I/We claim:
1. A clinical sample storage cassette (100, 200, 300, 400) comprising:
a top layer (102) comprising a first side (102a) to receive a clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104).
2. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (104) comprises a sample inlet port (302, 401) for introduction of the clinical sample into the clinical sample storage cassette (100, 200, 300, 400) and wherein the sample inlet port (302, 401) extends from the first side (102a) to the second side (102b) of the top layer (102).
3. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) comprises a plurality of sub-distributor layers (402), wherein the plurality of sub-distributor layers (402) comprises:
a top-most sub-distributor layer (402a) having the first distributor side (106a) coupled to the second side (102b) of the top layer (102);
a bottom-most sub-distributor layer (402n) having the second distributor side (106b) coupled to the storage membrane (104); and
a plurality of intermediate layers disposed between the top-most sub-distributor layer (402a) and the bottom-most sub-distributor layer (402n).
4. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 3, wherein each of the plurality of sub-distributor layers (402) comprises distributor ports (404).
5. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 4, wherein a number of distributor ports from the top-most sub-distributor layer (402a), through each of the plurality of intermediate layers, and to the bottom-most sub-distributor layer (402n) increases exponentially by an even power of 2.
6. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 4, wherein the top-most sub-distributor layer (402a) comprises 2 distributor ports and the bottom-most sub-distributor layer (402n) comprises 16 distributor ports.
7. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) is porous.
8. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (102) is fabricated from acrylic plastic.
9. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) is fabricated from one of glass fibers and acrylic plastic.
10. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (102), the distributor layer (106), and the storage membrane (104) are coupled to each other by a Pressure Sensitive Adhesive (PSA) tape.
11. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) comprises a fluid channel (204), wherein the fluid channel (204) comprises:
a main channel (204a) to receive the clinical sample from the top layer (102); and
a plurality of sub-channels (204b) extending away from the main channel (204a) to receive the clinical sample from the main channel (204a).
12. An assembly (500) for storage of clinical sample comprising:
a clinical sample storage cassette (100, 200, 300, 400) comprising:
a top layer (102) comprising a first side (102a) to receive a clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104); and
a container (502) to hold the clinical sample storage cassette (100, 200, 300, 400); and
a desiccant pack (504) provided within the container (502) to dry the storage membrane (104).
13. The assembly (500) as claimed in claim 12, wherein the distributor layer (106)
comprises a plurality of sub-distributor layers (402), wherein the plurality of sub¬
distributor layers (402) comprises:
a top-most sub-distributor layer (402a) having the first distributor side (106a) coupled to the second side (102b) of the top layer (102);
a bottom-most sub-distributor layer (402n) having the second distributor side (106b) coupled to the storage membrane (104); and
a plurality of intermediate layers disposed between the top-most sub-distributor layer (402a) and the bottom-most sub-distributor layer (402n).
14. The assembly (500) as claimed in claim 12, wherein the distributor layer (106)
comprises a fluid channel (204), wherein the fluid channel (204) comprises:
a main channel (204a) to receive the clinical sample from the top layer (102); and
a plurality of sub-channels (204b) extending away from the main channel (204a) to receive the clinical sample from the main channel (204a).
15. The assembly (500) as claimed in claim 12, wherein the container (502) is a centrifuge tube.
16. A method for collection and analysis of clinical sample comprising:
receiving by a clinical sample storage cassette (100, 200, 300, 400) the clinical sample, wherein the clinical sample storage cassette (100, 200, 300, 400) is held in a container (502), wherein the clinical sample storage cassette (100, 200, 300, 400) comprises:
a top layer (102) comprising a first side (102a) to receive the clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104);
drying the storage membrane (104) by a desiccant pack (504) provided within the container (502);
receiving by the container (502) an elution buffer; centrifuging the container (502) to extract the clinical sample from the storage membrane (104) to obtain a remnant fluid comprising a mixture of the elution buffer and the clinical sample; and
providing the remnant fluid for analysis.