Bicyclic Nitrogen Containing Aromatic Heterocyclic Amide Compound

Abstract: This invention relates to a bicyclic nitrogen containing aromatic heterocyclic amide compound of formula (I) or a salt thereof which has excellent Complex 1 inhibitory effect and AMPK activating effect and which is useful as a therapeutic drug for breast cancer. This compound has a cell growth inhibitory effect on a human PIK3CA mutation positive breast cancer cell line not expressing MCT4 and on a human breast cancer cell line not expressing MCT4 and not having a PIK3CA mutation and exhibits antitumor action in human PIK3CA mutation positive breast cancer cell line MDA MB 453 cell tumor bearing mice not expressing MCT4.

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