-23 |
| 10 | 1821-MUM-2014-US(14)-HearingNotice-(HearingDate-04-04-2022).pdf | 2022-03-08 |
| 10 | SERUM INSTITUTE OF INDIA_20110531182226.pdf | 2018-08-11 |
| 11 | 1821-MUM-2014-FER.pdf | 2021-10-03 |
| 11 | FORM-3.pdf | 2018-08-11 |
| 12 | 1821-MUM-2014-CLAIMS [15-07-2021(online)].pdf | 2021-07-15 |
| 12 | Form-2(Online).pdf | 2018-08-11 |
| 13 | 1821-MUM-2014-COMPLETE SPECIFICATION [15-07-2021(online)].pdf | 2021-07-15 |
| 13 | 1821-MUM-2014-FORM 5(24-9-2014).pdf | 2018-08-11 |
| 14 | 1821-MUM-2014-FER_SER_REPLY [15-07-2021(online)].pdf | 2021-07-15 |
| 14 | 1821-MUM-2014-Form 3-090715.pdf | 2018-08-11 |
| 15 | 1821-MUM-2014-FORM 1(24-9-2014).pdf | 2018-08-11 |
| 15 | 1821-MUM-2014-FORM 3 [15-07-2021(online)].pdf | 2021-07-15 |
| 16 | 1821-MUM-2014-Correspondence-090715.pdf | 2018-08-11 |
| 16 | 1821-MUM-2014-FORM 3 [31-03-2021(online)].pdf | 2021-03-31 |
| 17 | 1821-MUM-2014-Information under section 8(2) [31-03-2021(online)].pdf | 2021-03-31 |
| 17 | 1821-MUM-2014-CORRESPONDENCE(24-9-2014).pdf | 2018-08-11 |
| 18 | 15509-52-SPECIFICATION.pdf | 2018-08-11 |
| 18 | 1821-MUM-2014-FORM 3 [24-04-2019(online)].pdf | 2019-04-24 |
| 19 | 15509-52-COMP SPEC.pdf | 2018-08-11 |
| 19 | 15509-52-COMP SPEC.pdf_1987.pdf | 2018-08-11 |
| 20 | 15509-52-COMP SPEC.pdf | 2018-08-11 |
| 20 | 15509-52-COMP SPEC.pdf_1987.pdf | 2018-08-11 |
| 21 | 15509-52-SPECIFICATION.pdf | 2018-08-11 |
| 21 | 1821-MUM-2014-FORM 3 [24-04-2019(online)].pdf | 2019-04-24 |
| 22 | 1821-MUM-2014-CORRESPONDENCE(24-9-2014).pdf | 2018-08-11 |
| 22 | 1821-MUM-2014-Information under section 8(2) [31-03-2021(online)].pdf | 2021-03-31 |
| 23 | 1821-MUM-2014-Correspondence-090715.pdf | 2018-08-11 |
| 23 | 1821-MUM-2014-FORM 3 [31-03-2021(online)].pdf | 2021-03-31 |
| 24 | 1821-MUM-2014-FORM 3 [15-07-2021(online)].pdf | 2021-07-15 |
| 24 | 1821-MUM-2014-FORM 1(24-9-2014).pdf | 2018-08-11 |
| 25 | 1821-MUM-2014-FER_SER_REPLY [15-07-2021(online)].pdf | 2021-07-15 |
| 25 | 1821-MUM-2014-Form 3-090715.pdf | 2018-08-11 |
| 26 | 1821-MUM-2014-COMPLETE SPECIFICATION [15-07-2021(online)].pdf | 2021-07-15 |
| 26 | 1821-MUM-2014-FORM 5(24-9-2014).pdf | 2018-08-11 |
| 27 | 1821-MUM-2014-CLAIMS [15-07-2021(online)].pdf | 2021-07-15 |
| 27 | Form-2(Online).pdf | 2018-08-11 |
| 28 | 1821-MUM-2014-FER.pdf | 2021-10-03 |
| 28 | FORM-3.pdf | 2018-08-11 |
| 29 | 1821-MUM-2014-US(14)-HearingNotice-(HearingDate-04-04-2022).pdf | 2022-03-08 |
| 29 | SERUM INSTITUTE OF INDIA_20110531182226.pdf | 2018-08-11 |
| 30 | 1821-MUM-2014-Correspondence to notify the Controller [30-03-2022(online)].pdf | 2022-03-30 |
| 30 | 1821-MUM-2014-FORM 18 [23-05-2018(online)].pdf | 2018-05-23 |
| 31 | 1821-MUM-2014-FORM 3 [31-03-2022(online)].pdf | 2022-03-31 |
| 31 | 1821-MUM-2014-CORRESPONDENCE-(18-04-2016).pdf | 2016-04-18 |
| 32 | 1821-MUM-2014-Written submissions and relevant documents [18-04-2022(online)].pdf | 2022-04-18 |
| 32 | 1821-MUM-2014-FORM 1-(18-04-2016).pdf | 2016-04-18 |
| 33 | 1821-MUM-2014-MARKED COPY [18-04-2022(online)].pdf | 2022-04-18 |
| 33 | 1821-MUM-2014-FORM 2(TITLE PAGE)-(18-04-2016).pdf | 2016-04-18 |
| 34 | 1821-MUM-2014-GENERAL POWER OF ATTORNEY-(18-04-2016).pdf | 2016-04-18 |
| 34 | 1821-MUM-2014-CORRECTED PAGES [18-04-2022(online)].pdf | 2022-04-18 |
| 35 | 1821-MUM-2014-PatentCertificate22-04-2022.pdf | 2022-04-22 |
| 35 | 1821-MUM-2014-OTHERS-(18-04-2016).pdf | 2016-04-18 |
| 36 | Form 13 [05-01-2016(online)].pdf | 2016-01-05 |
| 36 | 1821-MUM-2014-IntimationOfGrant22-04-2022.pdf | 2022-04-22 |
| 37 | 1821-MUM-2014-ORIGINAL UR 6(1A) AFFIDAVIT-300922.pdf | 2022-10-04 |
| 37 | Other Document [05-01-2016(online)].pdf | 2016-01-05 |
| 38 | 1821-MUM-2014-FORM-27 [27-09-2024(online)].pdf | 2024-09-27 |
| 38 | REQUEST FOR CERTIFIED COPY [03-08-2015(online)].pdf | 2015-08-03 |
Search Strategy
| 1 | 2021-02-1113-48-03E_11-02-2021.pdf |