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Clinical Sample Storage Cassettes

Abstract: A clinical sample storage cassette and an assembly comprising the clinical sample storage cassette is provided. The clinical sample storage cassette can comprise a top layer (102), a distributor layer (106), and a storage membrane (104). The top layer can comprise a first side (102a) to receive a clinical sample and a second side (102b) coupled with a distributor layer. The distributor layer (106) is to receive the clinical sample from the top layer. The distributor layer can comprise a first distributor side (106a) coupled to the second side and a second distributor side (106b) coupled to the storage membrane to transfer the clinical sample to the storage membrane. The distributor layer and the storage membrane can have different flow rates of the clinical sample to allow for uniform flow and storage of the clinical sample on the storage membrane.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
04 May 2020
Publication Number
24/2020
Publication Type
INA
Invention Field
BIO-MEDICAL ENGINEERING
Status
Email
IPRDEL@LAKSHMISRI.COM
Parent Application
Patent Number
Legal Status
Grant Date
2023-07-31
Renewal Date

Applicants

INDIAN INSTITUTE OF SCIENCE
Office of Intellectual Property and Technology Licensing, Bangalore

Inventors

1. TOLEY, Bhushan Jayant
DV005 Vijnanpura IISc Residential Campus, ISRO Road Bangalore 560094

Specification

I/We claim:
1. A clinical sample storage cassette (100, 200, 300, 400) comprising:
a top layer (102) comprising a first side (102a) to receive a clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104).
2. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (104) comprises a sample inlet port (302, 401) for introduction of the clinical sample into the clinical sample storage cassette (100, 200, 300, 400) and wherein the sample inlet port (302, 401) extends from the first side (102a) to the second side (102b) of the top layer (102).
3. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) comprises a plurality of sub-distributor layers (402), wherein the plurality of sub-distributor layers (402) comprises:
a top-most sub-distributor layer (402a) having the first distributor side (106a) coupled to the second side (102b) of the top layer (102);

a bottom-most sub-distributor layer (402n) having the second distributor side (106b) coupled to the storage membrane (104); and
a plurality of intermediate layers disposed between the top-most sub-distributor layer (402a) and the bottom-most sub-distributor layer (402n).
4. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 3, wherein each of the plurality of sub-distributor layers (402) comprises distributor ports (404).
5. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 4, wherein a number of distributor ports from the top-most sub-distributor layer (402a), through each of the plurality of intermediate layers, and to the bottom-most sub-distributor layer (402n) increases exponentially by an even power of 2.
6. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 4, wherein the top-most sub-distributor layer (402a) comprises 2 distributor ports and the bottom-most sub-distributor layer (402n) comprises 16 distributor ports.
7. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) is porous.
8. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (102) is fabricated from acrylic plastic.
9. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) is fabricated from one of glass fibers and acrylic plastic.

10. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the top layer (102), the distributor layer (106), and the storage membrane (104) are coupled to each other by a Pressure Sensitive Adhesive (PSA) tape.
11. The clinical sample storage cassette (100, 200, 300, 400) as claimed in claim 1, wherein the distributor layer (106) comprises a fluid channel (204), wherein the fluid channel (204) comprises:
a main channel (204a) to receive the clinical sample from the top layer (102); and
a plurality of sub-channels (204b) extending away from the main channel (204a) to receive the clinical sample from the main channel (204a).
12. An assembly (500) for storage of clinical sample comprising:
a clinical sample storage cassette (100, 200, 300, 400) comprising:
a top layer (102) comprising a first side (102a) to receive a clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104); and

a container (502) to hold the clinical sample storage cassette (100, 200, 300, 400); and
a desiccant pack (504) provided within the container (502) to dry the storage membrane (104).
13. The assembly (500) as claimed in claim 12, wherein the distributor layer (106)
comprises a plurality of sub-distributor layers (402), wherein the plurality of sub¬
distributor layers (402) comprises:
a top-most sub-distributor layer (402a) having the first distributor side (106a) coupled to the second side (102b) of the top layer (102);
a bottom-most sub-distributor layer (402n) having the second distributor side (106b) coupled to the storage membrane (104); and
a plurality of intermediate layers disposed between the top-most sub-distributor layer (402a) and the bottom-most sub-distributor layer (402n).
14. The assembly (500) as claimed in claim 12, wherein the distributor layer (106)
comprises a fluid channel (204), wherein the fluid channel (204) comprises:
a main channel (204a) to receive the clinical sample from the top layer (102); and
a plurality of sub-channels (204b) extending away from the main channel (204a) to receive the clinical sample from the main channel (204a).
15. The assembly (500) as claimed in claim 12, wherein the container (502) is a centrifuge tube.
16. A method for collection and analysis of clinical sample comprising:

receiving by a clinical sample storage cassette (100, 200, 300, 400) the clinical sample, wherein the clinical sample storage cassette (100, 200, 300, 400) is held in a container (502), wherein the clinical sample storage cassette (100, 200, 300, 400) comprises:
a top layer (102) comprising a first side (102a) to receive the clinical sample and a second side (102b) opposite to the first side to couple with a distributor layer (106);
the distributor layer (106) coupled to the top layer (102) to receive the clinical sample from the top layer (102), wherein the distributor layer (106) comprises a first distributor side (106a) coupled to the second side (102b) of the top layer (102) and a second distributor side (106b) coupled to a storage membrane (104) to transfer the clinical sample from top layer (102) to the storage membrane (104); and
the storage membrane (104) to receive the clinical sample from the distributor layer (106) and to store the clinical sample, wherein a flow rate of the clinical sample through the distributor layer (106) is greater than a flow rate of the clinical sample through the storage membrane (104) to allow for uniform distribution and storage of the clinical sample in the storage membrane (104);
drying the storage membrane (104) by a desiccant pack (504) provided within the container (502);
receiving by the container (502) an elution buffer; centrifuging the container (502) to extract the clinical sample from the storage membrane (104) to obtain a remnant fluid comprising a mixture of the elution buffer and the clinical sample; and
providing the remnant fluid for analysis.

Documents

Orders

Section Controller Decision Date

Application Documents

# Name Date
1 202047019005-IntimationOfGrant31-07-2023.pdf 2023-07-31
1 202047019005.pdf 2020-05-04
2 202047019005-PatentCertificate31-07-2023.pdf 2023-07-31
2 202047019005-STATEMENT OF UNDERTAKING (FORM 3) [04-05-2020(online)].pdf 2020-05-04
3 202047019005-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [04-05-2020(online)].pdf 2020-05-04
3 202047019005-Information under section 8(2) [19-07-2023(online)].pdf 2023-07-19
4 202047019005-PETITION UNDER RULE 137 [19-07-2023(online)].pdf 2023-07-19
4 202047019005-FORM 1 [04-05-2020(online)].pdf 2020-05-04
5 202047019005-Written submissions and relevant documents [19-07-2023(online)].pdf 2023-07-19
5 202047019005-DRAWINGS [04-05-2020(online)].pdf 2020-05-04
6 202047019005-DECLARATION OF INVENTORSHIP (FORM 5) [04-05-2020(online)].pdf 2020-05-04
6 202047019005-Correspondence to notify the Controller [20-04-2023(online)].pdf 2023-04-20
7 202047019005-US(14)-HearingNotice-(HearingDate-04-07-2023).pdf 2023-04-17
7 202047019005-COMPLETE SPECIFICATION [04-05-2020(online)].pdf 2020-05-04
8 202047019005-Response to office action [29-08-2022(online)].pdf 2022-08-29
8 202047019005-FORM-26 [15-07-2020(online)].pdf 2020-07-15
9 202047019005-FORM 3 [13-05-2022(online)].pdf 2022-05-13
9 202047019005-Proof of Right [04-11-2020(online)].pdf 2020-11-04
10 202047019005-FORM 3 [04-11-2020(online)].pdf 2020-11-04
10 202047019005-Information under section 8(2) [13-05-2022(online)].pdf 2022-05-13
11 202047019005-EDUCATIONAL INSTITUTION(S) [07-10-2021(online)].pdf 2021-10-07
11 202047019005-Response to office action [13-05-2022(online)].pdf 2022-05-13
12 202047019005-FORM 18A [11-11-2021(online)].pdf 2021-11-11
12 202047019005-FORM 3 [12-05-2022(online)].pdf 2022-05-12
13 202047019005-FER.pdf 2021-11-16
14 202047019005-FORM 18A [11-11-2021(online)].pdf 2021-11-11
14 202047019005-FORM 3 [12-05-2022(online)].pdf 2022-05-12
15 202047019005-EDUCATIONAL INSTITUTION(S) [07-10-2021(online)].pdf 2021-10-07
15 202047019005-Response to office action [13-05-2022(online)].pdf 2022-05-13
16 202047019005-FORM 3 [04-11-2020(online)].pdf 2020-11-04
16 202047019005-Information under section 8(2) [13-05-2022(online)].pdf 2022-05-13
17 202047019005-Proof of Right [04-11-2020(online)].pdf 2020-11-04
17 202047019005-FORM 3 [13-05-2022(online)].pdf 2022-05-13
18 202047019005-FORM-26 [15-07-2020(online)].pdf 2020-07-15
18 202047019005-Response to office action [29-08-2022(online)].pdf 2022-08-29
19 202047019005-US(14)-HearingNotice-(HearingDate-04-07-2023).pdf 2023-04-17
19 202047019005-COMPLETE SPECIFICATION [04-05-2020(online)].pdf 2020-05-04
20 202047019005-DECLARATION OF INVENTORSHIP (FORM 5) [04-05-2020(online)].pdf 2020-05-04
20 202047019005-Correspondence to notify the Controller [20-04-2023(online)].pdf 2023-04-20
21 202047019005-Written submissions and relevant documents [19-07-2023(online)].pdf 2023-07-19
21 202047019005-DRAWINGS [04-05-2020(online)].pdf 2020-05-04
22 202047019005-PETITION UNDER RULE 137 [19-07-2023(online)].pdf 2023-07-19
22 202047019005-FORM 1 [04-05-2020(online)].pdf 2020-05-04
23 202047019005-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [04-05-2020(online)].pdf 2020-05-04
23 202047019005-Information under section 8(2) [19-07-2023(online)].pdf 2023-07-19
24 202047019005-STATEMENT OF UNDERTAKING (FORM 3) [04-05-2020(online)].pdf 2020-05-04
24 202047019005-PatentCertificate31-07-2023.pdf 2023-07-31
25 202047019005-IntimationOfGrant31-07-2023.pdf 2023-07-31
25 202047019005.pdf 2020-05-04

Search Strategy

1 SearchHistory202047019005E_15-11-2021.pdf

ERegister / Renewals

3rd: 17 Oct 2023

From 13/11/2020 - To 13/11/2021

4th: 17 Oct 2023

From 13/11/2021 - To 13/11/2022

5th: 17 Oct 2023

From 13/11/2022 - To 13/11/2023

6th: 17 Oct 2023

From 13/11/2023 - To 13/11/2024

7th: 17 Oct 2023

From 13/11/2024 - To 13/11/2025

8th: 17 Oct 2023

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9th: 17 Oct 2023

From 13/11/2026 - To 13/11/2027

10th: 17 Oct 2023

From 13/11/2027 - To 13/11/2028