FORM 2
THE PATENTS ACT, 1970
(39 of 1970)
&
THE PATENTS RULES, 2003
COMPLETE SPECIFICATION
[See section 10, Rule 13]
Biological Material Measuring Apparatus
MITSUBISHI ELECTRIC CORPORATION, A CORPORATION ORGANISED AND
EXISTING UNDER THE LAWS OF JAPAN, WHOSE ADDRESS IS 7-3,
MARUNOUCHI 2-CHOME, CHIYODA-KU, TOKYO 100-8310, JAPAN
THE FOLLOWING SPECIFICATION PARTICULARLY DESCRIBES THE
INVENTION AND THE MANNER IN WHICH IT IS TO BE PERFORMED.
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DESCRIPTION
TECHNICAL 5 FIELD
[0001] The present invention relates to biological material measuring apparatuses, and
more particularly, to a biological material measuring apparatus that uses infrared light
to measure a biological material such as sugar in a living body.
BACKGROUND ART
10 [0002] A conventional invasive sensor draws blood with a needle and analyzes a
component of a material in a living body. In particular, for blood sugar level sensors
commonly used, a non-invasive type is desired to alleviate patient's pain caused by
puncture. Although one type of non-invasive blood sugar level sensor using infrared
light is capable of directly detecting a fingerprint spectrum of sugar, infrared light
15 cannot reach a deep portion from a skin surface because infrared light is absorbed well
by water. Under the circumstances, such a technique is demanded that detects a blood
sugar level stably with high accuracy even when absorption by sugar in a living body is
little.
[0003] In response to such a demand, for example, the apparatus described in in PTL 1
20 measures a blood sugar level by the attenuated total reflection (ATR) method.
CITATION LIST
PATENT LITERATURE
[0004] PTL 1: Japanese Patent Laying-Open No. 2003-42952
SUMMARY OF INVENTION
25 TECHNICAL PROBLEM
[0005] According to PTL 1, a wavelength tunable laser is used because measurements
performed at a plurality of wavelengths are necessary for improved accuracy of
measurement. The wavelength tunable laser is, however, implemented as an external
resonator, leading to large size and high cost.
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[0006] An object of the present invention is therefore to provide a biological material
measuring apparatus capable of measuring an amount of a biological material at low
cost.
SOLUTION TO PROBLEM
[0007] A biological material measuring apparatus according to a first 5 aspect of the
present invention includes an infrared light source unit to radiate infrared light in
entirety or part of a wavelength region including absorption wavelengths of a biological
material, a prism to cause the infrared light radiated from the infrared light source unit
to pass therethrough and emit the infrared light to a living body surface while being in
10 contact with the living body surface, a light source to radiate light of a wavelength in a
visible light region or a near infrared region to the prism, and a light position detector
to detect a path of light from the light source by detecting light from the light source
which is emitted from the prism.
[0008] A biological material measuring apparatus according to a second aspect of the
15 present invention includes an ATR prism adherable to a living body surface, an infrared
light source unit to radiate, to the ATR prism, infrared light in entirety or part of a
wavelength region including absorption wavelengths of a biological material, and an
infrared photodetector to detect infrared light of at least one wavelength which is
emitted from the ATR prism.
20 [0009] A biological material measuring apparatus according to a third aspect of the
present invention includes an ATR prism adherable to a living body surface, an infrared
light source unit to radiate, to the ATR prism, infrared light in entirety or part of a
wavelength region including absorption wavelengths of a biological material, and an
infrared photodetector to detect infrared light emitted from the ATR prism. The
25 infrared light source unit comprises a plurality of light sources, each of which radiates
infrared light of a single wavelength included in a wavelength region detectable by the
infrared photodetector.
ADVANTAGEOUS EFFECTS OF INVENTION
[0010] The present invention eliminates the need for a wavelength tunable laser, and
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thus, can measure an amount of a biological material present in a surface of a living
body at low cost.
BRIEF DESCRIPTION OF DRAWINGS
[0011] Fig. 1 shows a configuration of a mobile, non-invasive biological material
measuring apparatus 80 5 of Embodiment 1.
Fig. 2 shows an example use of mobile, non-invasive biological material
measuring apparatuses 80 of Embodiments 1 to 6.
Fig. 3 shows a configuration of mobile, non-invasive biological material
measuring apparatus 80 of Embodiment 2.
10 Fig. 4 shows a fingerprint spectrum of sugar.
Fig. 5 shows a structure of a head of non-invasive biological material measuring
apparatus 80 of Embodiment 2.
Fig. 6 shows a spectrum of light output from an infrared light source unit 32 of
Embodiment 2.
15 Fig. 7 is a schematic view of a sensor array 1000 of an infrared photodetector
30.
Fig. 8 is a flowchart showing an operational procedure of non-invasive
biological material measuring apparatus 80 of Embodiment 2.
Fig. 9 shows a configuration of an infrared photodetector 30 of Embodiment 3.
20 Fig. 10 is a top view of a semiconductor optical device 100 of Embodiment 3.
Fig. 11 is a top view of semiconductor optical device 100 of Embodiment 3
excluding an absorber 10.
Fig. 12 is a sectional view of semiconductor optical device 100 of Fig. 11
(including absorber 10 and the like), as seen in the III-III direction.
25 Fig. 13 shows absorber 10 of semiconductor optical device 100 of Embodiment
3.
Fig. 14 shows a configuration of an infrared light source unit 32 of Embodiment
5.
Fig. 15 shows a spectrum of light output from infrared light source unit 32 of
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Embodiment 5.
Fig. 16 is a top view of a wavelength selection structure 11 of Embodiment 6.
Fig. 17 is a sectional view of wavelength selection structure 11 of Fig. 16, as
seen in the V-V direction.
DESCRIPTION 5 OF EMBODIMENTS
[0012] Embodiments of the present invention will now be described with reference to
the drawings.
Embodiment 1
Although description will be given below by taking a blood sugar level as an
10 example measuring object, a measuring apparatus of the present invention is applicable
to measurement of a blood sugar level, as well as measurement of any other biological
material.
[0013] In the ATR method described in PTL 1, a prism is brought into contact with a
measurement skin, which prevents evanescent light from penetrating deep into the
15 measurement skin. This leads to low measurement accuracy of an amount of a
biological material. The present embodiment measures an amount of a biological
material without using the ATR method.
[0014] Fig. 1 shows a configuration of a mobile, non-invasive biological material
measuring apparatus 80 of Embodiment 1.
20 [0015] Non-invasive biological material measuring apparatus 80 includes a light source
200, a prism 210, a light position detector 220, and an infrared light source unit 32.
[0016] Infrared light source unit 32 includes at least one or more infrared light sources.
Infrared light source unit 32 includes a wideband quantum cascade laser that radiates
infrared light in entirety or part of the wavelength region in the wavelength range of 8.5
25 μm to 10 μm, which includes wavelengths of a finger print spectrum of sugar. The
wavelengths for use in measurements are, for example, λ1, λ2, and λ3. Light of λ1
and light of λ2 are absorbed by a sugar in a human body. Light of λ3 is not absorbed
by sugar in a human body and is used as a reference wavelength. The wavelengths for
use in measurements may be four wavelengths further including λ4.
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[0017] Infrared light radiated from infrared light source unit 32 passes through prism
210 as incident infrared light 11a and enters a living body surface 40, which is a
subject's skin.
[0018] Prism 210 is made of a material such as zinc sulfide (ZnS) which is highly
transparent in a wavelength region of visible light to a wavelength 5 region of infrared
light.
[0019] Light source 200 is a laser that outputs light of one wavelength in the
wavelength region of visible light to a wavelength region of near infrared. Light
output from light source 200 enters prism 210 as incident light 230a, passes through
10 prism 210, and is then radiated from prism 210 as radiated light 230b or radiated and
refracted light 230c. A difference between radiated light 230b and radiated and
refracted light 230c arises from the change of state within the prism, which will be
described below. Radiated light 230b or radiated and refracted light 230c enters light
position detector 220.
15 [0020] Light position detector 220 detects a path of light from light source 200 by
detecting the light from light source 200 which is emitted from prism 210. Light
position detector 220 includes a photodetector capable of detecting radiated light 230b
or radiated and refracted light 230c. Light position detector 220 detects a position at
which light enters the photodetector. The material for light position detector 220 may
20 be, for example, an inexpensive photodiode or a plasmon with excellent wavelength
selectivity.
[0021] Next, an operation of measuring a blood sugar level in the present embodiment
will be described.
A state in which the light output from infrared light source unit 32 is zero is
25 referred to as a reference state. In the reference state, the state inside prism 210 is
uniform, and accordingly, light output from light source 200 is refracted only when
entering prism 210 and when exiting the prism. In the reference state, the position at
which radiated light 230b enters light position detector 220 is referred to as a reference
position.
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[0022] Then, infrared light source unit 32 outputs infrared light of a fingerprint
spectrum wavelength of sugar as incident infrared light 11a. Incident infrared light
11a enters living body surface 40 of the subject through prism 210. Infrared light is
absorbed by the sugar present in living body surface 40 of the subject. Absorption
heat is generated in living body surface 40 due to the absorption. 5 The generated
absorption heat is conducted to prism 210, causing a temperature gradient inside prism
210, which forms a refractive index gradient 240 in accordance with the temperature
gradient. This is because a refractive index changes as temperature changes. This
state is referred to as state 1.
10 [0023] In state 1, incident light 230a passes through refractive index gradient 240.
Incident light 230a is refracted in accordance with a refractive index at a position in
refractive index gradient 240 through which light passes.
[0024] The refracted incident light 230a is radiated from prism 210 as radiated and
refracted light 230c and enters light position detector 220. In state 1, the position at
15 which radiated light 230b enters light position detector 220 is referred to as a
displacement position.
[0025] A controller 250 measures an amount of the sugar in living body surface 40
based on a difference between the position of incidence of radiated light 230b which is
detected by light position detector 220 in the reference state in which the infrared light
20 source unit does not emit infrared light and the position of incidence of radiated and
refracted light 230c which is detected by light position detector 220 in state 1 in which
the infrared light source unit emits infrared light.
[0026] An effect of noise can be eliminated through the above operation performed at
wavelengths λ1 and λ2 at which light is absorbed by the sugar in a human body and at
25 λ3 at which light is not absorbed, enabling more accurate calculation of a blood sugar
level.
[0027] When a plasmon is used as light position detector 220, the wavelength
selectivity thereof allows calculation of a displacement position at each of λ1, λ2 and
λ3, enabling higher-accuracy measurement of a blood sugar level.
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[0028] Fig. 2 shows an example use of mobile, non-invasive biological material
measuring apparatuses 80 of Embodiments 1 to 6. As shown in Fig. 2, the blood
sugar level in a living body of a subject is measured with the head of mobile, noninvasive
biological material measuring apparatus 80 being brought into contact with a
subject's lip with a thin keratin layer. Although a measurement site 5 is desirably a lip
with a thin keratin layer, it may be another site. It suffices that the measurement site
is other than a site with a thick keratin layer, such as a palm. For example,
measurements can also be made on a cheek of a face, an earlobe, or the back of a hand.
[0029] [Notes]
10 The biological material measuring apparatus (80) of Embodiment 1 has the
following features.
[0030] (1) A biological material measuring apparatus (80) includes an infrared light
source unit (32) to radiate infrared light in entirety or part of a wavelength region
including absorption wavelengths of a biological material, a prism (210) to cause the
15 infrared light radiated from the infrared light source unit (32) to pass therethrough and
emit the infrared light to a living body surface (40) while being in contact with the
living body surface, a light source (200) to radiate light of a wavelength in a visible
light region or a near infrared region to the prism, and a light position detector (220) to
detect a path of light from the light source (200) by detecting light from the light source
20 (200) which is emitted from the prism (200).
[0031] With such a configuration, the path of light from the light source (200) is
detected, enabling high-accuracy measurement of an amount of a biological material
present in the living body surface.
[0032] (2) The infrared light emitted to the living body surface (40) is absorbed by the
25 biological material present in the living body surface (40), and the absorption generates
absorption heat to form a refractive index gradient (240) in the prism (210).
[0033] Such a configuration can generate the refractive index gradient (240)
corresponding to the biological material present in the living body surface (40) in the
path through which the light radiated from the light source passes.
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[0034] (3) The light radiated from the light source (220) passes through the refractive
index gradient (240) formed in the prism (210) due to the absorption heat of the
biological material.
[0035] Such a configuration can allow the light radiated from the light source (220) to
be refracted at a refractive index corresponding to the amount of the biological 5 material.
[0036] (4) The biological material measuring apparatus (80) includes a controller (250)
to measure an amount of the biological material based on a difference between a
position of incidence of light radiated from the light source (200) which is detected by
the light position detector (220) when the infrared light source unit (32) does not
10 radiate the infrared light and a position of incidence of light emitted from the light
source (200) which is detected by the light position detector (220) when the infrared
light source unit (32) radiates the infrared light.
[0037] Such a configuration enables measurement of an amount of a biological
material based on a difference in the position of incidence of light radiated from the
15 light source (200) which is detected by the light position detector (220) between when
the infrared light source unit (32) does not emit infrared light and when the infrared
light source unit (32) emits infrared light.
[0038] Embodiment 2
Fig. 3 shows a configuration of mobile, non-invasive biological material
20 measuring apparatus 80 of Embodiment 2.
[0039] Non-invasive biological material measuring apparatus 80 includes an ATR
prism 20, an infrared light source unit 32, an infrared photodetector 30, a controller 52,
and a user interface 54.
[0040] Infrared light source unit 32 includes at least one infrared light source.
25 Infrared light source unit 32 radiates infrared light in entirety or part of a wavelength
range with absorption wavelengths of a biological material.
[0041] Infrared photodetector 30 detects infrared light emitted from ATR prism 20.
Controller 52 controls infrared light source unit 32 and infrared photodetector
30. Controller 52 calculates the concentration of the blood sugar level of a living
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body based on the intensity of the infrared light detected by infrared photodetector 30.
[0042] User interface 54 includes a display 501, a keyboard 503, and a speaker 504.
[0043] ATR prism 20 is mounted in the head of non-invasive biological material
measuring apparatus 80. ATR prism 20 is adherable to living body surface 40 of the
5 subject.
[0044] Fig. 4 shows a fingerprint spectrum of sugar.
As shown in Fig. 3, when biological material measuring apparatus 80 is
activated with ATR prism 20 being brought into contact with living body surface 40 of
the subject, infrared light source unit 32 radiates infrared light in entirety or part of the
10 wavelength region in the wavelength range of 8.5 μm to 10 μm, which includes a
fingerprint spectrum of sugar as shown in Fig. 4.
[0045] Incident infrared light 11a emitted from infrared light source unit 32 is reflected
at an end face 20c of ATR prism 20 and then turns into propagating infrared light 11b.
Propagating infrared light 11b passes through ATR prism 20 being in contact with
15 living body surface 40 while repeating total reflection at end faces 20a and 20b of ATR
prism 20. Propagating infrared light 11b that has passed through ATR prism 20 is
reflected at an end face 20d of ATR prism 20 and then turns into radiated infrared light
11c. Infrared photodetector 30 detects the intensity of radiated infrared light 11c.
[0046] Evanescent light is generated at end face 20a which is the interface between
20 ATR prism 20 and living body surface 40. The evanescent light penetrates living
body surface 40 and is absorbed by sugar.
[0047] A smaller difference in the refractive index between living body surface 40 and
ATR prism 20 results in more intense evanescent light. The evanescent light which
has leaked from ATR prism 20 toward living body surface 40 in total reflection of
25 propagating infrared light 11b at end face 20a is absorbed by the biological material in
living body surface 40, so that the intensity of the infrared light totally reflected at end
face 20a attenuates. A larger amount of biological material accordingly leads to more
absorption of evanescent light, resulting in more attenuation of the intensity of the
infrared light totally reflected.
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[0048] A skin is composed of an epidermis near a skin surface and a corium below the
epidermis. The epidermis includes a stratum corneum, a stratum granulosum, a
stratum spinosum, and a stratum basale in order from the vicinity of the skin surface,
the thicknesses of which are 10 μm, about several micrometers, 100 μm, and about
several micrometers, respectively. Cells are produced in the 5 stratum basale and
stacked on the stratum spinosum. The cells die out in the stratum granulosum because
water (interstitial fluid) does not reach the stratum granulosum. The dead cells are
hardened in the stratum corneum. Sugar and any other biological material are present
in the interstitial fluid of the epidermis. The interstitial fluid increases from the
10 stratum corneum to the stratum spinosum. The intensity of the infrared light totally
reflected accordingly changes in accordance with the penetration length of evanescent
light. Herein, the penetration length is also referred to as a penetration depth.
[0049] Evanescent light attenuates exponentially from the interface toward living body
surface 40, and has a penetration length approximately equal to its wavelength.
15 Spectroscopy using ATR prism 20 can thus measure an amount of a biological material
in the region up to the penetration length. For example, a fingerprint spectrum of
sugar has wavelengths of 8.5 μm to 10 μm, and accordingly, an amount of sugar in the
region in such a range from the prism surface of ATR prism 20 can be detected.
[0050] Fig. 5 shows a structure of a head of non-invasive biological material measuring
20 apparatus 80 of Embodiment 2. The head is formed of a substrate 50, ATR prism 20,
infrared light source unit 32, and infrared photodetector 30.
[0051] ATR prism 20 has a shape of a rectangular parallelepiped with missing parts.
The cross-section of ATR prism 20 has a shape obtained by cutting two vertex angles
from a rectangle at a certain angle. A shorter surface on which the vertex angles are
25 cut as shown in Fig. 5 is brought into contact with living body surface 40 as a
measuring surface. The angle of end face 20c of ATR prism 20 is set such that
propagating infrared light 11b in ATR prism 20 is totally reflected at end faces 20a and
20b of ATR prism 20. The angle of end face 20d of ATR prism 20 is set such that
radiated infrared light 11c perpendicularly enters infrared photodetector 30.
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[0052] Antireflection coating is applied to end face 20c on which incident infrared light
11a from infrared light source unit 32 is incident and end face 20d from which radiated
infrared light 11c exits toward infrared photodetector 30. Alternatively, incident
infrared light 11a from infrared light source unit 32 may be made p-polarized light
(polarized light is parallel to substrate 50), and end surface 20c, which 5 is an incident
surface, and end surface 20d, which is an exit surface, may be chipped to make an
angle of incidence/exit a Brewster's angle.
[0053] The material for ATR prism 20 may be a single crystal of zinc sulfide (ZnS)
which is transparent in a mid-infrared range and has a relatively low refractive index.
10 The material for ATR prism 20 is not limited to the single crystal of zinc sulfide (ZnS)
and may be a known material such as zinc selenide (ZnSe). End surface 20a of ATR
prism 20 which comes into contact with the skin is coated with a thin film of, for
example, SiO2 or SiN to cause no harm to a human body.
[0054] In Embodiment 2, for example, a quantum cascade laser module is used as
15 infrared light source unit 32. The quantum cascade laser, which includes a single light
source and has a high output and a high signal-to-noise ratio (SN ratio), is capable of
high-accuracy measurements. A lens for collimating a beam is mounted in the
quantum cascade laser module. The quantum cascade laser radiates infrared light in
entirety or part of the wavelength region in the wavelength range of 8.5 μm to 10 μm,
20 in which the wavelengths of a fingerprint spectrum of sugar are present.
[0055] In order to improve accuracy of measurement, a wavelength tunable laser can
be used for measurements at a plurality of wavelengths. The wavelength tunable laser,
however, is implemented as an external resonator, leading to large size and high cost
due to complicated structure.
25 [0056] Fig. 6 shows a spectrum of light output from infrared light source unit 32 of
Embodiment 2.
Infrared light source unit 32 radiates infrared light in entirety or part of the
wavelength region in the wavelength range of 8.5 μm to 10 μm, which includes the
wavelengths of a fingerprint spectrum of sugar as shown in Fig. 6. Specifically, a
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wideband quantum cascade laser, not a wavelength tunable laser, is used as infrared
light source unit 32 as described above.
[0057] In place of the wideband quantum cascade laser, infrared light source unit 32
may be a thermal light source of such a type that flows current through a filament for
heating. In this case, temperature can be controlled by an amount of 5 a current applied,
and accordingly, wideband infrared rays according to black body radiation are radiated.
[0058] Alternatively, infrared light source unit 32 may not be a filament and may be a
plasmon or a metamaterial light source that has a periodic pattern provided in a heating
portion. In this case, infrared light source unit 32 is a high-efficiency light source
10 because the radiation wavelength range is defined by surface structure and accordingly
has reduced unnecessary radiation.
[0059] Fig. 6 shows the fingerprint spectrum of sugar, shown in Fig. 4, by a dotted line
for comparison. Amplified spontaneous emission is used as the light over a wide
wavelength region as shown in Fig. 6. This eliminates the need for using an
15 expensive wavelength tunable laser as infrared light source unit 32, so that a small-size,
low-cost light source can be used as infrared light source unit 32.
[0060] Light of at least one wavelength which is included in infrared light 11c radiated
from ATR prism 20 is detected by infrared photodetector 30. This enables
measurement of an amount of at least one biological material corresponding to at least
20 one absorption wavelength. Plasmon resonance occurs in the surface of the light
receiving portion of infrared photodetector 30, so that infrared light of at least one
wavelength is absorbed. At least one of the absorbed wavelengths corresponds to the
absorption wavelength of a biological material.
[0061] Fig. 7 is a schematic view of a sensor array 1000 of infrared photodetector 30.
25 Sensor array 1000 is formed of non-cooling infrared sensors (hereinafter, also referred
to as sensor pixels) 110, 120, 130, and 140 each detecting light having a different
wavelength.
[0062] Sensor pixels 110, 120, 130, and 140 each include, for example, a wavelengthselective
absorber using plasmon resonance in the surface of the light receiving portion.
- 14 -
Such a structure can detect infrared light of the selected wavelength. The use of
infrared photodetector 30 including an array of non-cooling infrared sensors which
detect only the infrared light of the selected wavelength allows simultaneous
measurements of a plurality of wavelengths, enabling a measurement in a short period
5 of time.
[0063] As described below, the use of plasmon resonance eliminates the need for a
spectral filter, simplifying the configuration of infrared photodetector 30, which leads
to lower cost. Although wavelength selectivity decreases due to the thermal radiation
of the spectral filter per se in an infrared wavelength range, the use of a plasmon
10 structure, not the spectral filter, improves wavelength selectivity. This leads to higher
sensitivity for detecting a trace amount of component, such as analysis of a blood sugar
level.
[0064] When the quantum cascade laser and plasmon are used simultaneously, the
selectivity of measurement wavelength is secured, and accordingly, black-body
15 radiation components of other than the absorption peak wavelength of glucose can be
removed. This leads to an improved SN ratio. Also, since a quantum cascade laser
does not always need to be used for a reference wavelength, a broad light source and a
plasmon enable selection of wavelengths. This leads to lower cost.
[0065] Further, when a diffraction grating is installed, wavelength resolution needs to
20 be increased, and thus, the infrared photodetector and the diffraction grating need to be
disposed apart from each other. However, the use of a plasmon as the light receiving
portion eliminates the need for optical components such as a diffraction grating and a
mirror. This can reduce the size of a biological material measuring apparatus.
[0066] The wavelengths for use in measurements are, for example, λ1, λ2, λ3, and λ4
25 in the wavelength range of 8.5 μm to 10 μm in which the fingerprint spectrum of sugar
is present. As described above, radiated infrared light 11c radiated from infrared light
source unit 32 passes through ATR prism 20 while repeating total reflection. At that
time, light of each of wavelengths λ1, λ2, and λ3 is absorbed by sugar in a human body,
and the intensity of the light attenuates before reaching infrared photodetector 30.
- 15 -
Thus, when the light of each of wavelengths λ1, λ2, and λ3 is measurable by infrared
photodetector 30, the blood sugar level in a human body can be measured. Also,
infrared light of wavelength λ4, which is not absorbed by sugar, is used as a reference
wavelength.
[0067] Sensor pixels 110, 120, 130, and 140 of infrared photodetector 5 30 detect
infrared light of wavelengths λ1, λ2, λ3, and λ4.
[0068] The infrared light of each of wavelengths λ1, λ2, λ3 is absorbed by sugar, as
well as by water and any other biological material. On the other hand, the infrared
light of wavelength λ4 is not absorbed by sugar but is absorbed by water and any other
10 biological material. Thus, the intensity of the detected infrared light of each of the
wavelengths λ1, λ2, and λ3 is corrected with the intensity of infrared light of
wavelength λ4, leading to improved accuracy of measurement.
[0069] The infrared rays radiated from an external background and a human body may
enter infrared photodetector 30. Wavelengths λ1, λ2, and λ3 can be set to values
15 extremely close to each other, thereby making the effects of the infrared rays radiated
from the background and the human body almost equal to each other, thus minimizing
the effects of noise.
[0070] In order to eliminate such noise, radiated infrared light 11c may be chopped at a
specific frequency using a chopper. Infrared light source unit 32 itself can be pulse20
driven, and infrared light can be chopped using the frequency thereof to increase
detection sensitivity. The signals output from sensor pixels 110, 120, 130, and 140
may be subjected to Fourier transform at a chopping frequency to obtain an output with
noise reduced.
[0071] It suffices that a sensor pixel may be added in order to increase wavelengths to
25 be detected. When a detection wavelength can be adjusted by controlling only the
surface periodic structure of a sensor pixel, as many wavelengths as the pixels formed
into an array can be detected.
[0072] Next, a specific example of infrared photodetector 30 will be described.
The modes of non-cooling infrared sensors (thermal infrared sensors) for use in
- 16 -
the sensor pixels of infrared photodetector 30 include pyroelectric sensors, bolometers,
thermopiles, and silicon on insulator (SOI) diodes. Even for different modes, plasmon
resonance can be used for the light receiving portion of the sensor, that is, an absorber
to enable the selection of wavelengths. The present embodiment can thus use not only
the mode of non-cooling infrared sensor but also any mode as the 5 mode of detecting
infrared photodetector 30.
[0073] Fig. 8 is a flowchart showing an operational procedure of non-invasive
biological material measuring apparatus 80 of Embodiment 2.
[0074] At S101, controller 52 determines whether a user has instructed to start
10 measurement via keyboard 503. When the user has instructed to start measurement,
the process proceeds to step S102.
[0075] At step S102, controller 52 outputs a message voice "measurement to be
started" through speaker 504, thereby informing the user of a start of measurement of a
blood sugar level.
15 [0076] At step S107, controller 52 starts measuring a blood sugar level.
At step S108, controller 52 determines whether the measurement of a blood
sugar level is complete. When the measurement is complete, the process proceeds to
step S109.
[0077] At step S109, controller 52 outputs a message voice "measurement complete"
20 through speaker 504.
[0078] At step S110, controller 52 calculates a blood sugar level based on the measured
intensity of infrared light.
[0079] At step S111, controller 52 displays the calculated blood sugar level on display
501.
25 [0080] [Notes]
The biological material measuring apparatus (80) of Embodiment 2 has the
following features.
[0081] (5) A biological material measuring apparatus (80) includes an ATR prism (20)
adherable to a living body surface (40), an infrared light source unit (32) to radiate, to
- 17 -
the ATR prism (20), infrared light in entirety or part of a wavelength region including
absorption wavelengths of a biological material, and an infrared photodetector (30) to
detect infrared light of at least one wavelength which is emitted from the ATR prism
(20).
[0082] Such a configuration can measure an amount of at least one biological 5 material
corresponding to at least one absorption wavelength.
[0083] (6) The infrared light source unit (32) comprises a single light source to radiate
infrared light in a wavelength region detectable by the infrared photodetector (30).
[0084] Such a configuration can intensify infrared light and increase the SN ratio,
10 enabling high-accuracy measurement.
[0085] (7) Infrared light of one or more wavelengths is absorbed upon generation of
plasmon resonance in a surface of a light receiving portion of the infrared photodetector
(30), and at least one of the one or more absorbed wavelengths corresponds to an
absorption wavelength of the biological material.
15 [0086] Such a configuration can detect infrared light of the selected wavelength,
enabling measurement of an amount of a biological material that absorbs the selected
wavelength.
[0087] Embodiment 3
Differences from Embodiment 2 will be described.
20 [0088] Fig. 9 shows a configuration of an infrared photodetector 30 of Embodiment 3.
Infrared photodetector 30 is an integrated wavelength-selective infrared sensor.
Infrared photodetector 30 includes a sensor array 1000 and a detection circuit 1010.
[0089] Sensor array 1000 includes 9×6 pixels (semiconductor optical devices) 100
arranged in rows and columns. On substrate 1, 9×6 semiconductor optical devices
25 100 are arranged in matrix (in array) in the X-axis and Y-axis directions. Light enters
from the direction parallel to the Z-axis. That is to say, infrared photodetector 30
perpendicularly receives infrared light emitted from ATR prism 20.
[0090] Detection circuit 1010 is provided around sensor array 1000. Detection circuit
1010 processes a signal detected by semiconductor optical device 100 to detect an
- 18 -
image. When the detected wavelengths are fewer, detection circuit 1010 is not
required to detect an image and is merely required to detect an output from each device.
[0091] Description will be given below by taking a thermal infrared sensor as an
example of semiconductor optical device 100.
Fig. 10 is a top view of semiconductor optical device 100 5 of Embodiment 3.
As shown in Fig. 10, semiconductor optical device 100 includes an absorber 10 serving
as a light receiving portion.
[0092] Fig. 11 is a top view of semiconductor optical device 100 of Embodiment 3
excluding absorber 10. Fig. 11 does not show a protective film and a reflection film
10 on a wire for clarification. Fig. 12 is a sectional view of semiconductor optical device
100 of Fig. 11 (including absorber 10 and the like), as seen in the III-III direction. Fig.
13 shows absorber 10 of semiconductor optical device 100 of Embodiment 3.
[0093] As shown in Fig. 12, semiconductor optical device 100 includes, for example, a
substrate 1 made of silicon. A hollow 2 is provided in substrate 1. A temperature
15 detection unit 4, which detects temperatures, is disposed above hollow 2.
Temperature detection unit 4 is supported by two support legs 3. As shown in Fig. 11,
support leg 3 has a bridge shape bent in an L-shape as seen from above. Support leg 3
includes a thin metal wire 6 and a dielectric film 16 supporting thin metal wire 6.
[0094] Temperature detection unit 4 includes a detection film 5 and thin metal wire 6.
20 Detection film 5 is formed of, for example, a diode containing crystal silicon. Thin
metal wire 6 is also provided in support leg 3 and electrically connects an aluminum
wire 7 and detection film 5, which are covered with an insulating film 12, to each other.
Thin metal wire 6 is made of, for example, titanium alloy having a thickness of 100 nm.
An electric signal output from detection film 5 is transmitted to aluminum wire 7
25 through thin metal wire 6 formed in support leg 3 and is extracted by detection circuit
1010 of Fig. 9. An electrical connection between thin metal wire 6 and detection film
5 and an electrical connection between thin metal wire 6 and aluminum wire 7 may be
provided via a conductor (not shown) extending thereabove or therebelow if necessary.
[0095] A reflective film 8, which reflects infrared rays, is disposed to cover hollow 2;
- 19 -
however, it is disposed to cover at least part of support leg 3 with reflective film 8 and
temperature detection unit 4 not being thermally connected to each other.
[0096] As shown in Fig. 12, a support pillar 9 is provided above temperature detection
unit 4. Absorber 10 is supported on support pillar 9. That is to say, absorber 10 is
connected to temperature detection unit 4 by support pillar 9. Since 5 absorber 10 is
thermally connected to temperature detection unit 4, a change in the temperature
generated in absorber 10 is conveyed to temperature detection unit 4.
[0097] At the same time, absorber 10 is disposed above reflective film 8 while it is not
thermally connected with reflective film 8. Absorber 10 extends laterally in a plate
10 shape so as to cover at least part of reflective film 8. As semiconductor optical device
100 is seen from above, thus, only absorber 10 is seen as shown in Fig. 10.
Alternatively, absorber 10 may be formed directly above temperature detection unit 4.
[0098] In the present embodiment, a wavelength selection structure 11, which
selectively absorbs the light of a certain wavelength, is provided in the surface of
15 absorber 10 as shown in Fig. 12. An anti-absorption film 13, which prevents light
absorption from the rear surface, is provided on the rear surface of absorber 10, that is,
on the support pillar 9 side. This configuration allows absorber 10 to selectively
absorb light of a specific wavelength. Since wavelength selection structure 11 may
also absorb light, absorber 10 includes wavelength selection structure 11 in the present
20 embodiment.
[0099] Next, description will be given of the structure in the case in which wavelength
selection structure 11 uses surface plasmon. Providing a periodic structure made of
metal in a light incidence surface causes surface plasmon at a wavelength
corresponding to a surface periodic structure, so that light is absorbed. Thus, the
25 surface of absorber 10 can be made of metal to control the wavelength selectivity of
absorber 10 by the wavelength of incident light, an angle of incidence, and a periodic
structure of the metal surface.
[0100] In the present embodiment, a phenomenon in which free electrons inside a
metal film make a contribution and the generation of a surface mode by a periodic
- 20 -
structure are regarded as being synonymous with each other in terms of absorption, and
they are referred to as surface plasmon, surface plasmon resonance, resonance, pseudosurface
plasmon, or metamaterial without differentiating therebetween. The
configuration of the present embodiment is also effective for light of a wavelength in a
wavelength region of other than infrared light, for example, a visible 5 light region, a
near infrared region, and a THz region.
[0101] As shown in Fig. 13, wavelength selection structure 11 that selectively increases
the absorption of light of a certain wavelength, which is provided in the surface of
absorber 10, includes a metal film 42, a main body 43, and recesses 45.
10 [0102] The type of metal film 42 provided in the outermost surface of absorber 10
serving as the light receiving portion is selected from metals that easily cause surface
plasmon resonance, such as Au, Ag, Cu, Al, Ni, and Mo. Alternatively, the type of
metal film 42 may be a material that causes plasmon resonance, such as metallic
nitrides including TiN, metallic borides, and metallic carbides. It suffices that metal
15 film 42 in the outermost surface of absorber 10 has such a thickness as not to allow
incident infrared light to pass therethrough. With such a film thickness, only surface
plasmon resonance in the outermost surface of absorber 10 affects absorption and
radiation of electromagnetic waves, and the material below metal film 42 does not
optically affect absorption or the like.
20 [0103] A thickness (skin depth) δ1 of a skin effect is represented by an expression
below:
[0104] δ1 = (2/μσω)1/2 ... (1)
where μ is a magnetic permeability of metal film 42, σ is an electric conductivity of
metal film 42, and ω is an angular frequency of incident light.
25 For example, when film thickness δ of metal film 42 in the surface of absorber
10 is at least twice δ1, that is, from about several tens of nanometers to about several
hundreds of nanometers, a leak of incident light to below absorber 10 can be made
sufficiently small.
[0105] For example, in comparison of heat capacity between gold and oxide silicon
- 21 -
(SiO2), oxide silicon has a smaller heat capacity. An absorber formed of main body
43 made of oxide silicon and the surface of metal film 42 made of gold can have a
smaller heat capacity than an absorber made of gold alone, and accordingly, can have a
higher response.
[0106] Next, a method of manufacturing absorber 10 5 will be described.
A periodic structure is formed on the front surface side of main body 43 formed
of a dielectric or semiconductor by photolithography and dry etching, and then, metal
film 42 is formed by sputtering or the like. Similarly for the rear surface,
subsequently, a periodic structure is produced, and then, metal film 42 is formed.
10 [0107] Since the diameter of recess 45 is as small as about several micrometers, a
manufacturing step is more simplified by forming metal film 42 after etching main
body 43 to form recesses than by directly etching metal film 42 to form recesses.
Since an expensive material, such as Au or Ag, is used for metal film 42, the use of
main body 43 of dielectric or semiconductor can reduce the amount of metal used for
15 reduced cost.
[0108] Next, the characteristics of absorber 10 will be described with reference to Fig.
13. Cylindrical recesses 45 each having a diameter d of 4 μm and a depth h of 1.5 μm
are arranged in tetragonal lattice with a period p of 8 μm. In this case, an absorption
wavelength is about 8 μm. Alternatively, cylindrical recesses 45 each having a
20 diameter d of 4 μm and a depth h of 1.5 μm are arranged in tetragonal lattice with a
period p of 8.5 μm. In this case, an absorption wavelength is approximately 8.5 μm.
[0109] The relationship between the absorption wavelength and radiation wavelength
of incident light and the period of recesses 45 is almost identical even when recesses 45
are arranged in tetragonal lattice or even when they are arranged in triangular lattice as
25 long as absorber 10 has a two-dimensional periodic structure. That is to say, an
absorption wavelength and a radiation wavelength are determined by the period of
recesses 45. Considering reciprocal vectors of the periodic structure, theoretically, the
absorption and radiation wavelengths are almost identical to the period in the tetragonal
lattice arrangement, whereas the absorption and radiation wavelengths are a period
- 22 -
×√3/2 in the triangular lattice arrangement. In actuality, however, the absorption and
radiation wavelengths vary slightly depending on diameter d of recess 45. It is thus
conceivable that incident light may be absorbed or radiated at a wavelength almost
identical to a period in both the periodic structures.
[0110] The wavelength of infrared light to be absorbed can thus be 5 controlled by the
period of recesses 45. Generally, diameter d of recess 45 is desirably not less than a
half of period p. If diameter d of recess 45 is smaller than a half of period p, a
resonance effect tends to be smaller to reduce an absorptivity. However, since
resonance is three-dimensional resonance in recess 45, sufficient absorption may be
10 achieved even when diameter d is smaller than a half of period p. The value of
diameter d with respect to period p is accordingly designed individually as appropriate.
What is important is that an absorption wavelength is controlled mainly by period p.
When diameter d is not less than a certain value with respect to period p, absorber 10
has sufficient absorption characteristics, providing ranges to design. Meanwhile,
15 referring to a general expression of dispersion relation of surface plasmon, the light to
be absorbed is irrelevant to depth h of recess 45 and depends on period p alone. The
absorption wavelength and radiation wavelength thus do not depend on depth h of
recess 45 shown in Fig. 13.
[0111] Although the absorber having recesses 45 arranged periodically has been
20 described above, similar effects can be achieved also with the structure having
projections 45a arranged periodically.
[0112] The absorption by absorber 10 having such an irregular structure reaches its
maximum in the case of normal incidence. When the angle of incidence on absorber
10 deviates from normal incidence, the absorption wavelength also changes. Infrared
25 photodetector 30 is thus disposed such that infrared light emitted from ATR prism 20 is
radiated perpendicularly to the surface of absorber 10 serving as the light receiving
portion.
[0113] [Notes]
The biological material measuring apparatus (80) of Embodiment 3 has the
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following features.
[0114] (8) Recesses (45) or projections (45b) are periodically formed in the surface of
the light receiving portion of the infrared photodetector (30), and an outermost surface
of the light receiving portion is a material that causes surface plasmon resonance.
[0115] Such a configuration allows the infrared photodetector (30) 5 to have wavelength
selectivity.
(9) A period of the recesses (45) or the projections (45b) in the surface of the
light receiving portion of the infrared photodetector (30) corresponds to an absorption
wavelength of the biological material.
10 [0116] With such a configuration, a biological material to be measured can be changed
by changing the period of the recesses (45) or projections (45b).
[0117] (10) The infrared light emitted from the ATR prism (20) perpendicularly enters
the surface of the light receiving portion of the infrared photodetector (30).
[0118] Such a configuration can maximize the absorption of infrared light in the
15 infrared photodetector (30).
[0119] Embodiment 4
Differences from Embodiment 3 will be described.
[0120] In Embodiment 4, a quantum cascade laser is used as infrared light source unit
32. The quantum cascade laser oscillates at one or more signal wavelengths in the
20 wavelength range of 8.5 μm to 10 μm in which the fingerprint spectrum of sugar is
present and at a reference wavelength deviated slightly from the above wavelength
range.
[0121] A Peltier device for stabilizing a wavelength and a leans for collimating a beam
are mounted in a quantum laser module of the present embodiment. The other
25 components are similar to those of Embodiment 3, which will not be repeated.
[0122] In measurement of a blood sugar level, the radiation from living body surface
40 is detected as noise, leading to reduced accuracy of measurement.
[0123] In the present embodiment, wavelengths for use in the quantum cascade laser
are set to appropriate ones, and infrared photodetector 30 is used to remove a radiation
- 24 -
spectrum from a living body. This enables high-accuracy measurement excluding
radiation from a living body.
[0124] Embodiment 5
Differences from Embodiment 2 will be described.
[0125] Fig. 14 shows a configuration of an infrared light source unit 5 32 of Embodiment
5. Fig. 15 shows a spectrum of light output from infrared light source unit 32 of
Embodiment 5.
[0126] Infrared light source unit 32 includes single-wavelength light sources 71a, 71b,
71c, and 71d. Single-wavelength light sources 71a, 71b, 71c, and 71d output infrared
10 light of single wavelengths A, B, C, and D, respectively, as shown in Fig. 15. Single
wavelengths A, B, C, and D are included in the wavelength region that can be detected
by infrared photodetector 30.
[0127] In the present embodiment, infrared photodetector 30 does not detect a radiation
spectrum from a living body but can detect infrared light of wavelengths in a wide
15 range (i.e., does not have wavelength selectivity).
[0128] For example, single-wavelength light sources 71a, 71b, 71c, and 71d can output
infrared light at different timings, and infrared photodetector 30 that has no wavelength
selectivity can receive infrared light of each single-wavelength light source.
[0129] [Notes]
20 The biological material measuring apparatus (80) of Embodiment 5 has the
following features.
[0130] (11) A biological material measuring apparatus (80) includes an ATR prism
(20) adherable to a living body surface (40), an infrared light source unit (32) to radiate,
to the ATR prism, infrared light in entirety or part of a wavelength region including
25 absorption wavelengths of a biological material, and an infrared photodetector (30) to
detect infrared light emitted from the ATR prism (20). The infrared light source unit
(32) comprises a plurality of light sources (71a, 71b, 71c, 71d), each of which radiates
infrared light of a single wavelength included in a wavelength region detectable by the
infrared photodetector (32).
- 25 -
[0131] Such a configuration allows the infrared photodetector (30) that does not have
wavelength selectivity to receive infrared light from a plurality of light sources when
the plurality of light sources output infrared light at different timings.
[0132] Embodiment 6
Differences from Embodiment 2 5 will be described.
[0133] Fig. 16 is a top view of a wavelength selection structure 11 of Embodiment 6.
Fig. 17 is a sectional view of wavelength selection structure 11 of Fig. 16, as seen in
the V-V direction.
[0134] Wavelength selection structure 11 includes a metal layer 14, an intermediate
10 layer 18 on metal layer 14, and metal patches 17 on intermediate layer 18.
[0135] Metal layer 14 is made of, for example, aluminum, gold, or the like.
Intermediate layer 18 is formed of an insulator such as oxide silicon, a dielectric,
or a semiconductor such as silicon or germanium. The selection of the material for
intermediate layer 18 can control wavelengths to be detected, the number of
15 wavelengths to be detected, and the band of wavelengths to be detected.
[0136] Metal patch 17 is formed of, for example, a metal such as gold, silver, or
aluminum, or of graphene other than metal. When metal patch 17 is made of
graphene, a film thickness can be reduced down to one atomic layer. This reduces a
thermal time constant, enabling a high-speed operation. Alternatively, the material for
20 metal patch 17 may be a material that causes surface plasmon resonance as described
above.
[0137] The wavelength at which plasmon resonance occurs can be controlled by the
size of metal patch 17 (the dimensions in the x and y directions of Fig. 16). Thus,
changing the size of metal patch 17 allows the selection of an absorption wavelength.
25 The size of metal patch 17 can accordingly be determined such that the wavelength
absorbed by absorber 10 matches the absorption wavelength of a biological material to
be measured. As shown in Fig. 16, in one example in which metal patch 17 has a
square shape, an absorption wavelength is about 7.5 μm when the length of one side is
3 μm, and an absorption wavelength is about 8.8 μm when the length of one side is 3.5
- 26 -
μm. In this case, the period of metal patches 17 is determined to be larger than the
absorption wavelength and larger than one side of metal patch 17. Consequently, the
period of metal patches 17 has almost no effect on the absorption wavelength.
[0138] The use of the absorber of the present embodiment can reduce the size of a pixel,
reducing the area of infrared photodetector 30 when the pixels are formed 5 into an array.
[0139] The absorption structure of wavelength selection structure 11 of the present
embodiment has no independence on an angle of incidence, and the absorption
wavelength does not change even when an angle of incidence is changed. Similarly,
when metal patch 17 has a symmetrical shape and a two-dimensional periodic structure,
10 the absorption structure has no polarization independence. Thus, a permissible range
is extended for the angle at which infrared photodetector 30 is installed. For a mobile
biological material measuring apparatus, since a deviation of infrared photodetector 30
is feared, the use of the absorption structure of the present embodiment has a
remarkable effect of good portability.
15 [0140] Although metal patches 17 are arranged with regular periods in matrix (twodimensionally)
in Fig. 16, they may be arranged one-dimensionally. Although
polarization dependence occurs in this case, stray light can be eliminated by matching
the direction of arrangement with the polarization of infrared light source unit 32. An
SN ratio can thus be improved, enabling higher-accuracy measurement of a blood sugar
20 level.
[0141] [Notes]
The biological material measuring apparatus (80) of Embodiment 6 has the
following features.
[0142] (12) The surface of the light receiving portion of the infrared photodetector (30)
25 is formed of a thin metal film (14), an insulating film (18), and metal patches (17)
stacked in order from inside, and an absorption wavelength of the biological material is
controllable in accordance with a size of each of the metal patches (17).
[0143] With such a configuration, a biological material to be measured can be changed
by changing the size of each of the metal patches (17).
- 27 -
[0144] (13) A period at which the metal patches (17) are arranged is larger than the
absorption wavelength of the biological material and is larger than one side of each of
the metal patches (17).
[0145] With such a configuration, the period of metal patches (17) has almost no effect
on an absorption 5 wavelength.
[0146] It is to be understood that the embodiments disclosed herein are presented for
the purpose of illustration and non-restrictive in every respect. It is therefore intended
that the scope of the present invention is defined by claims, not only by the
embodiments described above, and encompasses all modifications and variations
10 equivalent in meaning and scope to the claims.
REFERENCE SIGNS LIST
[0147] 1, 50 substrate, 2 hollow, 3 support leg, 4 temperature detection unit, 5
detection film, 6 thin metal wire, 7 aluminum wire, 8 reflective film, 9 support
film, 10 absorber, 11 wavelength selection structure, 11a incident infrared light,
15 11b propagating infrared light, 11c radiated infrared light, 12 insulating film, 13
anti-absorption film, 14 metal layer, 16 dielectric film, 17 metal patch, 18
intermediate layer, 20 ATR prism, 20a, 20b, 20c, 20d ATR prism end face, 30
infrared photodetector, 32 infrared light source unit, 40 living body surface, 42
metal film, 43 main body, 45 recess, 52, 250 controller, 54 user interface, 71a,
20 71b, 71c, 71d single-wavelength light source, 80 biological material measuring
apparatus, 100 semiconductor device, 110, 120, 130, 140 non-cooling infrared
sensor, 1000 sensor array, 1010 detection circuit, 200 light source, 210 prism,
220 light position detector, 230 prism, 230a incident light, 230b radiated light,
230c radiated and refracted light, 240 refractive index gradient.
25
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We Claim :
1. A biological material measuring apparatus comprising:
an infrared light source unit to radiate infrared light in entirety or part of a
wavelength region including absorption wavelengths of a biological 5 material;
a prism to cause the infrared light radiated from the infrared light source unit to
pass therethrough and emit the infrared light to a living body surface while being in
contact with the living body surface;
a light source to radiate light of a wavelength in a visible light region or a near
10 infrared region to the prism; and
a light position detector to detect a path of light from the light source by
detecting light from the light source which is emitted from the prism.
2. The biological material measuring apparatus according to claim 1, wherein
15 the infrared light emitted to the living body surface is absorbed by the biological
material present in the living body surface, and the absorption generates absorption heat
to form a refractive index gradient in the prism.
3. The biological material measuring apparatus according to claim 2, wherein
20 the light radiated from the light source passes through the refractive index gradient
formed in the prism due to the absorption heat of the biological material.
4. The biological material measuring apparatus according to claim 3,
comprising a controller to measure an amount of the biological material based on a
25 difference between a position of incidence of light radiated from the light source which
is detected by the light position detector when the infrared light source unit does not
radiate the infrared light and a position of incidence of light radiated from the light
source which is detected by the light position detector when the infrared light source
unit radiates the infrared light.
- 29 -
5. A biological material measuring apparatus comprising:
an ATR prism adherable to a living body surface;
an infrared light source unit to radiate, to the ATR prism, infrared light in
entirety or part of a wavelength region including absorption wavelengths of a biological
5 material; and
an infrared photodetector to detect infrared light of at least one wavelength
which is emitted from the ATR prism.
6. The biological material measuring apparatus according to claim 5, wherein
10 the infrared light source unit comprises a single light source to radiate infrared light in a
wavelength region detectable by the infrared photodetector.
7. The biological material measuring apparatus according to claim 5 or 6,
wherein infrared light of one or more wavelengths is absorbed upon generation of
15 plasmon resonance in a surface of a light receiving portion of the infrared photodetector,
and at least one of the one or more absorbed wavelengths corresponds to an absorption
wavelength of the biological material.
8. The biological material measuring apparatus according to claim 7, wherein
20 recesses or projections are periodically formed in the surface of the light receiving
portion of the infrared photodetector, and an outermost surface of the light receiving
portion is a material that causes surface plasmon resonance.
9. The biological material measuring apparatus according to claim 8, wherein
25 a period of the recesses or the projections in the surface of the light receiving portion of
the infrared photodetector corresponds to an absorption wavelength of the biological
material.
10. The biological material measuring apparatus according to claim 9,
wherein the infrared light
surface of the light receiving portion
11. The biological material measuring apparatus
5 wherein
the surface of the light receiving portion of the
of a thin metal film, an insulating
and
an absorption wavelength
10 accordance with a size of each of t
12. The biological material measuring apparatus
wherein a period at which
wavelength of the biological material
15 patches.
13. A biological material measuring apparatus
an ATR prism adherable to a
an infrared light source unit
20 entirety or part of a wavelength region including absorption wavelengths
material; and
an infrared photodetector
wherein the infrared light source unit
each of which radiates infrared light
25 region detectable by the
Dated this 06th day of July, 2020
30
- 30 -
emitted from the ATR prism perpendicularly
of the infrared photodetector.
according to claim 9 or 10,
infrared photodetector
film, and metal patches stacked in order from inside,
of the biological material is controllabl
the metal patches.
according to claim 11,
the metal patches are arranged is larger than the
and is larger than one side of each of
comprising:
living body surface;
to radiate, to the ATR prism, infrared light i
to detect infrared light emitted from
comprises a plurality of
of a single wavelength included in a
infrared photodetector.