Abstract: A respiratory treatment apparatus (1) provides blood glucose monitoring and breathing control based on detected blood glucose information. In an example embodiment, a flow generator provides a flow of breathable gas at a pressure above atmospheric to a patient interface according to a pressure treatment control protocol such as a CPAP, APAP, bi-level CPAP, etc. A detector determines a blood glucose condition indicator with one or more sensors that are used to sense physiological information. In response to signals from the sensors, a controller, such as a digital signal processor, controls adjustments to the flow of breathable gas provided by the flow generator. The adjustments are determined by the controller based on the detected blood glucose indicator and/or changes thereto.
We-Claim:
1. A device for treating sleep disordered breathing and diabetes comprising: at least one
sensor detecting a physiological signal and transmitting physiological data to a controller; said
controller to control a flow generator to provide pressurized gas to a patient at a fitst flow rate
and wherein said controller is adapted to determine a blood glucose level from the physiological
data and then adjust the flow rate based on the determined blood glucose level.
2. The device of claim. 1, wherein the controller compares the determined blood glucose
level to one or more thresholds.
3. The device of claim 2 wherein the one or more thresholds comprises a minimum
threshold value and a maximum threshold value.
4. The device of claim 3, wherein the minimum threshold value is within a range of about
2 to 3.5 mmol/L.
5. The device of claim 3, wherein the maximum threshold value is within a range of
about 5.6 to 9 mmol/L.
6. The device of claim 3, wherein said controller activates an alarm, when blood glucose
level is below the minimum or above the maximum threshold values.
7. A device for treating sleep disordered breathing: wherein said device includes a patient
interface, a flow generator operated by a controller and at least one sensor connected to
controller, wherein said controller determines glucose levels from the detected breathing pattern
of a patient.
8. A method in a controller of a respiratory treatment device for treating sleep disordered
breathing and diabetes, the method comprising:
sensing a physiological signal; detemrining blood glucose level from a physiological
signal and adjusting a control parameter of a flow generator to provide pressurized gas based on
the blood glucose level.
9. The method of claim 8, wherein said method further includes analyzing the determined
blood glucose level with respect to a minimum and maximum threshold value.
10. A respiratory treatment apparatus comprising:
a flow generator to provide a flow of breathable gas at a pressure above
atmospheric to a patient interface;
a detector to determine a blood glucose condition indicator with at least one
sensor;
a controller to adjust the flow of breathable gas of the flow generator based on the
detected blood glucose indicator.
11. The respiratory treatment apparatus of claim 10 wherein the blood glucose condition
indicator is a respiratory-based blood glucose condition indicator.
12. The respiratory treatment apparatus of claim 10 wherein the blood glucose condition
indicator is a sympathetic activation-based blood glucose condition indicator.
13. The respiratory treatment apparatus of claim 10 wherein the blood glucose condition
indicator is a direct blood glucose level.
14. The respiratory treatment apparatus of claim 10 wherein a blood glucose condition
indicator based adjustment by the controller to the flow of breathable gas of the flow generator
comprises a pressure treatment control protocol change.
15. The respiratory treatment apparatus of claim 14 wherein the pressure treatment
control protocol change of the controller comprises initiating ventilation control to satisfy a target
ventilation.
16. The respiratory treatment apparatus of claim IS wherein the controller is configured
with a protocol to control the flow of breathable gas to maintain an approximately constant
pressure level across a breathing cycle.
17. The respiratory treatment apparatus of claim 10 wherein the controller is configured
with a protocol to control the flow of breathable gas to vary pressure during a breathing cycle.
18. The respiratory treatment apparatus of claim 10 further comprising a Kussmanl
breathing pattern detector.
19. The respiratory treatment apparatus of claim 10 wherein an adjustment by the
controller based on the detected blood glucose indicator comprises an increase of a ventilation
control parameter.
20. The respiratory treatment apparatus of claim 10 wherein an adjustment by the
controller based on the detected blood glucose indicator comprises a decrease of a ventilation
control parameter.
21. A respiratory treatment apparatus comprising:
flow generation means for providing a flow of breathable gas at a pressure above
atmospheric to a patient interface;
detection means for determining a blood glucose condition indicator,
processing means for adjusting the flow of breathable gas of the flow generator
based on the detected blood glucose indicator.
22. The respiratory treatment apparatus of claim 21 wherein the blood glucose condition
indicator is a respiratory-based blood glucose condition indicator.
23. The respiratory treatment apparatus of claim 21 wherein the blood glucose condition
indicator is a sympathetic activation-based blood glucose condition indicator.
24. The respiratory treatment apparatus of claim 21 wherein the blood glucose condition
indicator is a direct blood glucose level.
25. The respiratory treatment apparatus of claim 21 wherein a blood glucose condition
indicator based adjustment by the processing means to the flow of breathable gas of the flow
generation means comprises a pressure treatment control protocol change.
26. The respiratory treatment apparatus of claim 21 wherein the pressure treatment
control protocol change of the processing means comprises initiating ventilation control to satisfy
a target ventilation.
27. The respiratory treatment apparatus of claim 21 wherein the processing means is
configured with a protocol to control the flow of breathable gas to maintain an approximately
constant pressure level across a breaming cycle.
28. The respiratory treatment apparatus of claim 21 wherein the processing means is
configured with a protocol to control the flow of breathable gas to vary pressure during a
breathing cycle.
29. The respiratory treatment apparatus of claim 21 further comprising a Kussmaul
breaming pattern detector.
30. The respiratory treatment apparatus of claim 26 wherein an adjustment by the
processing means based on the detected blood glucose indicator comprises an increase of a
ventilation control parameter.
31. The respiratory treatment apparatus of claim 26 wherein an adjustment by the
processing means based on the detected blood glucose indicator comprises a decrease of a
ventilation control parameter.
32. A positive pressure respiratory airway treatment device comprising:
a flow generator including a blower and servo, the flow generator configured to
provide a flow of breathable gas at a pressure above atmospheric to a patient interface;
sensor apparatus comprising at least one of a noninvasive
hyperglycemia/hypoglycemia monitor, an oximeter, a subcutaneous or semi-invasive blood
glucose monitor, the sensor apparatus to generate signals at least representative of one or more
physiological characteristics;
a processor to receive signals from the sensor apparatus and control the flow
generator, the processor being programmed with processor control instructions, the processor
control instructions comprising:
controlling determining of a blood glucose condition indicator; and
controlling adjusting a setting for the flow of breathable gas of the flow generator based
on the detected blood glucose indicator.
33. The respiratory treatment apparatus of claim 32 wherein the blood glucose condition
indicator is a respiratory-based blood glucose condition indicator.
34. The respiratory treatment apparatus of claim 32 wherein the blood glucose condition
indicator is a sympathetic activation-based blood glucose condition indicator.
35. The respiratory treatment apparatus of claim 32 wherein the blood glucose condition
indicator is a direct blood glucose level. i
A respiratory treatment apparatus (1) provides blood glucose monitoring and breathing
control based on detected blood glucose information. In an example embodiment, a flow
generator provides a flow of breathable gas at a pressure above atmospheric to a patient
interface according to a pressure treatment control protocol such as a CPAP, APAP, bi-level
CPAP, etc. A detector determines a blood glucose condition indicator with one or more
sensors that are used to sense physiological information. In response to signals from the
sensors, a controller, such as a digital signal processor, controls adjustments to the flow of
breathable gas provided by the flow generator. The adjustments are determined by the
controller based on the detected blood glucose indicator and/or changes thereto.
| # | Name | Date |
|---|---|---|
| 1 | 3450-KOLNP-2010-AbandonedLetter.pdf | 2018-03-26 |
| 1 | abstract-3450-kolnp-2010.jpg | 2011-10-07 |
| 2 | 3450-KOLNP-2010-FORM 4(ii) [11-12-2017(online)].pdf | 2017-12-11 |
| 2 | 3450-kolnp-2010-specification.pdf | 2011-10-07 |
| 3 | 3450-KOLNP-2010-PA.pdf | 2011-10-07 |
| 3 | 3450-KOLNP-2010-FER.pdf | 2017-06-13 |
| 4 | 3450-KOLNP-2010-OTHERS PCT FORM.pdf | 2011-10-07 |
| 4 | 3450-kolnp-2010-abstract.pdf | 2011-10-07 |
| 5 | 3450-kolnp-2010-international search report.pdf | 2011-10-07 |
| 5 | 3450-kolnp-2010-claims.pdf | 2011-10-07 |
| 6 | 3450-kolnp-2010-international publication.pdf | 2011-10-07 |
| 6 | 3450-KOLNP-2010-CORRESPONDENCE 1.2.pdf | 2011-10-07 |
| 7 | 3450-kolnp-2010-international preliminary examination report.pdf | 2011-10-07 |
| 7 | 3450-KOLNP-2010-CORRESPONDENCE 1.3.pdf | 2011-10-07 |
| 8 | 3450-kolnp-2010-form-5.pdf | 2011-10-07 |
| 8 | 3450-KOLNP-2010-CORRESPONDENCE-1.1.pdf | 2011-10-07 |
| 9 | 3450-kolnp-2010-correspondence.pdf | 2011-10-07 |
| 9 | 3450-kolnp-2010-form-3.pdf | 2011-10-07 |
| 10 | 3450-kolnp-2010-description (complete).pdf | 2011-10-07 |
| 10 | 3450-kolnp-2010-form-2.pdf | 2011-10-07 |
| 11 | 3450-kolnp-2010-drawings.pdf | 2011-10-07 |
| 11 | 3450-kolnp-2010-form-1.pdf | 2011-10-07 |
| 12 | 3450-KOLNP-2010-FORM 18.pdf | 2011-10-07 |
| 12 | 3450-KOLNP-2010-FORM 3 1.2.pdf | 2011-10-07 |
| 13 | 3450-KOLNP-2010-FORM 3 1.1.pdf | 2011-10-07 |
| 14 | 3450-KOLNP-2010-FORM 18.pdf | 2011-10-07 |
| 14 | 3450-KOLNP-2010-FORM 3 1.2.pdf | 2011-10-07 |
| 15 | 3450-kolnp-2010-drawings.pdf | 2011-10-07 |
| 15 | 3450-kolnp-2010-form-1.pdf | 2011-10-07 |
| 16 | 3450-kolnp-2010-description (complete).pdf | 2011-10-07 |
| 16 | 3450-kolnp-2010-form-2.pdf | 2011-10-07 |
| 17 | 3450-kolnp-2010-form-3.pdf | 2011-10-07 |
| 17 | 3450-kolnp-2010-correspondence.pdf | 2011-10-07 |
| 18 | 3450-KOLNP-2010-CORRESPONDENCE-1.1.pdf | 2011-10-07 |
| 18 | 3450-kolnp-2010-form-5.pdf | 2011-10-07 |
| 19 | 3450-kolnp-2010-international preliminary examination report.pdf | 2011-10-07 |
| 19 | 3450-KOLNP-2010-CORRESPONDENCE 1.3.pdf | 2011-10-07 |
| 20 | 3450-kolnp-2010-international publication.pdf | 2011-10-07 |
| 20 | 3450-KOLNP-2010-CORRESPONDENCE 1.2.pdf | 2011-10-07 |
| 21 | 3450-kolnp-2010-international search report.pdf | 2011-10-07 |
| 21 | 3450-kolnp-2010-claims.pdf | 2011-10-07 |
| 22 | 3450-KOLNP-2010-OTHERS PCT FORM.pdf | 2011-10-07 |
| 22 | 3450-kolnp-2010-abstract.pdf | 2011-10-07 |
| 23 | 3450-KOLNP-2010-PA.pdf | 2011-10-07 |
| 23 | 3450-KOLNP-2010-FER.pdf | 2017-06-13 |
| 24 | 3450-kolnp-2010-specification.pdf | 2011-10-07 |
| 24 | 3450-KOLNP-2010-FORM 4(ii) [11-12-2017(online)].pdf | 2017-12-11 |
| 25 | 3450-KOLNP-2010-AbandonedLetter.pdf | 2018-03-26 |
| 25 | abstract-3450-kolnp-2010.jpg | 2011-10-07 |
| 1 | 3450search_03-05-2017.pdf |