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“Clinical Diagnosis Of Hepatic Fibrosis Using A Novel Panel Of Low Abundant Human Plasma Protein Biomarkers”
Abstract: The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha- 1 -antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46 - 5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2- glycoprotein. These biomarkers can be used in conjunction with polypeptides in WO/2008/031051. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers.
Notices, Deadlines & Correspondence
Patent Information
Applicants
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Inventors
1. DWEK Raymond A.
2. GANGADHARAN Bevin
3. ZITZMANN Nicole
Specification
PLEASE SEE THE SPECIFICATION ATTACHED.
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 8623-CHENP-2011-AbandonedLetter.pdf | 2018-04-23 |
| 1 | Form5_As Filed_23-11-2011.pdf | 2011-11-23 |
| 2 | 8623-CHENP-2011-FER.pdf | 2017-10-04 |
| 2 | Form3_As Filed_23-11-2011.pdf | 2011-11-23 |
| 3 | Form2 Title Page_Complete_23-11-2011.pdf | 2011-11-23 |
| 3 | Correspondence by Agent_Form3_17-03-2015.pdf | 2015-03-17 |
| 4 | Form3_After Filing_17-03-2015.pdf | 2015-03-17 |
| 4 | Drawing_As Filed_23-11-2011.pdf | 2011-11-23 |
| 5 | Correspondence by Agent_Notarized Assignment_25-11-2011.pdf | 2011-11-25 |
| 5 | Correspondence by Agent_Form18_17-04-2013.pdf | 2013-04-17 |
| 6 | Correspondence by Agent_Form3_17-04-2013.pdf | 2013-04-17 |
| 6 | Assignment_After Filing_25-11-2011.pdf | 2011-11-25 |
| 7 | Form3_After Filing_17-04-2013.pdf | 2013-04-17 |
| 7 | Form26_Power of Attorney_25-01-2012.pdf | 2012-01-25 |
| 8 | Correspondence by Agent_PA_25-01-2012.pdf | 2012-01-25 |
| 8 | Correspondence by Agent_Form3_29-03-2012.pdf | 2012-03-29 |
| 9 | Form2 Title Page_Complete_01-02-2012.pdf | 2012-02-01 |
| 9 | Form3_After Filing_29-03-2012.pdf | 2012-03-29 |
| 10 | Correspondence by Agent_Form13_01-02-2012.pdf | 2012-02-01 |
| 10 | Form1_After Filing_01-02-2012.pdf | 2012-02-01 |
| 11 | Form13_Address of service Change_01-02-2012.pdf | 2012-02-01 |
| 12 | Correspondence by Agent_Form13_01-02-2012.pdf | 2012-02-01 |
| 12 | Form1_After Filing_01-02-2012.pdf | 2012-02-01 |
| 13 | Form2 Title Page_Complete_01-02-2012.pdf | 2012-02-01 |
| 13 | Form3_After Filing_29-03-2012.pdf | 2012-03-29 |
| 14 | Correspondence by Agent_Form3_29-03-2012.pdf | 2012-03-29 |
| 14 | Correspondence by Agent_PA_25-01-2012.pdf | 2012-01-25 |
| 15 | Form26_Power of Attorney_25-01-2012.pdf | 2012-01-25 |
| 15 | Form3_After Filing_17-04-2013.pdf | 2013-04-17 |
| 16 | Assignment_After Filing_25-11-2011.pdf | 2011-11-25 |
| 16 | Correspondence by Agent_Form3_17-04-2013.pdf | 2013-04-17 |
| 17 | Correspondence by Agent_Form18_17-04-2013.pdf | 2013-04-17 |
| 17 | Correspondence by Agent_Notarized Assignment_25-11-2011.pdf | 2011-11-25 |
| 18 | Drawing_As Filed_23-11-2011.pdf | 2011-11-23 |
| 18 | Form3_After Filing_17-03-2015.pdf | 2015-03-17 |
| 19 | Form2 Title Page_Complete_23-11-2011.pdf | 2011-11-23 |
| 19 | Correspondence by Agent_Form3_17-03-2015.pdf | 2015-03-17 |
| 20 | Form3_As Filed_23-11-2011.pdf | 2011-11-23 |
| 20 | 8623-CHENP-2011-FER.pdf | 2017-10-04 |
| 21 | Form5_As Filed_23-11-2011.pdf | 2011-11-23 |
| 21 | 8623-CHENP-2011-AbandonedLetter.pdf | 2018-04-23 |
Search Strategy
| 1 | 8623-CHENP-2011(1)_04-10-2017.pdf |