Abstract: The present invention provides Chitosan based hemostatic gel and methods of use thereof. The gel in the present invention can be applied on heavy (5) as well as moderate wounds caused by bullets (1), laceration (2), stab (3), and IED (4) (Improvised Explosive Device). The invention provides only hemostatic solution that can be used on multiple injuries and can be stored for later use. The present invention provides Chitosan based hemostatic gel which stops bleeding from wounds within 2-3 minutes of application. The Gel is effective at treating burns and promoting faster wound healing composed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The gel is composed to cater to bleeding injuries in all scenarios.
The present invention relates to the field of medical bio polymer and material science. More particularly, the present invention provides a Defender Blood Seal chitosan based gel composition and a method of use thereof.
Even more particularly, the present invention is designed specifically to cater heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The said gel is designed to cater to bleeding injuries in all scenarios, it stops bleeding within 2-3 min of application.
Background of the invention:
Various hemostatic gels have been invented in the field of medicine for the immediate treatment of the injured person.
The main reason for uncontrollable big bleeding is war, traffic accident and other accident deaths. It develops in the short time. The emergency survival hemostatic material of hemostasis, can be effectively reduced death caused by bleeding. Traditional hemostasis cotton yarn, bandage etc. is not for the haemostatic effect of the wounds such as regular shape, deep, narrow, arteriorrhexis is very unsatisfactory; although styptic powder is applicable in excellent wound Property, but easily enter blood obstruction distal aorta and flow to form thrombus. Therefore, there is a need of application on site with clinical emergency treatment, quickly, safe and efficient hemostatic material replaces traditional hemostatic material.
Chitosan is a kind of natural biological polysaccharide generated after chitin is deacetylated, is that the unique alkalinity of nature is more so far Sugar, natural resources very abundant. Due to excellent biocompatibility, broad spectrum bacterial, hemostasis wound healing promoting effect, and it is biodegradable safe and non-toxic, it is widely used in the fields such as medicine, food, bioengineering. Alginate is brown from ocean a kind of algal polysaccharides extracted in algae, it is nontoxic, and there are good biological degradability and compatibility. Stop blooding since it has, is anti-tumor, Immunological regulation, anti-oxidant, lipidemia, reduce blood glucose, it is anti-radiation the
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effects of, have been developed that into Medical coating in biomedicine field. The materials such as material, cartilage tissue engineered reparation, medicine sustained and controlled release carrier, protein and DNA carrier. It is contacted with wound fluid When, with the sodium ion in body fluid ion exchange can occur for the calcium ion in alginate, make it have good hygroscopicity and at colloidality energy. The liquid of 20 times or more oneself volumes can be absorbed in alginate and the exudate of wound can be absorbed, and reduces microorganism. When alginate material is used to contact wound surface, its phase interaction between wound With meeting forms one layer of stable network gel in wound surface, can keep certain humidity, be maintained at wound surface temperature 37 DEG C or so, be conducive to the formation of granulation tissue and reinforce the function of macrophage, mitigate pain and decompose necrotic tissue, provides The preferable healing environment of wound.
The immediate care required for the treatment of wounds is to stop the bleeding and to protect the wound from microbial infection. This remains a challenge because of the complexity development of products which should be quick and fast acting, without creating any inflammation. Chitosan based gel and wound dressing has attracted much of the attention because of its potential biological properties. Particularly, Chitosan based haemostatic gel. Some of them are discussed here.
Reference has been made to patent no. US6150581 by United States Surgical Corporation dated 1995.07.06. titled, “Chitosan/alginate anti-adhesion barrier”. The present invention relates to Chitosan/alginate post-surgical anti-adhesion barriers, methods of preventing post-surgical adhesions, and methods and devices for forming post-surgical anti-adhesion barriers are provided. An aqueous solution of chitosan and a complexing agent, and an aqueous solution of alginate are combined to form an anti-adhesion barrier at a site of surgical intervention. A medicinal agent may optionally be incorporated.
Reference has been made to patent no. CN101791425B by Zhao Xuelin dated 2010-03-30 titled, “Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof”. The invention relates
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to an antibacterial heal-promoting gel material used for preparing medical wound dressing and a preparation method thereof. The antibacterial heal-promoting gel material used for preparing the medical wound dressing is characterized in that the antibacterial heal-promoting gel material comprises natural gel agents, chitosan, bioactive materials, soluble silver salt and organic acids, water is added into the ingredients, the water content accounts for 5 to 20 times of the weight sum of the natural gel agents and the chitosan, and then, the antibacterial heal-promoting gel material of any forms can be obtained through cross-linked curing and after treatment. The antibacterial heal-promoting gel material is metered according to dry basis, and is prepared form the following ingredients in percentage by weight:57 to 90.9 percent of natural gel agents, 5 to 25 percent of bioactive materials, 2 to 8 percent of chitosan, 0.1 to 2 of soluble silver salt and 2 to 8 percent of organic acids. The antibacterial heal-promoting gel material has good biocompatibility, good antibiotic property, strong tissue regeneration promoting capacity and various forms, and can be easily and conveniently prepared into the medical wound dressing.
Reference has been made to patent no. CA2712527C by Igloo Zone Chile SL Gynopharm SA dated 2008-01-18 titled, “Chitosan gel for dermatological use, production method and use of same”. The invention relates to pharmaceutical compositions designed to leave a protective film on the skin, comprising chitosan and agents conferring curative, calming and hydrating properties on irritated skin. The gel is characterized in that it includes between 2 and 8 % chitosan and pre-defined proportions of other components such as between 0.1 and 90% Portulaca and between 0.1 and 45% Panthenol, which confer improved therapeutic characteristics on the product, and other components which provide the gel with particular characteristics and render same suitably stable over a prolonged period of time. Said gel is applied externally and is suitable for use on irritated skin, superficial burns, dermabrasions, post-dermabrasion, post-laser treatment and on eroded skin in general.
Reference has been made to patent no. WO2018005145A1 by Victor Matthew Phillips dated 2016-06-28 titled, “Flowable hemostatic gel composition and its methods of use”. The present invention relates a flowable hemostatic gel composition is provided for use at a site of a defect within a biological tissue. The
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flowable hemostatic gel composition includes a flowable gel solution that includes a biopolymer dissolved in a first solvent. The biopolymer is configured to cross- link with red blood cells at the site to facilitate clot formation at the site. The flowable hemostatic gel composition also includes at least one additional active agent.
Reference has been made to US patent no. US20180110897A1 by Tricol Biomedical Inc. dated 2015-04-10 titled, “Bioadhesive chitosan gel for controlling bleeding and for promoting healing with scar reduction without obscuring or interfering with access to a surgical field”. The present invention provides aqueous chitosan gel system of novel non-scarring, non-interfering, transparent, stable, solubilized chitosan that controls bleeding is described herein. The aqueous chitosan gel system can comprise water, chitosan, an acid, a plasticizer, a rheology modifying agent, an antioxidant stabilizer, an alcohol, and a multi-valent salt. Additional components of the aqueous chitosan gel system can comprise a bifunctional organic acid, a tnfunctional organic acid, a multi-functional organic acid, a phosphoric acid, a polyphosphoric acid and a salt.
Reference has been made to patent no. CN101053669B by Ocean University of China dated 2007-05-22 titled, “Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application”. The present invention relates to preparation method of water soluble chitosan group stanch wound sponge, which is characterized in dissolving water soluble chitosan derivatives in water, preparing 1%-10% weight percentage concentration of uniform colloid solution; subpackaging the colloid solution in mould, freezing in vacuum freeze drier at -20--60 DEG C, vacuum freeze drying 24-60 hours. The water soluble chitosan group stanch wound sponge of the invention is used for stanching and boosting wound healing of clinical operation, has advantages of convenient using, great mount of absorption solution, firm adhesion, better exerting function locally; selected material absorb water gradually to form gel in physiology pH condition during preparation, products have good local pasting property, exert stanching and boosting wound healing function so much the better; and products without immunogenicity in body, short degradation time, good compatibility with living body, better safety performance of clinic.
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Reference has been made to US patent no. US8269058B2 by Hem Con Medical Tech Inc. dated 2002-06-14 titled, “Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan”. The invention is generally directed to tissue dressings applied on a site of tissue injury, or tissue trauma, or tissue access to ameliorate bleeding, fluid seepage or weeping, or other forms of fluid loss, as well as provide a protective covering over the site.
Reference has been made to patent no. CN105617451A by Suzhou Baker Biological Technology Co., Ltd. dated 2016-02-29 titled, “Chitosan-based hemostatic material and preparation method thereof”. The present invention relates to chitosan-based hemostatic material and a preparation method thereof. The chitosan-based hemostatic material is prepared from, by mass, 20-40 parts of chitosan, 8-12 parts of corn starch, 1-5 parts of whey protein, 2-5 parts of wheat starch, 1-5 parts of glucose, 2-5 parts of sodium alginate, 2-10 parts of pectin, 1-4 parts of lecithin, 1-4 parts of citric acid, 1-3 parts of sodium fumarate, 1-4 parts of sodium chloride and 8-15 parts of polyhydric alcohol, wherein polyhydric alcohol adopts ethanol or glycerol, and preferably, 2-6 parts of vitamin C and 1-3 parts of vitamin E are included. The chitosan-based hemostatic material has the advantages that the excellent anti-bacterial, hemostatic and analgesic effects are achieved, defective tissue repairing can be facilitated, the anti-adhesive effect is good, the biocompatibility is achieved, the safety are good, the antigenicity does not exist, use is safe, the preparation method is simple, and use is convenient.
Reference has been made to patent no. US10159762B2 by Columbia University of New York, Yes Inc dated 2011-09-26 titled, “Hemostatic compositions and dressings for bleeding”. The present invention hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita), the leaves of dioecious nettle (Urtica dioica), kaolin, chitosan, fibrinogen and thrombin. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with superior and broad spectrum hemostatic capabilities, including the ability to arrest arterial hemorrhage. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses
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useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile, nettle, kaolin, chitosan, fibrinogen and thrombin components is applied to a textile or fabric material, for example a non-woven viscose.
Reference has been made to patent no. CN110448714A by Nantong University dated 2019-09-23 titled, “A kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing and preparation method”. The invention belongs to medical products technical fields, are related to the antibacterial chitosan of a kind of moisture absorption/sodium alginate intertexture type dressing and preparation method thereof. The invention discloses a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing preparation methods, chitosan solution is first lyophilized into chitosan foam-like timbering material, then sodium alginate solution is spread over into chitosan foam-like timbering material surface, infiltrate through sodium alginate solution in the porous structure of chitosan stent, cross-linking reaction in calcium chloride solution is immersed after freeze-drying again, obtains chitosan/sodium alginate intertexture type dressing. The chitosan that preparation method of the present invention obtains/sodium alginate intertexture type dressing can effectively absorb wound extract and inhibit bacterial growth, and entire dressing is easily removed.
However, none of the above discussed inventions provides Chitosan
based haemostatic gel composition and methods of use thereof as of our
present invention. The present invention is composed specifically to cater
heavy bleeding injuries that may be sustained by soldiers, policemen,
security forces personnel, as well as road accident victims,
haemophiliacs, household injuries, etc. The gel is composed to cater to bleeding injuries in all scenarios which stop bleeding within 2-3 min of application.
Objectives of the invention:
The main objective of the present invention is to provide Chitosan based hemostatic gel composition and methods of use thereof.
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Another objective of the present invention is to provide chitosan based hemostatic (blood clotting) gel that is composed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The gel is designed to cater to bleeding injuries in all scenarios.
Another objective of the present invention is to provide gel that stops bleeding from wounds within 2-3 minutes of application.
Another objective of the present invention is to provide is packaged gel in the form 30 gm. of tubes that can cater to 4-5 heavy bleeding injures, such as gunshot wounds, lacerations, IED blast injuries, splinter wounds, blunt trauma, arterial bleeding injuries, etc.
Another objective of the present invention is to provide only haemostatic solution that can be used on multiple injuries and can be stored for later use.
Another objective of the present invention is to provide gel for extremely heavy bleeding injuries, wherein the gel can be spread on non-adherent gauzes provided with each tube wherein gauzes can be pressed on the wound or packed inside the wound, allowing the gel to reach the innermost part of the wound from where the bleeding is occurring.
Another objective of the present invention is to provide gel which is effective at treating burns and promoting faster wound healing.
Another objective of the present invention is to provide methods of use.
Summary of the invention:
The present invention provides Chitosan based hemostatic gel and methods of use thereof. Chitosan based hemostatic (blood clotting) gel that is designed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The gel is designed to cater to bleeding injuries in all scenarios within 3 minutes of application.
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The packaged gel in the form 30 gm. of tubes that can cater to 4-5 heavy bleeding injures, such as gunshot wounds, lacerations, IED blast injuries, splinter wounds, blunt trauma, arterial bleeding injuries, etc. It provides only hemostatic solution that can be used on multiple injuries and can be stored for later use. The present invention provides a gel which is even effective at treating burns and promoting faster wound healing.
Statement of the invention:
The present invention provides Chitosan based hemostatic gel and methods of use thereof. The present invention provides Chitosan based hemostatic gel comprises of components; Chitosan, Acetic Acid, Anhydrous Calcium Chloride, Sodium Alginate, Water- Q.S. (quantity sufficient). The gel can be used for moderate wounds and heavy bleeding wounds as well. Chitosan based hemostatic (blood clotting) gel is designed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The gel is designed to cater to bleeding injuries in all scenarios within 3 minutes of application. The packaged gel in the form 30 gm. of tubes can cater to 4-5 heavy bleeding. For extremely heavy bleeding injuries, the gel can be spread on non-adherent gauzes provided with each tube. These gauzes can be pressed on the wound or packed inside the wound, allowing the gel to reach the innermost part of the wound from where the bleeding is occurring.
The gel is also effective at treating burns and promoting faster wound healing. The gel present in the invention save life by clotting blood immediately and stabilize injured even during 8-10 hour long evacuation period.
Brief Description of drawings:
Figure 1, shows application of gel on heavy bleeding wounds
Figure 2, shows various types of wounds caused by bullets (1), laceration (2),
Stab (3) and IED (4).
Figure 3, shows that for stab injury, involving a medium length cut, and the gel is spread on the pad.
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Figure 4, shows pressing the side of gel application Pad with gel on it over the wound.
Figure 5, shows covering the wound for 2-3 minutes, once the bleeding stops, remove the pad.
Figure 6, shows image of packed gel in 30 gm. and 10gm. tube.
Detailed description of the invention:
It should be noted that the particular description and embodiments set forth in the specification below are merely exemplary of the wide variety and arrangement of instructions which can be employed with the present invention. The present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. All the features disclosed in this specification may be replaced by similar other or alternative features performing similar or same or equivalent purposes. Thus, unless expressly stated otherwise, they all are within the scope of present invention. Various modifications or substitutions are also possible without departing from the scope or spirit of the present invention. Therefore, it is to be understood that this specification has been described by way of the most preferred embodiments and for the purposes of illustration and not limitation. Throughout this specification the word “comprise” or variations such as “comprises or comprising”, will be understood to imply the inclusions of a stated element, integer or step, or group of elements, integers or steps, but not the exclusions of any other element, integer or step or group of elements, integers or steps.
The present invention provides Chitosan based hemostatic gel and methods of use thereof. The present invention provides Chitosan based hemostatic gel comprises of components; Chitosan, Acetic Acid, Anhydrous Calcium Chloride, Sodium Alginate, Water- Q.S. (quantity sufficient). The gel in the present invention can be applied on heavy as well as moderate wounds caused by bullets (1), laceration (2), stab (3), and IED (4) (Improvised Explosive Device). The gel present invention is chitosan based hemostatic (blood clotting) gel that stops bleeding from wounds within 3 minutes of application. It is designed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs,
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household injuries, etc. The gel is designed to cater to bleeding injuries in all scenarios.
The gel is packaged in the form of tubes. A 30 gm. tube (6) of gel can cater to 4-5 heavy bleeding injures, such as gunshot wounds, lacerations, IED blast injuries, splinter wounds, blunt trauma, arterial bleeding injuries, etc.
One simply needs to apply required amount of gel on the bleeding wound and allow it 2-3 minutes to stop the bleeding. The remaining amount of gel is stored in the tube for later use. It is the only haemostatic solution on the market that can be used on multiple injuries and can be stored for later use. All other haemostatic agents on the market are one time use only, i.e. once their packaging is opened, they have to be used and disposed of.
For extremely heavy bleeding injuries, the gel can be spread on non-adherent gauzes provided with each tube. These gauzes can be pressed on the wound or packed inside the wound, allowing the gel to reach the innermost part of the wound from where the bleeding is occurring. The gel has also been found effective at treating burns and promoting faster wound healing.
In another embodiment, the preferred method of application of said chitosan based gel of the present invention comprises following steps:
1. For heavy bleeding wounds, gel is applied on single non-adherent gauze, in the shape of the wound.
2. For stab injury, involving a medium length cut, the gel is spread on the pad as shown in figure 3.
3. Pressing the side of gel application Pad with gel on it over the wound and after 2-3 minutes the pad is removed once the wound stops bleeding.
In an exemplary embodiment, the present invention provides Chitosan based hemostatic gel comprises of components; Chitosan, Acetic Acid, Anhydrous Calcium Chloride, Sodium Alginate, Water- Q.S.
a) Chitosan: Chitosan has been shown to be a potential biomaterial to be used in wound healing due to its anti-inflammatory and antibacterial nature. Effective dressings should have characteristics optimized for a
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particular type of wound at a reasonable low cost and with minimum
inconvenience to patients. There is need to manipulate the physical
properties of identified systems to achieve such objectives. Chitosan with
excellent properties like biodegradability, bio-compatibility, and non-
toxicity has proven to be remarkable product for preparation of dressings
for bleeding, burning wounds. It is a kind of natural biological
polysaccharide generated after chitin is de-acetylated, is that the unique
alkalinity of nature is more so far sugar, natural resources very
abundant. Due to excellent biocompatibility, broad spectrum
antibacterial, hemostasis wound healing promoting effect, and it is biodegradable safe and non-toxic, it is widely used in the fields such as medicine, food, and bioengineering. Chitosan with excellent properties like biodegradability, bio-compatibility, and non-toxicity has proven to be remarkable product for preparation of dressings for bleeding, burning wounds.
b) Sodium alginate: It is water soluble sodium salt of alginic acid. Alginic
acid is a linear unbranched copolymer composed of D-mannuronic acid
(M) and L-guluronic acid (G). The M and G monomers are 1, 4 linked by
glycosidic bonds, forming homopolymeric M or G blocks and
heteropolymeric MG blocks. The functional properties of alginate are strongly associated with the composition and sequence of M and G acids. Alginates polyanionic character is a result of carboxyl groups along its polymeric chain. Every sugar on the chain contains a carboxyl group. The degree of ionization of carboxyl groups is a function of pH and decreases as the pH decreases. Alginate maintains a negative charge under acidic conditions which is ideal for forming complexes with polyvalent cations such as chitosan, calcium, or aluminum. The cations act as bridges between the anionic polymer chains, constituting junction zones, forming a hydrogel network. Advantages of using sodium alginate include the ability to encapsulate lipophilic drugs, utilized in a multiplicity of techniques, high stability, simplicity, non-toxicity, biocompatibility, and low cost. Also, alginate has the highest mucoadhesive strength compared to other natural and synthetic polymers. Drawbacks of use are that the
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porous structure without addition of membrane coating to reduce permeability as well as the low viscosity of alginate solutions cause lack of mechanical and physical stability. Therefore, the use of alginate is limited due to its low physical stability and subsequent degradation at acidic pH ranges causing faster release of entrapped active ingredients.
c) Calcium chloride: It plays a key role in nanoparticle synthesis in the pre-gelation step. Calcium chloride is a commonly used cross-linker that interacts with G blocks of alginate due to structurally favorable chelation sites to form insoluble meshwork pre-gels.
In yet another embodiment of the present invention the Chitosan is used as active ingredient in the said gel.
In yet another embodiment of the present invention the Acetic Acid, Anhydrous Calcium Chloride, Sodium Alginate and Water is used as Gel base.
In another exemplary embodiment, the gel is designed specifically to cater to heavy bleeding injuries that may be sustained by soldiers, policemen, security forces personnel, as well as road accident victims, hemophiliacs, household injuries, etc. The gel is designed to cater to bleeding injuries in all scenarios.
In another exemplary embodiment, the gel stops bleeding from wounds within 2-3 minutes of application.
In another exemplary embodiment, the invention provide packaged gel in the form 30 gm. of tubes that can cater to 4-5 heavy bleeding injures, such as gunshot wounds, lacerations, IED blast injuries, splinter wounds, blunt trauma, arterial bleeding injuries, etc.
In another exemplary embodiment the invention provide only hemostatic solution that can be used on multiple injuries and can be stored for later use.
In another exemplary embodiment, it provides gel for extremely heavy bleeding injuries, wherein the gel can be spread on non-adherent gauzes provided with each tube; wherein gauzes can be pressed on the wound or packed inside the wound, allowing the gel to reach the innermost part of the wound from where bleeding is occurring.
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In another exemplary embodiment, the invention is to provide gel which is effective at treating burns and promoting faster wound healing.
In another embodiment, the preferred method of preparation of said chitosan based gel comprises of following steps:
1. Chitosan is added in acetic acid solution and to be stirred until chitosan is completely dispersed in it;
2. Sodium Alginate is mix in water solution until it is dissolved and dispersed in water and calcium chloride was mixed into it under continuous ultrasonication. The whole dispersion was mixed until completely dispersed and to form gel, and placed on 60 ºC -70 ºC of water-bath and is heated,
3. mix step (1) into step (2) until proper mixing followed by filling, sterilizing is carried out after standing defoaming, then carried out sterility test, after qualified.
Example:
The following examples are for the purpose of illustration only and should not be construed to limit and the scope of the present invention.
EXAMPLE 1:
Table 1: Formulation of said chitosan based gel contains:
S. No. Components Quantity in % from Quantity in % till
1. Chitosan 3 5
2. Acetic Acid 0.50 0.75
3. Anhydrous Calcium Chloride 0.20 0.25
4. Sodium Alginate 0.3 0.5
5. Water q.s q.s
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In Table 1, if a product is made of A, B, C and D ingredient then the amount used may be in the range of A = 1 – 100 %, B = 1 – 100 %, C = 1 – 100 % and D = 1-100%, respectively.
EXAMPLE 2
Table 2: The exact amount of the ingredients used, in the lab during experimentations of the invention, to prepare invented product / composition– Each gm. of 30gm. tube containing said chitosan based gel contains:
S. No. Components Weight % (Each gm contains)
1. Chitosan 5
2. Acetic Acid 0.75
3. Anhydrous Calcium Chloride 0.25
4. Sodium Alginate 0.5
5. Water Q.S.
While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications may be made without departing from this invention in its broader aspects and, therefore, the aim in the present invention is to cover all such changes and modifications as fall within the true spirit and scope of this invention.
Advantages of the invention:
1. The invention provides Chitosan based hemostatic gel.
2. Stops bleeding within 2-3 minutes of use.
3. Reusable
4. Immediate blood clotting and stabilization of injuries.
5. Effective at treating burns and promoting faster wound healing.
We Claim:
1.A chitosan based hemostatic gel composition and a method of use thereof,
said composition is comprises of ingredients in range:
a. Chitosan: 3-5% w/w
b. Acetic Acid- 0.5-0.75% w/v
c. Anhydrous Calcium Chloride- 0.20-0.25% w/w
d. Sodium Alginate-0.3-0.5% w/w
e. Water- Q.S.
Wherein, said composition is used for on-site/on-field, heavy bleeding injuries of any type; said chitosan gel being a hemostatic gel is able to stop bleeding from wounds of any type within 2-3 minutes of application.
2. The chitosan-based gel as claimed in claim 1; wherein said gel provides hemostatic solution that can be used on multiple injuries, effective at treating burns and promoting faster wound healing and can be stored for later use for long periods of time.
3. The chitosan-based gel as claimed in claim 1; wherein it is designed to cater to bleeding injuries in all scenarios.
4. The chitosan-based gel as claimed in claim 1; wherein it stops blood-flow by clotting blood immediately and stabilizes injuries even during 8-10 hour long evacuation/travel period to hospital.
5. The chitosan based gel as claimed in claim 1; wherein said gel is cost-effective with minimum inconvenience to patients.
| # | Name | Date |
|---|---|---|
| 1 | 202011056172-STATEMENT OF UNDERTAKING (FORM 3) [23-12-2020(online)].pdf | 2020-12-23 |
| 2 | 202011056172-PROVISIONAL SPECIFICATION [23-12-2020(online)].pdf | 2020-12-23 |
| 3 | 202011056172-FORM FOR STARTUP [23-12-2020(online)].pdf | 2020-12-23 |
| 4 | 202011056172-FORM FOR SMALL ENTITY(FORM-28) [23-12-2020(online)].pdf | 2020-12-23 |
| 5 | 202011056172-FORM 1 [23-12-2020(online)].pdf | 2020-12-23 |
| 6 | 202011056172-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [23-12-2020(online)].pdf | 2020-12-23 |
| 7 | 202011056172-EVIDENCE FOR REGISTRATION UNDER SSI [23-12-2020(online)].pdf | 2020-12-23 |
| 8 | 202011056172-DRAWINGS [23-12-2020(online)].pdf | 2020-12-23 |
| 9 | 202011056172-DECLARATION OF INVENTORSHIP (FORM 5) [23-12-2020(online)].pdf | 2020-12-23 |
| 10 | 202011056172-Proof of Right [04-01-2021(online)].pdf | 2021-01-04 |
| 11 | 202011056172-FORM-26 [04-01-2021(online)].pdf | 2021-01-04 |
| 12 | 202011056172-DRAWING [05-07-2021(online)].pdf | 2021-07-05 |
| 13 | 202011056172-COMPLETE SPECIFICATION [05-07-2021(online)].pdf | 2021-07-05 |
| 14 | 202011056172-Proof of Right [26-07-2021(online)].pdf | 2021-07-26 |
| 15 | 202011056172-FORM-26 [26-07-2021(online)].pdf | 2021-07-26 |
| 16 | 202011056172-Power of Attorney-230721.pdf | 2021-10-19 |
| 17 | 202011056172-OTHERS-010121.pdf | 2021-10-19 |
| 18 | 202011056172-OTHERS-230721.pdf | 2021-11-30 |