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Biological Component Adhesion Suppressing Material

Abstract: The purpose of the present invention is to provide a biological component adhesion-suppressing material that is able to suppress adhesion of platelets and proteins even when coming into contact with blood etc. The present invention comprises a substrate which is provided with a functional layer having fixed on a surface thereof that comes into contact with a biological component a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
11 February 2019
Publication Number
09/2019
Publication Type
INA
Invention Field
BIO-MEDICAL ENGINEERING
Status
Email
patent@depenning.com
Parent Application
Patent Number
Legal Status
Grant Date
2023-12-22
Renewal Date

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 103-8666

Inventors

1. USHIRO, Suguru
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
2. HAYASHI, Akihiro
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
3. UENO, Yoshiyuki
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558

Specification

WE CLAIM:
1. A biological component adhesion-suppressing material
comprising:
a substrate having a functional layer with a polymer immobilized on a surface that is in contact with a biological component, the polymer containing a saturated aliphatic monocarboxylic acid vinyl ester unit,
wherein
the number of carbon atoms in an aliphatic chain in a saturated aliphatic monocarboxylic acid ion signal detected in compositional analysis of the surface of the functional layer by a TOF-SIMS apparatus is 2 to 20, and
a peak derived from an ester group is present in XPS measurement of the surface of the functional layer.
2. The biological component adhesion-suppressing material according to claim 1, wherein the saturated aliphatic monocarboxylic acid ion signal is derived from a saturated aliphatic monocarboxylic acid vinyl ester homopolymer or a copolymer containing a saturated aliphatic monocarboxylic acid vinyl ester, and has antithrombogenicity.
3. The biological component adhesion-suppressing

material according to claim 1 or 2, wherein the number of carbon atoms in an aliphatic chain in the saturated aliphatic monocarboxylic acid ion signal is 2 to 9.
4. The biological component adhesion-suppressing •material according to any one of claims 1 to 3, wherein in XPS measurement of the surface of the functional layer, the area percentage of the carbon peak derived from an ester group is 0.5 to 25 (atomic%) where the total area of peaks derived from carbon is 100 (atomic%).
5. The biological component adhesion-suppressing material according to any one of claims 1 to 4, wherein in ATR-IR measurement of the surface of the functional layer, a peak is present in each of both a range of 1711 to 1751 cm-1 and a range of 1549 to 1620 cm-1, and the average of the ratio of the peak area Ac=o in the range of 1711 to 1751 cm-1 to the peak area Ac=c in the range of 1549 to 1620 cm-1 (Ac=o/Ac=c) is 0.01 to 1.0.
6. The biological component adhesion-suppressing material according to claim 5, wherein the peak present in the range of 1549 to 1620 cm-1 is derived from aromatic groups in a polysulfone-based polymer.

7. The biological component adhesion-suppressing material according to claim 5 or 6, wherein a peak is present in a range of 1617 to 1710 cm"1 in ATR-IR measurement of the surface of the functional layer.
8. The biological component adhesion-suppressing material according to claim 7, wherein the peak present in the range of 1617 to 1710 cm-1 is derived from an amide bond in a hydrophilic polymer containing a vinylpyrrolidone unit, a vinylcaprolactam unit, a vinylacetamide unit or an acrylamide unit.
9. The biological component adhesion-suppressing material according to any one of claims 1 to 8, which is used for blood purification; and
10. A blood purifier comprising the biological component adhesion-suppressing material according to any one of claims 1 to 9.

Documents

Application Documents

# Name Date
1 201947005234-IntimationOfGrant22-12-2023.pdf 2023-12-22
1 201947005234.pdf 2019-02-11
2 201947005234-PatentCertificate22-12-2023.pdf 2023-12-22
2 201947005234-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-02-2019(online)].pdf 2019-02-11
3 201947005234-STATEMENT OF UNDERTAKING (FORM 3) [11-02-2019(online)].pdf 2019-02-11
3 201947005234-FORM 3 [22-11-2022(online)].pdf 2022-11-22
4 201947005234-PROOF OF RIGHT [11-02-2019(online)].pdf 2019-02-11
4 201947005234-CLAIMS [04-03-2022(online)].pdf 2022-03-04
5 201947005234-PRIORITY DOCUMENTS [11-02-2019(online)].pdf 2019-02-11
5 201947005234-COMPLETE SPECIFICATION [04-03-2022(online)].pdf 2022-03-04
6 201947005234-POWER OF AUTHORITY [11-02-2019(online)].pdf 2019-02-11
6 201947005234-FER_SER_REPLY [04-03-2022(online)].pdf 2022-03-04
7 201947005234-FORM 3 [04-03-2022(online)].pdf 2022-03-04
7 201947005234-FORM 1 [11-02-2019(online)].pdf 2019-02-11
8 201947005234-Information under section 8(2) [04-03-2022(online)].pdf 2022-03-04
8 201947005234-DECLARATION OF INVENTORSHIP (FORM 5) [11-02-2019(online)].pdf 2019-02-11
9 201947005234-COMPLETE SPECIFICATION [11-02-2019(online)].pdf 2019-02-11
9 201947005234-OTHERS [04-03-2022(online)].pdf 2022-03-04
10 201947005234-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [11-02-2019(online)].pdf 2019-02-11
10 201947005234-FER.pdf 2021-11-03
11 201947005234-FORM 3 [27-05-2021(online)].pdf 2021-05-27
11 Correspondence by Agent_Form1_19-02-2019.pdf 2019-02-19
12 201947005234-FORM 3 [09-07-2019(online)].pdf 2019-07-09
12 201947005234-FORM 3 [18-11-2020(online)]-1.pdf 2020-11-18
13 201947005234-FORM 18 [12-03-2020(online)].pdf 2020-03-12
13 201947005234-FORM 3 [18-11-2020(online)].pdf 2020-11-18
14 201947005234-FORM 18 [12-03-2020(online)].pdf 2020-03-12
14 201947005234-FORM 3 [18-11-2020(online)].pdf 2020-11-18
15 201947005234-FORM 3 [09-07-2019(online)].pdf 2019-07-09
15 201947005234-FORM 3 [18-11-2020(online)]-1.pdf 2020-11-18
16 201947005234-FORM 3 [27-05-2021(online)].pdf 2021-05-27
16 Correspondence by Agent_Form1_19-02-2019.pdf 2019-02-19
17 201947005234-FER.pdf 2021-11-03
17 201947005234-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [11-02-2019(online)].pdf 2019-02-11
18 201947005234-COMPLETE SPECIFICATION [11-02-2019(online)].pdf 2019-02-11
18 201947005234-OTHERS [04-03-2022(online)].pdf 2022-03-04
19 201947005234-DECLARATION OF INVENTORSHIP (FORM 5) [11-02-2019(online)].pdf 2019-02-11
19 201947005234-Information under section 8(2) [04-03-2022(online)].pdf 2022-03-04
20 201947005234-FORM 1 [11-02-2019(online)].pdf 2019-02-11
20 201947005234-FORM 3 [04-03-2022(online)].pdf 2022-03-04
21 201947005234-FER_SER_REPLY [04-03-2022(online)].pdf 2022-03-04
21 201947005234-POWER OF AUTHORITY [11-02-2019(online)].pdf 2019-02-11
22 201947005234-COMPLETE SPECIFICATION [04-03-2022(online)].pdf 2022-03-04
22 201947005234-PRIORITY DOCUMENTS [11-02-2019(online)].pdf 2019-02-11
23 201947005234-CLAIMS [04-03-2022(online)].pdf 2022-03-04
23 201947005234-PROOF OF RIGHT [11-02-2019(online)].pdf 2019-02-11
24 201947005234-FORM 3 [22-11-2022(online)].pdf 2022-11-22
24 201947005234-STATEMENT OF UNDERTAKING (FORM 3) [11-02-2019(online)].pdf 2019-02-11
25 201947005234-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-02-2019(online)].pdf 2019-02-11
25 201947005234-PatentCertificate22-12-2023.pdf 2023-12-22
26 201947005234.pdf 2019-02-11
26 201947005234-IntimationOfGrant22-12-2023.pdf 2023-12-22

Search Strategy

1 2021-06-0212-59-01E_02-06-2021.pdf

ERegister / Renewals

3rd: 21 Mar 2024

From 28/07/2019 - To 28/07/2020

4th: 21 Mar 2024

From 28/07/2020 - To 28/07/2021

5th: 21 Mar 2024

From 28/07/2021 - To 28/07/2022

6th: 21 Mar 2024

From 28/07/2022 - To 28/07/2023

7th: 21 Mar 2024

From 28/07/2023 - To 28/07/2024

8th: 21 Jun 2024

From 28/07/2024 - To 28/07/2025

9th: 10 Jun 2025

From 28/07/2025 - To 28/07/2026