DESCRIPTION HENCE NOT PASTED

Claims
[Claim 1] Biaryl derivatives of Formula 1, or pharmaceutically acceptable salts or
isomers thereof: [Formula 1]
A and B represent independently phenyl or pyridine, any one of RrD- and R2-E- cannot exist, D and E represent inde¬pendently carbon, nitrogen, oxygen or sulfur, or represent direct bond, and any one of Ri and R2 cannot exist, or Ri and R2 represent inde¬pendently hydrogen, halogen, optionally substituted C,-C6-alkyl, C3-C|0 -cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3~C|0-heterocycloarkyl, C, -Qralkyl-QrCio-cycloalkyl, C[-Cf)-aIkyl-CrCio-rieterocycloalkyl, aryl, CrC6-alkylaryl, heteroaryl orCi-C6-a3kyl-C5-C6-heteroai7l, and when D and E represent nitrogen or carbon, R: and R2 can represent two or three optionally substituted C,-C6-alkyl, C3-C|0-cycloalkyl, C2-C6 -alkenyl, C2-C6~alkynyl, CrC6-aUcyl-C3-Ci(rcycloalkyl, aryl or C,-C6 -alkylaryl which may be the same or different,
G represents -J-(CR5R6)P, wherein J represents oxygen or sulfur, R5 and
Rf, represent independently hydrogen, halogen, optionally substituted
alkyl or cycloalkyl, hydroxyl or amine, and R5 and R6 which are sub¬
stituted at the same or different carbon may be connected to form op¬
tionally substituted cycloalkyl or cycloheteroalkyl,
R3 and R4 cannot independently exist depending on the number of m or
n, or represent independently hydrogen, halogen or optionally sub¬
stituted Ci-C6-alkyl or Ci-C6-alkoxy,
R7 represents hydrogen, alkyl or cycloalkyl,
m and n represent independently an integer of 0 to 5, and
p represents an integer of 1 to 6.
[Claim 2] The biaryl derivatives, or pharmaceutically acceptable salts or isomers
thereof according to Claim 1, selected from the following compounds: 4-[4-(6-phenoxy-2-pyridyl)phenoxy]bulyric acid;

4-[2,6-difluoro-4~(6-isopropylsulfanyl-2-pyridyI)phenoxy]bulyric acid; 4-[2,6-difluoro-4-(6-phenoxy-2-pyridyl)phenoxy]butyric acid; 4-[2-chloro-4-(6-isopropylsuIfanyl-2-pyridyl)phenoxy]butyric acid; 4-[2-fluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenoxy]butyric acid; 4-[4-(6-cyclopentylsulfanyl-2-pyridyl)-2,6-difluoro-phenoxy]butyric acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2-melhoxy-phenoxy]-butyric acid;
4-[2,6-difluoro-4-(2-isopropylsulfanyl-4-pyridyl)phenoxy]butyric acid; 4-[4-[6-(cycIopentoxy)-2-pyridylJ-2,6-difluoro-phenoxyjbutyric acid; 4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-dimethyl-phenoxy]-butyri c acid;
4-[4-[3-(cyclopentoxy)phenyl]-2,6-difluoro-phcnoxy]bulyric acid; 4-[2,6-difluoro-4-(6-pyrrolidin-l-yl-2-pyridyI)phenoxy]butyric acid; 4-[4-(2-5,(?c-butylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyric acid;
4-[4-[3-(cyclopentoxy)phenyl]-2,3-difluoro-phenoxy]butyric acid; 4-[2,6-difluoro-4-[6-(l-piperidyl)-2-pyridyl]phenoxy]butyric acid; 4-[4-(6-anilino-2-pyridyl)-2,6-difluoro-phenoxy]butyric acid; 4-[2,6-difluoro-4-[6-(N-methylanilino)-2-pyndyl]phenoxy]butyric acid; 4-[4-[6-(cyclopentylamino)-2-pyridy]j-2,6-difluoro-phenoxy]bulyric acid;
4-[4-r6-(cyclopropylmethylsulfanyl)-2-pyridyl]-2,6-difluoro-phcnoxy]b utyric acid;
4-[4-(6-cyclobutylsulfanyl-2-pyridyl)-2,6-difluoro-phenoxy]butyric acid;
4-[2,6-difluoro-4-(6-propylsulfanyl-2-pyridyl)phenoxy]bulyric acid; 4-[2,6-difluoro-4-(6-isopropoxy-2-pyridyl)phenoxy]butyric acid; 4-[2,6-difluoro-4-(6-prapoxy-2-pyridyl)phenoxy]butyric acid; 4-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-phenoxy]butyric acid;
4-[4-[6-(cyclobutoxy)-2~pyridyl]-2,6-difluoro-phenoxy]butyric acid; 4-[4-[6-(cyclobutoxy)-2-pyridyl]-2-methyl-phenoxy]butyric acid; 4~[4-[6-(cyclobutoxy)-2-pyridyl]-2-(trifluoromcthyl)phenoxy]butyric acid;
4-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]pentanoic acid; 4-[4-[6-(cyclobutoxy)-2-pyridyl]-2,6-difluoro-phenoxy]pentanoic acid;

4-[[5-(2-cycIobutylsulfanyl-3-pyridyl)-2-pyridyl]oxy]pentanoic acid; 4- {2,6-difluoro-4-[2-(3-methy l-butylsulfanyl)-pyridin-3-y 1] -phenoxy} -butyric acid;
4- {2,6-difluoro-4-[2-(2-fluoro-ethoxy )-pyridin-3-y l]-phenoxy} -butyric acid;
2-[l-[[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]methyl ] cyclopropyl] acetic acid;
2-[l-[[4-[3-(cyclobutoxy)phenyl]-2,6-difluoro-phenoxy]methyl]cyclopr opyl] acetic acid;
4-[[6-[3-(cyclobutoxy)phenyl]-3-pyridyl]oxy]butyric acid; 4-[[6~[3-(cyclopentoxy)phenyl]-3-pyridyl]oxy]butyric acid; 4-(2'-phenoxy-biphenyl-4-yloxy)-butyric acid; 4-[4-(2-isopropylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid; 4-(3,5-difluoro-2'-phenoxy-biphenyl-4-yloxy)-butyric acid; 4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid; 4-[2,6-difLuoro-4-(2-isopropylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid;
4-[2,6-difluoro-4-(2-phenoxy-pyridin-3-yl)-phenoxy]-butyric acid; 4-[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenoxy]-butyric acid; 4-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluora-phenoxy]-butyric acid;
4-[4-(2-cyclopentylsulfanyI-pyridin-3-yl)-2,6"diiluoro-phenoxyj-butyri c acid;
4-[4-(2-cyclopropylmcthoxy-pyridin-3-yl)-2,6-difluoro-phcnoxy]-butyr ic acid;
4-[4-(2~cyclopropylmethylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy] -butyric acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid; 4-[4~(2-cyclopropylmethylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyric acid;
4-[4~(2-propylsulfanyl-pyridin-3-yl)-phenoxy]-butyric acid; 4-(3,5-difluoro-2'"isopropoxy-biphenyl-4-yloxy)-butyric acid; 4-(2'-cyclobutoxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid; 4-(2'-cyclopropylmethoxy-3,5-difiuoro-biphcnyl'4-yloxy)-butyric acid; 4-(2'-cyclopentyloxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid; 4-(2'-cyclopentyloxy-biphenyl-4-yloxy)-butyric acid;

4-(2'-isopropoxy-biphenyl-4-yloxy)~-butyric acid;
4-(2'-cyclopropylmethoxy-biphenyl-4-yloxy)-butyric acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phcnoxy]-2-meth
yl-butyric acid;
2-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6~difluoro-phenoxymethyl3-
cyclopropanecai'boxylic acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,5-difluoro-phenoxy]-butyric
acid;
4-[4-(6-cyclobutylsLilfanyl-pyridin-2-yl)-2)5-difluoro-phenoxy]-butyric
acid;
4-[4-(2-r^rr-butylsuli:anyl-pyridin~3-yl)-2,6-difluoro-phenoxy]-butyric
acid;
6"[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)phcnoxy]hexanoic acid;
4-{2,6-difluoro-4-[6-(2-methyl-propenyl)-pyridin-2-yl]-phenoxy}-buty
ric acid;
4-[2,6-difluoro-4-(6-isobutyl-pyridin-2-yl)-phenoxy]-butyric acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-3,5-difluoro-phenoxy]-butyric
acid;
4-{2,6-difluoro-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-yI]-phenoxy
}-butyric acid;
4-{2,6-difiuoro-4-[2-(tetrahydro-iuran-3-yIoxy)-pyridin-3-yIJ-phenoxy
}-butyric acid;
4-[4-(2-cyclobutoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-bulyric acid;
4-{2,6-difluoro-4-[2-(2-mctrioxy-etrioxy)-pyndiii-3-yi]-phenoxy}-bulyr
ic acid;
4-[2,6-difluoro-4-(2-pyrrolidin-l-yl-3-pyridyl)phenoxy3butanoic acid;
4-[4-[2-(cyclopentylamino)-3-pyridyl]-2,6-difluoro-phenoxyjbutanoic
acid;
4-[4-[2-(cyclopropylm.ethylamino)-3-pyridyl]-2,6-difluoro-phenoxyjbut
aiioic acid;
4-[4-[6-(cyclopropylmethyiamino)-2-pyndyl]-2,6-diiluoro-phenoxy]but
anoic acid;
4-[2,6-difluoro-4-[2-(isopropylamino)-3-pyridyl]phenoxy]butanoic
acid;
4-[4-[2-(cyclopropylamino)-3-pyridyl]-2,6-difluoro-phciioxy]butanoic
acid;
4-[2,6-difluoro-4-[6-(isopropylamino)-2-pyridyl]phenoxy]butanoic
acid;

4-[4-[2-(cyclopentylamino)phenyl]-2,6-difluoro-phenoxy]butanoic acid;
4-[4-[3-(cyclopentylamino)phenyl]-2,6-difIuoro-phenoxy]butanoic acid;
4-[2)6-difluoro-4-[2-(propyiamino)phenyl3phenoxy]butanoic acid; 4-[4-[2-(cyclopropylmethylamino)phenyl]-2,6-difluoro-phenoxy]butan oic acid;
4-[2,6-difluoro-4-[2-(isopropylamino)phenyl]phenoxy]butanoic acid; 4~[4-[2-(cyclopenlylamino)phenyl3phenoxy]butanoicacid; 4-[4-[2-(cyclopropylmethylamino)phenylJphenoxyjbutanoic acid; 4-[4-[2"(propylamino)phenyl]phenoxy]butanoic acid; 4-[4-[2-(isopropylamino)phenyl3phenoxy]butanoic acid;
4-[4-[2-(cyclobutylainino)phenyl]phenoxy]butanoic acid; 4-[4-[2-(cyclobutylamino)phenyl]-2,6-difluoro-phenoxy]butanoic acid; 4-[4-[3~(cyclopropylmethylamino)phenyl3-2,6-difiuoro-phenoxy]butan oic acid;
4-[2,6-difluoro-4-[3-(isopropylamino)phenyl]phenoxy]butanoic acid; 4-[2,6-difluoro-4-(3-pyiTolidin-l-ylphenyl)phenoxy]butanoic acid; 4-[4-[3-(cyclobutylamino)phenyl]-2,6-difiuoro-phenoxy]butanoic acid; 4-[2,6-difluoro-4-[3-(propylamino)phenyl]phenoxy]butanoic acid; 4-[4-[5-chloro-2-(cyclopentylamino)phenyl]-2,6-diiluo]-o-phenoxy]buta noic acid;
4-[4-[2-(cyclopentylamino)-5-fluoro-phenyl]-2,6-difluoro-phenoxylbut anoic acid;
4-[4-(3-cyclopentylphenyl)-2,6-difiuoro-phenoxy]butanoic acid; 4-[4-[3-(cyclopentylmethyl)phenyl3-2,6-difluoro-phenoxy]butanoic acid;
4-[4-[2-(cyclopentylmethyl)pbenyl]-2,6-difluoro-phenoxy]butanoic acid;
4-[4-[6-(cyclopentylmethyl)-2-pyridyI]-2,6-difluoro-phenoxy]butanoic acid;
4-[4-[2-(cyclobutylmethyl)pheiiyl3-2,6-difluoro-phenoxyjbutaiioic acid: 4-[4-[3-(cyclobutylmethyl)phenyl]-2,6-difluoro-phenoxy]bulanoic acid; 4-[446-(cyclobutylmcthyl)-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid;
4-[4-(2-cyclopentylphenyl)-2,6-difluoro-phenoxy]butanoic acid; 4-[4-(6-cyclopentyl-2-pyridyl)-2,6-difluoro-phenoxy]bulanoic acid; 4-[2)6-difluoro-4-(2-isobutyl-3-pyridyl)phenoxy]butanoic acid;

4-[4-(2-cyclopentyl-3-pyridyl)-2,6-difluoro~phenoxy]butanoic acid; 4-[4-r2-(cyclopentylmethyl)-3-pyridyl]-2,6-difluoro-phenoxy]butanoic acid;
4-[2,6-difluoro-4-(2-pyrrol-l-yl-3-pyridyl)phenoxy]butanoic acid; 4-[2,6~difluoro-4-[2-(4-methylpyrazol-l-yl)-3-pyridyl]phenoxy]butanoi c acid;
4-[2,6-difluoro-4-(2-morpholino-3-pyridyl)phenoxy]butanoic acid; 4-[2,6-difluoro-4-[2-(tetrahydropyran-4-ylmethylamino)-3-pyridyl]phe noxy] butanoic acid;
4-[2,6-difluoro-4-[2-(l-piperidyl)-3-pyridyI]phenoxy]butanoic acid; (4S)-4-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]penta noic acid;
(4R)-4-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phcnoxy]penia noic acid;
(4R)-4-[4-[3-(cyclobutoxy)phenyl]-2,6-difluoro-phenoxy]pentanoic acid;
(4R)-4-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]pent anoic acid;
(4R)-4-[2,6-ditluoro-4-(3-phenoxyphenyl)phenoxy]pentanoic acid; 4-(3'~cydobutoxy-biphenyl-4-ylsulfanyl)-butyric acid; 4~t3'-isopropoxy-biphenyl-4-ylsuiranyl)-butyric acid; [i-(3,5-difluoro-3'-isopropoxy-biphenyi-4-y]sulfanylmcthyi)-cycloprop yl]-acetic acid;
4-(3'-cyclopcntyloxy-3,5-difluoro-biphcnyl-4-ylsulfanyl)-butyric acid; 4-[4-(2-cyclopentyloxy-pyridin~3-yl)-phenylsulfanyl]-butyric acid; 4-[4-(2-cyclopropylmethoxy-pyridin-3-y l)-phenylsulfany 1]-butyric acid;
4-(3'-phenoxy-biphenyl-4-ylsuIfanyl)-butyric acid; 4-(3'-cyclopentyloxy-biphenyl-4-ylsulfanyl)-butyric acid; 4-(3'-propoxy-biphenyl-4-ylsulfanyl)-butyric acid; 4-[4-(6-cyclobutoxy-pyridin-2-yl)-phenylsulfanylJ-butyric acid; 4-[4-(6-cyclopentyloxy-pyridin-2-yl)-phenylsulfanyl]-butyric acid; 4-[4-(6-isopropoxy-pyridin-2-yl)-phenylsulfanyl]-butyric acid; 4-[4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyl]-butyric acid; 4-[4-(6-propoxy-pyridin-2-yl)-phenylsulfanyl]-butyric acid; 4-[4-(6-cyclopentylsuIfanyl-pyridin-2-yl)-phenylsulfanyl]-butyric acid; 4-(3'-cyclobutoxy-3,5-difluoro-biphenyl-4-ylsulfanyl)-butyric acid; 4-(3,5-difluoro-3l-isopropoxy-biphenyl-4-ylsulfanyl)-butyric acid;

4-[2,6-difluoro-4-(6-propoxy-pyridin-2-yl)-phenylsulfanyl]-butyric acid;
4-[2,6-difluoro-4-(6-isopropoxy-pyridin-2-yl)-phenyIsLilfanyl]-butyric acid;
4-[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyi]-butyric acid;
4-[2,6-difluoro-4-(2-propoxy-pyridin-3-yl)~phenylsulfany]]-butyric acid;
4-[2,6-difluoro-4-(6-isopropylsulfanyi-pyridin-2-yl)-phenyIsulfanyl]-bu
tyric acid;
4-[2,6-difluoro-4-(6-propylsulfanyl-pyridin-2-yl)-phenylsulfanyI]-butyr
ic acid;
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoi-o-pheiiylsulfanyl]-b
utyric acid;
4-[4-(2-cyclobutoxy-pyridin-3-yl)-phenylsulfanyl]-butyric acid;
4-[4-(2-cyclobutoxy-pyridin-3-yl)-2,6-difluoro-phenylsu]fanyl]-but.yric
acid;
4-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenylsulfanylj-buty
ric acid;
4-[2,6-dinuoro-4-(2-isopropylsulfanyl-pyridin-3-yl)-phenylsuIfanyl]-bu
tyric acid;
4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylsuli'anyl]-
butyric acid;
4_[4_(2-isopropylsulfaiiyl-pyridin-3-yl)-phenyIsulfanyl]-butyricacid;
4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenyIsulfanyi]-butyric acid;
4-[2-fluoro-4-(6-isopropoxy-pyridin-2-yl)-phenylsulfanyl]-butyric acid;
4-[4-(2-cyclopentyloxy-pyi'idin-3-yl)-2-fluoro-phenylsulfany3]-butyric
acid;
4-[4-(2-cyclobutylsuIfanyl-pyridin-3-yl)-2-fluoro-phenylsulfanyl]-butyr
ic acid;
4-[4-(2-cyclobutylsulianyl-pyridin-3-yl)-phenylsuiranylj-butyricacid;
4-[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenylsulfanyl]-butyric
acid;
4-[4-(6-cyclopentyloxy-pyridin-2-yl)-2,6-difluoro-phenylsulfanyl]-buty
ric acid;
4-[4-(6-cyclobutylsulfanyl-pyridin-2-yl)-phenylsulfanyl]-butyric acid;
4-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenylsulfanyl]
-butyric acid;

4-[4-(6-cycIobutyIsulf;anyl-pyridin-2-yl)-2,6-difluoro--phenylsulfanyl3-b utyric acid;
4-[4-(6-cyclopcntylsulfanyl-pyridin-2-yl)-2,6-difluoro-phenyIsulfanyl]-butyric acid;
4-(2'-cyclopentylamino-3-fluoro-biphenyl-4-ylsulfanyl)-butyric acid; 4-(2'-cyclopentylamino-3,5-difluoro-biphenyI-4-ylsulfanyl)~butyric acid;
4-[2'-tcyclopropylmethyl-amino)-3,5-difluoro-biphenyl-4-ylsulfanylJ-b utyric acid;
4-[2-fIuoro-4~(2-isopropylsulfanyl-pyridin-3-yl)-phenyIsulfanylj-butyri c acid;
4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2-fluoro-phenylsulfanyl]-but yric acid;
4-(3,5-difluoro-2'-isopropylamino-biphenyl-4~ylsulfanyl)-butyric acid; 4-(3,5-difluoro-2'-propylamino-biphenyl-4-ylsulfanyl)-butyric acid; 4-[4-(2-cyclopropylmethoxy-pyridin~3-yl)-2)6-difluoro-pheiiylsuli'any]] -butyric acid;
4-[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phenylsulfanyl]-butyr ic acid;
4-[4-(6-cyc]obutylsulfanyl-pyridin-2-yl)-2-fluoro-phenylsulfanylj-butyr ic acid;
4-[4-(2-cyclopentylamino-pyridin-3-yl)-2-nuoro-phenylsulfanyI]-bulyri c acid;
4~[2-fluoro-4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyl3-butyric acid; 4-[4-(2-cyclobutoxy-pyridin-3-yl)-2-fluoro-phenylsulfanyl]-butyric acid;
4-[2-fluoro-4-(2-pyrrolidin-l-yl-pyridin-3-yl)-phenylsulfanyl]-butyric acid;
4-[2-fluoro-4-(2-isopropylamino-pyridin-3-yl)-pheiiylsuifanyl]-butyric acid;
4-t2'-cycIopentylamino-3,5'-difluoro-biphenyl-4-ylsulfanyl)-butync acid;
4-(2'-cyclopentylamino-5'-fluoro-biphenyl-4~ylsulfanyl)-butyric acid; 4-(2'-cyclopentyloxy-5'-methyl-biphenyl-4-ylsulfanyl)-butyric acid; 4-(2'-cyclopentyloxy-4'~methoxy-biphenyl-4-ylsulfanyl)-butyric acid; 4-(2'-cyclopentyloxy-5'-fluoro-biphenyl-4-ylsulfanyl)-butyric acid; 4-(2'~cyclopentyloxy-3,5'-difiuoro-biphenyl-4-ylsulfanyl)-butyric acid; 4-[4-(2-cyclopentyloxy-5-methyl-pyridin-3-yi)-phenylsulfanyl]-butyric

acid;
4-(2'-cyclopentyloxy-3,5,5'-trifluoro-biphenyl-4-ylsulfanyl)-butyric
acid;
4-(2'-cyclopentyIoxy-3-fluoro-4'-methoxy-biphenyl-4-ylsulfanyl)-butyr
ic acid;
4-(2'-cyclopentyloxy-3,5-difluoro-4'-methoxy-biphenyl-4-ylsulfanyl)-b
utyric acid;
4~(3-fluoro-2'-isopropoxy-4'-methoxy"biphenyl-4-ylsulfanyl)-butyric
acid;
4-[4-(2-cyclopentyloxy-5-methyl-pyridin-3-yl)-2-fluoro-phenylsulfanyI
]~butyric acid;
4-[2-fluoro-4-(2-isopropoxy-5-methyl-pyridin-3-yl)-phenylsulfanyl]-bu
tyric acid;
4-(3,5,-difluoro-2'-isopropoxy-biphenyl-4-ylsulfanyl)-butyric acid;
4-[4-(2-cyclopentyloxy-6-meihyl-pyridin-3-yl)-2-fluoro-phcnylsulfanyl
]-butyric acid;
4-(3,3'-difluoro-2'-isopropoxy-5'-methyl-bipheiiyl-4-ylsulfanyl)"butyric
acid;
4-(3,3,-difluoro-5r-methyl-2'-propoxy-biphenyl-4-ylsulfanyl)-butyric
acid;
4-(3-fluoro-2',4r-dipropoxy-biphenyl-4-ylsulfanyl)-butyric acid;
4-(6'-cyclopentyloxy-3,2'-difluoro-3'-melhyl-biphenyl-4-ylsuIfanyl)-but
yric acid;
4-(2'-cyclopentyloxy-3,3'-difluoro-biphenyl-4-ylsulfanyl)-butyric acid;
4-(2'-cyclopentyloxy-3,3'-difl.uoro-5'-methyl-biphenyl-4-ylsulfanyl)-but
yric acid;
5-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-pentan
oic acid;
5-[4-(2-cyclopropoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-pentanoic
acid;
4-[4-(2-cycIopentyloxy-5-methyl-pyridin-3-yl)-2,6-diiluoro-phenylsuir
anyl]-butyric acid;
4-[4-(2-cyclopentyloxy-pyridin-3-yl)-phenylsulfanyl]-pentanoic acid;
4-[4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyl]-pentanoic acid;
4-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-penL
anoic acid;
4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-
penlanoic acid;

4-[4-[2"(2-dimethylammoethyloxy)-3~pyridyl]-2,6-ditluoro-phenoxy]b
utanoic acid;
4-[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phenoxy]-butanoic
acid;
4-[4-(2-cyclopropylsulfanyl-pyridin-3-yI)-2,6-difluoro-phenoxy]-butan
oic acid;
4-[4-(2-ethylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy]-butanoic
acid;
4-[4-(2-butylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy]-butanoic
acid;
4-(2'-cyclopentylamino-biphenyl-4-ylsulfanyl)-butyric acid;
4-[4~(2-cyclopentyloxy-5-methyl-pyridin-3-yl)-2,6-difluoro-phenoxyi-
butyric acid;
4-[4-(6-isopropylsulfanyl-2-pyridyl)phenoxy]butanoic acid;
4-[2,6-difluoro-4-(3-phenoxyphenyl)phenoxy3butanoic acid;
4-[4-[6-[3-(dimethylamino)pyiTolidin-l-yl]-2-pyridyl]-2,6-difluoro-phe
noxy]butanoic acid;
5-[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenoxy]-pentanoic
acid;
5-[4-(2-cycIobutoxy-pyridin-3-y1)-2,6-difluoro-phenoxyj-pentanoic
acid;
4-[4-[2-(3,3-difluoropyrrolidin~l-yl)-3-pyridyl]-2,6-difluoro-phenoxy]b
utanoic acid;
4-[2,6-difluoro-4-[2-(4-methylpiperazin-l-yl)-3-pyridyl]phcnoxy]butan
oic acid;
4-[2,6-difluoro-4-[2-(5-methylisoxazol-3-yl)oxy-3-pyridyl]phenoxy]but
anoic acid;
4-[4-[2-[2-(aziridin-l-yl)ethoxy3-3-pyridyl]-2,6-difluoro-phenoxy]buta
noic acid;
4-[2,6-difiuoro-4-[2-(3-furyhnethoxy)-3-pyridyl]phenoxy]butanoic
acid;
4-[2,6-difluoro-4-[2-(2-furylmethoxy)-3-pyridyl]phenoxy]butanoic
acid;
4-[2,6-difluoro-4-[2-[(3-methyloxetan-3-yl)methoxy]-3-pyridyl]phcnox
y] butanoic acid;
4-[2,6-difluoro-4-[2-(tetrahydrofuran-3-ylmethoxy)~3-pyridyl]phenoxy]
butanoic acid;
4-[2,6-difluoro-4-[2-(tetrahydrofuran-2-ylmethoxy)-3-pyridyl]phenoxy]

butanoic acid;
4-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyric
acid;
4-[4-(2-cyclopropoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyric acid; 4-(4-{2-[3-(tert-butyl-dimethyl-silanyloxy)-cycIopentyloxy]-pyridin-3-yl}-2,6-difluorophenoxy)-butyric acid;
4-{2,6-difluoro-4-[2-(3-hydroxy-cyclopentyloxy)-pyridin-3-ylj-phenox
y}-butyric acid;
4-[4-(2-cyclohexyloxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyiic
acid;
4-[4-(2-cyclopentyimelhoxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyri
c acid;
4-[2,6-difluoro-4-(2~isobutoxy-pyridin-3-yl)~phcnoxy]-butyric acid;
4-{4-[2~(2,2-dimethy-propoxy)-pyridin-3~yl]-2,6-difluorO"phenoxy}-bu
tyric acid;
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenoxy]-pcntanoic
acid;
5-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]pentanoic
acid;
5-t4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy3pcntanoic
acid;
5-[2,6-ditluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenoxy]pentanoic
acid;
5-[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)phcnoxy]pcntanoic acid;
5-[2,6-difluoro-4-(6~isopropylsulfanyl-2-pyridyl)phenoxy]pentanoic
acid;
5-[2,6-difluoro-4-(6-isopropoxy-2-pyridyl)phenoxy]pentanoic acid;
5-[4_[2-(cyclopropylmethoxy)-3-pyridyl]-2,6-difluoro-phenoxy]pentan
oic acid;
5~[2,6-difluoro-4-(2-tetrahydrofuraii-3-yloxy-3-pyridyl)phenoxy]pentan
oic acid;
5-[2,6-di±luoro-4-(2-tetrahydi'opyrari"4-yloxy~3-pyridyl)phenoxy]penta
noic acid;
4-[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyI]-pentanoi
c acid;
4-[4-(2-cycIopentylsuIfanyl"pyriditi-3-yl)-phenylsulfanyl]-pentanoic
acid;
4-{2-fluoro-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-phenylsulfan

yl) -butyric acid;
4-{2-fluoro-4-[2-(tetrahydrofuran-3-yloxy)-pyridin-3-yl]-phenylsulfany
1}-butyric acid;
4-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2-fluoro-phenylsulfanyl3-buty
ric acid;
4-{2,6-difluoro-4-[2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl3-phcnylsulfa
nyl} -butyric acid;
4-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-
butyric acid;
4-[4-(2-cydopentylamino-pyridin-3-yl)-2,6-difiuoro-phenylsulfanyIJ-b
utyric acid;
4-[2,6-diLluoro-4-(2-isopropylamino-pyridin-3-yl)-phenylsulfanyl|-buty
ric acid;
4-{4-[2-(cyclopropylmethyl-amino)-pyridin-3-yl]-2,6-difluoro-phenyls
ulfanyl}-butyric acid;
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-pent
aiioic acid;
5-[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenyIsulfanyl]-pentanoi
c acid;
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-phenylsulfanyl]-pentanoic acid;
5-[4-(2-isopropoxy-pyridin-3-yl)-phenylsulfanyl]-pentanoic acid;
5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-
pentanoic acid;
5-[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phcnylsulfanyl]-penla
noic acid;
5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenylsulfanyl]-pentanoic
acid;
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-phenylsulfanyl]-pentanoic
acid;
5-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6"difluoro-phenylsulfanyl]-
pentanoic acid;
5-[4-(2-cycIobutoxy-pyridin-3-yl)-2,6-ditluoro-phenylsulfanyl]-pentan
oic acid;
6-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenoxy3-hcxanoic
acid;
7-[4-(2-cycIopentyloxy-pyridin-3-yl)-2,6-difluoro-phenoxyj-heptanoic
acid;
5-[2-fluoro-4~(2-isopropoxy-pyridin-3-yl)-phenoxy]-pentanoic acid;

5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2-fluoro-phenoxy]-pentanoic
acid;
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2-fluoro-phcnoxy]-pcntanoic
acid;
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2-fluoro-phenoxy]-pentanoic
acid;
4-[2,6-difluoro-4-(2-methoxy-pyridin-3-yl)-phenoxy]-butyric acid;
4-[4-(2-alIyloxy-pyridin-3-yI)-2,6-difluoro-phenoxy]-butyric acid;
4-[4-(2-but-2-yiiyloxy-pyridin~3-yl)-2,6-difluon>phenoxy]-butyric
acid;
6-[4-[2-(cyclobutoxy)-3-pyridyl]-2,6-difluoro-phenoxy]hexanoic acid;
6-[4-[2-(cyclobutylmethoxy)-3-pyridyl]-2,6-difiuoro-phenoxy]hexanoic
acid;
6-[4-[2-(cyclopropylmethoxy)-3-pyridyl]-2,6-difluoro-phenoxy3hexano
ic acid;
6-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]hexanoic
acid;
6-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]hexanoic
acid;
6-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difIuoro~phenylsulfanyl]-hexa
noic acid;
6-[4-(2-cycIopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-
hexanoic acid;
6-[4-(2-cycIobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylsulfanyl]-h
exanoic acid; and
6-[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phenylsulfanyl]-hexa
noic acid,
[Claim 3] A pharmaceutical composition as GPR120 agonists, comprising the
biaryl derivatives, pharmaceutic ally acceptable salts or isomers thereof
according to Claim 1 and a pharmaceutically acceptable carrier.
[Claim 4] A pharmaceutical composition for preventing or treating diabetes, com-
plications of diabetes, obesity, non-alcoholic fatty liver, sieatohepatitis,
osteoporosis or inflammation, comprising the biaryl derivatives, phar-maceutically acceptable salts or isomers thereof according to Claim 1
and a pharmaceutically acceptable carrier.
[Claim 5] A composition for lowering blood glucose level, comprising the biaryl
derivatives, pharmaceutically acceptable salts or isomers thereof
according to Claim 1 and a pharmaceutically acceptable carrier.

[Claim 6] A method for preparing a composition for preventing or treating
diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis, osteoporosis or inflammation, which comprises the step of mixing the biaryl derivatives, pharmaceutically acceptable salts or isomers thereof according to Claim 1 with a pharmaceutically ac¬ceptable carrier.