Abstract: The purpose of the present invention is to provide a biological component adhesion-suppressing material that is able to suppress adhesion of platelets and proteins even when coming into contact with blood etc. The present invention comprises a substrate which is provided with a functional layer having fixed on a surface thereof that comes into contact with a biological component a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.
WE CLAIM:
1. A biological component adhesion-suppressing material
comprising:
a substrate having a functional layer with a polymer immobilized on a surface that is in contact with a biological component, the polymer containing a saturated aliphatic monocarboxylic acid vinyl ester unit,
wherein
the number of carbon atoms in an aliphatic chain in a saturated aliphatic monocarboxylic acid ion signal detected in compositional analysis of the surface of the functional layer by a TOF-SIMS apparatus is 2 to 20, and
a peak derived from an ester group is present in XPS measurement of the surface of the functional layer.
2. The biological component adhesion-suppressing material according to claim 1, wherein the saturated aliphatic monocarboxylic acid ion signal is derived from a saturated aliphatic monocarboxylic acid vinyl ester homopolymer or a copolymer containing a saturated aliphatic monocarboxylic acid vinyl ester, and has antithrombogenicity.
3. The biological component adhesion-suppressing
material according to claim 1 or 2, wherein the number of carbon atoms in an aliphatic chain in the saturated aliphatic monocarboxylic acid ion signal is 2 to 9.
4. The biological component adhesion-suppressing •material according to any one of claims 1 to 3, wherein in XPS measurement of the surface of the functional layer, the area percentage of the carbon peak derived from an ester group is 0.5 to 25 (atomic%) where the total area of peaks derived from carbon is 100 (atomic%).
5. The biological component adhesion-suppressing material according to any one of claims 1 to 4, wherein in ATR-IR measurement of the surface of the functional layer, a peak is present in each of both a range of 1711 to 1751 cm-1 and a range of 1549 to 1620 cm-1, and the average of the ratio of the peak area Ac=o in the range of 1711 to 1751 cm-1 to the peak area Ac=c in the range of 1549 to 1620 cm-1 (Ac=o/Ac=c) is 0.01 to 1.0.
6. The biological component adhesion-suppressing material according to claim 5, wherein the peak present in the range of 1549 to 1620 cm-1 is derived from aromatic groups in a polysulfone-based polymer.
7. The biological component adhesion-suppressing material according to claim 5 or 6, wherein a peak is present in a range of 1617 to 1710 cm"1 in ATR-IR measurement of the surface of the functional layer.
8. The biological component adhesion-suppressing material according to claim 7, wherein the peak present in the range of 1617 to 1710 cm-1 is derived from an amide bond in a hydrophilic polymer containing a vinylpyrrolidone unit, a vinylcaprolactam unit, a vinylacetamide unit or an acrylamide unit.
9. The biological component adhesion-suppressing material according to any one of claims 1 to 8, which is used for blood purification; and
10. A blood purifier comprising the biological component adhesion-suppressing material according to any one of claims 1 to 9.
| # | Name | Date |
|---|---|---|
| 1 | 201947005234-IntimationOfGrant22-12-2023.pdf | 2023-12-22 |
| 1 | 201947005234.pdf | 2019-02-11 |
| 2 | 201947005234-PatentCertificate22-12-2023.pdf | 2023-12-22 |
| 2 | 201947005234-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-02-2019(online)].pdf | 2019-02-11 |
| 3 | 201947005234-STATEMENT OF UNDERTAKING (FORM 3) [11-02-2019(online)].pdf | 2019-02-11 |
| 3 | 201947005234-FORM 3 [22-11-2022(online)].pdf | 2022-11-22 |
| 4 | 201947005234-PROOF OF RIGHT [11-02-2019(online)].pdf | 2019-02-11 |
| 4 | 201947005234-CLAIMS [04-03-2022(online)].pdf | 2022-03-04 |
| 5 | 201947005234-PRIORITY DOCUMENTS [11-02-2019(online)].pdf | 2019-02-11 |
| 5 | 201947005234-COMPLETE SPECIFICATION [04-03-2022(online)].pdf | 2022-03-04 |
| 6 | 201947005234-POWER OF AUTHORITY [11-02-2019(online)].pdf | 2019-02-11 |
| 6 | 201947005234-FER_SER_REPLY [04-03-2022(online)].pdf | 2022-03-04 |
| 7 | 201947005234-FORM 3 [04-03-2022(online)].pdf | 2022-03-04 |
| 7 | 201947005234-FORM 1 [11-02-2019(online)].pdf | 2019-02-11 |
| 8 | 201947005234-Information under section 8(2) [04-03-2022(online)].pdf | 2022-03-04 |
| 8 | 201947005234-DECLARATION OF INVENTORSHIP (FORM 5) [11-02-2019(online)].pdf | 2019-02-11 |
| 9 | 201947005234-COMPLETE SPECIFICATION [11-02-2019(online)].pdf | 2019-02-11 |
| 9 | 201947005234-OTHERS [04-03-2022(online)].pdf | 2022-03-04 |
| 10 | 201947005234-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [11-02-2019(online)].pdf | 2019-02-11 |
| 10 | 201947005234-FER.pdf | 2021-11-03 |
| 11 | 201947005234-FORM 3 [27-05-2021(online)].pdf | 2021-05-27 |
| 11 | Correspondence by Agent_Form1_19-02-2019.pdf | 2019-02-19 |
| 12 | 201947005234-FORM 3 [09-07-2019(online)].pdf | 2019-07-09 |
| 12 | 201947005234-FORM 3 [18-11-2020(online)]-1.pdf | 2020-11-18 |
| 13 | 201947005234-FORM 18 [12-03-2020(online)].pdf | 2020-03-12 |
| 13 | 201947005234-FORM 3 [18-11-2020(online)].pdf | 2020-11-18 |
| 14 | 201947005234-FORM 18 [12-03-2020(online)].pdf | 2020-03-12 |
| 14 | 201947005234-FORM 3 [18-11-2020(online)].pdf | 2020-11-18 |
| 15 | 201947005234-FORM 3 [09-07-2019(online)].pdf | 2019-07-09 |
| 15 | 201947005234-FORM 3 [18-11-2020(online)]-1.pdf | 2020-11-18 |
| 16 | 201947005234-FORM 3 [27-05-2021(online)].pdf | 2021-05-27 |
| 16 | Correspondence by Agent_Form1_19-02-2019.pdf | 2019-02-19 |
| 17 | 201947005234-FER.pdf | 2021-11-03 |
| 17 | 201947005234-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [11-02-2019(online)].pdf | 2019-02-11 |
| 18 | 201947005234-COMPLETE SPECIFICATION [11-02-2019(online)].pdf | 2019-02-11 |
| 18 | 201947005234-OTHERS [04-03-2022(online)].pdf | 2022-03-04 |
| 19 | 201947005234-DECLARATION OF INVENTORSHIP (FORM 5) [11-02-2019(online)].pdf | 2019-02-11 |
| 19 | 201947005234-Information under section 8(2) [04-03-2022(online)].pdf | 2022-03-04 |
| 20 | 201947005234-FORM 1 [11-02-2019(online)].pdf | 2019-02-11 |
| 20 | 201947005234-FORM 3 [04-03-2022(online)].pdf | 2022-03-04 |
| 21 | 201947005234-FER_SER_REPLY [04-03-2022(online)].pdf | 2022-03-04 |
| 21 | 201947005234-POWER OF AUTHORITY [11-02-2019(online)].pdf | 2019-02-11 |
| 22 | 201947005234-COMPLETE SPECIFICATION [04-03-2022(online)].pdf | 2022-03-04 |
| 22 | 201947005234-PRIORITY DOCUMENTS [11-02-2019(online)].pdf | 2019-02-11 |
| 23 | 201947005234-CLAIMS [04-03-2022(online)].pdf | 2022-03-04 |
| 23 | 201947005234-PROOF OF RIGHT [11-02-2019(online)].pdf | 2019-02-11 |
| 24 | 201947005234-FORM 3 [22-11-2022(online)].pdf | 2022-11-22 |
| 24 | 201947005234-STATEMENT OF UNDERTAKING (FORM 3) [11-02-2019(online)].pdf | 2019-02-11 |
| 25 | 201947005234-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-02-2019(online)].pdf | 2019-02-11 |
| 25 | 201947005234-PatentCertificate22-12-2023.pdf | 2023-12-22 |
| 26 | 201947005234.pdf | 2019-02-11 |
| 26 | 201947005234-IntimationOfGrant22-12-2023.pdf | 2023-12-22 |
| 1 | 2021-06-0212-59-01E_02-06-2021.pdf |